• 제목/요약/키워드: 원자력학회지

검색결과 904건 처리시간 0.028초

Effect of Gamma Irradiation on the Splenocyte Proliferation and Cytokine Production of Chaga Mushroom Hot Water Extract (방사선 조사된 차가버섯 열수 추출물의 비장세포 증식능 및 사이토카인 발현에 미치는 영향)

  • Sung, Nak-Yun;Kim, Jae-Hun;Choi, Jong-Il;Song, Beom-Seok;Kim, Jae-Kyung;Park, Jong-Heum;Kim, Jin-Kyu;Lee, Ju-Woon
    • Journal of Radiation Industry
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    • 제5권2호
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    • pp.169-173
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    • 2011
  • This study investigated the effect of gamma irradiation on immune enhancing activity of Chaga mushroom extract (CME). CME was prepared by hot water extraction at $70^{\circ}C$ for 4 hours and lyophilized. Lyophilized CME powder was dissolved with deionized water at $10mg\;ml^{-1}$ and then irradiated at the doses of 10, 30 and 50 kGy by cobalt 60 gamma irradiator. The gamma-irradiated and non-irradiated CME were treated into the splenocyte separated from mouse. Cell proliferation and cytokine production of the immune cells were increased by gamma-irradiated CME and these increases were more prominent when CME was irradiated at higher doses. Therefore, it is considered that gamma irradiation can be an effective method for improvement of the immunomodulating activity Chaga mushroom extract.

Synthesis of 18F Labeled Clotrimazole Derivatives as a Potential PET Imaging Agent (18F을 표지 암 영상용 클로트리마졸 유도체의 합성)

  • Jung, Soon Jae;Kim, In Jong;Park, Jeong Hoon;Lee, Heung Nae;Kim, Sang Wook;Hur, Min Goo;Choi, Sang Moo;Yang, Seung Dae;Yu, Kook Hyun
    • Journal of Radiation Industry
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    • 제4권1호
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    • pp.7-11
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    • 2010
  • Clotrimazole [1-{(2-chlorophenyl)-diphenylmethyl}-1H-imidazole, CLT] has been reported to inhibit the proliferation of vascular endothelial and act as an in vitro anti-VEGF drug. It is also shown to inhibit angiogenesis in an animal model. The radioisotope labeled clotrimazole derivative can be utilized to monitor the physiologic processes of cancer. In this study, we synthesized [$^{18}F$]fluoride labeled clotrimazole derivatives as a new tumor imaging agent for PET. The references were prepared by a refluxing with clotrimazole and an excess of fluoroalkyltosylate in acetonitrile for 36 h and clotrimazole reacted with ditosylalkane to give precursors. [$^{18}F$]Fluoride labeled reaction was performed with precursor in Kryptofix[2.2.2]/$K_2CO_3$ for 10 min at $80^{\circ}C$. The radiolabeling mixture was passed through a silica Sep-Pak cartridge to remove $^{18}F^-$. The [$^{18}F$]F-clotrimazole derivatives were synthesized with a 20~25% yield. In the radiofluorination step, we used acetonitrile and DMSO as a solvent and observed a higher yield at the acetonitrile (25%) reaction compared with the DMSO reaction (5%).

Radiation Preparation and Characterization of Antimicrobial Hydrogels (방사선 이용 항균성 천연추출물 함유 하이드로겔 제조 및 특성 연구)

  • Gwon, Hui-Jeong;Park, Eun Ji;Choi, Jong-Bae;Lim, Jong-Young;Jeong, Jin-Oh;Shin, Young Min;Jeong, Sung In;Park, Jong-Seok;Lim, Youn-Mook
    • Journal of Radiation Industry
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    • 제7권1호
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    • pp.87-91
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    • 2013
  • Taraxacum platycarpum (TP) has been used for years without restriction on usual dose for its non-toxic nature and nonexistence of the side effects. To develop antimicrobial hydrogel, poly (vinylalcohol) (PVA) hydrogels containing the aqueous extracted TP as an antimicrobial agent were prepared by using gamma-rays irradiation. The antimicrobial activities of the TP hydrogels were tested against Staphylococcus aureus and Staphylococcus epidermidis by disc diffusion method. The inhibition zones (IZ) of the TP extracts and TP hydrogels against S. aureus were 16 mm and 20 mm and against S. epidermidis was 10 mm and 13 mm, respectively. In conclusion, the TP hydrogel that has an excellent antimicrobial activity was proved to be a valuable material for functional skin care.

Reliability Prediction of Long-term Creep Strength of Gr. 91 Steel for Next Generation Reactor Structure Materials (미래형 원자로 구조 재료용 Gr. 91 강의 장시간 크리프 강도의 신뢰성 예측)

  • Kim, Woo-Gon;Park, Jae-Young;Yin, Song-Nan;Kim, Dae-Whan;Park, Ji-Yeon;Kim, Seon-Jin
    • Korean Journal of Metals and Materials
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    • 제49권4호
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    • pp.275-280
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    • 2011
  • This paper focuses on reliability prediction of long-term creep strength for Modified 9Cr-1Mo steel (Gr. 91) which is considered as one of the structural materials of next generation reactor systems. A "Z-parameter" method was introduced to describe the magnitude of standard deviation of creep rupture data to the master curve which can be plotted by log stress vs. The larson-Miller parameter (LMP). Statistical analysis showed that the scattering of the Z-parameter for the Gr. 91 steel well followed normal distribution. Using this normal distribution of the Z-parameter, the various reliability curves for creep strength design, such as stress-time temperature parameter reliability curves (${\sigma}$-TTP-R curves), stress-rupture time-reliability curves (${\sigma}-t_{r}-R$ curves), and allowable stress-temperature- reliability curves ([${\sigma}$]-T-R curves) were reasonably drawn, and their results are discussed.

Application of Minimum Commitment Method for Predicting Long-Term Creep Life of Type 316LN Stainless Steel (Type 316LN 스테인리스강의 장시간 크리프 수명 예측을 위한 최소구속법의 적용)

  • Kim, Woo-Gon;Yin, Song-Nan;Ryu, Woo-Seog;Lee, Chan-Bock
    • Korean Journal of Metals and Materials
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    • 제46권3호
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    • pp.118-124
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    • 2008
  • Abstract: A minimum commitment method(MCM) was applied to predict the long-term creep rupture life for type 316LN stainless steel(SS). Lots of the creep-rupture data for the type 316LN SS were collected through world-wide literature surveys and the experimental data of KAERI. Using these data, the long-term creep rupture life above ${10}^5$ hour was predicted by means of the MCM. In order to obtain the most appropriate value for the constant A being used in the MCM equation, trial and error method was used for the wide ranges from -0.12 to 0.12, and the best value was determined by using the coefficient of determination, $R^2$ which is a statistical parameter. A suitable value for the A in type 316LN stainless steel was found to be at -0.02 ~ -0.05 ranges. It is considered that the MCM will be superior in creep-life prediction to commonly-used timetemperature parametric method, because the P(T) and G($\sigma$) functions are determined from the regression method based on experimental data.

원전 사이버 보안 취약점 점검 기술 동향 및 개발 사례

  • Choi, Yangseo;An, Gaeil
    • Review of KIISC
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    • 제30권5호
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    • pp.35-44
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    • 2020
  • 정보화 시대의 도래와 함께 원자력발전소 등 사회 간접자본의 중요 시설에서 운영되는 각종 장치들 역시 디지털화되면서 기존에 존재하지 않았던 사이버 공격에 대한 위협이 현실화되고 있다. 이러한 중요 사회 간접자본 등의 운영에 위협을 가하는 행위는 사회적으로 경제적으로 매우 큰 재난을 발생시킬 수 있기 때문에 공격 발생 이전에 사전 방어 체계를 구축해야 하는데, 이때, 실질적으로 위협이 되는 취약점의 존재 여부를 사전 인지하는 것이 매우 중요하다. 이를 위하여 본 논문에서는 원자력발전소의 계측제어계통에서 운영되는 국산화된 디지털 장치에 대하여 관련 취약점을 확인하고 확인된 취약점의 실질적인 위험도를 장치의 운영환경 특징을 반영하여 도출하며, 주요 기기의 운영 규제지침의 준수 여부를 점검하는 도구의 개발 결과를 소개한다. 본 논문은 원자력발전소 상에서 운영되는 시스템을 주요 대상으로 작성되었다.

분산제어방식을 적용한 CANDU형 발전소의 계측제어계통

  • 김영백;홍형표;한재복
    • ICROS
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    • 제2권5호
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    • pp.56-62
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    • 1996
  • 캐나다 원자력공사(AECL)에 의하여 1960년대 초에 개발되어 상업운전중이거나 건설중인 CANDU 6 발전소는 중앙집중제어방식을 채택하여 계통의 성능 및 신뢰성이 입증되었으나 경제성 및 유지보수의 어려움으로 인하여 현재 개발이 진행중인 CANDU3과 CANDU9 발전소에서는 프로그래머블 콘트롤러를 이용한 분산제어방식을 기반으로 하여 계측제어계통이 설계되고 있다. 분산제어계통은 우수한 확장성과 신뢰성으로 인하여 이미 일반 산업 분야에서 널리 활용되고 있으며 최근에는 원자력발전소에도 적용범위가 계속해서 확대되고 있다. 본 보고서는 최신의 계측제어기술을 적용하여 차세대 대용량 원자력발전소로 개발중인 CANDU9 발전소의 발전소 전제어계통과 핵연료취급제어계통 등 계측제어계통에 대한 주요 계통설계 방안과 분산제어계통의 설계개념을 소개하고 CANDU 발전소에 분산제어방식을 적용한 장점을 고찰하고자 한다.

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An Analysis on Policy Trends of the Use and Development of Nuclear Power in Nuclear Advanced Countries (주요국의 원자력이용개발 정책동향 분석)

  • 차종희;조흥곤;양맹호
    • Journal of Korea Technology Innovation Society
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    • 제6권4호
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    • pp.462-479
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    • 2003
  • The policy trends of use and the development of nuclear power in the United States, France, United Kingdom. Germany, Russia, China, Japan and Korea are briefly investigated. Nuclear power technology has been developed as the national policy in the nuclear-advanced countries. 50 years has passed since the declaration of "Atoms for Peace" by USA President Eisenhour in December 1953. Recently, it appears to revitalize the nuclear power program in world major countries in order to recover the shortage of electric power and to curb the excess emission of carbon dioxide as well as to secure competitiveness in electricity markets. Advanced countries are making new initiatives for the development of the fourth generation nuclear power system. Furthermore, wide-ranged use and development of nuclear power technologies are expected in district heating in commercial sectors, power in the space exploration, and propulsion power of large tankers and spaceships. High temperature gas cooled nuclear power reactor will be applied for mass production of hydrogen energy in the future.

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국외 원전 디지털자산 공급망 사이버보안 규제 동향

  • LIM, SOO MIN;KIM, ARAM;SHIN, ICKHYUN
    • Review of KIISC
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    • 제26권1호
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    • pp.54-60
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    • 2016
  • 기업들의 생산 공정이 세분화되면서 하나의 디지털 기기는 여러 단계의 공급망을 통해 원자력 발전소 외부에서 제작된 후 공급된 기기들과 소프트웨어의 조합으로 최종 완성품이 제작된다. 이러한 공정 과정을 거치는 다양한 나라, 회사에서 제작된 수많은 부품들과 소프트웨어의 조합은 어느 하나의 단계에서 발생한 의도되거나 의도되지 않은 결함 또는 사이버 위험을 포함한 최종제품이 될 가능성을 가지고 있으며 실제로 공급망을 위협하는 사례가 발생하기도 하였다. 이러한 결과로 공급망을 통한 사이버공격의 보안 위험 사례를 관리하는 것이 디지털화가 급격하게 진행되고 있는 원자력발전소와 같은 주요기반시설의 안전과 보안을 유지하는데 고려해야하는 중요한 요소가 되고 있다. 본 논문에서는 공급망을 통한 사이버보안 위험 사례와, 원자력발전소 디지털 자산 공급망 위험관리를 위한 해외 사례를 살펴보고자 한다.

A Study on Nuclear Information Management System Utilizing Microcomputer (마이크로 컴퓨터를 이용한 원자력 분야 정보 관리 시스템 개발)

  • 김규선;김태승
    • Journal of the Korean Society for information Management
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    • 제6권1호
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    • pp.15-36
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    • 1989
  • The r a p i d i n c r e a s e o f microcomputer technology has r e s u l t e d i n t h e broad a p p l i c a t i o n t o various f i e l d s . The purpose of t h l s paper 1s to design a computerized r e t r i e v a l system f o r nuclear information m a t e r i a l s using a microcomputer.

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