Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Novel Function of Lycopene in Vascular Endothelial Cell

Lycopene의 새로운 혈관내피세포 생리활성

  • Cho, Jin-Gu (Department of Molecular Biology & Insitute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook University) ;
  • Kim, Sung-Hyen (Department of Molecular Biology & Insitute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook University) ;
  • Seo, Jeong-Hwa (Department of Molecular Biology & Insitute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook University) ;
  • Ahn, Sun-Young (Department of Molecular Biology & Insitute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook University) ;
  • Jeong, Eun-Sil (Department of Molecular Biology & Insitute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook University) ;
  • Park, Heon-Yong (Department of Molecular Biology & Insitute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook University)
  • 조진구 (단국대학교 분자생물학과, BK21 RNA 전문인력양성팀, 나노센서바이오텍연구소) ;
  • 김성현 (단국대학교 분자생물학과, BK21 RNA 전문인력양성팀, 나노센서바이오텍연구소) ;
  • 서정화 (단국대학교 분자생물학과, BK21 RNA 전문인력양성팀, 나노센서바이오텍연구소) ;
  • 안선영 (단국대학교 분자생물학과, BK21 RNA 전문인력양성팀, 나노센서바이오텍연구소) ;
  • 정은실 (단국대학교 분자생물학과, BK21 RNA 전문인력양성팀, 나노센서바이오텍연구소) ;
  • 박헌용 (단국대학교 분자생물학과, BK21 RNA 전문인력양성팀, 나노센서바이오텍연구소)
  • Received : 2010.04.12
  • Accepted : 2010.04.29
  • Published : 2010.07.30
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Abstract

Little is known about the cardiovascular effects of Lycopene, an anti-cancer and anti-oxidative agent. In this study, we executed a series of experiments with vascular endothelial cells to disclose the cardiovascular functions of lycopene. From our in vitro experiments, lycopene was determined to act as a stimulant to induce endothelial cell proliferation and migration. In addition, lycopene was shown to inhibit lipopolysaccharide (LPS)-induced adhesion of THP-1 leukocytes to endothelial cells, as well as activating mitogen activated protein kinase (MAPK) family members, ERK, JNK and p38 MAPK. Both ERK and p38 MAPK were involved in lycopene-induced cell proliferation, while JNK was involved in lycopene-dependent cell migration. Taken together, lycopene activates MAPK family members which regulate cell proliferation and migration. Lycopene differentially blocks LPS-dependent adhesion for THP-1 to endothelial cells, indicating that lycopene is likely to regulate a variety of vascular functions.

항암 효과와 항산화 기능을 가지는 것으로 알려진 lycopene은 심혈관에서의 기능이 현재까지 잘 알려져 있지 않다. 본 연구에서는 lycopene의 심혈관 기능을 알기 위해 혈관내피세포를 이용해 다양한 세포실험을 수행하였다. 그 결과, lycopene은 내피세포의 성장 및 이동을 촉진하였으나 세포사멸에는 영향이 없었다. 또한, 백혈구의 혈관내피세포 부착을 억제하였고 내피세포 내 신호전달물질인 MAPK들의 활성을 촉발하였다. MAPK의 활성 억제제를 이용한 신호전달기전 연구실험 결과, ERK와 p38 MAPK의 활성은 세포성장에 관여하고, JNK의 활성은 세포이동에 관여함을 확인하였다. 종합하면, lycopene은 혈관내피세포의 신호전달 물질인 MAPK들를 통해 세포성장 및 이동을 촉진시키며, LPS에 의한 THP-1의 내피세포 부착을 억제 하는 등 혈관내피세포의 다양한 생리활성을 조절한다. Lycopene의 이러한 혈관내피세포 기능들은 lycopene이 혈관질환 치료제로 응용될 가능성이 있음을 의미한다.

Keywords

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