• Journal of the Korean Society of Radiology
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• v.79 no.6
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• pp.311-314
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• 2018

Cavernous hemangioma of the breast is a rare benign vascular tumor. It is usually diagnosed as non-palpable mass during imaging examination, incidentally. Common sonographic finding of the breast hemangioma is a superficially located, oval shape, circumscribed margin mass. But the appearance of breast hemangioma is variable and it can be difficult to diagnose in preoperatively. Here, we report a 68-year-old female case with palpable breast mass and increased size on follow up ultrasonography.

• Journal of the Korean Society of Radiology
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• v.17 no.5
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• pp.751-759
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• 2023

Breast ultrasonography is difficult to image in fatty breasts and to find micro-calcification, but the discovery of micro-calcification is very important for breast cancer screening. Among the color Doppler artifact of ultrasound, twinkle artifact mainly occur on strong reflectors such as stones or calcification in images, and evaluation methods using them are clinically being used. In this study, we are conducting experiments on the color Doppler settings of ultrasound equipment, such as repetition frequency, ensemble, persist, wall filtering, smoothing, linear density, and dissociation value, by producing a breast simulation phantom using the largest amount of calcium phosphate among breast implants. The purpose of this study was to improve the contrast of twinkle artifact in breast ultrasound examinations and to maximize their use in clinical practice. As a result, the pulse repetition frequency occurred in the range of 3.6 kHz to 7.2 kHz, and did not occur above 10.5 kHz. For ensembles, twinkle artifact occurred in all sizes of calcification under low conditions, and in threshold settings, the twinkle artifact increased slightly only under 80 to 100 conditions, and did not occur in 1 mm size calcification. Persist, wall filter, smoothing, and line density settings did not have much meaning in the setting variable because conditions did not increase by condition, and pulse repetition frequency, ensemble, and thresholds had the greatest impact on the twinkling artifact image. This study is expected to help examiners select optimal conditions to effectively increase twinkle artifact by adjusting color Doppler settings.

• Journal of radiological science and technology
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• v.32 no.1
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• pp.45-52
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• 2009

Digital Mammography is an efficient imaging technique for the detection and diagnosis of breast pathological disorders. Six mammographic criteria such as number of cluster, number, size, extent and morphologic shape of microcalcification, and presence of mass, were reviewed and correlation with pathologic diagnosis were evaluated. It is very important to find breast cancer early when treatment can reduce deaths from breast cancer and breast incision. In screening breast cancer, mammography is typically used to view the internal organization. Clusterig microcalcifications on mammography represent an important feature of breast mass, especially that of intraductal carcinoma. Because microcalcification has high correlation with breast cancer, a cluster of a microcalcification can be very helpful for the clinical doctor to predict breast cancer. For this study, three steps of quantitative evaluation are proposed : DoG filter, adaptive thresholding, Expectation maximization. Through the proposed algorithm, each cluster in the distribution of microcalcification was able to measure the number calcification and length of cluster also can be used to automatically diagnose breast cancer as indicators of the primary diagnosis.

• 전기의세계
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• v.38 no.8
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• pp.9-18
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• 1989

초음파 CT는 시기적으로 가장 빨리 X-ray CT와 함께 연구되어 왔으나 인체내의 투과성, 난반사, 긴파장등에 의해 실용화가 아직은 요원하다. 초음파 CT는 크게 Time of flight (TOF)CT, Attenuation CT, Reflection CT, Diffraction CT등으로 나눌수 있다. 초기에는 TOF CT, Attenuation CT의 연구가 주로 이루어 졌으나 투과의 문제로 인하여 실제로는 유방의 진단에 국한되고 있다. Reflection CT는 초음파의 특성상 실용화가 가장 쉬우나 Transducer 크기등의 문제로 연구가 지연되고 있다. Diffraction CT는 모든 초음파 CT의 특성을 갖고 있으며 현재에 실용화는 요원한 실정이다. KAIST에서는 TOF CT와 Reflection CT의 특징을 결합한 초음파 CT를 연구 발표한 바 있다. 3-D Image은 지금까지의 초음파진단장치에서 표시하는 2-D Image가 갖고 있는 제반의 문제들을 극복하기 위해 현재 KAIST에서 활발히 연구가 진행중에 있다.

• The Korean Journal of Nuclear Medicine
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• v.33 no.5
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• pp.452-460
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• 1999

Purpose: The purpose of this study was to evaluate the diagnostic usefulness of scintimammography per-formed with Tc-99m tetrofosmin in the detection of primary breast cancer Materials and Methods: Sixty-one patients underwent Tc-99m tetrofosmin scintimammography, plain-film mammography and ultrasonography. After intravenous injection of Tc-99m tetrofosmin (740 MBq), prone lateral and anterior scintimammograms were obtained. Scintimammogram was visually interpreted as positive, probably positive, probably negative and negative for malignancy. The tumor to background count ratio (T/B) was measured at 5 minutes and 1 hour. Plain-film mammogram was interpreted as one of 5 categories. Final diagnosis was achieved by surgical histology (58/61) or fine needle aspiration (3/61). Of 61 patients, 44 had cancer and 17 had benign lesion. Tumor size of malignant and benign lesions on ultrasonogram were $2.51{\pm}1.30cm$ (range 1-8 cm), $2.50{\pm}1.35cm$ (range 0.96-6 cm), respectively. Results: The sensitivity of plain-film mammography was 88.6%, specificity 58.8%, positive predictive value 84.7%, and negative predictive value 66.7% The sensitivity of Tc-99m tetrofosmin scintimammography was 90.9%; specificity, 88.2%; positive predictive value, 94.9%, negative predictive value, 18.9%. Of 25 patients with indeterminate degree of suspicion for malignancy on plain-film mammogram, 23 were correctly diagnosed by scintimammography. The T/B at 5 minutes and 1 hour were $3.78{\pm}2.21$, $3.25{\pm}1.80$ respectively. The T/B was decreased significantly at 1 hour (p<0.001). Conclusion: Tc-99m tetrofosmin scintimammography was useful dia-gnostic procedure in the detection of primary breast cancer, especially in patients with indeterminate degree of suspicion for malignancy on plain-film mammogram.

• Journal of the Korean Society of Radiology
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• v.17 no.5
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• pp.743-749
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• 2023

Breast ductal carcinoma in situ(DCIS) refers to cases in which breast epithelial cells have become malignant but are still limited to normal ducts, and has been increasing rapidly in recent years. In this case, a two-year follow-up revealed findings on mammography and ultrasonography that indicated a small mass classified as BI-RADS Category 3, However far from typical malignant tumor these findings were. In the second year of follow-up, a hypoechoic mass with an indistinct boundary of the right breast in the 6 o'clock direction, on mammography appeared to be about 2.1×1.3 cm in size, and biopsy diagnosed it as ductal carcinoma. Since ductal endothelial cancer has no characteristic clinical findings and can show positive clinical and imaging findings in the early stages, regular follow-up is considered important for early diagnosis, and detection of ductal endothelial cancer through mammography and ultrasound is important for improving the prognosis of all breast cancer patients. During the initial examination conducted four years ago, we reported cases of intra ductal cancer in which asymmetric shading, microcalcification, and branched mass, indicative of intra ductal cancer, were observed during follow-up. It is advisable to concurrently explore methods for reducing X-ray dosage to mitigate potential side effects of contrast medium.

• Radiation Oncology Journal
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• v.19 no.4
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• pp.312-318
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• 2001

Purpose : To assess the locoregional recurrence rate, survival rate and prognostic factors after modified radical mastectomy and postoperative adjuvant radiation therapy with or with chemotherapy in high-risk breast cancer patients. Methods : Between $1984\~1995$, 48 patients underwent postoperative irradiation to the regional lymphatics and chest wall due to large tumor size $(\geq5\;cm)$ or small tumor size (<5 cm) with axillary lymph node involvement after modified radical mastectomy. The median age of the patients was 47 years (range, $31\~79\;years$). The clinical tumor size was <2 cm in 1 patient, $2\~5\;cm$ in 15 patients, and >5 cm in 32 patients. Thirty two patients had positive axillary lymph nodes. Forty two patients were irradiated to the chest wall and regional lymph node and 6 patients were irradiated in the chest wall only. Radiation dose to the chest wall and regional lymph node was 5040 cGy/28 fraction. The median follow-up time was 61 months. Results : Locoregional recurrence rate was $8\%$ and distant metastatic rate was $14\%$. The actuarial overall survival rate and disease-free survival rate was $53\%\;and\;62\%$ at 5 years, respectively. The median survival time was 57 months. Five-year overall survival rate by the stage is $70\%$ in IIB and $58\%$ in IIA. The significant prognostic factor for survival on multivariate analysis was the stage. Conclusion : Postoperative adjuvant radiation therapy in high-risk breast cancer can reduce the locoregional recurrence rate and increase the survival time by combined chemotherapy. The significant prognostic factor for survival rate was the stage.

• Journal of the Korean Society of Radiology
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• v.81 no.5
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• pp.1266-1271
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• 2020

We report herein a 46-year-old woman who presented with mucinous breast carcinoma that appeared as a coarse and densely calcified mass on mammography. The lesion was a 4.6-cm-sized palpable, hyperechoic, calcified mass with posterior shadowing on ultrasonography. This finding is a unique feature of mucinous breast carcinoma and is also observed in unusual breast cancer variants such as metaplastic breast cancer with chondroid differentiation, extraosseous osteosarcoma, and breast chondrosarcoma. The lesion showed a slow-growing pattern throughout the 4-year observation period. Mammography performed 4 years ago revealed faint, grouped microcalcifications; the lesion increased in size over 2 years, presenting as a well-circumscribed, calcified mass, mimicking dystrophic calcification. As several unusual variants of breast cancer, including mucinous carcinoma, may present as coarse and densely calcified masses on mammography, immediate biopsy should be considered when they are observed.

• The Korean Journal of Nuclear Medicine
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• v.34 no.2
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• pp.119-128
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• 2000

Purpose: The aim of this study was to investigate the diagnostic role of $^{99m}Tc$-Tetrofosmin in detection of breast cancer and compared with that of $^{99m}Tc$-MIBI. Material and Methods: Forty-eight patients with a clinically palpable mass or abnormal mammographic or ultrasonographic findings had $^{99m}Tc-MIBI\;and\;^{99m}Tc$-Tetrofosmin scintimammographies after intravenous injection of 925 MBq of radiopharmaceuticals. The scintimammographs were correlated with histopathologic findings. Results: Thirty-three patients were diagnosed with breast cancer and 15 patients with benign breast diseases. The numbers of true positive, true negative, false positive, and false negative cases of $^{99m}Tc$-MIBI scintimammography were 29, 10, 5, and 4 respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of $^{99m}Tc$-MIBI scintimammographies were 87.8%, 66.7%, 85.3%, and 71.4% respectively. The numbers of true positive, true negative, false positive, and false negative cases of $^{99m}Tc$-Tetrofosmin were 31,10, 5, and 2 respectively. The sensitivity, specificity, positive predictive value, negative predictive value of $^{99m}Tc$-Tetrofosmin were 93.9%, 66.7%, 86.1%, and 73.3% respectively. One patient was false negative in both $^{99m}Tc-MIBI\;and\;^{99m}Tc$-Tetrofosmin acintimammographies and its size was 0.5 cm. Conclusion: $^{99m}Tc-Tetrofosmin\;and\;^{99m}Tc-MIBI$ were non-invasive and useful in detection of breast cancer and $^{99m}Tc$-Tetrofosmin was comparable to the $^{99m}Tc$-MIBI in detection of primary breast cancer.

• Journal of Sasang Constitutional Medicine
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• v.11 no.1
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• pp.281-293
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• 1999

1. The backdrop of the study. Accurate diagnasis of the constitution is very important Sasang constitution medicine. This study make research of man's penis and woman's breast, make observation these are significant or not in diagnosis of the constitution. 2. The process. The constitution of the people was diagnosed by QSCCII, specialist, (86 persons, men 39, women 47), the men was taken measure of atony and excited length, thickness of the penis with a rule, thread. the women have a personal interview about her height, weight, the girth of the breast, brassiere cup size. 3.The result. This study shows that Tae-eum-in Is 28 persons(32.6%), So-eum-in 37 persons (43%), So-yang-in 21 persons(24.4%). Man's observation is insignificant statistically, woman's observation is insignificant statistically too.