• Korean Journal of Clinical Laboratory Science
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• v.51 no.1
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• pp.1-14
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• 2019

The names of medical technologist in Korea, Japan, and the United State of America vary depending on the medical system, educational system, and work areas. Conventionally, jobs equal or similar to medical technologist (commonly known as clinical laboratory technologist, medical laboratory technologist, clinical laboratory scientist, and medical laboratory scientist), histotechnologist, cytotechnologist, and genetic technologist. Jobs, such as extracorporeal technologist, medical electrophysiology technologist, and medical sonographer, allow other allied health professionals including medical technologists, to obtain their qualification. The work areas of medical technologists are classified into clinical pathologic technology, pathologic technology, clinical genetics technology, nuclear medicine in vitro technology, and clinical physiologic technology. New titles of Korean specialized medical technologists refer to certification systems, such as CLMJ, CMAJ, ASCP, IAC, ABRET, and ARMDS. Currently, there are eight types of specialized medical technologists under the cooperation of specialized academic societies. They are hematology, transfusionology, chemistry, immunology, microbiology, histology, cytology, nuclear medicine. It can be further divided into 20 categories according to the work areas such as mass spectrometry, infection control, Pathologists' Assistant, flow cytometry, HLA, cytogenetics, molecular genetics, cardiopulmonary physiology, neurophysiology (EEG/EMG/PSG/etc.), cardiac sonography, neurosonography (TCD/carotid), and medical device quality manager.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.2
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• pp.81-85
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• 2021

This study aims to report a case of oculomotor nerve palsy with mydriasis improved by Sa-Am acupuncture (大腸正格). The patient visited our clinic due to Right oculomotor nerve palsy with symptoms such as periocular pain, diplopia, vertigo, ptosis, eye adduction disorder, and mydriasis on November 11th, 2019. For the treatment, Sa-Am acupuncture (大腸正格) which used to give a significant effect on eye diseases and headaches and to remove toxins from the body was performed every time the patient visited the clinic. About a month after the treatment, ptosis disappeared, and eye adduction disorder also changed from -2 to 2 points, showing a significant improvement. Subjective symptoms such as vertigo, diplopia, and eye pain also significantly decreased from 13 to 4 points. At the second month of treatment, the eye adduction disorder improved to a normal level, and subjective ocular discomforts disappeared. The pupil size decreased from 5 mm to 2.5 mm. After 3-4 months from the start of treatment, most of the symptoms including the light reflex returned to normal. After a total of 32 acupunctures treatment, subjective symptoms such as periocular pain, diplopia and vertigo, as well as ptosis and eye adduction disorder disappeared, and the pupil size, including the light reflex, also improved to the normal level.

• Journal of Physiology & Pathology in Korean Medicine
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• v.36 no.4
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• pp.138-142
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• 2022

This study aimed to evaluate the effectiveness of Korean rehabilitation treatement for patients with post-TKR. The medical records of inpatients undergoing Korean rehabilitation treatment after TKR from 2016.01.01. to 2021.12.31. during the admission, were analyzed retrospectively. The effect of treatment was evaluated by using a numeric rating scale(NRS) and range of motion(ROM) of knee. Statistical analysis was done using the IBM SPSS statistics 26 program. If the period of hospitalization was within 7 days or change of NRS and ROM was not recorded properly, the case was excluded. All inpatients received acupuncture treatment, Electro-acupuncture. Soyeom pharmaco-acupuncture were used at a high rate. Blood letting cupping therapy, dry cupping therapy, Interferential Current Therapy(ICT) continuous passive motion(CPM), cryotherapy were used at a high rate. A significant improvement was noted when comparing the NRS and knee ROM results at the time of admission and discharge. Korean medical rehabilitation can be effectively used for patients who have undergone TKR, to relieve pain and enable returning to daily activities. It is expected to be helpful in future studies of post-TKR in Korean Medicine. Also It can be used for medical treatment of post-TKR in Korean Medicine Hospital and clinic. However, further research with a high level of evidence is necessary to support this finding.

• Journal of Physiology & Pathology in Korean Medicine
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• v.37 no.1
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• pp.1-8
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• 2023

The aim of this study is to evaluate the antidiabetic effect of the water extract of Aurantii fructus immaturus (WAF), in diabetic models using enzyme, cells and mice, and to suggest a putative mechanism explaining its antidiabetic effect. In an enzyme model using the enzyme α-glucosidase, WAF had no significant effect on α-glucosidase, as compared with acarbose, an antidiabetic drug. Nonetheless, WAF was capable of reducing the blood glucose levels during oral sucrose tolerance test and oral glucose tolerance test, implying that there would be other antidiabetic pathways in no relation to inhibition of α-glucosidase. In cell models using RIN-m5f β-cells and L6 myotubes, WAF, at its non-cytotoxic doses, augmented the secretion of insulin in RIN-m5f β-cells stimulated with 5 mM glucose. In addition, it enhanced the cellular uptake of glucose in L6 myotubes stimulated with deprivation of glucose for 12 h. Therefore, it is most likely that WAF may exert its antidiabetic effects, at least in part, by enhancing insulin secretion and glucose uptake. Meanwhile, in diabetic mice induced with peritoneal injection of streptozotocin (STZ), WAF significantly improved fast blood glucose levels, glycosylated hemoglobin levels, body weight loose, blood pressure, and diabetic adverse effects on functions of the kidney and the liver. Taken together, the water extract of Aurantii fructus immaturus may ameliorate diabetes in mice injected with STZ, at least in part, by enhancing insulin secretion and glucose uptake.

• The Science & Technology
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• v.29 no.7 s.326
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• pp.32-33
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• 1996

날씨가 더울때 땀이 흐르는 것은 높아진 체온을 떨어뜨리려는 생리현상이다. 그러나 땀은 사람의 정신상태에 따라 크게 영향을 받으며 땀을 많이 흘리는 사람은 인정이 많다고도 한다. 땀이 나와야 할때 나오지 않는 것도 문제지만 너무 많이 흘려도 안된다. 여름철을 맞아 땀의 건강학을 짚어본다.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.4
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• pp.233-238
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• 2019

The aim of this study was to investigate the effect of Korean medicine treatments on pain reduction and functional improvement of patients after rotator cuff surgery. We studied 10 patients who had admitted to Dunsan Korean Medical hospital after have being diagnosed as rotator cuff tear and got a surgery at other hospital from April 30, 2014 to April 30, 2019. This study was conducted as retrospective study which analyzes patient's medical records. Statistical analysis was performed using the IBM SPSS statistics 24 program. We used Numeric Rating Scale to evaluate pain reduction, Range of Motion to evaluate shoulder functional improvement and Five-point likert scale to evaluate the patient's satisfaction. The result showed that Korean medicine treatments statistically significantly reduced pain on the patients after rotator cuff surgery. Although there were improvement of Range of Motion, it wasn't statistically significant. In conclusion, we found that the Korean medicine treatments showed a positive effect on pain reduction of patients after rotator cuff surgery and got a high satisfaction.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.4
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• pp.219-225
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• 2019

The objective of this study is to observe the effectiveness of complex Korean Medicine treatments on pain reduction of patients after meniscal surgery. We analyzed 16 patients who have been diagnosed as Meniscal injury on Magnetic Resonance Imaging(MRI) scan and had admitted to Dunsan Korean Medical hospital from January 30, 2014 to April 30, 2019. The analysis was conducted as retrospective study which analyzes patient's medical records. Statistical analysis was performed using the IBM SPSS statistics 25 program. We used Numeric Rating Scale to evaluate pain reduction, Five-point likert scale to asses treatment satisfaction. The result showed that there were statistically significant pain reduction on the postoperative meniscal injury patients treated with complex Korean Medicine treatments. In conclusion, we found that the complex Korean Medicine treatments showed a positive effect on pain reduction of postoperative meniscal injury patients. Further research is required to confirm the effectiveness of Korean Medicine treatment.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.5
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• pp.263-268
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• 2020

The aim of this study was to observe the effectiveness of Korean Medicine treatments on pain reduction of patients who were diagnosed hip fracture - Acetabulum and Proximal Femur. We reviewed the 17 patients' records who had admitted to Daejeon Korean Medical hospital and diagnosed fracture of acetabulum or proximal femur bones from January 1, 2011 to April 30, 2020 during the admission retrospectively. Statistical analysis was done using the IBM SPSS statistics 25 program. We measured Numeric Rating Scale to evaluate the treatment's efficacy. Korean Medicine treatments reduced median of Numeric Rating Scale reduced statistically significantly from 6.00 to 3.00(p<0.05). During the admission, patients didn't experience the side effects of Korean Medicine treatments. In conclusion, these results implied that Korean medicine treatments showed a positive effect on pain reduction of hip fracture patients. Further research is required to confirm the effectiveness of Korean Medicine treatments.

• The Journal of Korean Medical History
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• v.16 no.2
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• pp.17-34
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• 2003

지금까지 서양의학의 도입이란 측면에서만 조명되어온 정약용의 의학사상은 이제 한의학 이론의 발전과정이라는 새로운 관점에서 재조명할 필요가 있다. "의령(醫零)"에서 나타나는 그의 의학사상에는 미끼 사카에가 지적한 바와 같이, 음양오행론(陰陽五行論)에 입각한 "소문(素問)"의 병리론과 음양(陰陽)으로 논해온 '근시(近視)'에 대한 기존 이론에 대해 서학(西學)의 사행설(四行說)과 갈렌생리학, 그리고 광학이론을 가지고 비판을 가한 측면이 있다. 그러나, 좀 더 자세하게 검토해 보면 이런 서학(西學)의 영향은 정약용의 의학사상을 구성하는데 있어서 부분에 불과할 뿐만 아니라 그가 구상하고 있던 새로운 철학을 위해 취사선택된 것임을 알 수 있다. "육기론(六氣論)"에서 제시되는 사정설(四情說)의 경우, 서학의 사행설(四行說)을 그대로 답습한 것이 아니라 자신의 주역(周易)철학의 소산이다. 서학(西學) 뿐만 아니라 명대(明代)의 온보학파(溫補學派) 특히 장경악(張景岳) 의학사상의 영향도 주목해야 한다. "의령(醫零)"에서 논의된 의론(醫論)의 상당부분에서 장경악(張景岳)의 "전충록(傳忠錄)"과의 연관성이 상당히 많이 발견된다. 그러나 장경악(張景岳)이론의 정치(精緻)한 면에 대해서 찬사를 보내고 있지만, 그의 숭고주의(崇古主義)와 정치(精緻)한 음양오행(陰陽五行)에 대한 논의에 대해서도 동의한 것은 아니다. 정약용은 서학(西學)과 장경악(張景岳)을 비롯한 온보학파의 의학사상을 종합한 토대위에서, 즉 원기(元氣)의 운행(運行)이란 관점으로 의학을 재구성하려는 시도를 했다고 평가된다. "육기론(六氣論)"에서 시작된 육기병리설(六氣病理說)에 대한 비판은 "외감론(外感論)"에서 "이증론(裡證論)"을 거쳐 "허실론(虛實論)"으로 이어지면서 오행상극설(五行相剋說)에 의거한 병인론, 삼음삼양론(三陰三陽論)에 의거한 경락장부론(經絡臟腑論), 내외상론(內外傷論)을 모두 반박하면서 이러한 새로운 의학을 건설하려 하였다. "허실론이(虛實論二)"에서 장경악(張景岳)의 "풍한적체(風寒積滯), 담음어혈지속(痰飮瘀血之屬), 기불행칙사불제(氣不行則邪不除), 차기지실야(此氣之實也)."라는 말을 인용한 점은 이런 점에서 시사하는 바가 크다.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.4
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• pp.191-197
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• 2019

This study aims to evaluate the effects of the root bark of Morus alba (RMA) on the regulation of the Hippo-YAP pathway. Hippo-YAP signaling is a critical regulator in controlling organ size and tissue homeostasis. Hippo, the serine/threonine kinase phosphorylate the LATS. Phosphorylated LATS then phosphorylates and inactivates the YAP and TAZ, which are two closely related transcriptional co-activator. Here we report RMA activates the Hippo signaling, thereby inhibits the YAP/TAZ activity. First, we examine the cytotoxic effects of RMA by MTT assay. RMA was cytotoxic at concentrations higher than $50{\mu}g/ml$ in HEK293A cells. The reporter gene assay was performed to measure the activity of TEAD, a key transcription factor that controls cell growth and proliferation. RMA significantly suppressed the luciferase activity. By phos-taq gel shift assay, and western blotting, we showed that RMA enhanced the phosphorylation of YAP in wild type cells, but not in LATS1/2 knock out cells, which means RMA activates classical Hippo pathway. RMA induced the cytoplasmic sequestration of YAP. RMA also suppressed the mRNA expression of CTGF and CYR61; the two major YAP dependent genes. Taken together, RMA is considered to be a good candidate for proliferative disease such as cancer, by facilitating cell death through activating the Hippo signaling pathway.