Journal of Medicine and Life Science

Institute for Medical Science (제주대학교 의과학연구소)
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Effect of active ingredients in the Citrus fruits on the proliferation of hepatocellular carcinoma cells

감귤 내 생리활성성분이 간암세포의 생존에 미치는 영향

  • Kim, Soo Jung (Department of Medicine, Jeju National University School of Medicine) ;
  • Park, Deok Bae (Laboratory of Histology, Jeju National University School of Medicine)
  • 김수정 (제주대학교 의학전문대학원 의학과) ;
  • 박덕배 (제주대학교 의학전문대학원 조직학교실)
  • Received : 2018.05.31
  • Accepted : 2018.06.12
  • Published : 2018.06.30
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Abstract

Previous studies have suggested that Citrus fruits might suppress the proliferation of various cancer cells. However, little is known about any specific ingredients in the extract of Citrus fruits to exert its anti-proliferative activity in cancer cells. The present study aimed to identify the active ingredients in Citrus fruits to suppress the proliferation of rat hepatocellular carcinoma cells. Among tested compounds, two polymethoxylated flavones (nobiletin and tangeritin) showed significant anti-proliferative activity whereas other compounds (synephrine, rutin, hesperidin) did not. Interestingly, nobiletin as well as tangeritin also decreased the protein amount of gluconeogenic enzymes, PEPCK and G6Pase. The possible involvement of gluconeogenic activity in the proliferation of hepatocellulacarcinoma cells are further to be investigated.

Keywords

References

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