• Title/Summary/Keyword: 악성중피종

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Efficiency, Ignorance, and Environmental Effect - long-run Relationship between Asbestos Consumption and the Incidence of Mesothelioma - (효율성과 무지, 그리고 환경피해 - 석면 사용과 악성중피종 발생의 장기관계 -)

  • Son, Donghee;Jeon, Yongil
    • Environmental and Resource Economics Review
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    • v.26 no.3
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    • pp.287-317
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    • 2017

  • Asbestos has been actively used for various places. Since it was designated as the first grade carcinogen in the 1970s, strict regulations on using asbestos has been implemented globally. Considering long-term latent periods between asbestos exposure and environmental diseases, we analyze the time lag between asbestos consumption and the incidence of mesothelioma in Korea and estimate the long-run relationship. In addition, we conduct a comparative analysis on the effectiveness of asbestos regulations in the United Kingdom and the United States, which have accumulated long-term time-series observations. The latent period analysis indicates that the consumption of asbestos and the incidence of the disease are highly correlated in all three countries, being long-term lags of more than 30 years. Also, we find a long-run equilibrium relationship between asbestos consumption and the incidence of mesothelioma in the presence of long-term lags between the variables in all three countries. Furthermore, using a distributed lag model, asbestos consumption has statistically significant positive effects on mesothelioma with a long-term lag.

  • https://doi.org/10.15266/KEREA.2017.26.3.287 인용 PDF

Differential Diagnosis of Pleural Mesothelioma and Metastatic Adenocarcinoma by Immunohistochemistry (면역조직화학염색법을 이용한 흉막의 악성중피종과 전이성 선암의 감별진단)

  • Ko, Kyung-Haeng;Park, Chang-Min;Rim, Myung-Soo;Kim, Yoo-Il;Jang, Il-Gweon;Hwang, Joon-Hwa;Lim, Sung-Chul;Kim, Young-Chul;Park, Kyung-Ok;Park, Chang-Soo
    • Tuberculosis and Respiratory Diseases
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    • v.47 no.4
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    • pp.478-487
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    • 1999

  • Background : Differential diagnosis of pleural malignant mesothelioma from secondary metastatic adenocarcinoma is often difficult. A variety of pathologic techniques have been developed to make a differential diagnosis of carcinoma from mesothelioma. Immunohistochemistry detecting diverse antigenic substances such as CEA, Leu-M1, Bn-3, S-100 protein, vimentin, CK and EMA has been claimed to be of value as a panel in the differential diagnosis of adenocarcinoma from mesothelioma. The aim of this study was to investigate the suitable antibodies to distinguish mesothelioma from metastatic adenocarcinoma and establish candidate markers in a panel. Methods : Complete, one-hour immunohistochemical staining using antibodies against cytokeratin (CK), epithelial membrane antigen(EMA), S-100 protein, vimentin, B72-3, Leu-M1, and carcino-embryonic antigen(CEA) was applied to cell blocks from 7 mesotheliomas and 7 adenocarcinomas which were confirmed by electron microscopic and histpathologic methods. Results : All adenocarcinomas and 71.4% of mesotheliomas expressed the cytokeratin and EMA. S-100 protein and vimentin were expressed in 57.1% and 42.9% of mesotheliomas and 14.3% and 28.5% of adenocarcinomas, respectively. B72-3 was expressed in all adenocarcinomas, but in none of mesotheliomas. Leu-M1 was positive in 71.4% of the adenocarcinoma and 14.3% of the mesotheliomas. CEA was positive in all adenocarcinomas and 42.9% of mesotheliomas. Leu-M1 and B72-3 were coexpressed in 71.4% of adenocarcinomas but in none of mesothelioma. B72-3 and CEA were coexpressed in all adenocarcinomas, but in none of mesotheliomas. Conclusion : We concluded that B72-3 immunohistochemistry or panel staining of B72-3 and CEA could be recommanded for the differential diagnosis of pleural mesothelioma from metastatic adenocarcinoma.

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