• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제7권2호
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• pp.170-178
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• 2004

Purpose: Helicobacter pylori (H. pylori) infection has been known to be vital in the pathogenesis of duodenal ulcer disease in children as well as in adults. But the relationship between H. pylori infection and the histopathologic findings of the duodenum has not been explained obviously in children yet. So the aim of this study is to determine whether duodenitis and/or gastric metaplasia in the duodenum increases the risk of duodenal ulcer disease in children infected by H. pylori. Methods: From October 2001 to April 2004 gastric and duodenal biopsies were performed in 177 children who visited Department of Pediatrics, Gil Hospital, Gachon Medical School. Biopsy sections were stained with hematoxylin and eosin and also with Giemsa for identification of H. pylori. The grades of duodenitis and gastric metaplasia were classified from 0 to 3 and from 0 to 4, respectively. Results: The incidence of H. pylori infection was 54% in total patients. Amongst 163 children with duodenitis there was a lack of correlation between H. pylori infection and the grade of duodenitis. Amongst 11 patients with duodenal ucler, only 4 children were infected by H. pylori. And amongst 5 patients with gastric metaplasia, H. pylori and duodenal ulcer were detected in 2 and 3 children, respectively. The occurrence of duodenal ulcer and gastric metaplasia were increased significantly in proportion to the grade of duodenitis (p<0.0001 and p=0.0365, respectively). Conclusion: As opposed to the results of previously reported articles, there were lacks of correlation between H. pylori infection and duodenitis, duodenal ulcer, and gastric metaplasia. So further study hould be done to clarify the effect of H. pylori on the duodenal histopathology in children infected by H. pylori.

• The Journal of Internal Korean Medicine
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• 제22권1호
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• pp.21-27
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• 2001

목적 : 본 연구는 배기음(排氣飮)이 토끼의 위장관내에서 화학물질에 의해 유발된 장관의 궤양에 유효한 효과를 발휘할 수 있는지를 검증하기 위한 실험이다. 방법 : 토끼 5마리를 한 군으로 하여 정상군과 체중 1kg당 200mg 분량의 mepirizole을 경구 투여한 군과 100mg/kg의 배기음(排氣飮)(경구투여)과 800Units/kg 분량의 catalase(정맥주사)를 mepirizole을 경구투여하기 2시간 전에 각각 전처치한 군으로 나누었다. Mepirizole을 경구 투여한 후 각각 24hr와 48hr에 토끼를 희생시켜 위장, 십이지장부의 궤양성 병변을 관찰하였다. 결과 : Mepirizole을 경구투여하여 위장 및 십이지장 기부의 궤양성 병변이 유발되었다. 배기음(排氣飮)(경구투여)과 catalase(정맥주사)를 전처치하였을 경우 궤양의 크기가 현저하게 줄어들었다. Mepirizole은 십이지장 점막에서 지질의 과산화를 증가시키는데 이는 수산화기와 관련되어 있음을 시사한다. 배기음(排氣飮)과 catalase를 전처치함으로써 mepirizole에 의해 유발된 지질의 과산화가 현저하게 억제되었다. 형태학상의 연구에서도 mepirizole의 처치에 의한 십이지장의 손상과 배기음(排氣飮)에 의한 방지효과가 나타났다. 결론 : 이러한 결과들로 볼 때 반응성산소기는 mepirizole에 의해 유발된 위장관 궤양의 병리변화 형성에 주요한 영향을 미치며 배기음(排氣飮)이 항산화작용을 통해 궤양의 형성을 억제하는 역할을 하고 있음을 나타낸다. 따라서 본 연구는 배기음(排氣飮)이 반응성산소기에 의해 매개된 인체 위장관질환에 치료적 역할을 할 수 있음을 제시하고 있다.

• Journal of Chest Surgery
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• 제30권12호
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• pp.1251-1253
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• 1997

Gastrointestinal complications, especially duodenal complication after cardiopulmonary bypass are rare, but often fatal. We experienced 1 case of duodenal ulcer bleeding and 2 cases of duodenal ulcer perforation developing after cardiopulmonary bypass from August 1994 to April 1996. In the case of duodenal ulcer bleeding, palpitation, dizziness, tachycardia and melena were the clues leading to diagnosis, and in the cases of perforation, abdominal distension with pain, tachycardia, hypotension, oliguria were the clues. Duodenal perforations were diagnosed by abdominal paracentesis. The patient with duodenal bleeding was treated by H-2 receptor antagonist, antacids and transfusion. And emergency laparotomy was required for the patients with duodenal perforation. In addition to ulcer prophylaxis including H-2 receptor antagonist and antacids, a high index of suspicion and timely surgery are necessary for early diagnosis and appropriate treatment of duodenal complication developing af er cardiopulmonary bypass.

• 건강소식
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• 제15권9호통권154호
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• pp.20-24
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• 1991

• 건강소식
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• 제15권9호통권154호
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• pp.25-29
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• 1991

• 간의등불
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• 통권23호
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• pp.26-27
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• 2002

• 건강소식
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• 제12권2호통권111호
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• pp.28-31
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• 1988

스트레스의 극복을 위해서는 규칙적 운동, 정신적ㆍ신체적 휴식, 술, 담배를 끊음으로서 신체적 탄력과 적응력을 고양시켜주어야 한다.

• Journal of Yeungnam Medical Science
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• 제6권1호
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• pp.43-46
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• 1989

Primary peptic ulcer disease is not known to be the result of underlying illness or traum. These are most frequently duodenal or prepyloric. Since clinical features of peptic ulcer in children can easily be confused with many other disorders, the diagnosis is usually made when one of the more dramatic presentations, such as perforation, bleeding and obstruction. Recently, we experienced 2 cases of duodenal obstruction due to peptic ulcer in children. So, we report it with review of references.

• Journal of the Korean Society of Food Science and Nutrition
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• 제22권4호
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• pp.374-380
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• 1993

Effect of green tea extract, on duodenal ulceration was studied in male Sprague Dawley rats treated with cysteamine, a drug, which causes duodenal ulcers in experimental animal. As a result, in the proximal duodenum, a significant decrease of ulceration was detected twenty four hours after cysteamine injection in rats raised in green tea extract for 63days. Special reference to duodenal alkaline phosphatase activity was measured in mucosal homogenates. In control rats raised in tap water Riven saline, significant decrease was observed in proximal duodenal alkaline phosphataes activity. The decrease effect seems site specific, since the enzyme in the distal duodenum remains. Moreover the effect cysteamine in control rats alkaline phosphatase is specific, because, in rats raised in green tea extracts did not show significant change in activity. It is suggested that green tea extract acts in ideal properties as an anti-duodenal ulcer agent.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제8권2호
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• pp.226-232
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• 2005

Peptic ulcer disease complicated with gastric outlet obstruction is rare in children. Even though NSAIDs have been reported to cause various adverse events, they are still regarded as safe and, therefore, widely utilized in children. In the past, pediatric patients who were at risk of seizure due to high fever, were treated with dipyrone (Metamizole sodium) injection which inhibits cyclooxygenase-1 and inhibit prostaglandin, to weaken the gastro-duodenal defensive mechanism. A case of an infant with multiple esophagogatroduodenal ulcers and bleeding caused by NSAID complicated with gastric outlet obstruction is reported in this paper.