• Journal of Chest Surgery
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• v.26 no.9
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• pp.686-695
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• 1993

A total of eighty one patients with resected stage II and IIIA non-small cell lung cancer treated with postoperative adjuvant radiation therapy between Jan. 1971 and Dec. 1990 were retrospectively analysed to evaluate whether postoperative radiation therapy improves survival. Patterns of failure and prognostic factors were also analysed. The 5 year overall and disease free survival rate were 40.5%, 43.4% and median survival 30 months. The 5 year actuarial survival rates by stage II and IIIA were 53.9% and 36.2%. Loco-regional failure rate was 14.7% and distant metastasis rate was 33.3% and both 4%. Statistically significant prognostic factor affecting survival was presence of mediastinal lymph node metastasis[N2]. This retrospective study suggests that postoperative radiation therapy in resected stage II and IIIA non-small cell lung cancer can reduce loco-regional recurrence and may improve survival rate as compared with other studies which were treated by surgery alone.

• The Hankook-Saengyark Bo
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• no.266
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• pp.1-8
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• 2006

GAP인증약재 고품질 브랜드로 차별화/약용작물 GAP 인증사업 본격 착수/수급조절대상한약재 14종으로 축소/엄경섭 회장 제 14대 회장에 재선/GAP 농산물 이력추적관리제 워크숍/홍천군 생명.건강연구장비센터 완공/'동의보감타워' 개장/인삼, 다양한 포장단위로 판매 가능/인증품의 차별화로 '신뢰쌓기' 급선무/나는 이렇게 생각한다-"국산한약재 그리고 GAP/'광범위계 농약' 예방 목적으로 사용해야/경남도농업기술원 시험/백두대간 청정지역에서 GAP 오미자 재배/생강 인공토굴 저장 부패율 3%/4년간 인삼 직파재배용 차광망 선발/일당귀 소비증가 시세도 토당귀 '두배'/씀바귀, 암 예방 보약/함양산삼축제/감초로 스트레스성 속쓰림 방지/한약재 4가지+빵 '한약웰빙빵' 나왔다/"옻음료, 약국서 찾으세요"/GAP재배지 입간판 설치/허브산업 육성 업무제휴 협약서 체결/사무국 회무일지/제 113차 중앙이사회 이모저모/14대 임원진 명단/약초이야기-구릿대(백지)/국산한약재-소매시세표

• THE HEALTH and ORGANIC FARMING
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• no.242
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• pp.1-12
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• 2007

2007년도 지회장단 연찬회 성료/광주.전남도지부장 이.취임식/'저출산고령화대책연석회의' 의장께 드리는 건의문/2007년도 전국 지회장단 연찬회 이모저모/유기농식품 인증제 이르면 2008년 도입/유기재배 꽃 등장/화훼산업의 친환경인증제도 MPS/전통식품산업의 지연화와 세방화/글로벌시장에 '유기농 에코라벱' 바람/식물영양소 기능과 정식준비/골다공증의 원인과 예방 및 관리법/<암을 이기는 음식>(7) 부추/유기자연농업의 원조를 찾아서/서울시 친환경농산물 지원조례 제정/우리의 산야초-팽나무/사과나무의 적정 시비기술의 실제/지역거점 급식지원센터 운영 및 친환경농산물 급식방안

• The Korean Journal of Applied Statistics
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• v.17 no.3
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• pp.419-430
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• 2004

Since cDNA microarray experiments can monitor expression levels for thousands of genes simultaneously, the experimental designs and their analyzing methods are very important for successful analysis of microarray data. The loop design is discussed for selecting differentially expressed genes among several treatments and the analysis of variance method is introduced to normalize microarray data and provide estimates of the interesting quantities. MA-ANOVA is used to illustrate this method on a recently collected loop designed microarray data at Cancer Metastasis Research Center, Yonsei University.

• The Science & Technology
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• v.31 no.2 s.345
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• pp.67-71
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• 1998

1990년 9월 프렌치 엔더슨(현 남가주대학 유전자치료센터 소장)과 2명의 동료들이 미 연방정부의 승인을 받고 처음으로 유전자를 이용하여 중증 종합면역결핍증(SCID)을 앓고 있던 아샨티 데실비양을 치료한 이래 유전자치료에 대한 관심은 전세계적으로 번져 나가 현재 2천5백명 이상의 환자들이 이런 요법의 임상실험을 받고 있다. 우리나라에서도 1995년 서울대병원을 시작으로 1996년에는 중앙대병원과 삼성서울병원에서 말기 암환자를 대상으로 유전자치료 임상시험을 하고 있다. 그런데 열성적인 일부 연구자들과 업계대표들 그리고 매체들의 유전자치료의 '장미빛 미래'를 지나치게 강조한 나머지 일반인에게 유전자치료가 이미 광범위한 응용단계로 들어갈 정도로 발전한 것 같은 인상을 주고 있다. 그러나 전세계를 통틀어 유전자치료를 받거나 받고 있는 환자중에서 결정적으로 완쾌된 환자는 아직도 거의 없다는 것이 오늘의 현실이다. 유전자치료의 현황과 그 앞날을 알아본다.

• Journal of the Korean Society for Precision Engineering
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• v.19 no.1
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• pp.127-134
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• 2002

This study present a direct steering system using rack and pinion for ultra-small vehicles. The traditional small vehicles for special use had the limitation of space by reason of short wheel tread. These vehicles has adopted a indirect steering system or a center arm system for steering. The disadvantages of these system were deterioration of gear efficiency and increase of parts. For direct-linkage to both knuckles, steering system is made up of out-side tie rods, tie-rod ends, and gear box. Thus, the proposed system has a minimum number of parts. The experimental results show a maximum efficiency at minimum steering angle and a minimum clearance circle. These effects were accomplished by adopting a Ackerman-Jantaud theory.

• Proceeding of EDISON Challenge
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• 2015.03a
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• pp.53-60
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• 2015

본 연구에서는 random walk하는 입자와 암세포 확산을 비교하여 Fick's law를 따르는 확산 모형과 암세포 확산의 차이를 밝힌다. 암세포 확산은 암 전이 메커니즘을 이해하는데 매우 중요하다. 하지만 아직까지 암세포 확산은 정확하게 이해되지 않고 있다. 따라서 이번 연구에서는 가장 간단한 2차원 random walk와 암세포 확산을 비교하고, 동역학적인 차이를 규명해 암세포 확산을 이해하고자 한다. Random walk하는 입자는 EDISON 전산화학 전문센터의 프로그램 중 dynamic Monte Carlo(dynamic MC) 전산 모사 소프트웨어를 이용하여 2차원에서 움직이는 레나드-존스 입자의 운동을 통해 살펴보았다. 암세포 확산은 실제 암세포의 시간에 따른 위치 변화 정보 (세포의 궤적)를 직접 구하여 분석하였다. Dynamic MC 결과는 Fickian 확산 모형을 잘 따르는 것을 평균 제곱 거리와 밀도 함수를 통해 확인할 수 있었다. 암세포 확산의 경우 평균 제곱 거리는 시간에 대해서 선형적으로 비례하지만 밀도 함수는 가우시안 형태로 나오지 않으며 Fick's law를 따르는 확산 모형과 다른 확산 형태를 보인다. 이러한 확산 형태는 암세포의 동역학적인 다양성 때문에 나타나며 각각의 암세포가 다른 운동성을 가지는 것에 기인하는 것으로 보인다.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.32 no.3
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• pp.242-252
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• 2022

Objectives: Firefighters and police officers are exposed to various occupational hazards. No studies in Korea have investigated the occurrence of cancer by type of cancer for the two occupations. This study aims to investigate the risk of occurrences associated with types of cancers in firefighters and police officers. Methods: Utilizing National Health Insurance(NHI) Claims data from 2006-2015, the study included 8,871,468 general workers, 25,001 firefighters, and 102,274 police officers. Using general workers as a control group, we calculated the standardized incidence ratios(SIR) by types of cancer for firefighters and police officers. After calculating the SIR for all subjects, the SIR was calculated by stratifying according to gender. Results: SIR of colon cancer 1.38(95% CI, 1.11-1.69), cancer of the liver and intrahepatic bile ducts 1.27(95% CI, 1.04-1.54), and 1.88(95% CI, 1.28-2.65) bladder cancer were higher firefighters than general workers. SIR of Lip, oral cavity, and pharynx 1.26(95% CI, 1.07-1.47), Stomach 1.14(95% CI, 1.06-1.23), colon 1.33(95% CI, 1.21-1.46), liver and intrahepatic bile ducts 1.21(95% CI, 1.10-1.32), pancreas 1.24(95% CI, 1.02-1.49), other skin 1.60(95% CI, 1.26-2.00), bladder 1.27(95% CI, 1.04-1.54), other urinary tract 1.46(95% CI, 1.27-1.68), other parts of central nervous system 1.68(95% CI, 1.10-2.46) were higher police officers than general workers. Conclusions: Both firefighters and police officers are exposed to various cancer occurrence risks, necessitating the development of occupational medical protection measures to reduce risk exposure factors.

• Korean Journal of Environmental Biology
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• v.41 no.4
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• pp.427-438
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• 2023

Biocide dichlofluanid breaks down quickly and accumulates easily in sediment, potentially causing a persistent impact on various marine organisms. We analyzed the potential toxicity of dichlofluanid on major aquaculture species in Korea, Undaria pinnatifida. Female gametophytes of U. pinnatifida were exposed to dichlofluanid at concentrations of 0, 1, 2, 4, 8, 16, and 32 mg L^-1, and their survival and relative growth rate were analyzed. The no observed effect concentration(NOEC), lowest observed effect concentration (LOEC), and median lethal concentration (LC₅₀) for female gametophyte survival were determined as 1, 2, and 10.82 (95% CI: 8.87-13.23) mg L^-1, respectively. The NOEC, LOEC, and median effective concentration (EC₅₀) for relative growth rate were 1, 2, and 6.58 (95% CI: 6.03-7.17) mg L^-1, respectively. Female gametophytes of U. pinnatifida were expected to experience toxic effects at concentrations above 2 mg L^-1 of dichlofluanid. These research findings are expected to serve as important reference data for evaluating the toxicity effects of U. pinnatifida in its early life stages when exposed to dichlofluanid.

• Journal of Hospice and Palliative Care
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• v.2 no.2
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• pp.114-124
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• 1999

Purpose : To clarify the relation between psychosocial variables and cancer in Korea. Methods : Case-control study. Participants: 239 subjects in 2 university hospitals in Seoul completed a series of psychometric instruments(the Olson's FACES III and the Lee's 98-items life event scale). Results : In bivariable analysis, there were statistically significant difference in age and economic status(income): marginal significance in education status and marital status between the cases and controls. The family function type and stress score were not significantly different. The result of multivariable logistic regression, analysis showed that the risk of cancer was associated with economic status and marital status, but neither the family function nor the life event stress. Conclusion : In this study, we cannot prove the statistical association between the family function, life event stress and cancer. It is necessary to persevere in our efforts to clarify the relation between stress and disease and to develop the useful tools to measure the Korean family function and life event stress.