• Title/Summary/Keyword: 유지경화

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Effects of Antihypertensive Drugs on Renal Function and Glomerular Morphology in Chronic Renal Failure Rats (만성신부전 백서에서 항고혈압제의 종류에 따른 신부전의 진행과 사구체의 형태학적 변화)

  • Hong Sung-Jin;Kim Kyo-Sun;Kim Pyung-Kil;Park Kyung-Hwa;Kim Kee-Hyuck
    • Childhood Kidney Diseases
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    • v.6 no.2
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    • pp.169-177
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    • 2002
  • Purpose: Hypertension accelerates the progression of chronic renal disease, whether it results from, or causes, the renal disease. Therefore, the control of hypertension is one of the important factors that retard the rate of renal deterioration. We compared the effects of different antihypertensive agents on renal function and glomerular morphology In subtotal nephrectomized rats. Materials and methods: After induction of chronic renal failure with 5/6 nephrectomy, the rats were divided into three groups; control group (Group C), enalapril group (Group E), and nicardipine group (Group N). Systolic blood pressure was measured by tail cuff method every 4 weeks until 12 weeks after nephrectomy. At 12 weeks after nephrectomy, all rats were placed in metabolic cages for 24 hour urine collections to measure urinary protein and creatinine excretion. After urine collection and blood sampling for serum creatinine, all rats were sacrificed. The renal tissue was processed for morphometric study with light microscope and electron microscope. Results: 1. The blood pressure of Group C increased progressively, but both enalapril and nicardipine prevented the development of hypertension, and the two drugs were equally effective in maintaining normal blood pressure throughout the study. 2. Twenty-four hour urinary protein excretion was lower in Group E compared to Group C and Group N 3. Mesangial expansion score in both treated groups were significantly lower than the control group. Mean glomerular volume in Group E was significantly reduced compared to Group C and Group N. There was no significant difference in mean glomerular volume between Group C and Group N. 4. There was no significant difference in podocyte structural changes, estimated by filtration slit length density, among control, enalapril and nicardipine treated groups. Conclusion: Control of hypertension with enalapril or nicardipine afforded considerable protection from mesangial expansion in the rat remnant kidney model. But protein excretion and glomerular growth were significantly reduced in Group E compared to Group N. There was no significant difference in podocyte structural changes among the 3 groups.

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Studies on Sericin Fixation by Use of Alum Meal (명반처리에 의한 견직물개선연구 -Sericin 정착을 중심으로 하여-)

  • 최병희;남중희
    • Journal of Sericultural and Entomological Science
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    • v.21 no.2
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    • pp.11-19
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    • 1979
  • This has been carried out how the sericin insoluble fixations of raw silk should be with potassium alum. This is learned from the leather tanning technique which the process works with collagen, a kind of proteins. Former reports had shown such works, however, they did not consider the moisture absorbability after their process reports by using chromium alum, formalin or vinyl acetate grafting. This report, however, paid attention to protect such absorbability as well as sericin fixation, so far it may be useful for plactical use of silk. In order to clear how the sericin is fixed with such chemicals, fundermental mechanism of weding process and chemical reaction against proteins were also discussed. The obtained results of the report are as followings. 1. Alum should not be treated for raw silk with high temperature bath like other reports because such treat induces raw silk to be stiffly after the treat. 2. It is recommended that raw silk should be treated with alum solution at room temperature for more than three hours. Even in this case, the use of only alum with raw silk could to fix sericin some how, but it increased the water proofness of the silk. 3. 1% of alum solution was found to be able to fix the sericin of raw silk. 4. In case we consider only sericin fixations, a combination treat of 1% alum for three hours and 0.5% NaOH for ten minutes method showed the best result. 5. In case we consider sericin insoluble fixation and moisture absorbility, the reversive combination of the above process was found to be the best results. 6. Sericin fixing evidence was shown with drying feature curves of wed each treated silk where we could to analyze how the chemical nature is changed after each treat. 7. Deguming ratio may be obtained up to 4.3% after the alum combination treat with regular raw silk. Such ratio was considered to be good enough for the purpose when the textile is washed with warm soap water. 8. Moisture absorbability of the combination treat of alum and NaOH was found to be good enough as well as non treated silk. 9. The tenacity and elongation of the treated silk did not change even after three month. 10. Above all, this method is considered to be better process than other coloured fixing (tannin method. Cr-alum method) or smell fixing (formalin method. vinyl acetate method).

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Effects of Small Colored Potato Extracts by High-Pressure Extraction on Serum Lipid Levels in High Fat Diet Fed Rats (꼬마색깔감자 초고압 추출물이 고지방식이를 섭취한 흰쥐의 혈청지질농도개선 미치는 영향)

  • Rha, Young-Ah;Choi, Mi-Sook;Kwon, Min-Soo;Hwang, Young-Jeong;Park, Sung-Jin
    • Culinary science and hospitality research
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    • v.20 no.4
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    • pp.157-168
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    • 2014
  • We investigated the anti-obesity effects of small colored potato extracts by high pressure water extraction process on body weight, plasma lipid levels in high-fat diet-induced obese mice. Experimental groups were divided into basal diet only (Normal), high fat diet control (HFD), small colored potato water extracts (CP), and high-fat diet and small colored potato water high pressure extracts (HCP) groups. The levels of hematological variables were not significantly different among the four groups. Compared with the HFD group's serum total cholesterol level of $86.01{\pm}1.16mg/dL$, the levels of the CP and HCP groups were significantly lowered to $80.29{\pm}1.28$ and $77.21{\pm}4.21mg/dL$, respectively. Compared with the HFD group's LDL-cholesterol level of $18.92{\pm}2.44mg/dL$, the LDL-cholesterol levels of the CP and HCP groups were significantly lowered to $13.52{\pm}1.26$ and $12.93{\pm}1.26mg/dL$, respectively. Also, compared to the HFD group's serum triglyceride level of $82.71{\pm}3.94mg/dL$, the level of the HCP group was significantly lowered to $63.24{\pm}6.32mg/dL$. These results suggested that dietary supplementation of small colored potato extracts using high pressure water extraction does not have any adverse effects on the hematological variables, while improving the lipid content and reducing hepatic damage of the high-fat fed rats.

Effect of Cynanchi wilfordii Radix Extracts on Lipid Compositions and Blood Pressure in Spontaneously Hypertensive Rats (백하수오(Cynanchi wilfordii Radix) 추출물이 선천성 고혈압 흰쥐의 지질성분 및 혈압에 미치는 영향)

  • Choi, Jun-Hweok;Lee, Hye-Sung;Kim, Young-Eon;Kim, Byoung-Mok;Kim, In-Ho;Lee, Chang-Ho
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.41 no.3
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    • pp.345-350
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    • 2012
  • The purpose of this study was to observe the effects of Cynanchi wilfordii Radix extracts (CRE) on the improvement of the lipid compositions and blood pressure level in spontaneously hypertensive rats (SHR) fed an experimental diet for 5 weeks. The rats were divided into 3 groups: a control group, a 0.5% CRE treated group, and a 1% CRE treated group. Consumption of CRE extract for 5 weeks in SHR significantly suppressed blood pressure rise with aging (p<0.05). After eating the experimental diets, the triglycerides in serum was significantly lower in the CRE group than that in the control group. The fasting glucose levels of the 0.5% and 1% CRE group had a tendency to be lower compared with those of the control group. Total cholesterol, HDL-cholesterol and HTR (HDL-cholesterol/total cholesterol) of the SHR in the 0.5% and 1% CRE diet were significantly increased compared to the control diet. Thus, long term consumption of CRE might be beneficial in lowering high blood pressure and the improvement of lipid metabolism in SHR rats.

Application of PCM Technology to Concrete II : Effects of SSMA(Sulfonated Styrene-Maleic Anhydride) on the Properties of the 1-Dodecanol Micro-Capsule (PCM 기술의 콘크리트 적용 II : 계면중합법에 의한 1-도데카놀 마이크로 캡슐에 있어서 계면활성제로 사용된 SSMA의 표면활성도가 마이크로 캡슐의 특성에 미치는 영향)

  • Shin, Se-Soon;Jung, Jae-Yun;Lim, Myung-Kwan;Choi, Dong-Uk;Kim, Young-Ho
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.1 no.1
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    • pp.17-25
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    • 2013
  • Thermal storage technology used for indoor heating and cooling to maintain a constant temperature for a long period of time has an advantage of raising energy use efficiency. This, the phase changing material, which utilizes heat storage properties of the substances, capsulizes substances that melt at a constant temperature. This is applied to construction materials to block or save energy due to heat storage and heat protection during the process in which substances melt or freeze according to the indoor or outdoor temperature. The micro-encapsulation method is used to create thermal storage from phase changing material. This method can be broadly classified in 3 ways: chemical method, physical and chemical method and physical and mechanical method. In the physical and chemical method, a wet process using the micro-encapsulation process utilized. This process emulsifies the core material in a solvent then coats the monomer polymer on the wall of the emulsion to harden it. In this process, a surfactant is utilized to enhance the performance of the emulsion of the core material and the coating of the wall monomer. The performance of the micro-encapsulation, especially the coating thickness of the wall material and the uniformity of the coating, is largely dependent on the characteristics of the surfactant. This research compares the performance of the micro-capsules and heat storage for product according to molecular mass and concentration of the surfactant, SSMA (sulfonated styrene-maleic anhydride), when it comes to micro-encapsulation through interfacial polymerization, in which Dodecan-1 is transformed to melamin resin, a heat storage material using phase changing properties. In addition, the thickness of the micro-encapsulation wall material and residual melamine were reduced by adjusting the concentration of melamin resin microcapsules.

A Study on the Serum Concentrations of Glucose, Insulin and Lipid in Elementary School Children by Body Weight (체중에 따른 일부 초등학교 아동의 혈청 중 포도당, 인슐린 및 지질농도에 관한 연구)

  • Han, Gi-Hyung;Kim, Gyeong-Eup;Yoon, Gi-Young;Cheong, Hyo-Sook;Kim, Sung-Hee
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.34 no.9
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    • pp.1375-1380
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    • 2005
  • The purpose of this study was to investigate anthropometric values, serum biochemical levels and their correlation in elementary school children. The subjects were 98 boys and girls in the $4{\~}6$ grade and divided into three groups by body size. The mean height of under-weight group (boys: $14.9\pm7.8\;cm$, girls: $144.9\pm9.6\;cm$) was the highest of the groups. The systolic and diastolic blood pressure of all the groups ranged from $111.56\pm13.51\;mmHg/72.86\pm7.26\;mmHg\;to\;117.50\pm10.00\;mmHg/75.31\pm9.51\;mmHg$, all within the normal levels. As subject was fatter, serum concentrations of triglyceride, total cholesterol, LDL-cholesterol insulin and atherogenic index (AI) in the boys, and serum concentrations of triglyceride, insulin and AI in the girls were significantly higher The concentrations of serum glucose, insulin, triglyceride, total cholesterol and LDL- cholesterol were significantly positively correlated with BMI and WHR. No significant correlation was found with blood pressure and serum lipid concentrations. Serum insulin levels was significantly positively correlated with serum glucose and triglyceride concentrations. Thus, this study implicates that obesity in childhood may be relevant to hyperlipidemia, atherosclerosis and diabetes mellitus.

Studies on Epicotyl Grafting of Hardwood Scion of Walnut (호도(胡桃)나무 유태접목(幼台接木)에 관(関)한 연구(硏究))

  • Kim, Su In
    • Journal of Korean Society of Forest Science
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    • v.55 no.1
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    • pp.68-75
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    • 1982
  • This study was carried out to promote percent survival of the walnut seedling grafting. The hardwood scions of the walnut were grafted on the nures seed-stock of the Juglans mandshurica Mat in an electric heating bed, then planted in field. The results obtained from the study were as follows : The optimum time of scion cpllection was from January to February. The best medium of the seed bed was sandy soil. The best grafting time was form the early to the 20the of the march. When the grafted seedling in the heating bed was trans-planted on filed 90percent of the seedlings was survived until autmn. The percent grafting on the elective heating bed was 90%. Crown gall occuring frequently in chestnut nurse graft was not appeared in juglans mandshurica Max grafted seedling of after outplanting. The grafted seedlings have not shown any physiological defects but developed normaly 3 years since grafting.

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Effect of Follicular Fluid on Sperm Swim-up Separation with Sucrose Layer (난포액이 Sucrose 층을 이용한 정자의 Swim-up 분리에 미치는 효과)

  • 김경화;여영근;박영식
    • Journal of Embryo Transfer
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    • v.13 no.3
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    • pp.277-289
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    • 1998
  • To establish a system for sperm swim-up separation through sucrose layer, indiscreet sperm migration should sufficiently to block but movement of sperm shouldn't inhibit. Thus, the effects of sucrose levels in sucrose layer, incubation times and types of sucrose layer on sperm separation were examined. And the results obtained were as follows; 1. Layer of 10mM sucrose inhibited sperm swim-up migration through sucrose layer. 2. Incubation for 25 minutes without sucrose layer significantly increased sperm swim-up migration. However, incubation for 10 minutes to induce swim-up through sucrose layer significantly stimulated sperm migration and maintained sperm movement. 3. There was no significant difference between Type I and Type II in barrier effect of sucrose layer. However, sucrose layer of Type II with shorter distance of barrier was efficient for sampling. To elucidate a function of follicular fluid on sperm chemotaxis using in vitro system of sucrose layer of Type II and incubation for 10 minutes, the effects of dilution, heat treatment, and protein and lipid extracts of follicular fluid on sperm swim-up separation were examined. And the results obtained were as follows; 4. Follicular fluid stimulated sperm migration and movement, and significantly-attracted capacitated-sperm at 10% level. 5. Follicular fluid heated at 55$^{\circ}C$ for 30 minutes maintained the effect of follicular fluid stimulating sperm migration and movement. 6. Follicular protein stimulated sperm movement that was reduced by filtration of the protein. 7. Follicular lipid didn't significantly stimulate sperm migration and movement. 8. Both of follicular protein and lipid reduced the effect of follicular fluid stimulating sperm migration and movement. In conclusion, sucrose layer could be used for a barrier against indiscreet sperm migration by swim-up. And follicular fluid stimulated migration and movement of sperm and attracted capacitated-sperm through sucrose layer. Especially, heat-resistant protein of follicular fluid stimulated sperm migration.

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Quality Characteristics of Pound Cake with Addition of Cashew Nuts (캐슈를 첨가한 파운드케이크의 품질특성)

  • Choi, Soon-Nam;Chung, Nam-Yong
    • Korean journal of food and cookery science
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    • v.26 no.2
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    • pp.198-205
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    • 2010
  • In this study, the effect of added cashew nuts on the quality characteristics of pound cake were investigated. The weight and volume of the cake increased with the addition of cashew nuts concentration, whereas the dough yield and baking loss decreased. Furthermore, the hardness, penetration and, degree of retrogradation significantly decreased during storage with the addition of cashew nuts. As the cashew concentration was increased, the lightness and redness values of the crumb decreased and the yellowness values increased. In terms of sensory evaluation, when compared to the control group, the cashew nuts pound cake was superior in taste, flavor, chewiness and overall acceptability.

Enhancement of the Thermostability of a Fibrinolytic Enzyme from Bacillus amyloliquefaciens CH51 (Bacillus amyloliquefaciens CH51이 생산하는 혈전용해효소의 열안정성 개선)

  • Kim, Jieun;Choi, Kyoung-Hwa;Kim, Jeong Hwan;Song, Young-Sun;Cha, Jaeho
    • Journal of Life Science
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    • v.23 no.1
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    • pp.15-23
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    • 2013
  • AprE51 from Bacillus amyloliquefaciens CH51 is a 27 kDa subtilisin-like protease with fibrinolytic activity. AprE51-6 showing increased catalytic activity was produced previously. To enhance the thermostability of AprE51-6, 2 residues, Gly-166 and Asn-218 based on B. subtilis subtilisin E were mutated by site-directed mutagenesis. The results of the mutational analysis showed that substitution of arginine for Gly-166 (AprE51-7) increased the fibrinolytic activity 1.8-fold. An N218S mutant (AprE51-8) also increased the fibrinolytic activity up to 4.5-fold in a fibrin plate assay. Purified AprE51-7 and AprE51-8 mutants had a 1.9- and a 2.5-fold higher $k_{cat}$, respectively, and a 2.1-1.9-fold lower $K_m$, respectively. This resulted in a 3.8- and a 4.7-fold increase in catalytic efficiency ($k_{cat}/K_m$), respectively, relative to that of wild-type AprE51. AprE51-8 had a broader pH range than AprE51-6 and nattokinase, especially at an alkaline pH value. In addition, AprE51-8 showed higher thermostability than AprE51-6 at $60^{\circ}C$. The half-lives of AprE51-7 and AprE51-8 at $50^{\circ}C$ were 21.5 and 27.3 min, respectively, which are 2.0 and 2.6 times longer, respectively, than that of the wild-type AprE51.