• The Science & Technology
• /
• v.26 no.1 s.284
• /
• pp.94-95
• /
• 1993

우리 역사 속에서 과학기술자를 찾는다는 것은 상당히 어려운 작업이다. 우리가 과학기술이라 부르는 것이 근대서양의 산물이라는 고정관념이 우리 머리 속에 꽉 차있다고해도 지나친 말이 아니기 때문이다. 그런대로 옛 선조들 가운데 과학기술에 관련이 있는 인물을 찾아 볼 경우 그런 인물들은 대개 과학기술 보다는 다른 분야에 뚜렷한 업적을 가진 사람일 경우가 더 많다. 말하자면 과학기술의 전문가로서의 그런 인물을 찾기란 더욱 어렵다는 말이 된다. 이 연재를 시작하면서 처음으로 소개하는 유순도 역시 그런 범위를 크게 벗어날 수 없는 인물이다. 아직 내가 이 과학자에 대해 어디에 소개한 글을 쓴 적도 없고, 아마 다른 어떤 사람도 유순도라는 옛 과학자에 대해 글을 썼을 것으로는 보이지 않는다. 말하자면 유순도에 대한 이 글은 바로 이곳 「과학과 기술」의 「역사의 인물」이라는 연재를 시작하면서 내가 처음으로 바치는 정성의 표시라고도 할 수 있다. 앞으로는 이미 조금씩은 알려져 있는 과학기술의 옛 선조들을 소개하겠지만, 처음에는 전혀 새 인물을 한 사람 발굴해 소개하고 싶은 것이다.

• The Journal of Korean Medical History
• /
• v.18 no.1
• /
• pp.155-173
• /
• 2005

• Journal of Chest Surgery
• /
• v.39 no.8 s.265
• /
• pp.579-587
• /
• 2006

Background: Preoperative risk analysis for Fontan candidates is still less than optimal in that patients with apparently low risks may have poor surgical outcome; prolonged pleural drainage, protein losing enteropathy, pulmonary thromboembolism and death. We hypothesized that low pulmonary vascular compliance (PVC) is a risk factor for prolonged pleural effusion drainage after the Fontan operation. Material and Method: A retrospective review of 96 consecutive patients who underwent the Extracardiac Fontan procedures (median age: 3.9 years) was performed. Fontan risk score (FRS) was calculated from 12 categorized preoperative anatomic and physiologic variables. PVC $(mm^2/m^2{\cdot}mmHg)$ was defined as pulmonary artery index $(mm^2/m^2)$ divided by total pulmonary resistance $(W.U{\cdot}/m^2)$ and pulmonary blood flow $(L/min/m^2)$ based on the electrical circuit analogue of the pulmonary circulation. Chest tube indwelling time was log-transformed (log indwelling time, LIT) to fit normal distribution, and the relationship between preoperative predictors and LIT was analyzed by multiple linear regression. Result: Preoperative PVC, chest tube indwelling time and LIT ranged from 6 to 94.8 $mm^2/mmHg/m^2$ (median: 24.8), 3 to 268 days (median: 20 days), and 1.1 to 5.6 (mean: 2.9, standard deviation: 0.8), respectively. FRS, PVC, cardiopulmonary bypass time (CPB) and central venous pressure at postoperative 12 hours were correlated with LIT by univariable analyses. By multiple linear regression, PVC (p=0.0018) and CPB (p=0.0024) independently predicted LIT, explaining 21.7% of the variation. The regression equation was LIT=2.74-0.0158 PVC+0.00658 CPB. Conclusion: Low pulmonary vascular compliance is an important risk factor for prolonged pleural effusion drainage after the extracardiac Fontan procedure.

• Journal of Chest Surgery
• /
• v.41 no.2
• /
• pp.177-188
• /
• 2008

Background: To evaluate the effects of inhaled nitric oxide (NO) and sphingosine 1-phosphate (S1P) as potential therapeutic agents of acute lung injury, we analyzed the morphology in vivo of the pulmonary microstructure using intravital videomicroscopy in a rat model of acute lung injury. Material and Method: Sprague Dawley rats were divided into five groups: a control group that underwent normal saline aspiration, an acute lung injury (ALI) group that underwent hydrochloric acid aspiration, and three treatment groups that underwent hydrochloric acid aspiration and were administered therapeutic agents- the S1P group, the NO group, and the S1P+NO group (n=7 per group). To quantify alveolar compliance and interstitial edema, the diameters of all measurable alveoli and interalveolar septa were averaged at one and two hours after aspiration. Alveolar compliance was determined according to diameter changes during the respiratory cycle and the change in tidal volume. Result: At two hours after aspiration, the mean alveolar compliance (% change) in the All group decreased significantly versus the control group of rats (respiratory cycle: 1.9% for the ALI group vs 6.5% for the control group, p=0.03; tidal volume: 3.2% for the ALI group vs 9.1% for the control group, p=0.003) and versus the NO group (tidal volume: 3.2% for the ALI group vs 16.9% for the NO group, p=0.001). At two hours after aspiration, the mean interalveolar septal thickness in the NO group tended to be smaller as compared to that in the All group ($15.2{\mu}m$ for the ALI group vs $12.3{\mu}m$ for the NO group, p=0.06). S1P did not exert a significant effect on the pulmonary microstructure of the injured rat lung. Conclusion: Improved alveolar compliance and reduced interstitial edema, observed by intravital videomicroscopy, suggest that inhaled NO ameliorates lung injury.

• Journal of Chest Surgery
• /
• v.43 no.6
• /
• pp.565-575
• /
• 2010

Background: Various decellularization methods have been studied in order to develop tissue graft which is less immunogenic and more durable. This study was performed to investigate the physico-dynamic and histological effect of trypsin pretreatment on decellularization protocols. Material and Method: Two groups of bovine pericardium specimen each underwent decellularization process based on SDS and Triton X-100 or N-lauroylsarcosinate and Triton X-100. Two more groups additionally underwent pretreatment with 0.1% Trypsin/0.1% EDTA. After decellularization process, mechanical tensile strength was tested, then biomechanical test of permeability and compliance was tested before and after fatigue test. Light microscopy and electron microscopy was performed to observe histological findings. Result: There was no difference in mechanical tensile strength between groups, but permeability and compliance was decreased in trypsin pretreated groups. Light microscopic and electron microscopic findings revealed damage of the extracellular matrix in trypsin pretreated groups and in groups which underwent the fatigue test also. Conclusion: Trypsin pretreatment in decellularizing process of bovine pericardium damages extracellular matrix and increases permeability and compliance of the bovine pericardium, but did not decrease tensile strength. Further studies are needed to use enzymatic treatments in decellularization protocols.

• 학교보건
• /
• s.12
• /
• pp.20-21
• /
• 1983

• The Monthly Diabetes
• /
• s.177
• /
• pp.62-65
• /
• 2004

• ETRI Journal
• /
• v.4 no.2
• /
• pp.84-94
• /
• 1982

• The Monthly Diabetes
• /
• s.176
• /
• pp.70-72
• /
• 2004

• Proceedings of the Korean Society of Veterinary Service Conference
• /
• 1999.05a
• /
• pp.188.2-189
• /
• 1999