• Patent21
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• s.73
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• pp.10-15
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• 2007

• Journal of Life Science
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• v.28 no.8
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• pp.931-937
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• 2018

Triptolide is a compound found in Tripterygium wilfordii and reported to have an anti-inflammatory and anti-oxidant activities. A previous study shows that the dietary supplementation with triptolide increases resistance to environmental stressors, including oxidative stress, heat shock, and ultraviolet irradiation, and extends lifespan in C. elegans. Here, we investigated the underlying mechanisms involved in the lifespan-extending effect of triptolide. The effect of triptolide on age-related diseases, such as diabetes mellitus and Alzheimer's disease, was also examined using animal disease models. The longevity phenotype conferred by triptolide was not observed in the eat-2 mutant, a well-known genetic model of dietary restriction, while there was an additional lifespan extension with triptolide in age-1 and clk-1 mutants. The long lifespan of age-1 mutant is resulted from a reduced insulin/IGF-1-like signaling and the clk-1 mutant lives longer than wild-type due to dysfunction of mitochondrial electron transport chain reaction. The effect of dietary restriction using bacterial dilution on lifespan also overlapped with that of triptolide. The toxicity of high glucose diet or transgenic human amyloid beta gene was significantly suppressed by the supplementation with triptolide. These findings suggest that triptolide can mimic the effect of dietary restriction on lifespan and onset of age-related diseases. We conclude that triptolide can be a strong candidate for the development of dietary restriction mimetics.

• The Journal of Korean Academy of Prosthodontics
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• v.34 no.4
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• pp.746-754
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• 1996

The purpose of this study was to evaluate the fracture strength of porcelain laminate veneer with various lingual extention length when incisal restoring. Sixty recently extracted, intact maxillary incisors were used and stored in a physiologic saline solution from the time of extraction. Seating form was preparation at the labial surface of each tooth with a water-cooled round diamond bur. Standard block was formed with 32 gauge and 24 gauge wax at tooth labial and lingual surface. Lingual extention length differed according to each group. (group I : 0.5mm, group II : 1 mm, group III : 2mm, group IV : 0mm) All tooth specimens were impressioned with examix(GC Inc., Japan). Refractory cast were maked with refractory die material(Ceramco Inc., U.S.A.) Laminate porcelain (Ceramco II Veneer porcelain, Ceramco Inc., U.S.A.) was condensed in refractory die cast and baked according to the manufacturer's recommendations. Each surface was contoured with low speed diamond bur according to guide block. All porcelain specimens were sandblasted and ultrasonically cleaned in distlled water for 3 minutes. Then, all porcelain specimen were etched with 8% hydrofluoric acid for 5 minutes. Sixty specimens were bonded with composite resin cement(Choice Porcelain Veneer System, Bisco Inc., U.S.A.) according to manufacture's directions. The fracture loads of the specimen were measured by Instron universal testing machine. The mean values of fracture loads for the groups were statistically compared by Duncan's multiful range test. The result were as follows : Mean fracture strengths of each group were 86.95Mpa in no lingual extention group, 44.98Mpa in 0.5mm lingual extention group, 27.47Mpa in 1mm lingual extention group, 19.61Mpa in 2mm lingual extention group. There was a statistically significant difference between all group(p<0.01).

• Journal of Advanced Marine Engineering and Technology
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• v.40 no.1
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• pp.10-16
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• 2016

Fatigue analysis for life extension of a ship is different from that of a newly constructed ship since the current corrosion margin and voyage routes of the past and future must be considered, thereby complicating the life extension procedure. This research introduces the fatigue analysis case for the life extension project of a moss LNG carrier using full spectral fatigue analysis, which has been previously used for newly constructed ships. It is expected that the fatigue analysis methodologies and full spectral fatigue analysis program used in this study will be applicable to other life extension projects.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.12 no.2
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• pp.30-37
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• 2013

An extended loop antenna, to be continued BLA(Branch Loop Antenna) in the previous volume, for the mobile handset is designed in this paper. It's introduced an ELA(Extended Loop Antenna) that is added extended loops to rectangular loop, and verified antenna performances for applying to mobile handset. Extended loops are located upside, left and right side of rectangular loop, and low resonance is obtained by the length of line. Multiple resonances are established by the extended loops, and obtained the desired service bands by the connection points and lengths. By the implementation and measurement for the multiband ELA, it's showed -3.0~-1.46dBi average gains with 50.15~71.41% efficiencies at CDMA/GSM frequency band, and -8.28~-1.7dBi average gains with 14.87~67.68% efficiencies at DCS/USPCS/WCDMA frequency band.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.22 no.4
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• pp.391-400
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• 2004

Railway curved zone have crucial effects on the speed of train. Length of transition curve is one of the important factor for alignment compatibility estimation in this sections, this value is decided by running speed and Cant. In this study, the extension method of transition curve is evaluated, based on the alignment of Jang Hang-Line, investigated field conditions of the sections in the curves exist. This research result show that changing of transition curve was proved by necessary to approximately two thirds of the curved sections, and method of fixing central point of track centerline and changing radius of curvature minimize the maximum shift in track centerline and deviation of radius, and also may be effective method for alignment suitability and speed up in case overall improvement is difficult.

• Journal of the Korean Data and Information Science Society
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• v.24 no.4
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• pp.773-781
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• 2013

Recently, an extended warranty of the system following the expiration of the basic warranty is becoming increasingly popular to the user. In this respect, we suggest a preventive maintenance model following the expiration of extended warranty with minimal repair warranty from the user's point of view in this paper. Under basic warranty and extended warranty, the failed system is minimally repaired by the manufacturer at no cost to the user. For the preventive maintenance model, we derive the expressions for the expected cycle length, the expected total cost and the expected cost rate per unit time. Also, we determine the optimal preventive maintenance period and the optimal preventive maintenance number by minimizing the expected cost rate per unit time. Finally, the numerical examples are presented to illustrate the purpose when the failure time of the system has a Weibull distribution.

• Proceedings of the Korean Institute of Industrial Safety Conference
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• 2003.05a
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• pp.229-236
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• 2003

철도는 국가의 물류 및 인적자원을 수송하는 주요한 수송수단으로 1899년 9월 연장 33.2km의 경인선을 시작으로 선로가 지속적으로 증설되어 현재 총영업연장은 6,683km에 달하고 있다. 현재 국내에는 총 2,500여개소의 철도교가 있는데, 이 중에서 강교량에 대해서 연장이 차지하는 비율은 약 48%이고, 공용기간이 50년 이상인 강교량이 전체교량의 약 46%를 차지하고 있으므로 이들 강철도교는 노후화가 상당히 진행되고 있을 것으로 판단된다.(중략)

• Proceedings of the Korean Information Science Society Conference
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• 2008.06b
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• pp.584-587
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• 2008

매크로-스타그래프와 전위그래프는 Cayley 그래프로 널리 알려지니 상호연결망이다. 본 논문에서는 매크로-스타그래프와 전위그래프에 연장을 5, 확장률 1에 임베딩 가능함을 보인다. 또한, 전위그래프를 매크로-스타 그래프에 임베딩하는 연장율이 O(n)이지만, 평균 연장율이 2이하임을 보인다. n은 전위 그래프의 차원이다.

• Journal of the KSME
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• v.55 no.9
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• pp.45-48
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• 2015

국내 500MW 표준석탄화력 발전설비가 준공 후 20년을 경과함에 따라 수명연장 및 성능개선이 요구되고 있다. 1993년 이후 운전연수가 20년이 초과된 보령화력 3-6호기를 포함한 국내 20여 기가 여기에 해당한다. 국내 여건상 신규발전소 건설이 어렵고, 탄소배출권 거래제 시행에 따른 노후 발전설비의 효율 향상이 필요하기 때문에 성능개선 및 수명 연장에 대한 수요는 계속될 전망이다. 따라서 노후 발전설비의 성능개선을 수행하기 전에 설비의 정확한 현재 상태를 진단하여 평가하고, 이를 토대로 경제성을 반영한 증기온도조건 상승에 필요한 설비개선 방안을 수립하는 것이 불필요한 자원낭비를 방지하고 최적의 성능개선을 통한 비용 최소화를 위해 중요하다고 할 수 있다.