• Journal of Animal Science and Technology
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• v.48 no.1
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• pp.29-38
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• 2006

The objective of this study was to estimate genetic variances of growth curve parameters in Hanwoo cows. The data used in this study were records from 1,083 Hanwoo cows raised at Hanwoo Experiment Station, National Livestock Research Institute(NLRI). First evaluation model(Model I) fit year-season of birth and age of dam as fixed effects and second model(Model II) added age at the final weight as a linear covariate to Model I. Heritability estimates of A, b and k from Gompertz model were 0.22, 0.11 and 0.07 using modelⅠ and 0.28, 0.11 and 0.12 using modelⅡ. Those from Von Bertalanffy model were 0.22, 0.11 and 0.07 using modelⅠ, 0.28, 0.11 and 0.12 using modelⅡ. Heritability estimates of A, b and k from Logistic model were 0.14, 0.07 and 0.05 using modelⅠ, 0.18, 0.07 and 0.12 using modelⅡ. Heritability estimates of A from Gompertz model were higher than those from Von Bertalanffy model or Logistic model in both model Ⅰand model Ⅱ. Heritability estimates of b from Logistic model were higher than those from Gompertz model or Von Bertalanffy model in both modelⅠand model Ⅱ. Heritability estimates of birth weight, weaning weight, 3 month weight, 6 month weight, 9 month weight, 12 month weight, 18 month weight, 24 month weight, 36 month weight were after linear age adjustment 0.27, 0.11, 0.19, 0.14, 0.16, 0.23, 0.52 and 0.32, respectively. Heritability estimates of birth weight, weaning weight, 3 month weight, 6 month weight, 9 month weight and 24 month weight fit by Gompertz model were larger than those estimated from linearly adjusted data. Heritability estimates of 12 month weight, 18 month weight and 36 month weight fit by Von Bertalanffy model were larger than those estimated from linearly adjusted data. In the multitrait analyses for parameters from Gompertz model, genetic and phenotypic correlations between A and k parameters were －0.47 and －0.67 using modelⅠand －0.56 and －0.63 using model Ⅱ. Those between the A and b parameters were 0.69 and 0.34 using modelⅠand 0.72 and 0.37 using model Ⅱ. Those between the b and k parameters were －0.26 and 0.01 using modelⅠand －0.30 and 0.01 using model Ⅱ. In the multitrait analyses for parameters from Von Bertalanffy model, genetic and phenotypic correlations between A and k parameters were －0.49 and －0.67 suing model Ⅰ and －0.57 and －0.70 using modelⅡ. Those between the A and b parameters were 0.61 and 0.33 using modelⅠ and 0.60 and 0.30 using model Ⅱ. Those between the b and k parameters were －0.20 and 0.02 using modelⅠ and 0.16 and 0.00 using modelⅡ. In the multitrait analyses for parameters from Logistic model, genetic and phenotypic correlations between A and k parameters were －0.43 and －0.67 using model Ⅰ and －0.50 and －0.63 using modelⅡ. Those between the A and b parameters were 0.47 and 0.22 using modelⅠ and 0.38 and 0.24 using modelⅡ. Those between the b and k parameters were －0.09 and 0.02 using model Ⅰ and －0.02 and 0.13 using model Ⅱ.

• The Korean Journal of Applied Statistics
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• v.28 no.2
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• pp.295-308
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• 2015

We have experienced a substantial improvement in and cost-drop for genotyping that enables genetic epidemiological studies with large-scale genetic data. Genome-wide association studies have identified more than ten thousand causal variants. Many statistical methods based on linear mixed models have been developed for various goals such as estimating heritability and identifying disease susceptibility locus. Empirical results also repeatedly stress the importance of linear mixed models. Therefore, we review the statistical methods related with to linear mixed models and illustrate the meaning of their estimates.

• Proceedings of the Korea Information Processing Society Conference
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• 2010.04a
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• pp.1106-1108
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• 2010

이 연구에서는 유전자알고리즘과 인공신경망의 특성을 결합한 유전자신경망모형에 대하여 논의한다. 이 모형을 이용하여 단기 시계열자료를 예측한다. 그 예측 결과는 유전자신경망모형이 역전파 신경망모형에서 보다 더 작은 예측오차를 보였다. 역전파 신경망보다 더 효과적임을 보임으로써 유전자신경망모형을 이용한 시계열자료 예측이 보다 효율적인 방법임을 제시한다.

• Journal of the Korean Data and Information Science Society
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• v.27 no.3
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• pp.741-747
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• 2016

The aim of study was to estimate genetic parameter of carcass traits in commercial Hanwoo steer using national animal model for selection of superior bull. Analyzed data (n=5,843) on carcass traits was collected from 107,020 Hanwoo steer. The animal model was used to estimate heritability and genetic correlations. The estimated heritability of carcass traits were 0.19, 0.17, 0.20 and 0.23 for carcass weight, eye muscle area, backfat thickness and marbling score, respectively. The estimated heritability for carcass traits in commercial Hanwoo are low than estimated heritability of national progeny test population for selection of superior bull because breeding environment, genetic performance of cow and feeding day was different. Therefore, we suggests that animal model can include practical genetic variable based on national animal model to improve genetic performance in commercial Hanwoo.

• Journal of the Korean Data and Information Science Society
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• v.25 no.5
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• pp.1025-1038
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• 2014

Linear mixed model has often been utilized for genetic association analysis with family-based samples. The correlation matrix for family-based samples is constructed with kinship coefficient and assumes that parental phenotypes are independent and the amount of correlations between parent and offspring is same as that of correlations between siblings. However, for instance, there are positive correlations between parental heights, which indicates that the assumption for correlation matrix is often violated. The statistical validity and power are affected by the appropriateness of assumed variance covariance matrix, and in this thesis, we provide the linear mixed model with flexible variance covariance matrix. Our results show that the proposed method is usually more efficient than existing approaches, and its application to genome-wide association study of body mass index illustrates the practical value in real data analysis.

• 한국방재학회:학술대회논문집
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• 2007.02a
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• pp.587-590
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• 2007

한계자기회귀모형(TAR)을 응용하여 동시에 해조와 홍수의 영향을 받을 때 삽교천 감조구간의 삽교호수위관측소의 월 최고수위를 예측하는 모형을 구축하였으며, 모형구축과정에서 유전알고리즘으로 한계값과 자기회귀계수의 매개변수를 최적화한다. 계산결과 한계자기회귀모형은 감조하천의 비선형성특성을 모의 할 수 있으며, 예측의 정확도와 예측성능의 안정성을 확보할 수 있다. 연구결과 유전한계자귀회귀모형으로 감조하천구간의 월 최고수위를 예측하는 것이 가능하며, 또한 감조하천구간에서 기타 수문요소의 비선형성 서열예측 중에서도 광범한 실용가치가 있다고 본다.

• Journal of Korea Water Resources Association
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• v.31 no.1
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• pp.59-69
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• 1998

A regression model with basin physiographic characteristics as independent variables was calibrated for regional flood frequency analysis. In case that high correlations existing among the independent variables the ridge regression has been known to have capability of overcoming the problems of multicollinearity. To optimize the ridge regression model the cost function including regularization parameter must be minimized. In this research the genetic algorithm was applied on this optimization problem. The genetic algorithm is a stochastic search method that mimic the metaphor of natural biological heredity. Using this method the regression model could have optimized and stable weights of variables.

• The Journal of Korean Academic Society of Nursing Education
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• v.17 no.3
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• pp.524-535
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• 2011

유전 위험 사정과 상담서비스가 임상실무에 널리 적용되어 감에 따라, 다양한 비용효율 면에서 다양한 상담서비스 모델을 사정하고, 대상자의 임상 요구와 건강문제를 해결하는데 어떤 모델이 유용한 지 확인할 필요가 있다. 본 연구의 목적은 114건의 현장 관찰과 문헌고찰을 통하여 3가지 유전상담 모형을 분석하였다. 유전의학 전문가 모델, 유전상담사 모델, 임상연구전문가 모델을 중심으로 각 모델의 구조, 전문가의 역할 및 기능, 목표, 물리적 세팅, 교육도구 등을 분석하였다. 각 모형 안에서 환자에게 기대되는 결과 면에서 질적 서비스가 보장되는지 확인하기 위하여 이론적 분석을 실시하였다. 본 연구를 통하여 각 모형의 상담 전, 중, 후 환자 만족, 지식 변화, 상담 효과 및 커뮤니케이션 효과 등을 분석하였지만, 결론적으로 상담서비스가 이루어지고 있는 기관의 구조를 충분히 고려하지 않은 상태에서 최상의 서비스 모델을 제시하기 어려울 것임을 논의하였다.

• Journal of Korean Society of Transportation
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• v.19 no.2
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• pp.61-72
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• 2001

기존의 링크교통량으로부터 OD추정모형은 기존 OD에 대한 추정의 종속성이 커, 기존 OD나 관측링크교통량의 오차에 따라 추정결과가 일관적이지 않은 문제점을 가지고 있다. 또한 관측링크교통량의 정확도가 중요함에도 불구하고 차종구분 없이 링크교통량을 이용하여 정보의 손실을 초래하였고 결과적으로 OD 추정력을 저하시켰다. 그렇지만 다차종 링크교통량으로부터 다차종 OD를 구하는 연구는 거의 없었으며, 그 추정결과가 단일차종에 대한 추정결과와 어떻게 다른지에 대한 연구도 전무하였다. 본 연구의 목적은 기존의 OD 추정모형이 기존 OD에 대해 종속성을 가지며 차종구분 없이 모형을 구성함으로써 추정력의 저하를 초래하였음을 밝히고, 이에 대한 대안으로 종속성 문제를 완화하고 차종구분을 통해 OD 추정모형의 추정력을 증진시키자 하는 것이다. 이를 위해 유전알고리즘을 이용한 다차종 OD행렬 추정모형(GAMUC)을 구축하고, 이를 기존의 바이레벨 모형의 IEA 알고리즘 및 다차종으로 확장한 모형(IEAMUC)과 게임이론측면에서 검토하였으며, 사례네트워크에 대해 각 기법을 비교하였다. 본 연구는 유전알고리즘을 이용한 OD 추정기법을 축도로에 적용한 임용택 등(2000)과 이를 네트워크로 확장한 백승걸 등(2000)의 연구를 다차종으로 확장한 것이다. 사례분석 결과 기존 OD의 오차변화나 관측링크교통량의 오차변화 등에 있어 GAMUC가 IEA나 IEAMUC보다 추정력이 양호하여, 실제 OD를 알 수 없는 도시부 네트워크에서 GAMUC 모형의 적용력이 우수하였다. 또한 차종을 구분하지 않은 기존 모형은 실제 OD와는 전혀 다른 OD 구조를 도출할 수 있음을 보였으며, 단일 차종을 여러 차종으로 구분하여 OD를 추정하는 것이 더 양호한 추정력을 확보하는 것으로 나타났다.

• Journal of Animal Science and Technology
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• v.46 no.4
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• pp.509-516
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• 2004

This study is to investigate the amount of biased estimates for heritability and genetic correlation according to data structure on marbling scores in Korean cattle. Breeding population with 5 generations were simulated by way of selection for carcass weight, Longissimus muscle area and latent values of marbling scores and random mating. Latent variables of marbling scores were categorized into five by the thresholds of 0, I, 2, and 3 SD(DSI) or seven by the thresholds of -2, -1, 0,1I, 2, and 3 SD(DS2). Variance components and genetic pararneters(Heritabilities and Genetic correlations) were estimated by restricted maximum likelihood on multivariate linear mixed animal models and by Gibbs sampling algorithms on multivariate threshold mixed animal models in DS1 and DS2. Simulation was performed for 10 replicates and averages and empirical standard deviation were calculated. Using REML, heritabilitis of marbling score were under-estimated as 0.315 and 0.462 on DS1 and DS2, respectively, with comparison of the pararneter(0.500). Otherwise, using Gibbs sampling in the multivariate threshold animal models, these estimates did not significantly differ to the parameter. Residual correlations of marbling score to other traits were reduced with comparing the parameters when using REML algorithm with assuming linear and normal distribution. This would be due to loss of information and therefore, reduced variation on marbling score. As concluding, genetic variation of marbling would be well defined if liability concepts were adopted on marbling score and implemented threshold mixed model on genetic parameter estimation in Korean cattle.