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Artificial Trachea Covered by Ipithelium (상피세포 피복 인공기관의 개발)

  • 김광택;이윤신
    • Journal of Chest Surgery
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    • v.30 no.8
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    • pp.739-746
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    • 1997
  • A variety of experiments concerning the development of ideal prosthetic grafts for correcting circumferential tracheal defects have been performed. The requirements for an ideal tracheal prosthesis are impermeability to air, consistency to prevent collapse, and acceptance by the host tissue causing a minimum inflammatory reaction, allowing fibroblastic infiltration and epithelialization. The synthetic material, polyurethane(PU), is known as a biocompatible polymer with an inert component. In this study, the tracheal prosthesis was made from microporous PU(30 micrometer in diameter) coated with gelatin and reinforced with isoplastic rings. This procedure provides the prosthesis with a compression strength. The out side diame er of the prosthesis was 20 mm with a length of 30 mm. The gelatin used in the study was obtained from pig skin and immobilized and cross-linked by irradiation(60 Co gamma ray) to promote host tissue incorporation and render the prosthesis epithelization after implantation. Animal experiments using 10 mongrel dogs were performed to compare three kinds of prosthesis; gelatin coated polyurethane graft, uncoated polyurethane graft, and prosthesisf pericadium complex graft. After 6 weeks of implantation, the epithelialization of implants was seen on the gelatin-coated and prosthesisfpericadium complex grafts. Implanted prosthesis were complicated by airway obstruction due to anastomosis granuloma. Early tracheal stenosis was found in the uncoated graft group. Two kind of anastomosis techniques were tested on the gelatin-coated prosthesis. Everted anastomosis resulted severe granuloma than the inverted anastomosis. In the prosthesislpericadium complex graft, bacteria and inflammation at a anastomotic site was found. Based on these results, gelatin coated porous polyurethane trachea prosthesis is biocompatible and may be useful in clinical application with further investigation.

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Occupational Radiation Exposure in Korea: 2002 (2002년 국내 방사선 작업종사자의 직업군별 피폭선량)

  • Jeong, Je-Ho;Kwon, Jeong-Wan;Lee, Jai-Ki
    • Journal of Radiation Protection and Research
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    • v.30 no.4
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    • pp.175-183
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    • 2005
  • Dose distribution of Korean radiation workers classified by occupational categories was analyzed. Statistics of the occupational radiation exposure(ORE) in 2002 of the radiation workers in diagnostic and dental radiology were obtained from the Korea Food and Drug Agency(KFDA) who maintains the database for individual radiation dose records. Corresponding statistics for the rest of radiation workers were obtained by processing the individual annual doses provided by the Korea Radioisotope Association(KRIA) after deletion of individual information. The ORE distribution was classified in term of 28 occupational categories, annual individual dose levels, age groups and gender of 52733 radiation workers as of the year of 2002. The total collective dose was 66.4 man-Sv and resulting average individual ORE was 1.26 mSv. Around 80% of the workers were exposed to minimal doses less than 1.2 mSv. However, it appeared that the recorded doses exceeded 20 mSv for 43 workers in the industrial radiography and for 147 workers in the field of radiology. Particularly, recorded doses of 23 workers in radiology exceeded the annual dose limits of 50 mSv, which is extraordinary when the working environment is considered. It is uncertain whether those doses are real or caused by careless placing of dosimeters in the imaging rooms while the X-ray units are in operation. No one in the workforce of 16 operating nuclear power plant units was exposed over 20 mSv in 2002. Number of workers was the largest in their 30's of age and the mean individual dose was the highest in their 20's. Women were around 20% of the radiation workers and their average dose was around one half of that of man workers.

Synthesis and Characterization of trans-Dichlorocobalt(Ⅲ) Complex Containing N,N'-bis-[2(S)-pyrrolidinylmethyl]ethane-1,2-diamine (N,N'-bis-[2(S)-pyrrolidinylmethyl]ethane-1,2-diamine이 배위된 trans-Dichlorocobalt(Ⅲ) 착물의 합성과 특성)

  • Kim, Dong Yeup;Kim, Nam Jin;Son, Byung Sam;Lee, Dong Jin;Oh, Chang Eon;Doh, Myung Ki
    • Journal of the Korean Chemical Society
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    • v.39 no.12
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    • pp.940-945
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    • 1995
  • The SS-epm(N,N '-bis-[2(S)-pyrrolidinylmethyl]ethane-1,2-diamine) ligand having stereospecificity has been prepared and reacted with $CoCl_2{\cdot}6H_2O$ or trans-$[Co(pyridine)_4Cl_2]Cl.$ The resultants are green crystals, both of which are identified to be trans-$[Co(SS-epm)Cl_2]_2(COCl_4)$ by elemental analysis and absorption spectra. CD spectrum of trans complex shows negative (-) cotton effect at long wavelength due to the vicinal effect of the stereospecifically chelated ligands. The conformation of SS-epm in trans complex is ${\delta}{\lambda}{\delta}$(SRRS) for each of the five membered chelated ring. $Co(II)Cl_4^{2-}$ as counter ion plays an importance role in the ionic association of the formation of trans complex with SS-epm. Furthermore, according to orientation of secondary amine, total strain energy on each isomers was calculated by molecular mechanics (MM) to verify structural characterization and spectral data.

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Development of a Prototype for the Digitalized Nuclear Power Plant's Main Control Room (원자력발전소 디지털형 주제어실 모형 개발)

  • Jung, Yeon-Sub;Cho, Sung-Jae
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.9 no.4
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    • pp.145-152
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    • 2009
  • Domestic Kori-1 MCR was partially modified in 2007 and will be renovated entirely in 2013. Digital devices partially replacing original analog devices have been introduced and standard alone computer systems such as SPDS have been integrated into the plant computer. Upgrading KSNP's MCR based on the ditalization is planned for 2015. However, the site engineers and operators are reluctant to the advanced systems. Therefore, a prototype for the KSNP's advanced MCR has been developed to increase the acceptance level of the operators and field engineers and also, to evaluate user interfaces and I&C architecture. For enhancing support of the operators' work, a P&ID based display system composed of multi-layers, which are linked through a context sensitive menu each other, has been adopted. The $1^{st}$ layer displays a simplified P&ID, the $2^{nd}$ layer control related diagrams such as controllers and logic diagrams, the $3^{rd}$ layer trends, etc. The end point view of MCR for KSNP is also suggested considering reliability and operability of the digital systems. Additionally, modernization strategies over the overhaul periods, that do not have much impact on operation and configuration efforts are suggested.

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Synthesis, Spectral and Thermal Studies of Lanthanide(III) Complexes of Phenylbutazone (Phenylbutazone의 란탄(III) 착물에 대한 합성, 스펙트럼 및 열적 연구)

  • Anoop, M.R.;Binil, P.S.;Jisha, K.R.;Suma, S.;Sudarsanakumar, M.R.
    • Journal of the Korean Chemical Society
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    • v.55 no.4
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    • pp.612-619
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    • 2011
  • Lanthanide(III) complexes of 1,2-diphenyl-4-butyl-3,5-pyrazolidinedione(phenylbutazone, PB) have been synthesized and characterized by elemental analyses, molar conductance measurements, IR, UV-Vis. and NMR spectra. The spectral data reveal that the PB acts as a bidentate and mono-ionic ligand coordinating through both the carbonyl oxygens of the pyrazolidinedione ring. The molar conductance data suggest that the complexes are non-electrolytes. The thermal behaviour of the complexes was studied by TG and DTG in air atmosphere and the results provide information about dehydration, thermal stability and thermal decomposition. The final products are found to be the corresponding metal oxides. The thermodynamic parameters and kinetic parameters were evaluated for the dehydration and decomposition stages. The negative entropy values of the decomposition stages indicate that the activated complexes have a more ordered structure than the reactants and that the reactions are slower than normal. Based on these studies, the complexes have been formulated as $[Ln(PB)_3]{\cdot}5H_2O$(Ln=La and Ce) and $[Ln(PB)_3(H_2O)_2]{\cdot}2H_2O$(Ln=Pr, Nd and Sm).

Analysis on Risk Factors of Reactor Containment Building Construction using Analytic Hierarchy Process (계층 분석 방법을 이용한 원자로 격납 건물 시공의 리스크 요인 분석)

  • Shin, Dae-Woong;Shin, Yoonseok;Kim, Gwang-Hee
    • Journal of the Korea Institute of Building Construction
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    • v.15 no.4
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    • pp.425-431
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    • 2015
  • Since the construction of Kori 1 was completed in 1978, the construction projects for nuclear power plant are increasingly expanded into domestic and foreign sites. However, some of construction sites of nuclear power plant have the problems of process delay and cost loss due to lack of ability of risk management. The construction of reactor containment building in nuclear power plant is especially dotted with many risk factors because it needs professional skills and large-scale resources due to long duration compared with different construction phase. Therefore, it needs the study that analyzes risk factors expected in construction of reactor containment building and suggests way of stable performance of projects. So, this study assesses risk factors of construction of reactor containment building. For the objectives, this study uses survey for group of minority specialists of 36 experts. The risks of 24 factors is classified by criterions of process, cost, safety, and quality and the results of assessment is analyzed by analytic hierarchy process. As the results, the importance and priority of risk factors classified by each criterion were calculated and the applicability of analytic hierarchy process was identified to analyze risk factors of nuclear power plant construction. These will be baseline data for risk management in construction phase of reactor containment building.

A Comparative Study on the Importance of the Components of the Community Disaster Resilience on Disaster Response (지역사회 재난회복력 구성요소와 재난관리정책 결정요인 분석)

  • Kim, Jinkeun;Park, Chanseok
    • Journal of the Society of Disaster Information
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    • v.15 no.3
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    • pp.339-346
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    • 2019
  • Purpose: In fact, to manage response and recovery successfully, although mitigation and preparedness should be accomplished naturally and automatically through thorough analysis and assessment, response, recovery, mitigation, and preparedness have not done in the way of virtuous cycles and continued broken disaster management repeatedly. Method: By Analysis through the critical methods, to enhance the community disaster resilience centered by social disaster management system in Korea, Result: (1) public training & education preparing for emergency or disaster (2) supplying public with disaster, or hazards information, and sharing at real time (3) networking emergency and disaster informational communication system & alarm system (4) analysis and assessment of risk(or disaster) in community (5) inter-governmental cooperative relationship and agreements (6) adopting and implementing disaster or hazards mitigation plan Conclusion: These will be able to be fully melt down into and specifically focused in the disaster policies in Korea for the better disaster management.

Correction of the Ground Subsidence Risk Ratings during Open Cut Excavation (개착식 굴착공사 중 지반함몰 위험등급 분류시트의 등급 보정에 관한 연구)

  • Shin, Sang-Sik;Kim, Hak Joon
    • The Journal of Engineering Geology
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    • v.31 no.2
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    • pp.135-148
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    • 2021
  • Ground subsidence risk ratings obtained from the site investigation during pre-excavation stages could be changed depending on the parameters revealed during construction activities. A method of correcting the pre-excavation ground subsidence risk ratings based on the site conditions observed in the field is suggested in this study. The elevation of groundwater table during the excavation may be different from the predicted value depending on the application of waterproofing methods and construction conditions. The drastic drawdown of groundwater table during the excavation could cause ground subsidence due to soil volume decrease related to consolidation or compression of the ground, whereas the rising of groundwater table caused by the intense rainfall may result in a high potential for ground subsidence due to heaving or boiling of the excavation bottom. Excessive displacements of retaining walls or ground settlements may cause ground subsidence, which also results in a high risk of ground subsidence caused by the destruction of buried pipelines. Reevaluation of ground subsidence risk ratings is suggested considering the fluctuation of groundwater table, condition of groundwater leakage, measured ground displacements, and soil types. Finally, the ground subsidence risk rating system is improved for better evaluation by using 12 factors in 5 categories.

Improvement of Antifungal Activity of for Water-Dispersed Cosmetic Formulations (수분산 제형의 화장품에 대한 항진균력 향상)

  • Lee, Ye Ji;Seo, Jae Yong;Yang, Hyeon Gap;Lee, Ju kyeong;Baek, Sol Bee;Cho, Hyun Dae;Jeong, Noh Hee
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.48 no.2
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    • pp.135-146
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    • 2022
  • In order to prevent microbial contamination and safely use cosmetics, it is essential to possess preservative power. In this study, the antifungal effect was confirmed by improving the preservative system of the aqueous dispersion formulation, which has a weak preservative power against fungi, and various preservative systems were established to strengthen the preservative power against fungi. Five kinds of raw materials (sodium anisate, p-anisic acid, caprylhydroxamic acid, o-cymen-5-ol, hydroxyacetophenone) that have a benzene ring structure having a hydroxyl group and exist as protonated form in cosmetic formulations expected to improve antifungal activity in cosmetics were selected, and the minimum growth inhibitory concentration of the raw materials was determined through MIC assay. It was confirmed that the preservative power against mold was improved through the preservative efficacy test of 4 types of water dispersion formulations (cream, lotion, toner, and sun cream) in which 4 types of raw materials showing antimicrobial activity against mold were added to the preservative system. When p-anisic acid was used, it was confirmed that the preservative activity against mold was strengthened without the effect of inhibiting the preservative power against bacteria and yeast in all four formulations.

Analysis of Food Sources of Pre- and Post-diet in a Bivalve Using DNA Metabarcoding (DNA metabarcoding을 이용한 이매패류 공식 전후 먹이원 분석)

  • Bong-Soon Ko;Jae-won Park;Chang Woo Ji;Ihn-Sil Kwak
    • Korean Journal of Ecology and Environment
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    • v.55 no.4
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    • pp.360-367
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    • 2022
  • Research on food sources through DNA metabarcoding is being used for various organisms based on high resolution and reproducibility. In the study, we investigated the difference in food sources between pre and post-starving in the three bivalve species (Anemina acaeformis, Anodonta woodiana, and Unio douglasiae) through DNA metabarcoding using 18S rRNA V9 primer. The food source of pre-starving appeared in 87 genera, 71 families, 51 orders, 35 classes, and 22 phyla. The primary food sources were the zoo and phytoplankton, including Chlamydomonadales, Euglenales, Ploima, Sphaeropleales, and Stephanodiscales. However, all zoo and phytoplankton were not observed after starving except Schizopyrenida and Rotifera. In Levin's niche breadth analysis, the Bi index of A. woodiana is 0.3, which was higher than A. acaeformis(0.14) and U. douglasiae (0.21), indicating that they feed on various food sources. The niche overlap of A. acaeformis was measured as 0.78 in A. woodiana, 0.7 in U. douglasiae showing a relative high value compared to other bivalves. The trophic level of A. acaeformis, A. woodiana, and U. douglasiae based on the food source information were investigated as 2.0, 2.0, and 2.5, respectively. The results of the previous study on the trophic level using stable isotopes showed 1.8 to 2.4 values were similar to the results of this study. These results suggest that DNA metabarcoding can be an effective analyzing tool for the gut content in the bivalves.