• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.05a
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• pp.293-293
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• 2004

최근 교통사고의 증가와 평균수명의 연장으로 인한 노인 인구의 급증으로 중추신경계의 기능에 손상을 초래하는 각종 질환들 즉 뇌졸중, 외상성 뇌손상, 뇌성마비 및 퇴행성 뇌질환 등이 더욱 많아지고 있다. 이러한 질환들은 뇌기능 장애로 인한 운동, 감각 및 인지능력 저하를 일으켜 보행과 일상생활 동작수행에 큰 장해를 초래하게 된다. 특히 보행능력의 장해는 일상생활 및 사회생활에 필요한 기동력을 제한하므로 결국 타인에 의존적이 되고 사회로부터 고립되는 심각한 기능장애를 일으키게 된다.(중략)

• The Journal of the Korea Contents Association
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• v.9 no.1
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• pp.348-358
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• 2009

Diffuse axonal injury(DAI) is a common form of traumatic brain injury and thought to be a major contributor to cognitive dysfunction. Physical activity has been shown to beneficial effects on physical health and influences in hippocampus which is an important location for memory and learning. The purpose of this study was to investigate the effect of motor training on motor performance and axonal regeneration in hippocampus through the immunoreactivity of GAP-43 after diffuse axonal injury in the rats. The experimental groups were applied motor training(beam-walking, rotarod, and Morris water maze) but control groups were not. The time performing the motor tasks and GAP-43 immunohistochemistry were used for the result of axonal recovery. There were meaningful differences between experimental groups and control groups on motor performance and GAP-43 immunohistochemistry. The control groups showed increasing tendency with the lapse of time, but experimental groups showed higher. Therefore, Motor training after DAI improve motor outcomes which are associated with dynamically altered immunoreactivity of GAP-43 in axonal injury regions, particularly hippocampus, and that is related with axonal regeneration.

• Korean Journal of Psychosomatic Medicine
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• v.7 no.2
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• pp.184-195
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• 1999

Objectives : As traumatic brain injury(TBI) leaves chronic sequelae in mind and body, the injured patients should rectify the meaning and object that they have pursued in their lives and set up a new purpose in life that they may make the rest of their lives meaningful. This study was designed to investigate the purpose and quality of life levels and the influence of demographic and clinical variables on the levels in the patients with TBI, and to be of some help to their rehabilitation. Methods : In order to assess the purpose in life(PIL) and the quality of life(QOL) levels, Purpose-in-Life Test, Sickness Impact Profile, Quality of Life Index, Head Injury Symptom Ckecklist, and Neurobehavioral Rating Scale were administered to the subjects. The subjects were thirty-two patients with TBI and the same numbered normal controls. The TBI group was composed of 16 to 65 year-aged patients who had received mild or severe TBI at least 12 months before, and the controls were siblings or friends of the patients whose age, sex, and educational level were similar to them. Results : 1) The PIL and QOL levels of the patients with TBI remained significantly lower than that of control group after their symptoms of injury were stabilized(p<.01, p<.01). 2) The mean PIL score of TBI group was $58.8{\pm}23.2$, which was to be regarded as the level of existential vacuum. 3) The PIL level of TBI group was significantly correlated with the QOL level(p <.01). 4) The subgroup with lower PIL level in patients with TBI has significantly higher rate of female than that with higher PIL(p<.05), the PIL level of female patients was significantly lower than that of male patients(p <.05). 5) The significant differences in PIL levels were not found, in which comparison was performed between each pair of subgroups of patients with TBI divided by severity of injury(mild vs severe), marital status(married vs unmarried), and occupational status prior to injury(employed vs unemployed). Conclusion : The PIL of patients with TBI still remained the level of existential vacuum after symptoms of sequelae had been stabilized, The QOL level was also extremely low, and as the PIL level was low the QOL was also low. The demographic and clinical variables except sex did not have influence on the PIL level in brain-injured patients. It is suggested that every patient should admit their mental and physical limitations caused by brain injury and revise their purpose in life for successful rehabilitation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.8
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• pp.171-180
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• 2017

The purpose of this study is to determine an effective training method to improve sequela, since traumatic brain injury sequela is a major factor in determining the quality of life. Neurofeedback training was conducted for an adolescent who had experienced traumatic brain injury during his childhood and who had difficulty in cognitive learning and emotional aspects. The assessment of an adolescent was conducted using K-WAIS-IV intelligence test and QEEG brain wave analysis. In the neurofeedback training, T3 alpha wave compensation and T4 alpha wave inhibition training were performed 36 times for 30 minutes three times a week. In addition to the neurofeedback training, respiratory meditation was also made available to the adolescent. As a result, the adolescent showed a stable condition as indicated by taking a good sleep, reducing test anxiety, and satisfaction with final exam results. This study revealed the possibility for hidden physical and psychological problems arising due to childhood brain trauma. It has also recently been discovered that a more diverse set of tools can be found. In addition, these childhood traumatic brain injuries can be improved through brain training and meditation. The study finding is meaningful for its suggestion of a fusion method for developing mind and body therapy in terms of brain science.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.5
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• pp.3344-3352
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• 2015

The purpose of this study is to investigate the effects of Korean computer-based cognitive rehabilitation program (CoTras) on frontal-executive functions in patients with traumatic brain injury (TBI). This study was performed at C hospital in Changwon, Gyeongsangnam-do, Korea from August 2013 to March 2014. Ten patients with TBI were randomly divided into two groups. The experimental group had been given CoTras once a day, five times a week for four weeks, whereas the control group had performed self-cognitive training under the same conditions. To verify the effect of intervention, the following executive function measures were used: Korean Montreal Cognitive Assessment (K-MoCA), Executive Clock Drawing Test (ECDT), Trail Making Test (TMT), Rey-Complex Figure Test (RCFT). Intervention group showed significant increase in K-MoCA, TMT, RCFT-delayed recall (p<.05). However, control group showed no significant change in any test. There was significant difference of changed scores (post test-pre test) between two groups in K-MoCA, TMT and RCFT-delayed recall (p<.05). This study showed that CoTras is effective to improve frontal-executive functions in patients with traumatic brain injury.

• Journal of Korea Entertainment Industry Association
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• v.13 no.6
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• pp.277-286
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• 2019

The aim of this study was to investigate the effects of computer-based cognitive rehabilitation and traditional cognitive training on the working memory and executive function of patients with mild traumatic brain injury. The sample consisted of 20 patients with mild traumatic brain injury who had received rehabilitation treatment in a rehabilitation unit. The subjects were assigned to either the experimental (n = 10) or control group (n = 10). The experimental group received computer-based cognitive rehabilitation and traditional cognitive training for 60 minutes, whereas the control group received only traditional cognitive training for 60 minutes. Both the groups received their respective interventions for 60 minutes a day and 5 times per week across a period of 4 weeks. Working memory and executive function were assessed using the digit span test (forward and backward), visual memory 1 and 2 of the Motor-free Visual Perception Test-3, trail making test, and Stroop test (A and B) both before and after the intervention. The experimental group showed a significantly greater improvement in visual memory and performance on the Stroop test A than the control group. These findings suggest that computer-based cognitive rehabilitation and traditional cognitive training are more effective in promoting positive changes in the working memory and executive function of individuals with mild traumatic brain injury than traditional cognitive training.

• Sleep Medicine and Psychophysiology
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• v.6 no.2
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• pp.97-101
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• 1999

Sleep disorders are relatively common occurrence after traumatic brain injury. Sleep disturbances often resulted in difficulties in sleep onset and sleep maintenance, nonrestorative after sleep, poor daytime performances and poor individual sense of wellbeing. Unfortunately, there has been minimal attention paid to this common and disabling sequela of brain injury. Better undertanding about problem, pathophysiology and treatment of sleep disorder after traumatic brain injury will improve the cognitive function, social adjustment and rehabilitation for injured patients. Also it may be helpful to reduce traumatic brain injury in patients with sleep apnea.

• Composites Research
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• v.37 no.1
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• pp.21-31
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• 2024

This review paper investigates the use of shockwave attenuating materials within composite structures to enhance personnel protection against blast-induced traumatic brain injury (bTBI). This paper also introduces experimental methodologies exploited in the generation and measurement of shockwaves to evaluate the performance of the shock dissipating composites. The generation of shockwaves is elucidated through diverse approaches such as high-energy explosives, shock tubes, lasers, and laser-flyer techniques. Evaluation of shockwave propagation and attenuation involves the utilization of cutting-edge techniques, including piezoelectric, interferometer, electromagnetic induction, and streak camera methods. This paper investigates phase-separated materials, including polyurea and ionic liquids, and provides insight into composite structures in the quest for shockwave pressure attenuation. By synthesizing and analyzing the findings from these experimental approaches, this review aims to contribute valuable insights to the advancement of protective measures against blast-induced traumatic brain injuries.

• Korean Journal of Biological Psychiatry
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• v.5 no.1
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• pp.71-82
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• 1998

The neuropsychiatric sequelae of traumatic brain injury are effects on complex aspect of cognition, emotion and behavior. They include problems with attention and arousal, concentration, executive function, intellectual changes, memory inpairments, personality changes, affective disorders, anxiety disorders, psychosis, apathy, aggression, and irritability. There are many useful therapeutic approaches available for people who have been brain injuries. Although a multifactioral, multidisciplinary, collaborative approach to treatment is proposed, for purposes of exposition the author have divided treatment into psychopharmacological, cognitive, behavioral, psychological, and social interventions.

• Progress in Medical Physics
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• v.14 no.4
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• pp.259-267
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• 2003

In vivo $^1$H magnetic resonance spectroscopy (MRS) at 4.7 T was applied to investigate the cerebral metabolite changes of mice brain before and after experimental brain trauma. In vivo $^1$H MR spectra were acquired from a voxel covering right parietal cortex in normal brain, used as control subjects. After experimental brain trauma using the fluid percussion injury (FPI) method, $^1$H MR spectra were acquired from the same lesion three days after trauma. Metabolite ratios of the injured lesion were compared to those of controls. After trauma, N-acetylaspartate (NAA)/creatine (Cr) ratio, as a neuronal marker was decreased significantly versus controls, indicating neuronal loss. The ratio of NAA/Cr in traumatic brain contusion was 0.90$\pm$0.11, while that in normal control subjects was 1.13$\pm$0.12 (P=0.001). Choline (Cho)/Cr ratio had a tendency to rise in experimental brain contusion (P=0.02). Cho/Cr ratio after trauma was 0.91$\pm$0.17 while that before traumas was 0.76$\pm$0.15. Cho/Cr ratio was increased and this might indicate a inflammatory activity. However, no significant difference of [(glutamate＋glutamine) (Glx)]/Cr was established between experimental traumatic brain injury models and normal controls. Lactate (Lac)/Cr ratio was appeared as a sign of shifted posttraumatic energy metabolism and increased versus controls. These findings strongly suggest that in vivo $^1$H MRS may be a useful modality for clinical evaluation of traumatic contusion and could aid in better understanding the neuropathologic process of traumatic contusion induced by FPI. In the present study, in vivo $^1$H MRS was proved to be a useful non-invasive method for in vivo diagnosis and monitoring of posttraumatic metabolism in models of brain contusion.