• Journal of the Korean Society of Marine Environment & Safety
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• v.24 no.4
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• pp.422-429
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• 2018

To make students recognize the danger of fire smoke that may occur in ships and to improve the response capability, spaces for safety educ ation were built inside the training ship, and scenarios were developed. This study is an analysis of the movement characteristics of the students acquire d under each scenario. Followings are the summary of the analysis results. In the non-smoke environments, there was no difference in the velocity of escape movement between the case of without block on the familiar route and the case of with unexpected block. However, when the indoor was filled with smoke, the visibility became very low because of the smoke density and the average velocity was 62.5 % slower than the case where it was not. Regardless of the scenarios, the average equivalent velocity on the complex path was faster than the simple straight path, and the standard deviation was smaller. Under the smoke-fullfilled environment, although the relative velocity probability distributions of the complex passage and the entire passag e are very similar, the inter-individual fluctuation of the relative velocity ratio of the complex passage to that of the entire passage was very large. On the other hand, equivalent velocity could be expressed by the logarithmic function of the visibility. Also, as the tension of the students increased, the equivalent velocities were accelerated on all scenarios.

• Journal of the Korean Society for Railway
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• v.11 no.5
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• pp.441-448
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• 2008

Increasing urban sprawl and climate changes have been causing unexpected high-intensity rainfall events. Thus there are needs to enhance conventional disaster management system for comprehensive actions to secure safety. Therefore long-term and comprehensive flood management plans need to be well established. Recently torrential snowfall are occurring frequently, causing have snow traffic jams on the road. To secure safety and on-time operation of the Bi-modal tram system, well-structured disaster management system capable of analyzing the show pack melt/freezing due to unexpected snowfall are needed. To secure safety of the Bi-modal tram system due to torrential snow-fall, the snow melt simulation capability was investigated. The snow accumulation and snow melt were measured to validate the SWMM snow melt component. It showed that there was a good agreement between measured snow melt data and the simulated ones. Therefore, the Bi-modal tram disaster management system will be able to predict snow melt reasonably well to secure safety of the Bi-modal tram system during the winter. The Bi-modal tram disaster management system can be used to identify top priority area for know removal within the tram route in case of torrential snowfall to secure on-time operation of the tram. Also it can be used for detour route in the tram networks based on the disaster management system prediction.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.14 no.1
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• pp.12-25
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• 2003

Objectives：As increasing number of new antidepressants have been being introduced in clinical practice, pharmacological understanding has been broadened. These changes mandate new information and theories to be incorporated into the treatment process of children with depressive disorders. In light of newly coming knowledge, this review intended to recapitulate the characteristics of new antidepressants and to consider the pivotal issues to develope guidelines for the treatment of depression in childhood and adolescence. Methods：Searching the Pub-Med online database for the articles with the key words of 'new', 'antidepressants' and 'children' ninety-seven headings of review articles were obtained. The author selected the articles of pertinent subjects in terms of either treatment guideline or psychopharmacology of new antidepressants. When required, articles about the clinical effectiveness of individual antidepressants were separatedly searched. In addition, the safety information of new antidepressants was acquired by browsing the official sites of the United States Food and Drugs Administration and Department of Health and Human Services. Results：1) For the clinical course, treatment phase, and treatment outcome, the reviews or treatment guidelines adopted the information from adult treatment guidelines. 2) Systematic and critical reviews unambiguously concluded that selective serotonin reuptake inhibitors(SSRIs) excelled tricyclic antidepressants( TCAs) for both efficacy and side effect profiles, and were recommend for the first-line choice for the treatment of children with depressive disorders. 3) New antidepressants generally lacked treatment experiences and randomized controlled clinical trials. 4) SSRIs and other new antidepressants, when used together, might result in pharmacokinetic and/or pharmacodynamic drug-to-drug interaction. 5) The difference of the clinical effectiveness of antidepressants between children and adults should be addressed from developmental aspects, which required further evidence. Conclusion：Treatment guidelines for the pharmacological treatment of childhood and adolescence depression could be constructed on the basis of clinical trial findings and practical experiences. Treatment guidelines are to best serve as the frame of reference for a clinician to make reasonable decisions for a particular therapeutic situation. In order to fulfill this role, guidelines should be updated as soon as new research data become available.

• Tuberculosis and Respiratory Diseases
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• v.40 no.2
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• pp.123-134
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• 1993

Background: Tissue-type plasminogen activator is a physiologic activator, which has high affinity for fibrin and is activated by fibrin. Because of these properties, t-PA has the potential to induce effective thrombolysis without producing a systemic lytic state. In practice, however, therapeutically efficacious doses of t-PA has been associated with the development of a systemic lytic state. As experience with t-PA has accumulated, it has suggested that the fibrin selectivity is influenced by the dose and duration of t-PA infusion, and many studies have performed in an attempt to optimize the duration of t-PA regimen. Methods: This study was designed to assess the thrombolytic efficacy of t-PA and the differences of two dosing regimens of t-PA (infusion of 1 mg/kg t-PA over 15 or 180 minutes) in a canine model of pulmonary embolism, induced by injection of radioactive autologous blood clots. By continuously counting over both lung fields with a external gamma counter, we correlated rate and extent of pulmonary thrombolysis with corresponding pulmonary hemodynamics in addition to the gas analyses of arterial and mixed venous blood. Results: 1) While total clot lysis was similar ($36.2{\pm}3.3%$ and $39.6{\pm}2.3%$ respectively, p>0.05) when t-PA was infused over 15 or 180 minutes, the rate of lysis during infusion was markedly increased with the shorter infusion ($81.4{\pm}16.8%/hr$ vs $37.3{\pm}2.4%/hr$, p<0.05). 2) The duration of thrombolysis was $63.3{\pm}22.2$ minutes although t-PA was administered over 15 minutes, and it was only $148.5{\pm}14.0$ minutes in case of the infusion over 180 minutes (p<0.05). 3) The increased rate of thrombolysis with the shorter infusion was accompanied by a faster amelioration of cardiopulmonary impairment from pulmonary embolism (p<0.05). Conclusion: It is concluded that the shorter (15 minutes) infusion of t-PA is superior to the longer (180 minutes) infusion when the dose is equal, in consideration of the faster improvement in cardiopulmonary impairment from pulmonary embolism.

• Journal of Food Hygiene and Safety
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• v.21 no.2
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• pp.100-106
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• 2006

The use of underarm and body care cosmetics with oestrogenic chemical excipients (particularly the parabens) and the hypothesized association with breast cancer incidence, particularly in women. It is noted that the type of cosmetic product is irrelevant (e.g. antiperspirant/deodorant versus body lotion, moisturizers or sprays versus creams) and attention must focus on issues of actual exposure to chemicals through continued dermal application of body care products and the endocrine/hormonal activity and toxicity of the chemicals in the formulations. To evaluate the estrogenic activities of parabens such as ethylparaben, butylparaben, propylparaben, isobutylparaben and isopropylparaben, we used recombinant yeasts containing the human estrogen receptor [Saccharomyces cerevisiae ER+LYS 8127], human breast cancer MCF-7 cell lines and human estrogen receptor ${\alpha}\;and\;{\beta}$. In E-screen assays, isopropylparaben is the most estrogenic paraben, and in ER competition assay, isobutylparaben is the most estrogenic paraben. We evaluated isopropylparaben was most active in the recombinant yeast assay, followed by propylparaben, ethylparaben, isobutylparaben and butylparaben. Results from this study demonstrate that parabens are observed in human endocrine system. Therefore, we have shown that the parabens is induced the estrogenic activities similar to $17{\beta}$-estradiol and Bisphenol-A.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.05a
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• pp.329-336
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• 2008

Nowadays with advancement in technology and aging society, the number of disabled citizens is increasing. The disabled citizens always need a caretaker for daily life routines especially for mobility. In future, the need is considered to increase more. To reduce the burden from the disabled, various devices for healthcare are introduced using computer technology. The power wheelchair is an important and convenient mobility device. The demand of power wheelchair is increasing for assistance in mobility. In this paper we proposed a robotic wheelchair for mobility aid to reduce the burden from the disabled. The main issue in an autonomous wheelchair is the automatic detection and avoidance of obstacles and going to the pre-designated place. The proposed algorithm detects the obstacles and avoids them to drive the wheelchair to the desired place safely. By this way, the disabled will not always have to worry about paying deep attention to the surroundings and his path.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.10 no.2
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• pp.133-139
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• 2016

An electric wheelchair is a assistive device to maneuver on the ground. Tip-over of an electric wheelchair is increasing every year. Dynamic stability metric test item in KS P 7176 has not ensured safety of electric wheelchair on the slope. This study presents design the foldable electric wheelchair that can load in the car and analysis of tip-over measurement which is easily computed for electric wheelchair. Wheelchair frame is designed with a four-bar link mechanism for a foldable structure, and seat module, battery and power driving module can be separated. This analysis is performed during a maneuver on the ground by force-moment stability metric. Several elements, center of gravity position, rotational radius and acceleration, were evaluated how to affect stability metric. This stability metric can reduce tip-over of wheelchair and provide a clue to make of dynamic stability test item.

• Journal of the Korea Institute of Construction Safety
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• v.2 no.2
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• pp.56-62
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• 2019

As of 2015, the number of handicapped people accounted for 26 percent of the total population and the number has been increasing every year. There are many restrictions on transportation, especially for visually impaired and wheelchair users, from existing buildings to other buildings. This study takes note of this and develops algorithms for producing applications for the direction of traffic for people who are blind and wheelchair users The algorithms developed through this study take into account stairs, thresholds and widths for wheelchair users, while guiding elevators and ramps first and supporting all guidance, including obstacles, by voice for the blind. This study is judged to contribute greatly to the development of applications for the actual traffic infirm in the future.

• The Journal of the Korea Contents Association
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• v.16 no.8
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• pp.202-208
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• 2016

The scope of activities of the visually impaired is increasing. But they are not easy to visit the destination safely because the building was complicated and larger than ever. There is a guide system for visually impaired such as GPS and Audio alerts, Braille guide block, Acoustic signaller, etc. But they are not suitable for indoor because most of them are the outdoor guide system. Therefore, in this paper, I propose a system that provides guidance information to the visually impaired using Voice Technology, TTS (Text to Speech) and Haptic Technology, Beacon based on the wireless sensor networks. It informed the visually impaired of guidance information about destination such as distance, height, and obstacle to the destination using the generalized smart phone. The user could be received guide info about searches for the optimal route to the destination using the TTS technology and Haptic technology in test result of the proposed system.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.9 no.4
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• pp.366-372
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• 2016

This paper advances the software, hardware and mechanical design that the visually impaired can recognize the position and distance of the obstacle while walking. The first software implementation is proposed a method to implement the algorithm graph for the ratio of the distance measuring ultrasonic sensors for voltage. And it was extracted by the precise distance measuring parameter values from simulation to measure the precise distance. Second hardware implementation was designed to be able to detect obstacles in a relatively simple sensor-based walking aid for the visually impaired. In addition, using the switching regulator IC of high performance it was designed to be used to boost the Li-ion battery 3.7V to 5V. The third mechanism was developed by analyzing the sensor angle and the cane angle.