• Analytical Science and Technology
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• v.25 no.2
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• pp.152-157
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• 2012

Currently, many types of compound preparations are being used but the quality control guidelines for their use are lacking. In case of single compound drug, the quality control methods are specified in the pharmacopeia. However, there is no method to simultaneously analyze compound preparations. In this study, a simple validated analytical method for HPLC separation of chlorquinaldol and promestriene is introduced. Validation was divided into categories including linearity, precision, accuracy (recovery) and system suitability. The contents of the products which are on the market were monitored using the validated analytical method and the robustness of the analytical method was tested by conducting an inter-laboratory validation.

• The Korean Journal of Blood Transfusion
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• v.23 no.2
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• pp.145-151
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• 2012

배경: 채혈 후 제제 경과시간에 따른 동결혈장의 혈액응고인자의 활성도와 이에 영향을 미치는 요인을 분석하여, 혈액응고인자제제의 원료혈장의 사용범위를 확장 가능한지 확인하고자 동결혈장의 채혈시간과 응고인자 특성을 측정하였다. 방법: ALT 부적격 혈장을 채혈 후 동결시간의 특성에 따라 4단계로 구분하였고, 6종류의 혈액 응고인자 활성도와 혈액형을 검사하였고, SAS 9.2 프로그램을 사용하여 통계처리 하였다. 결과: 혈액제제간 FVIII 활성도를 분석한 결과 PL-A>FFP>FP(8-24)${\approx}$FP(24-72) 순으로 유의하게 낮아졌고 혈액형에 따라서는 AB형이 제일 높고, O형이 제일 낮았다. 대한적십자사의 원료혈장에 대한 FVIII 활성 품질기준을 적용할 경우 PL-A, FFP와 FP24는 각각 85.0%와 82.5%로 적합하였다. 캐나다 퀘백 주처럼 FP24의 FVIII 활성이 0.52 IU/mL 이상을 적용할 경우 PL-A, FFP와 FP24는 각각 95.0%, 96.3%, 82.6%로 적합하였다. 또한 FP(8-24)의 A형과 AB형, FP(24-72)의 경우 AB형이 각각 82.1%, 83.3%, 100%로 적합하였다. 결론: 혈액응고인자제제용 원료혈장의 범위는 외국의 기준에 비추어 채혈 후 24시간 내에 동결된 혈장(FP24)으로 확대 사용이 가능하다. 이를 위해서는 채혈 후 동결시간과 혈액응고인자에 대한 품질기준을 유럽약전 또는 WHO 가이드라인과 비교하여 완화하는 것이 필요하다.

• Korean Journal of Plant Resources
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• v.28 no.2
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• pp.178-192
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• 2015

This study was carried out to investigate the vascular plants of Neunggyeong-bong, Gangwond-do, South Korea. The vascular plants that were collected 7 times from 2008 and 2013 consisted a total of 440 taxa; 75 families, 261 genera, 383 species, 4 subspecies, 48 varieties and 5 forms. Among them, 15 taxa of Korean endemic plants and 11 taxa of rare and endangered plants were included. The floristic regional indicator plants found in this area were 11 taxa of grade IV, 22 taxa of grade III. Naturalized plants consisted of 29 taxa that made up 6.6% of the total vascular plants in this area. Medicinal plants of the Korean Pharmacopoeia and Korean Herbal Pharmacopoeia distributed in this area consisted of 60 taxa.

• Journal of Ginseng Culture
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• v.6
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• pp.80-104
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• 2024

Ginseng, a representative medicinal plant of South Korea, is also highly valued in North Korea. However, due to limited access to information about North Korea, the actual cultivation, research and development trends, and related industry status of ginseng in North Korea are not well known. In this study, we aimed to understand the current status and research trends of the ginseng industry in North Korea based on limited available literature. In the North Korean pharmacopoeia, ginseng is referred to as "Koryo ginseng" and is defined as the roots of 6-year-old ginseng cultivated in the Kaesong region. The pharmacopoeia includes 22 types of ginseng preparations. In addition, 10 ginseng preparations are included in North Korea's Essential Drug List, and various health supplements, cosmetics, and toothpastes containing ginseng have been developed, distributed, and sold. Since 2014, the ginseng industry and research in North Korea have become more active overall. During this period, the ginseng cultivation area in Kaesong has been significantly expanded, and the facilities have been renovated. The Kaesong Koryo Ginseng Processing Plant has been equipped with sterilized, modernized facilities since 2016 and has been in operation. Since 2017, there has been a growing interest in quality control research, leading to the introduction of quality management regulations and certification systems in 2019. In the 1990s, there was significant research on ginseng product development, and since the 2000s, studies on the pharmacological effects and clinical research of ginseng have been reported. Additionally, research on ginseng cultivation and ginseng processing industries to increase yield has been emphasized. Ginseng, as a representative medicinal crop of Korea, holds great importance for both South and North Korea. Given its significance and the potential for synergy through mutual cooperation, ginseng serves as an ideal subject for inter-Korean exchange and collaboration.

• Journal of Pharmaceutical Investigation
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• v.1 no.1
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• pp.70-77
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• 1971

The ointment, had discovered and used from the ancient, have not ever defined to qualitity as the hardness concerned with the absorned With the absorption of the effect of durg through the skin. Auther, for the first time, suggest the apparent logarithmic hardness against the penetration of ointment registered on the pharmacopeia of the Republic of Korea, the results are as the followings. 1. The speciality of this apparent logarithmic hardness ie in proportion for the solidity on the contrary to the penetration of oiniment, and the distribution range of it are between 1.68 to 3.53 for their ointments examined. 2. The specific gravity of the verious ointments according to the apparent logarithmic hardness may be ignore on the calculaiotn, the mean valve of the samples was 2.9303. 3. The determination of apparent logarithmic hardness(H) by the penetration method follows the under equation. $H=log_{10}({\frac{P-0.545h^3}{0.855h^2}})$ where, the h is the penetrate length described centimeter, and p is the weight of the cone.

• Journal of Pharmaceutical Investigation
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• v.39 no.2
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• pp.93-95
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• 2009

To compare the water vapor transmission rate (WVTR) of PVA/Dextran blended hydrogel obtained by European Pharmacopiea (EP) and Japanese Industrial Standards 1099 (JIS) method, the hydrogels with various PVA/Dextran rates were prepared and their WVTR values were then checked. As dextran in the hydrogel was increased, the WVTR of hydrogel was increased. The WVTR of hydrogels were 660-1500 and $730-1900\;g/m^2$-day in EP and JIS method, respectively. There were no significant differences between the WVTRs of the hydrogels obtained by EP and those obtained by JIS method. Thus, JIS method was recommended as a WVTR method of hydrogel due to relatively simpler and shorter time.

• Korean Journal of Medicinal Crop Science
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• v.21 no.4
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• pp.268-275
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• 2013

This text was analyzed and investigated the distribution of medicinal plants in Cheongoksan Bonghwagun Korea, in order to search the medicinal resources that are used in modern medicine. Medicinal plants of the Korean Pharmacopoeia (10th edition) distributed in Cheongoksan Bonghwagun were consisted of 93 taxa ; 82 species, 10 varieties, 1 forma of 79 genus, 50 families. In medicinal plants of the Korean Pharmacopoeia, rate of native species and exotic species was 89.2% (83 taxa) and 10.8% (10 taxa) respectively. Family classification was the most of compositae of 8 taxa, and life form classification was most of herb of hemicryptophyte species. The classification by using parts were 34 taxa of root use and the classification of efficacy utilization was 24 taxa of Cheongyeolyak (heat-clearing drug) use.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.20 no.10
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• pp.27-34
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• 2006

This paper proposes a new method of on-line estimation for rotor resistance of the induction motor in the indirect vector controlled drive, using artificial neural network (ANN). The back propagation algorithm is used for training of the neural networks. The error between the desired state variable of an induction motor and actual state variable of a neural network model is back propagated to adjust the weight of a neural network model, so that the actual state variable tracks the desired value. The performance of rotor resistance estimator and torque and flux responses of drive, together with these estimators, are investigated variations rotor resistance from their nominal values. The rotor resistance are estimated analytically, using the proposed ANN in a vector controlled induction motor drive.

• The Korea Journal of Herbology
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• v.25 no.1
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• pp.45-54
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• 2010

Objectives : The purpose of this study is to determine the impurity tolerance of Zanthoxylum Peel. Methods : Compare with medicinal Herb Books and the Pharmacopoeia of 6 nations. Results : Current Pharmacopoeia show different Zanthoxylum Peel's Purity, such as 2.0% of seeds and fruit stalk, etc. in North Korea, 2% of seeds in Vietnam, totally 3% in China. On the other hand, Korea and Japan set the total number 26.0% including the specific numbers such as 20.0% of seeds, 5.0% of fruit stalk, 1.0% of the other foreign matter. This Zanthoxylum Peel's Purity, 26.0%, is too high compared to that of other medical matters specified by The Korean Pharmacopoeia Ninth Edition. When The Japanese Pharmacopoeia Sixth Edition firstly set the Zanthoxylum Peel's Purity, the herbal name was Fructus. However, since the part for medical usage in origin is well-ripen pericarp, not seed, the permissible level, 30.0%, is supposed to be simple error range, 3.0%. Conclusions : As a result, I think bills concerning the Zanthoxylum Peel's Purity should be revised to the total number 3.0% or specifically set the level 2.0% of seeds, 1.0% of fruit stalk, twig and so on.

• Journal of Plant Biology
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• v.2 no.1
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• pp.35-42
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• 1959

The cuttings and apical portion of stein in sweet potato were growlh under artificial light and specific photoperied and temperature. Though the plant growth was poor under insufficient light intensity of artificial light, the tuber formations were induced at long light period (16L+8D) and not induced at short light period (8L+16D) and low temperature of darkparied. The determinative factor for tuber formation of sweet potato seems to be a stimulation which has intimate relationship with specific photoperiod and temperature and no direct relation with the growth of plant body and light intensity. The root pattern of inductive state for tubers and non-inductive state were different distinctly, the former were silky and slender, the latter were branchy, and stout appearence. This different root pattern must be due also to the specific photoperiod and temperature and may have any relationship with the stimulation for tuber formation from the point of auxin physiology etc.