• The Journal of the Korean life insurance medical association
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• v.17
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• pp.77-83
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• 1998

당사에서는 악성 종양에 대한 위험선택의 수단으로써 1997년 1월부터 종양표식자 중 CEA와 AFP 검사를 사의 진단에 한하여 실시하고 있다. 검사의 실시조건은 의사의 진찰소견으로 필요하다고 인정되는 경우와 관련병력의 고지가 있는 경우로 한하였다. 1997년 1월부터 10월말까지 실시한 건에 대해서만 분석을 하였으며 CEA 534건, AFP 608건를 실시하였다. 그 결과 기준치를 초과하는 경우는 CEA 33건, AFP 23건이었다. 표준체로 판정된 경우의 CEA의 평균치는 1.5ng/ml, AFP는 2.6ng/ml였다. CEA와 AFP의 검사결과나 그 이외의 원인으로 사절체의 판정을 받은 경우의 CEA의 평균치는 3.2ng/ml AFP의 경우는 20.7ng/ml로 나타났다. 본연구에서는 생명보험회사에서 종양표식자 검사의 의미를 검토해 보고자 하였다.

• Journal of Chest Surgery
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• v.36 no.1
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• pp.47-50
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• 2003

Pulmonary carcinoid tumors are thought to Originate from neuroendocrine Kulchitsky's cells in the bronchial epithelium. The majority of typical carcinoid tumors arc located centrally. However, atypical carcinoids are frequently situated peripherally and display malignant histologic features with aggressive behavior. Few reports arc discribing carcinoid tumors originating from the pleura. We report a typical carcinoid tumor located mainly in the parietal pleura invading the chest wall wilhout evidence of pulmonary parenchymal invasion.

• Tuberculosis and Respiratory Diseases
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• v.59 no.5
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• pp.556-560
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• 2005

지방종은 아주 흔한 양성종양이지만 흉막에서 발생한 지방종은 드물다. 대부분 무증상이며 우연히 발견되는 경우가 많다. 단순 흉부 X-선 사진상 양성종괴의 모습을 보이며, 전산화 단층촬영에서 특징적인 균질한 지방으로 구성된 종양의 모습을 보인다. 흉막의 지방종의 경우 다른 종양이나 악성 종양을 배제하기 위하여 개흉술을 통한 종양의 제거를 해왔으나 수술 후 통증이 적고 회복이 빠른 흉강경으로 지방종을 제거한 53세 여자환자 1례를 경험하였기에 보고하는 바이다.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1981.05a
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• pp.11.4-12
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• 1981

Some reports pointed out that the nasopharyngeal cancer presents not only various symptoms and signs due to the anatomical characteristics of the nasopharynx but also poor prognosis in the cases which are detected in advanced stage. This malignant tumor is not common than that of the other area, and is quite different incidence according to the geographical area and races. The oriental people especially southern Chinese have a high incidence and it was also reported to occur in the family. Recently authors had experienced a case of nasopharygeal cancer in the sister and report with review of literatures.

• Journal of Chest Surgery
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• v.34 no.6
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• pp.494-498
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• 2001

Primary cardiac tumors are rare, and primary malignant cardiac tumors are even rarer. Of these, angiosarcoma was uncommon, Surgical resection of the tumor was very difficult because symptoms were nonspecific and did not become present until the tumor had advanced. A 15-year-old male patient was diagnosed with primary cardiac angiosarcoma by microscopic examination under surgery and underwent resection of the tumor, which compressed and obstructed the right atrium. He was discharged from the hospital after 15 days without any problems.

• Korean Journal of Bronchoesophagology
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• v.3 no.2
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• pp.277-286
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• 1997

We have reviewed a 9-year experience with 47 patients treated for salivary tumors which arose In the parotid gland (23 patients; 48.9%), submandibular gland (15 Patients, 31.9%), minor salivary gland (8 patients; 17.0%), and sublingual gland (1 patient; 2.1%). The age of patients ranged from 12 to 71 with a mean of 42.9 years. The male to female ratio showed a female preponderance, 19:28 (1:1.5). An asymptomatic mass (91.5%) was most common presentation. With fine-needle aspiration, the predictive value of a neoplasm was 88.9%. Histopathologically, the most common salivary gland tumors was Pleomorphic adenoma(57.4%). The pleomorphic adenoma was most common in benign tumor group, and the mucoepidermoid carcinoma was most common in malignant tumor group. Of the salivary gland tumors, the incidence of cervical metastasis was 22.2%. Major postoperative complications were facial nerve paralysis and wound infection.

• Journal of Korea Multimedia Society
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• v.13 no.7
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• pp.1044-1050
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• 2010

Endoscopic ultrasonography is a medical procedure in endoscopy combined with ultrasound to obtain images of the internal organs. It is useful to have a predictive pathological manifestation since a doctor can observe tumors under mucosa. However, it is often subjective to judge the degree of malignant degeneration of tumors. Thus, in this paper, we propose a feature analysis procedure to make the pathological manifestation more objective so as to improve the accuracy and recall of the diagnosis. In the process, we extract the ultrasound region from the image obtained by endoscopic ultrasonography. It is necessary to standardize the intensity of this region with the intensity of water region as a base since frequently found small intensity difference is only to be inefficient in the analysis. Then, we analyze the spot region with high echo and calcium deposited region by applying LVQ algorithm and bit plane partitioning procedure to tumor regions selected by medical expert. For detailed analysis, features such as intensity value, intensity information included within two random points chosen by medical expert in tumor region, and the slant of outline of tumor region in order to decide the degree of malignant degeneration. Such procedure is proven to be helpful for medical experts in tumor analysis.

• Journal of Yeungnam Medical Science
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• v.10 no.2
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• pp.417-422
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• 1993

Diagnosis of malignant germ cell tumors of the ovary is usually difficult because many ovarian neoplasms have similar clinical and radiologic manifestations. We reviewed retrospectively 12 cases of ovarian malignant germ cell tumor and evaluated with respect to size, mass characteristics on computed tomography for differential diagnosis. Endodermal sinus tumors were mainly cystic mass with some solid component and septations. Immature teratomas showed typical manifestations, such as fatty tissue, calcifications, cysts, and irregular shaped soft tissue densities. Dysgerminoma was mainly solid mass without cystic component, and mixed germ cell tumor showed nonspecific manifestations. All cases were relatively large in size, and young in age. In conclusion, CT findings of malignant germ cell tumors are helpful in differential disgnosis.

• Korean Journal of Head & Neck Oncology
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• v.2 no.1
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• pp.13-22
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• 1986

Nasal fossae 의 암이란 비강과 부비동들에서 발생하는 것으로서 환자를 가장 괴롭히며 또한 가장 믿을수 없는 악성종양들중의 하나이다. 비록 본 예수병원 암환자 등록부에 의하면 전 암환자의 2.2% 발생빈도로서 주요한 발생빈도를 보이지는 않지만, 이 부위의 암을 치유하는데는 세심하고 철저한 모든 진단적 검사와 과감한 외과 및 치료방사선의 병합치료가 요구된다. 저자들은 지난 22 년간 비강 및 부비동 (Nasal fossae) 에서 발생한 원발성 악성종양중 치유목적의 근치수술을 시행한 68 예를 임상고찰 하였다. 근치수술을 시행했던 68 예중 91% 에서 제 3 병기 또는 4 병기의 진행된 경우 이었다. 외과적 수술은 한예의 사골동 (篩骨洞) 종양적출술 및 부분상악동(上顎洞)절제술 한 예를 제외한 66 예 모두에서 전상악동(全上顎洞)절제술 (total maxillectomy) 또는 확장 전상악동(全上顎洞)절제술 (extended total maxillectomy) 을 시 하였다. 저자들은 역학적(疫學的), 병리학적(病理學的), 병기(病期) 및 치료, 재발율과 생존율들을 분석 고찰하였으며 3가지 치료형태를 서로 비교하였다. 즉 수술만 시행한 군, 수술전 방사선 치료 및 수술병합군, 수술과 수술후 방사선치료 병합 군으로 나눴다. 저자들의 예비적 (preliminary) 관찰 결과는 2 년간 무병생존율 (disease-free 2-year survival) 만을 볼때, 수술만 시행한 군에서 40%로써 통계학적으로는 가장 좋았으나 실제는 수술만 시행한 군에서는 단지 40%만이 제 4 병기(病期)의 진행된 경우였으나 수술전 방사선치료 또는 수술후 방사선치료등의 병합치료에서는 제 4 병기(病期)의 진행된 상태가 무려 60 %나 되었다. 전체적인 재발율 (Overall recurrence rate) 은 68.2%로써 무서울 정도로 높았으며 전체적인 2 년 무병율은 23.7%였다. 저자들은 이 분야에서 실패의 원인분석과 치료방법의 선택등에 대한 지침을 제시하고저 한다.

• Journal of Korean Neurosurgical Society
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• v.30 no.4
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• pp.522-527
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• 2001

We present a case of recurrent extraventricular neurocytoma with malignant glial differentiation in left temporoparietal area. A 37-year-old man with presentation of generalized seizure had undergone biopsy of brain tumor in left parietal area in 1987, which revealed extraventricular neurocytoma and radiotherapy was followed. Postoperative course was uneventful until eleven years after biopsy, when he became gradually aphasic and right hemiplegic. Brain CT and MRI revealed enlargement of tumor with peritumoral edema and calcifications. He underwent subtotal tumor removal in 1998. Microscopic examination of second biopsy specimen revealed presence of large areas composed of anaplastic glial cells with frequent mitosis, nuclear pleomorphism, large eosinophilic cytoplasm and eccentric nuclei, resembling gemistocytes, which were strongly immunoreactive to glial fibrillary acidic protein(GFAP) but not to synaptophysin(SNP). Also focal areas of neuronal cells were found, which were immunoreactive to SNP but not to GFAP. These histologic findings imply that this recurred tumor was a high grade, mixed tumor with divergent differentiation of neuronal and astrocyte lineage. We report a rare case of extraventricular cerebral neurocytoma with malignant glial differentiation with review of the literature.