• Journal of Life Science
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• v.9 no.2
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• pp.194-200
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• 1999

Grinding aid is a necessary unit operation when the raw materials are handled in solid form, and the purpose is to improve the bioavailability by reducing the particle size. For the particle design of pefloxacin, the dry planetary ball-mill was used. With the drying process, 330 g of zirconia ball with its size of 2 mm in diameter and 10 g of pefloxacin were transferred to the pot and mixed well. The mixture was ground at 112 rpm (60 Hz) for 15, 30, and 60 min, respectively. The most satisfactory grinding products were generated at 15 min of grinding time for their particle size. The volume mean diameter $\X_50$ of the grinding products was 2.97 $\mu$m. X-ray diffraction (XRD), differential scanning calorimeter (DSC), and infrared spectroscopy (IR) patterns were relatively unchanged before pulverizing pefloxacin and in the progress of grinding. Thus, these results suggest that this pulverizing method can be used for grinding products without evident effect on stability of the drug pefloxacin. Dissolution test was carried out to set up the optimal detective condition against residual antibacteria of fish by HPLC. The grinding pefloxacin for 15 min is most effective in dissolution test.

• Journal of KIISE:Software and Applications
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• v.34 no.12
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• pp.1056-1064
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• 2007

Biomolecular computing is a new computing paradigm that uses biomolecules such as DNA for information representation and processing. The huge number of molecules in a small volume and the innate massive parallelism inspired a novel computation method, and various computation models and molecular algorithms were developed for problem solving. In the meantime, the use of biomolecules for information processing supports the possibility of DNA computing as an application for biological problems. It has the potential as an analysis tool for biochemical information such as gene expression patterns. In this context, a DNA computing-based model of a biomolecular perceptron has been proposed and the result of its experimental implementation was presented previously. The weight encoding and weighted sum operation, which are the main components of a biomolecular perceptron, are based on the competitive hybridization reactions between the input molecules and weight-encoding probe molecules. However, thermodynamic symmetry in the competitive hybridizations is assumed, so there can be some error in the weight representation depending on the probe species in use. Here we suggest a generalized model of hybridization reactions considering the asymmetric thermodynamics in competitive hybridizations and present a weight encoding method for the reliable implementation of a biomolecular perceptron based on this model. We compare the accuracy of our weight encoding method with that of the previous one via computer simulations and present the condition of probe composition to satisfy the error limit.

• Geotechnical Engineering
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• v.14 no.4
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• pp.61-76
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• 1998

Various kinds of reinforced soil methods have been developed by many researchers or companies for their economic merits mainly. These methods have generally used sandy soils which have high permeability as embanking or backfill material. That is because, if poor embanking materials, especially like a clayey soil which has very low permeability, are used in a reinforced soil embanking, and if excessive pore water pressure is produced by external factors, the friction resistance between reinforcing members and Boils decrease, as a result possible damage or collapse of the body of a reinforced embankment. In fact, clayey Boils can also be used as a embanking materials with reinforcement which has high permeable capacity, and are expected to be able to dissipate the excess pore water pressure effectively. In this study reinforcing effects have been examined through a serries of direct shear tests in which clayey soils are reinforced with nonwoven geotextiles of which permeability is very high and tensile strength is relatively weaker than geogrids which are usually used in reinforced soil wall. Even though such nonwoven geotextile are used as reinforcement of high saturated clayey soils. the test results show the possibility that nonwoven geoteztiles could be used as a reinforcement for reinforced soil walls effectively.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.21 no.6
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• pp.323-330
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• 1988

The spatial distribution of sea water temperature variation pattern in the South-eastern coastal region of Korea was studied by empirical orthogonal function (E. O. F) analysis in several depths from surface to 300m using the monthly mean water temperature averaged for 23 years, water mass analysis by T. S diagram and sectional diagram of water temperature. Typical type of water temperature variation in this area can be divided into surface (0m-50m), subsurface (100m-150m) and intermediate (200m-300m) layer. The first mode value of water temperature change on the surface layer showed $99\%$ of total variation, and decreased with the increase of the depth. It is deduced to be in the range of $60-70\%$ on the 300m layer. The representative type of water temperature fluctuation by the first mode in each layer is as follows. Water temperature change in the surface layer showed a seasonal variation. In the subsurface layer, it is governed by the interaction of the Tsushima Warm Current water with the cold water and by the heat transfer process from the upper layer. In the intermediate layer, water temperature variation seems to be governed by the advection of the bottom cold water.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2006.04a
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• pp.166-170
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• 2006

본 연구에서는 폐광산 주변에 산재되어 있는 광미/광폐석을 처리하기 위하여 고형화 실증 실험을 수행하였다. 고형화 공정에서 흔히 사용하는 포틀랜드 시멘트와 MSG-E, MSG-N을 고화제로 사용하였으며 현장 광미 및 광폐석을 대상으로 고화체를 양생하고 고화체의 압축강도 및 중금속 용출 정도를 측정하였다. 고화체의 물리/화학적 특성을 비교하기 위해 광미/고화제 비율, 배합수/고화제 비율 그리고 고화체 양생기간을 실험인자로 설정하였다. 실험 결과 광미/고화제의 비율 1:1 만을 고려하더라도 중금속 용출의 급격한 감소가 이루어지는 것을 확인할 수 있었으며 광미/고화제의 비율을 3:1 이하로 유지시키는 경우, 고화체의 압축강도가 현행 폐기물 관리법(20조 관련)에서 규정하고 있는 차단형 매립시설 내부막의 압축강도 기준인 $0.21kgf/mm^2$ 보다 높은 것으로 나타났다. 다양한 pH를 갖는 수용액에 대하여 시간에 따른 고화체의 중금속 용출률을 측정한 결과, 수용액의 pH가 1과 13인 강산/강염기 용액에서 일부 중금속의 용출 농도가 지하수 생활용수 기준치를 초과하였으나, pH와 3 - 11인 경우에는 중금속 용출률이 급격히 감소하여 모두 기준치 이하를 나타내었다. 또한, pH가 1과 13인 수용액의 경우에도 고화체와 반응하는 시간이 증가할수록 고화체의 buffering 효과에 의해 수용액의 pH가 감소하였다. 이러한 결과는 현장에서 접촉수의 pH가 강산이나 강염기라 하여도, 고화체의 buffering 효과에 의해 시간이 지남에 따라 수용액의 pH가 낮아져 고화체로부터의 중금속 용출은 매우 감소할 것임을 의미한다.ss of an active application defined using the model. The technique is developed in a platform- and language-independent way, and it is algorithmic and can be automated by computer program. We give an example dealing with network auction to illustrate the use of the model and the verification technique.품으로 내부 온도분포를 측정하였으며, 유한차분법 프로그램으로 대류열전달계수를 결정하였다. 대류열전달계수는 792에서 2,107 W/m$^2$로 분석되었다. 대류열전달 계수는 액상식품과의 상대속도가 증가함에 따라서 증가하였고, 점도가 증가함에 따라서는 감소하였다.ce of precision/recall of 90.99%/92.52%, and 93.39%/93.41% respectively. 의한 변성에 부분적으로 보호 작용을 나타 낼 것으로 추정된다.경(製麴72時間頃)의 활성(活性)은 보리쌀국(麴), 밀가루국(麴), 찹쌀국(麴), 고구마국(麴)의 순이었다.험 결과 오전용 사료는 관행적인 산란계 배합사료에서 Ca공급제를 제외한 것을 급여하고, 오후용 사료는 Ca공급제를 3배 첨가한 T2처리로 15:00~16:00시에 교체급여를 하면 사료섭취량 감소와 사료비 절감면에서 바람직할 것으로 사료되며, 고에너지-고단백질-저Ca의 분말사료와 저에너지-저단백질-고Ca의 펠렛사료를 혼합급여하면 산란계의 사료

• Fire Science and Engineering
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• v.17 no.4
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• pp.124-130
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• 2003

This research focuses on analysis of a interaction fracture of various glasses due to contact of water sprayed curtain on hot glass surface with high temperature produced from convective heat source near glass wall. A large scaled experimental test was done in order to find the range of the glass surface temperature to be able to cause the breakage of the glasses when water droplets reach on the hot surface. This paper shows the allowable temperature of the glass surface for prevention of the cooling down breakage before water curtain droplets contact the surface. Allowable Temperature if $250^{\circ}C$ for the tempered glass but general glass is very relatively low. Therefore if the water curtain spray system was adequately activated by a thermal detector installed below ceiling adjacent glass wall with water curtain nozzle system, all hot glass would not break out by cooling water droplet's contact on the hot surface due to convective heat released by adjacent fire source near the glass wall.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.13 no.3
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• pp.197-205
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• 2020

Korean language has the characteristics that the pronunciation of phoneme units such as vowels and consonants are fixed and the pronunciation associated with a notation does not change, so that foreign learners can approach rather easily Korean language. However, when one pronounces words, phrases, or sentences, the pronunciation changes in a manner of a wide variation and complexity at the boundaries of syllables, and the association of notation and pronunciation does not hold any more. Consequently, it is very difficult for foreign learners to study Korean standard pronunciations. Despite these difficulties, it is believed that systematic analysis of pronunciation errors for Korean words is possible according to the advantageous observations that the relationship between Korean notations and pronunciations can be described as a set of firm rules without exceptions unlike other languages including English. In this paper, we propose a visualization framework which shows the differences between standard pronunciations and erratic ones as quantitative measures on the computer screen. Previous researches only show color representation and 3D graphics of speech properties, or an animated view of changing shapes of lips and mouth cavity. Moreover, the features used in the analysis are only point data such as the average of a speech range. In this study, we propose a method which can directly use the time-series data instead of using summary or distorted data. This was realized by using the deep learning-based technique which combines Self-organizing map, variational autoencoder model, and Markov model, and we achieved a superior performance enhancement compared to the method using the point-based data.

• Korean Journal of Microbiology
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• v.47 no.4
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• pp.364-374
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• 2011

Lactobacillus brevis DK25 isolated from Dongchimi was identified by physiological and biochemical tests and 16S rDNA sequence analysis. Bacteriocin of L. brevis DK25 exhibits inhibitory activity against Enterococcus faecalis and Listeria monocytogenes when using agar well diffusion method. Maximal production of bacteriocin was reached in the beginning of the stationary phase, and inhibitory activity declined after the late stationary phase. This result suggested that bacteriocin was produced in a growth-associated manner. Complete inactivation of bacteriocin activity was observed after treatment with protease, but the activity was stable between pH 4-9 and heat resistant (30 min at $100^{\circ}C$). Bacteriocin showed a concentration-dependent antimicrobial activity against L. monocytogenes KCTC 3569. Moreover, the application experiment showed that combination of bacteriocin (320 AU/ml) with potassium benzoate (0.05%) could significantly reduce the counts of L. monocytogenes KCTC 3569 in mayonnaise during storage at 4 or $25^{\circ}C$ for 10 days. Thus, bacteriocin from L. brevis DK25 may be used for hurdle technology by combination with potassium benzoate in order to increase pathogenic bacteria inactivation in food processing and food safety control.

• Proceedings of the KWS Conference
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• 2009.11a
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• pp.121-121
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• 2009

자동차는 코너 주행 시 In-corner와 Out-corner 의 바퀴 궤적이 달라지므로, 특별한 장치가 없이 좌우 구동 측의 바퀴가 같은 속도로 회전을 하게 되면 정상적인 주행이 불가능하다. 따라서 정상적인 코너 주행이 가능 하려면, 코너 안쪽 바퀴보다 바깥쪽 바퀴가 더 빨리 회전해야 하며 이러한 회전 차를 보상받지 못할 경우 바깥쪽 바퀴가 끌리는 현상이 발생하는데 이를 방지하기 위해 디퍼렌셜 기어가 필요하다. 현재 디퍼렌셜 기어는 디퍼렌셜 케이스와 링기어를 볼트로 체결하는 조립 공법을 통해 생산되고 있다. 하지만 볼트 체결 공법은 조립을 위한 볼트와 볼트 체결을 위한 플랜지와 볼팅을 위한 홀을 가공하는 공정이 필요하기 때문에 재료비 절감 및 생산 효율 향상에 매우 불리하고 볼트체결을 위한 부분 때문에 불필요한 무게가 증가하게 된다. 따라서 본 연구에서는 이러한 기계적 체결 방식을 레이저 용접 방식으로 대체하여 재료비를 절감하고 무게 저감을 통해 주행성능을 향상시키고자 하였다. 링기어의 소재는 침탄처리강(SCM420H)이며 디퍼렌셜 케이스의 소재는 주철(GCD500)을 사용하고 있다. 주철은 용접시 용접부와 열영향부에서 마르텐사이트 조직과 레데브라이트, 시멘타이트 조직이 생성되며 고탄소 모재의 탄소 확산으로 인한 부분 혼합영역에서 탄소 합금이 생성되어 균열이 발생하는 등 용접성이 매우 좋지 않은 것으로 알려져 있다. 이러한 주철의 난용접성을 해결하는 방법으로는 고탄소 모재 용접시 발생하는 탄소의 확산을 억제하거나 예열이나 후열 처리를 통한 냉각 속도의 제어하는 방법과 오스테나이트 안정화 원소를 첨가한 필러와이어를 사용하여 용접시 마르텐사이트와 시멘타이트의 성장을 방해하는 방법 등이 이용되고 있다. 본 연구에서는 예열처리나 후열처리를 통한 주철의 용접법은 대량 생산을 통한 원가절감을 노리는 자동차 업계의 특성에 비추어 볼 때 비용이나 프로세스 구성 면에서 적용하는 것이 어려울 것이라 판단하여 Ni-base filler metal을 통한 주철의 용접법을 선택하였고 그 결과 실차에 적용하기 위한 비틀림 강성 테스트나 내구 테스트는 통과하였으나 NVH 테스트 결과 볼팅 체결 방식에 비하여 소음이 커지는 문제가 발생하고 링기어의 HAZ부가 고경화 되는 문제가 발생하였다. 때문에 용입깊이를 초기 시제품인 5mm에서 4mm로 변경시켜 입열량 감소 및 용접변형을 줄여 소음 문제를 해결하고자 하였으며 링기어의 침탄층을 1mm 절삭하여 링기어 HAZ부의 고경화 문제를 해결하고자 하였다. 이러한 용접 구조 변경이 용접변형 및 강성과 피로에 미치는 영향력을 알아보고자 용접 및 열처리 상용 소프트웨어인 SYSWELD, 구조해석 상용소프트웨어인 NX_NASTRAN, 피로 해석 상용 소프트웨어인 FEMFAT을 이용하여 시뮬레이션 하였고 실제 구조 변경한 용접 시제품과 비교, 분석하였다.

• Journal of Mushroom
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• v.16 no.4
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• pp.279-286
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• 2018

The button mushroom, Agaricus bisporus, is one of the most widely cultivated mushrooms. The domestic production of cultivated mushrooms in 2016 was approximately 10,173 tons, with a total value of 59 billion won. Currently, 10 cultivars have been developed; however, Korean farmers continue to demand new cultivars of mushrooms with improved quality. To breed superior lines, KMCC00754 and KMCC00775 were selected as mother strains from the 170 collected genetic resources. The putative homokaryotic strains were 25 strains from the 120 SSIs of KMCC00754 and six strains from the 120 SSIs of KMCC00775 selected by using the AbSSR45 marker. These homokaryotic strains were crossed with each other and the crossing was confirmed by SSR analysis. Seventy-four lines were crossed into 150 lines for a 50% ratio of crossing. Abs2-2015-16 was selected as a superior line by three cultivations. A new cultivar, 'Dodam', was developed in 2017.