• The Korean Journal of Applied Statistics
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• v.34 no.2
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• pp.255-266
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• 2021

The purpose of this study is to compare the effects of treatment on stage III stomach cancer data obtained from the SEER program of the National Cancer Institute and to identify the significant risk factors for the survival rates of stage III stomach cancer. Since the proportional hazards assumption was violated for treatment, we used the restricted mean survival time as an alternative to the proportional hazards model. The restricted mean survival time was estimated using pseudo-observations, and the effects of treatment were compared using a test statistic based on the estimated restricted mean survival times. We conducted the regression analysis using a generalized linear model to investigate the significant predictors for the restricted mean survival time of patients with stage III stomach cancer. We found that there was a significant difference between the restricted mean survival times of treatment groups. Age at diagnosis, race, substage, grade, tumor size, surgery, and treatment were significant predictors for the restricted mean survival time of patients with stage III stomach cancer. Surgery was the most significant predictor for increasing the restricted mean survival time of patients with stage III stomach cancer.

• Journal of Gastric Cancer
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• v.7 no.1
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• pp.47-54
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• 2007

Purpose: To investigate the characteristics and chronological changes of gastric cancer in Korea, the Information Committee of the Korean Gastric Cancer Association performed nationwide survey for 2004. Materials and Methods: The data on patients who underwent gastric cancer surgery in 2004 were collected from 57 institutes and compared with those of 1995 and 1999 which were reported in 2002. Fourteen factors (sex, age, tumor location and size, gross type, approach to operation, radicality, operative method, reconstruction method, WHO and Lauren classification, UICC stage, and numbers of positive and retrieved lymph nodes) were analyzed. According to the annual number of gastric cancer operations, 57 institutes were divided into 4 groups (group 1, <100; 100 ${\leq}$ group 2 < 200 operations; 200 ${\leq}$ group 3 < 500 operations; group 4, ${\geq}500$). Results: Data on 11,293 patients were collected. The sex ratio (M : F) was 2.05 : 1 (7,586/3,705). The mean age was 58.0 years old. The age of highest incidence in both male and female has increased recently. The proportion of early gastric cancer has increased from 28.6% in 1995 and 32.8% in 1999 to 47.4% in 2004. The mean number of retrieved lymph nodes was 34.0 (32.8, 34.0, 36.1, and 32.9 for group 1, 2, 3, and 4 respectively). Conclusion: Early gastric cancer has increased in 2004 compared to 1995 and 1999. Gastric cancer surgery seems to be performed with acceptable quality in view of number of retrieved lymph nodes. These data presented in nationwide survey could be used as a fundamental resource for gastric cancer in Korea.

• Journal of Gastric Cancer
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• v.8 no.4
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• pp.244-249
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• 2008

Konkuk University Hospital (KUH), which opened in September 2005, is currently categorized as a secondary hospital. Early on after its establishment, the surgical residents and nurses were relatively inexperienced in the treatment of stomach cancer. Therefore, the quality of surgery for stomach cancer at KUH may be different from that of the existing large-scale tertiary hospitals. The purpose of this study is first to investigate the clinicopathological characteristics of the gastric cancer patients at the KUH, and second to compare our morbidity & mortality rates with those of previous studies, and we also analyzed the risk factors of morbidity at the early stage of a training hospital. Materials and Methods: This study retrospectively collected the clinicopathological characteristics and the post-operative morbidity rates and mortality rates with using the electronic medical records of all the patients who went under a gastric cancer operation at KUH from September 2005 to April 2008. Results: The total number of gastric cancer patients who underwent operation was 201. The morbidity rate and death rate at KUH were 10.4% and 0.5%, respectively. The morbidity has increased with an older age. The other variables had no influence on morbidity. Conclusion: The morbidity rate, death rate and the clinicopathological characteristics of gastric cancer patients at KUH were similar to those of the previous reports. We found that age is the main factor affecting the morbidity rate after stomach cancer surgery. For further surgical qualification of stomach cancer surgery at KUH, it is necessary to collect the survival data of patients who undergo stomach cancer surgery.

• Journal of Digestive Cancer Reports
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• v.8 no.2
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• pp.102-108
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• 2020

Background: This study was performed to evaluate the effect of gastric cancer screening through analysis of screening-related data. Methods: We investigated claims data of gastric cancer from 2009 to 2015. We evaluated whether the screening was performed to prior to registration as patients with gastric cancer. The effect of gastric cancer screening was also analyzed by gender. Results: We collected total 196,293 patients with gastric cancer. 74% of them had previous experience of gastric cancer screening. In patients with screening, early gastric cancer was 33.4% and advanced gastric cancer was 17.3%. 22,548 (15.5%) patients were diagnosed with gastric cancer within 2 years after screening. In the case of patients without screening, early gastric cancer was 15.1% and advanced gastric cancer was 25.3%. In case of men, 76% of them confirmed gastric cancer through screening, and 70.2% of women confirmed the gastric cancer. In both men and women, the rate of early gastric cancer was higher among those with screening than those without screening. Conclusion: In this study, we were able to indirectly confirm the stage shift of gastric cancer screening. However, within 2 years after screening, not a few patients with gastric cancer were diagnosed. Therefore, more studies are warranted to in the future.

• The Journal of the Korean life insurance medical association
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• v.25
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• pp.25-48
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• 2006

연구배경 : 우리나라에서 암발생 및 암사망이 지속적으로 증가하면서 암관리에 대한 국가적인 관리가 시행되고 있으나, 이에 필수적인 암사망통계 자료 및 연구는 미흡한 실정이다. 따라서 자료원별로 암사망통계를 조사하고 비교 분석하고자 한다. 연구방법 : 1997년부터 2002넌까지 통계청의 사망원인통계연보, 보험개발원의 생명보험 사망원인통계자료를 수집하고 연령별, 성별, 암종류별로 비교 분석하였다. 연구결과 : 전체 암종류별 사망분율은 통계청 자료에서는 폐암이 가장 높았고 보험개발원 자료에서는 간암이 가장 높은 분포를 나타냈다. 남자의 경우 통계청과 보험개발원의 암종류별 사망분율은 모두 간암이 가장 높은 분포를 위암, 폐암 순이었다. 여자의 경우 두 자료원 모두 위암의 사망분물이 가장 높았으나, 통계청 자료에서는 간암, 유방암 순이었고, 보험개발원 자료에서는 유방암, 간암 순이었다. 결론 : 본 연구를 통해 사망자료원에 따라 암사망통계의 내용과 결과가 차이가 있으며, 이는 자료원의 목적과 성격에 차이가 있기 때문인 것으로 생각된다. 따라서, 이를 해석하고 이용하는데 자료원에 따라 충분한 검토와 주의가 요망된다.

• The Korean Journal of Applied Statistics
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• v.12 no.2
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• pp.325-333
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• 1999

경북대학교병원에서 1985년에서 1994년까지 위암 때문에 위 절제수술을 받은 1,192명의 환자에 대한 자료를 이용하여 5년 생존율에 관해 분석하고자 한다. 일반적으로 위암 진단을 받은 환자가 수술을 받으려고 할 때 또는 수술을 직후에, 환자의 임상적 특성들을 이용하여 수술후 생존시간과 수술후 5년 생존 여부는 큰 의미가 있다. 그러나 많은 경우에 있어서 실제 임상자료는 연구가 진행 중에 있으므로 생존시간이 우측 중도절단된 형태로 관측되어 기존의 판별분석과 로짓분석을 적용할 수 없다. 본 논문에서는 Buckley와 James가 제안한 의사확률변수를 이용하여 수술전과 수술직후, 두 시점에서 중도절단된 자료를 보완하고, 판별분석과 로짓분석을 통하여 수술전과 수술직후에 환자들의 각 특성이 5년 생존여부에 미치는 영향을 분석을 한다.

• Proceedings of the KAIS Fall Conference
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• 2009.05a
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• pp.123-127
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• 2009

본 논문은 국내 일부지역 주민의 건강행태가 위암발생에 영향을 미치는 요인들을 규명하기 위해 시행하였다. 이를 위해 서울에 소재한 한 종합병원에 위암관련 검진을 받기 위해 내원한 환자로 조직병리검사상 위암으로 확진받은 91명을 환자군으로 선정하였다. 대조군도 환자군과 동일한 기간, 동일한 병원 내과에 내원하여 동일한 방법으로 검진한 결과 위암에 속하지 않는 것으로 진단된 환자군과 연령, 성별에 대해 짝짓기하여 선정된 91명이었다. 자료수집은 2008년 12월 20일부터 2009년 1월 30일까지 설문과 면접조사의 방법을 병행하여 진행하였다. 연구결과 첫째, 취미활동량은 취미활동을 전혀 하지 않는 군에 비해 일일 평균 300kcal 미만 또는 그 이상의 열량을 소모하는 군에서 교차비가 각각 0.27과 0.33으로 위암발생 위험을 유의하게 감소시켰다(P<0.05). 둘째, 음주경험이 없는 군에 비해 있는 군(OR=1.85, 95% Cl=1.02-3.36), 총 음주기간이 30년 이상인 경우(OR=5.91, 95% Cl=1.78-19.95)에서 유의하게 높았다. 셋째, 탄음식을 주 3회 이상 섭취할 경우(OR=4.85 95% Cl=1.61-9.84), 짠음식의 섭취빈도가 주 3회 이상인 경우(OR=1.49 95% Cl=0.26-0.91) 위암발생과 유의하게 관련되었다. 넷째, 다중 로지스틱 회귀분석결과 위암발생에 영향을 미치는 요인은 월평균소득, 10년 전 BMI, 취미활동량, 알코올 섭취량, 탄류 및 짠류 섭취였다. 이러한 연구결과를 토대로 적당한 취미활동이 육체적 활동량의 증가뿐만 아니라 건강행동변화를 유도하여 결과적으로 위암예방 효과를 높일 수 있을 것이라 본다.

• Journal of Preventive Medicine and Public Health
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• v.35 no.3
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• pp.245-254
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• 2002

Objective : To test if the intake of $H_2$ receptor antagonists ($H_2$-RAs) increases the risk of gastric cancer in the elderly. Methods : The source population for this study was drawn from the responders to a questionnaire survey administered to the Korea Elderly Pharmacoepidemiological Cohort (KEPEC), who were beneficiaries of the Korean Medical Insurance Corporation, were at least 65 years old, and residing in Busan in 1999. The information on $H_2$-RAs exposure was obtained from a drug prescription database compiled between inn. 1993 and Dec. 1994. The cases consisted of 76 gastric cancer patients, as confirmed from the KMIC claims data, the National Cancer Registry and the Busan Cancer Registry. The follow-up period was from Jan. 1993 to Dec. 1998. Cancer free controls were randomly selected by 1:4 individual matching, which took in to consideration the year of birth and gender. Information on confounders was collected by a mail questionnaire survey. The odds ratios, and their 95% confidence intervals, were calculated using a conditional logistic regression model. Results : After adjusting for a history of gastric ulcer symptoms, medication history, and body mass index, the adjusted OR (aOR) was 4.6 (95% CI=1.72-12.49). The odds ratio of long term use (more than 7 days) was 2.3 (95% CI=1.07-4.82). The odds ratio of short term use was 4.6 (95% CI=1.26-16.50). The odds ratio of parenteral use was 4.4 195% CI=1.16-17.05) and combination use between the oral and parenteral routes (aOR, 16.8; 95% CI=1.21-233.24) had the high risk of gastric cancer. The aOR of cimetidine was 1.7 (95% CI=1.04-2.95). The aOR of ranitidine was 2.0 (95% CI=1.21-3.40). The aOR of famotidine was 1.7 (95% CI=0.98-2.80). Conclusion : The intake of $H_2$-RAs might increase the risk of gastric cancer through achlorhydria in the elderly.

• 대한예방의학회:학술대회논문집
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• 2001.10a
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• pp.236-236
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• 2001

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.1
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• pp.456-465
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• 2018

This study was conducted to investigate the relationships among self-efficacy, family support, and self-care performance of gastric cancer surgery patients. The study was conducted from 11 October to 15 November 2013. Data were collected by self-report questionnaires from 121 patients who were diagnosed with stomach cancer and had undergone surgery at D university hospital in B city and were in follow-up care for 3 months to 5 years after surgery. Data were analyzed using SPSS/PC WIN 18.0 to obtain the percentage, average, mean rating, and standard deviation. In addition, t-test, ANOVA, Scheffe's test, Pearson's correlation and stepwise multiple regression were conducted. The degree of self-care performance in research targets showed significant differences by sex (t=-2.25, ｐ=0.027), religion (F=3.67, ｐ=0.028) and profession (F=4.17, ｐ=0.008). Self-care performance was positively correlated (r=0.60, ｐ<0.001) with the degree of specific self-efficacy. There was a significant difference in self-care performance by specific self-efficacy, religion and gender. The total explanatory power was 37.9% and the explanatory power of the degree of specific self-efficacy (${\beta}=0.53$) was greater than that of other factors. Therefore, it is necessary to provide interventions that improve specific self-efficacy to help patients with gastric cancer patients conduct self-care performance, and practical measures should be made with respect to religion and gender.