• The Journal of the Korean dental association
• /
• v.25 no.2 s.213
• /
• pp.177-183
• /
• 1987

저자는 지난 1년간 서울대학교병원 치과진료부 구강외과에 래원한 아프타성 구내염 환자 10명에 대하여 한냉외과 시술과 보존요법으로 치료하여 창상치유 및 동통호소에 관한 임상적 연구를 하였던 바 다음과 같은 결과를 얻었다. 1. 보존적 치료를 받았던 아프타성 구내염 병소는 대체로 14일 후에 치유됨을 관찰할수 있었다. 2. 한냉외과적 치료를 받았던 아프타성 구내염 병소는 시술후 5~7일경에 치유되었다. 3. 보존적 치료를 받은 환자는 음식물 섭취시 대체로 7~10일간 동통을 호소하였다. 4. 한냉외과적 처치를 받았던 환자는 1일후부터 음식물 자극에 대하여 하등 동통을 호소하지 않았다.

• Journal of Oral Medicine and Pain
• /
• v.34 no.4
• /
• pp.363-369
• /
• 2009

Erosive oral lichen planus (EOLP) and recurrent aphthous stomatitis (RAS) are T-cell mediated inflammatory immune disorders. It was investigated mRNA expression pattern of several regulatory factors, such as, CD28, CD45, CD152, CD154, CD279, which influence T lymphocyte in unstimulated whole saliva (UWS) of EOLP and RAS patients. It was collected unstimulated whole saliva during 10 minute in EOLP 18 people, RAS patients 12 people, healthy control 8 people. We investigated mRNA expression of T lymphocyte regulatory factors, such as, CD28, CD45, CD152, CD154, CD279, with real time reverse transcription polymerase chain reaction. In EOLP group, CD45, CD279 expressed higher and CD154 expressed lower than control. In RAS, CD45, CD270 expressed higher and CD28, CD154 expressed lower than control. In addition CD152 salivary mRNA expression of EOLP is higher than that of RAS. The above results were suggested that the mRNA expression of T lymphocyte regulatory factors in unstimulated whole saliva of EOLP and RAS contributes to diagnosis of diseases.

• RED RIBBON
• /
• s.66
• /
• pp.16-17
• /
• 2005

에이즈 환자에게서 흔히 나타나는 구강 내 병변은 충치, 구강칸디다증, 구강 모상 백반증(oral hairy leukoplakia),재발성 아프타성 구내염(recurrent aphthous stomatitis),재발성 포진성 구내염(recurrent herpetic stomatitis),치주염, 카포시 육종, 비호치킨성 림프종 등이다. 이 중 에이즈 환자에게 비교적 특징적인 병변은 구강 칸디다증, 입안털백색판증, 카포시 육종 등이지만 일반인들에서 흔히 관찰되는 충치라고 하더라도 치주염이나 농양으로 빠르게 진행한다면 에이즈를 의심해 보아야 하며, 반복적인 아프타성 궤양이나 포진성 궤양이 유달리 크고 오래 지속된다면 역시 에이즈의 가능성을 생각해 봐야 한다. 구강 병소는 에이즈 환자에게서 흔히 발견되며 이 질환의 초기 상태를 제시할 수 있다는데 의의가 있다.

• The Journal of the Korean dental association
• /
• v.21 no.6 s.169
• /
• pp.449-452
• /
• 1983

구강내에서 발생하는 연조직 질환중 궤양을 수반하여 환자로 하여금 통증을 호소하게 하는 질환으로는 급성 괴사성 궤양성 치간염 (Acute Necrotizing Ulcerative Gingivitis), 급성 수포성 구내염(Acute Herpetic Gingivo Stomatitis), 재발성 구순포진(Recurrent Herpes Labialis), 재발성 아프타성 구내염(Recurrent Aphthous Stomatitis), 대상성 포진(Herpes Zoster) 등이 있으며, 다른 질환보다도 그 발생빈도가 높아 임상에서 접하게 되며 그 치유속도가 늦어 가끔 당혹감을 느끼는 수가 있다. 이들 질환의 임상적 소견과 그 질환에 대한 치료법의 예를 간략하게 생각해 보고져 한다.

• Journal of Oral Medicine and Pain
• /
• v.34 no.1
• /
• pp.55-62
• /
• 2009

In most cases, it is difficult to diagnose ulcerative diseases of the mouth, because they have many similar clinical appearance. For the diagnosis of oral ulcerative lesions, the clinician should check a detailed history of the patient and consider the relation with systemic diseases. In this case report, we introduced two patients with erythematous multiforme, phemphigus, lichenoid reaction and aphthous stomatitis as clinical diagnosis. The lesions were improved by medication.

• Journal of Oral Medicine and Pain
• /
• v.37 no.4
• /
• pp.195-203
• /
• 2012

Recurrent aphthous ulcer(RAU) is the most frequent form of oral ulceration with a prevalence in the general population ranging between 5% and 60%. The peak age of onset is between 10 and 19 years of age, and it can persist into adulthood and throughout the patient's lifespan, with no gender predilection. The disease is characterized clinically into three types: minor aphthous ulcer, major aphthous ulcer and herpeticform ulcers. The cause of RAU is unknown and thought to be multifactorial with many triggers or precipitating factors that include familial tendency or genetic predisposition, allergy, medications, hormones, stress or anxiety, and immunologic abnormalities. The need for consideration of psychological factors in the pathogenesis of oral disease has been increasingly acknowledged over the last decades and many studies have highlighted the psycho-social impact of oral conditions. In this study, we tried to evaluate the influence of emotional stress in RAU. There were thirty patients with a clinical diagnosis of RAU and other subjects who did not show any signs of systemic disorders include RAU. They are evaluated by using modified Holmes and Rahe's Social Readjustment Rating Scale (SRRS). As a result, a significantly higher level of stress was found in the RAU patients than the control group. Therefore it can be concluded that psychological stressors play an important role in the RAU.

• Journal of Sasang Constitutional Medicine
• /
• v.32 no.2
• /
• pp.80-95
• /
• 2020

Introduction This study is the first case report to observe a significant improvement of clinical symptoms of both Recurrent Aphthous Stomatitis(RAS) and pompholyx treating with modified Palmulgunja-tang for Soeum-type. Case presentation A 37-year-old female patient complained of pain by ulcers on her mouth and tongue, and of itching caused by vesicles on her palms and soles was diagnosed with RAS, pompholyx, and, especially moderate pattern of 'Congestive Hyperpsychotic symptomatology' according to the theory of Sasang Constitutional Medicine(SCM). During inpatient and outpatient treatment, she took modified Palmulgunja-tang, and was treated with acupuncture, moxibustion, and cupping therapy. The effectiveness of these therapies was assessed with subjective Neumeral Rating Scale(NRS) and Dyshidotic Eczema Area and Severity Index(DASI). Conclusion After the treatment according to the theory of SCM, NRS, and DASI score about RAS and pompoholyx was decreased, and the general condition of the patient also has improved.

• Journal of Pharmaceutical Investigation
• /
• v.25 no.4
• /
• pp.339-345
• /
• 1995

For the effective treatment of aphthous stomatitis, the matrix type mucoadhesive patches containing triamcinolone acetonide have been formulated. The drug layer was obtained by drying the polymer gel which was prepared with carbomer 934P, ammoniomethacrylate copolymer, titanium dioxide and polyethylene glycol 400. The effects of the content of additives on physical characteristics of the polymer gel and the drug layer were evaluated. The addition of carbomer increased the yield point and the zero-shear viscosity of polymer gel as well as the thickness, the water absorption ratio, the adhesive time and $T_{50%}$ of drug layer. The adhesive time and the water absorption ratio of drug layer were also improved by the addition of ammoniomethacrylate copolymer, but the addition of titanium dioxide had decreased the zero-shear viscosity of polymer gel and the adhesive time of drug layer.

• Journal of Yeungnam Medical Science
• /
• v.3 no.1
• /
• pp.307-311
• /
• 1986

Beh,cet's disease was originally described as a triple symptom complex of oral aphthous ulceration, genital ulceration, and hypopyon iritis. It is now known to have a wide systemic manifestations. Among them, the central nervous system involvement should be diagnosed earlier because of it's lethal potential. Recently the authors experienced a case of Behcet's disease with CNS involvement. A 51-year-old female patient was admitted due to deterioration of mentality and generalized ache since 2 years prior to admission. The findings on physical examination were compatible with Behcet's disease, but without cerebrospinal pleocytosis. The manifestations were improved with medications of prednisolone, chlorambucil, colchicine, but relapsed 2 months later during subsequent tapering of prednisolone and chlorambucil. The patient is now on medication again. A case of Beh,cet's disease with CNS manifestations is reported with review of literature.

• Journal of Dental Rehabilitation and Applied Science
• /
• v.29 no.4
• /
• pp.391-398
• /
• 2013

Botulinum toxin has been used for treating strabismus, blepharospasm, cerebral palsy, cervical dystonia, hyperhydrosis, facial wrinkle and chronic migraine under US Food and Drug administration approval. Also it has been tried spasticity-induced pain, post-herpetic neuralgia, myofascial pain and aphthous ulcer as off-label use. In this study, we reviewed recent studies that suggested effects of botulinum toxin on snoring and sleep apnea.