• 제목/요약/키워드: 심혈관 기능

검색결과 133건 처리시간 0.127초

Effect of Aerobic Exercise and Gym-ball Exercise on the Liver Function Test Index, Adipokines, and Cardiovascular Risk Factors in Obese Children with Nonalcoholic Fatty Liver Disease (유산소 운동과 짐볼 운동이 비알코올성 지방간 비만아의 간 기능평가 지수와 Adipokine 및 심혈관 질환 위험인자에 미치는 영향)

  • Lee, Sung-Soo
    • Journal of Life Science
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    • 제22권9호
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    • pp.1261-1267
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    • 2012
  • The aim of the present study was to investigate effects of a 12-week aerobic exercise training program and a gym-ball exercise training program on body composition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), adipokines, and cardiovascular risk factors in obese children with nonalcoholic fatty liver disease. The subjects were separated into two groups, an aerobic exercise group (n=10), which practiced moderate aerobic exercise training for 12 weeks, and a gym-ball exercise group (n=13), which practiced resistance exercise training for 12 weeks. The results of the analyses are as follows: Weight, body mass index, and body fat were significantly lower (p<0.01, respectively), whereas the $VO_2$ max was higher in both groups (p<0.01). Fasting glucose, insulin and HOMA-IR levels were significantly decreased in the gym-ball exercise group (p<0.05), whereas adiponectin, AST, and ALT levels were significantly increased (p<0.05, p<0.001, p<0.001, respectively) in both groups after the 12-week exercise training program. In addition, our results showed that HOMA-IR, insulin, and concentrations of C-reactive protein (CRP) were significantly lower in both groups. They demonstrate that a 12-week program of regular aerobic exercise or gym-ball exercise yields beneficial effects such as an amelioration of cardiovascular risk factors, body indices, and liver function in obese children with nonalcoholic fatty liver disease.

Novel Function of Lycopene in Vascular Endothelial Cell (Lycopene의 새로운 혈관내피세포 생리활성)

  • Cho, Jin-Gu;Kim, Sung-Hyen;Seo, Jeong-Hwa;Ahn, Sun-Young;Jeong, Eun-Sil;Park, Heon-Yong
    • Journal of Life Science
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    • 제20권7호
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    • pp.1093-1099
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    • 2010
  • Little is known about the cardiovascular effects of Lycopene, an anti-cancer and anti-oxidative agent. In this study, we executed a series of experiments with vascular endothelial cells to disclose the cardiovascular functions of lycopene. From our in vitro experiments, lycopene was determined to act as a stimulant to induce endothelial cell proliferation and migration. In addition, lycopene was shown to inhibit lipopolysaccharide (LPS)-induced adhesion of THP-1 leukocytes to endothelial cells, as well as activating mitogen activated protein kinase (MAPK) family members, ERK, JNK and p38 MAPK. Both ERK and p38 MAPK were involved in lycopene-induced cell proliferation, while JNK was involved in lycopene-dependent cell migration. Taken together, lycopene activates MAPK family members which regulate cell proliferation and migration. Lycopene differentially blocks LPS-dependent adhesion for THP-1 to endothelial cells, indicating that lycopene is likely to regulate a variety of vascular functions.

Inhibitory effects of artemether on thrombus formation via regulation of cyclic nucleotides in collagen-induced platelets (콜라겐-유도의 혈소판에서 사이클릭 뉴클레오티드의 조절을 통한 Artemether의 항혈전 효과)

  • Chang-Eun Park;Dong-Ha Lee
    • Journal of Applied Biological Chemistry
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    • 제65권4호
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    • pp.239-245
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    • 2022
  • Although normal activation of platelets is important in the process of hemostasis, excessive or abnormal activation of platelets can lead to cardiovascular diseases. Therefore, the discovery of novel substances capable of regulating or inhibiting platelet activation may be helpful in the prevention and treatment of cardiovascular diseases. Artemether is a derivative of artemisinin, known as an active ingredient of Artemisia annua, which has been reported to be effective in treating malaria, and is known to function through antioxidant and metabolic enzyme inhibition. However, the role of artemether in platelet activation and aggregation and the mechanism of action of artemether in collagen-induced human platelets are not known until now. This study investigated the effects of artemether on platelet activation and thrombus formation induced by collagen. As a result, cAMP level was significantly increased by artemether, and VASP and IP3R, substrates of cAMP-dependent kinase, were phosphorylated. IP3R phosphorylation by Artemether inhibited Ca2+ recruitment into the cytoplasm, and phosphorylated VASP inhibited fibrinogen binding by inactivating αIIb/β3 located on the platelet membrane. Consequently, artemether inhibited thrombin-induced fibrin clot formation. Therefore, we propose that artemether can act as an effective prophylactic and therapeutic agent for cardiovascular diseases caused by excessive platelet activation and thrombus formation.

Association between cardiovascular disease and periodontal disease prevalence (치주질환에 의한 심장질환 발생의 관련성)

  • Jeong, Mi-Ae;Kim, Jee-Hee
    • Journal of the Korea Convergence Society
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    • 제2권4호
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    • pp.47-52
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    • 2011
  • Periodontal disease is a common inflammatory disorder that is being considered as a risk factor for atherosclerotic complication. Recent epidemiological evidence also supports that its potential association with increased blood pressure levels and hypertensive prevalence. Data from cross-sectional studies suggest that in hypertensive patients periodontal disease may enhance the risk and degree of target organ damage. So dental infections have been associated with cardiovascular diseases. There are potential pathophysiologic links between hypertension and periodontits. The role of the inflammatory pathway include C-reactive protein(CRP). CRP is an inflammatory mediator that has been shown to predict the development of hypertension independently of baseline BP and traditional risk factors, has been consistently reported as at least mildly elevated in patients with periodontal disease. Reactive oxygen species produced by locally infiltrating neutrophils participate in periodontal tissue destruction. Periodontits can lead to inflammatory responses in the atrial myocardium, which disturbs the structural and electrophysiologic properties of the atrium and facilitates atrial fibrillation in the animal experiment.

A development of a multimodal patch-type probe for measuring blood flow and oxygen saturation in carotid artery (경동맥 혈류 속도 및 산소 포화도 측정을 위한 다중모드 패치형 프로브 개발)

  • Youn, Sangyeon;Lee, Kijoon;Kim, Jae Gwan;Hwang, Jae Youn
    • The Journal of the Acoustical Society of Korea
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    • 제38권4호
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    • pp.443-449
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    • 2019
  • To protect the patient's internal organs when a patient with cardiovascular disease occurs, it is important to reduce the elapsed time by providing emergency medical services. Decisions for conducting cardiopulmonary resuscitation are mainly made using the carotid palpation method, which directs the pulse of the carotid artery, which can diagnose the patient's condition according to one's own subject and cause cerebral blood flow to be blocked by excessive pressure in the carotid due to the weaken cardiopulmonary function. In this study, we developed a multimodal patch-type probe based on multi-channel ultrasound Doppler pairs and oxygen saturation measurement modules which can monitor cardiopulmonary functions. From the in-vivo experiments, the developed probe can be utilized as a novel tool that can increase the survival rate of cardiovascular disease patients by objectively monitoring the cardiopulmonary function of the patient quantitatively and promptly in an emergency situation.

Work Load Dependency of Heart Rate Variability (HRV) (심박변이도의 운동부하 의존성)

  • Kwon J.H.;Kim C.S.;Eom G.M.
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 한국정밀공학회 2006년도 춘계학술대회 논문집
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    • pp.641-642
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    • 2006
  • The purpose of this work is to investigate the effect of work load on heart rate variability (HRV) which is widely used marker of the autonomic nervous system activity. Average heart rate, rating of perceived exertion, and the power spectrum of heart rate variability were investigated in seven healthy males during exercise at various work loads. The subjects were divided into two groups according to the average heart rate during exercise, group 1 with lower heart rate and group 2 with higher heart rate. HF component showed decrease followed by increase with workload. Accordingly, the LF/HF ratio showed increase followed by decrease with workload. The peak in LF/HF ratio of group 1 was at the lower workload than that of group 2.

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carbofuran Induces Cardiovascular Dysfunction in Rat (휜쥐의 심혈관 기능에 대한 carbofuran독성작용)

  • 정이숙;이수환;백은주;문창규;문창현
    • YAKHAK HOEJI
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    • 제45권6호
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    • pp.739-745
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    • 2001
  • Of all pesticides, carbamates are known to be most common, since alternatives such as organophosphates have long lifetime and are extremely toxic to produce a delayed neurotoxic effect. Although a number of studies about toxicity of carbofuran, a most widely used carbamate, have been reported, its cardiovascular toxicity has not yet been studied. In the present study, we investigated its cardiovascular toxic effect in anesthetized rat in vivo and in isolated Langendorff rat heart, In anesthetized rat model, carbofuran (10 mg/kg) significantly reduced heart rate, and transiently increased blood pressure. In isolated rat heart, carbofuran (10${\mu}{\textrm}{m}$) caused a significant depression in the left ventricular developed pressure (LVDP), indicating contractile dysfunction by carbofuran. Carbofuran (10${\mu}{\textrm}{m}$) also decreased coronary flow rate (CFR) in isolated heart, indicating carbofuran-induced coronary dysfunction. These results suggest that carbofuran can cause cardiac dysfunction in rat in vivo and vitro.

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The development of new functional ingredients for menopausal women and cardiovascular health (갱년기 여성 및 심혈관 건강을 위한 새로운 기능소재의 개발)

  • Choi, Eun Hye;Park, Kum Ju;Kang, Jung Il;Lee, Sang Yun
    • Food Science and Industry
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    • 제53권4호
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    • pp.374-381
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    • 2020
  • As Korea became the aged society, people pay more attention to their health and disease prevention. For a better and healthy aging, it is even more important for active seniors to manage their health. The development of functional ingredients targeted for active seniors, which may improve cardiovascular and menopausal women's health, and their certification as individually recognized functional materials could serve as a new growth engine for the functional foods industry as well as contribute to the improvement of public health.

Patient-driven Physio-Grid Service with Ambient Mobile Widget Manager (앰비언트 모바일 위젯 매니저를 이용한 환자 지향의 Physio-Grid 서비스)

  • Kim, Moonjung;Youn, Chan-Hyun
    • Proceedings of the Korea Information Processing Society Conference
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    • 한국정보처리학회 2010년도 춘계학술발표대회
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    • pp.554-557
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    • 2010
  • 실시간 모바일 웹 환경이 e-Healthcare 시스템과 통합 적용되었을 때, 보다 사용자 중심적이고 효율적인 서비스를 제공할 수 있다. 심혈관 질환 진단 시스템인 PhysioGrid 시스템의 의료 정보 서비스를 모바일 환경 하에서 고품질의 사용자 중심적인 의료서비스가 가능하도록 시스템 인터페이스상 개선 방안을 제시한다. 구체적으로 우리는 최근 모바일 인터페이스에 매우 큰 변화를 가져온 모바일 위젯 형태의 어플리케이션을 도입한 서비스 모델을 정의하였다. 또한 정보 전달 기능을 향상시키고 사용자에게 진보된 경험 수준을 제공할 수 있는 앰비언트 디스플레이(Ambient display) 개념을 적용하여, 기존 시스템의 문제점에 대한 해결 방안을 검토하고 평가한다.

계절건강 지킴이 - 잘 자요! 당신의 굿~잠을 위하여

  • Lee, Eun-Jeong
    • 건강소식
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    • 제38권8호
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    • pp.24-25
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    • 2014
  • 국민건강보험공단에 따르면, 수면 장애를 앓고 있는 사람이 지난 2008년 22만 8,000명에서 2012년 35만 7,000명으로 5년 사이에 약 13만명이 늘었다. 하루 이틀 잠을 설친다고 큰 병이 나는 건 아니나, 당장 피로와 두통을 느끼고 판단력 등 인지능력이 떨어지기 쉽다. 또 매번 밤잠을 설치면 매사에 의욕이 없고, 면역기능이 떨어져 병에 걸릴 확률도 높다. 당뇨나 심혈관질환, 뇌졸중 발생 위험이 폭발적으로 증가하게 된다. '짐이 보약'이라는 얘기를 허투루 들을 수 없는 이유다. 행복하고 개운한 굿~잠, 방법이 없을까.

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