• Journal of the Korean Society of Radiology
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• v.13 no.5
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• pp.729-737
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• 2019

Fatty pancreas is an abnormal process of lipid deposition in cells, resulting in increased fat tissue and obesity. The result is a risk factor for cardiovascular and metabolic diseases. The aim of this study was to evaluate the usefulness of pancreatic fat as a predictor of cardiovascular disease and metabolic syndrome in pancreatic ultrasonography. In 407 patients who underwent a comprehensive screening at the W Health Care Center in Busan from September 2. 2018 to December 31, 2018, the degree of fat deposition in the pancreas was evaluated as the degree of mild, moderate. Data on non-obstructive atherosclerosis, BMI, hyperlipidemia, hypertension, and diabetes were collected to assess the association of pancreatic fat deposition with cardiovascular disease and metabolic syndrome. In addition, we tried to analyze the correlation between liver dysfunction and thyroid dysfunction as the degree of fat pancreas increased. We examined the relationship between six parameters including atherosclerosis, BMI, hyperlipidemia, hypertension, diabetes, liver dysfunction, and thyroid dysfunction among patients with fatty pancreas. We concluded that the carotid intima-media thickness of atherosclerosis, which is a risk factor of cardiovascular disease, is most closely related to fatty pancreas.

• Journal of Life Science
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• v.19 no.11
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• pp.1644-1650
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• 2009

The purpose of this study was to investigate the effects of 12-week walking exercise on body composition, physical fitness, cardiovascular function, blood lipids, GH, IGF-1and leptin in obese and normal middle school girls. Participants included 12 pairs of middle school girls who were matched for sex, age and stratified by BMI (Obese Group: BMI$\geq$25.0; Normal Group: BMI<23.0). The variables of all factors were measured in all the subjects before and after the 12-week walking exercise program. The test data were analyzed by paired t-test, and t-test using the SPSS 14.0 statistics package and the alpha level of p<0.05 was set for all tests of significance. Body composition showed a significant difference in both groups, but the variables of physical fitness, cardiovascular function, blood lipids, growth hormone, and leptin did not show a significant difference in the two groups. We conclude that regular and continuous walking exercise improved body composition, physical fitness, cardiovascular function, blood lipids, and insulin factors in both groups. Consequently, these findings suggest that walking exercise will be effective for preventing obesity and improving health-related factors in the middle school girls.

• Journal of Life Science
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• v.30 no.7
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• pp.651-659
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• 2020

Cardiovascular disease is one of the leading causes of death across the world, and gold-standard treatments such as percutaneous coronary intervention and artery bypass grafting have various limitations including myocardial damage and subsequent maladaptive cardiac remodeling. To overcome this, stem-cell therapies are emerging as a promising strategy for cardiovascular regeneration. Endothelial progenitor cells (EPCs) have high potential to proliferate and differentiate into endothelial cells for vascularization and tissue regeneration, and several clinical trials have explored EPC function in tissue repair in relation to clinical safety and improving cardiac function. Consequently, EPC has been suggested as a feasible stem-cell therapy. However, autologous EPC transplantation in cardiovascular disease patients is restricted by risk factors such as age, smoking status, and hypertension that lead to reduced bioactivity in the EPCs. New approaches for improving EPC function and stem-cell efficacy have therefore been suggested, including cell priming, organoid culture systems, and enhancing transplantation efficiency through 3D bioprinting methods. In this review, we provide a comprehensive understanding of EPC characteristics, therapeutic approaches, and the current state of clinical research into EPCs as stem-cell therapy for cardiovascular disease.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.4
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• pp.366-379
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• 2017

In this study, we performed a systematic review and meta-analysis to identify the effects of exercise on endothelial progenitor cells (EPCs) in patients with cardiovascular disease (CVD). We conducted database searches (Cochrane Library, PubMed, EMBASE, ScienceDirect, CINAHL, Scopus, KoreaMed, KISS, RISS, KMBASE) for the effect of exercise on cardiovascular disease, using heart disease, coronary artery disease, heart failure, cardiovascular disease, exercise, motor activity, rehabilitation, and endothelial progenitor cells as the keywords. Of the 539 studies identified, 9 met the inclusion and exclusion criteria. Comprehensive Meta-Analysis version 2.0 was used to analyze the effect size and the publication bias was checked with a funnel plot. Exercise was found to improve the VEGF (vascular endothelial growth factor), CD34+KDR+, and endothelial function, assessed via FMD (flow-mediated dilation), in the exercise vs. control groups, viz. 2.008 (95% CI 0.204-3.812), 1.399 (95% CI 0.310-2.489), and 1.881 (95% CI 0.848-2.914), respectively. Exercise improved the VEGF, number of EPCs, and endothelial function in the CVD patients. Considering the increasing prevalence and mortality rates for cardiovascular disease in Korea, the findings of this study that analyzed the effects of exercise on EPCs might provide guidelines for planning exercise interventions for patients with CVD.

• Journal of Life Science
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• v.22 no.4
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• pp.545-551
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• 2012

Pressurization walk training (PWT) with blood flow occlusion has been investigated with regard to muscle hypertrophy and physical fitness function in athletes and healthy people. However, the cardiorespiratory and cardiovascular responses of obese people to PWT are unknown. Thus, we investigated the effects of PWT on body composition (Weight, FM, LBM, %fat, BMI), cardiovascular responses (HR, SV, CO, TVC), and cardiorespiratory responses ($VO_2max$, VEmax, HRmax) in middle-aged obese women. They participated in walk training with (n=15) blood flow occlusion and cross-sectional areas of the quadriceps on both legs. Five sets of 3-min walking (5.5 km/h at 5% grade) and 1-min resting were performed twice a day, 5 days/week for 3 weeks. The results showed that the LBM was significantly increased, and decreased body weight of reducing FM, %bodyfat in PWT ($p$<0.05). For the cardiovascular response, SBP and TPR were significantly decreased ($p$<0.05), and CO increased ($p$<0.05). In addition, the $VO_2max$ and VEmax were improved through PWT. Therefore, this study suggests that the presence of obesity in middle-aged women may result in body composition, cardiorespiratory, and cardiovascular responses caused by PWT.

• The Monthly Diabetes
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• s.257
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• pp.32-33
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• 2011

건강한 치아는 오복(五福) 중의 하나로 여길 만큼 우리 몸에서 중요한 기능을 담당한다. 한 연구결과에 따르면 당뇨병환자가 치주질환이 있으면 헐당조절이 어려워질 뿐 아니라 뇌졸중, 심혈관질환 등 합병증이 조기에 발생할 수 있는 것으로 밝혀졌다. 당뇨병이 있으면 치주질환이 잘 생기는데 제대로 관리하지 않고 방치하면 전선질환까지 발생할 수 있는 것이다.

• Proceedings of KOSOMES biannual meeting
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• 2007.05a
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• pp.97-99
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• 2007

대기중 이산화탄소 농도상승을 억제하기 위하여 $CO_2$를 해양에 처리하는 방안이 제안되고 있으며 해양생태계 및 해양생물에 대한 생물학적 영향에 대한 검토가 신중하게 검토되어야 할 것으로 생각된다. 본 연구에서는 고농도의 이산화탄소 환경에서 천해어종인 방어 및 넙치의 심혈관계 반용을 비교 검토하였다. 5% $CO_2$ 환경에서 방어는 8시간 이내에, 넙치는 48 시간 이내에 100% 폐사하였으며, 넙치는 혈액 pH가 회복하였음에도 불구하고 폐사하는 경향이었다. 방어의 cardiac output (심박출량)은 stroke volume (박동량)의 변화에 의해서 영향을 받으며, 넙치는 heart rate (심박수)의 변화가 심박출량의 변화에 큰 영향을 끼치는 것으로 나타났다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2012.07a
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• pp.227-228
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• 2012

맥압증폭은 대동맥과 말초기관과의 혈압기능 평가 및 심혈관 질환을 예측하는 주요 매개변수로 나이와 관련이 높다. 그러나, 기존의 맥압증폭을 구하기 위해서는 관혈적인 방법으로 대동맥압을 측정하거나 혹은 전달함수와 같은 복잡한 대동맥압 추정 알고리즘을 구현하여 측정하여야 한다. 그러나, 유헬스를 활용한 스마트케어 환경에서 복잡한 알고리즘은 오히려, 계산량을 높이고, 시스템가격을 높일 수 있으므로, 최대한 단순화된 알고리즘이 필요하다. 본 논문에서는 맥압증폭을 주파수영역의 에너지 관점으로 맥압증폭을 접근하였고, 대동맥압 추정없이 추정할 수 있는 새로운 지수를 제안한다.

• Journal of the Korean Applied Science and Technology
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• v.40 no.4
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• pp.674-684
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• 2023

The purpose of this study was to investigate the effect of acute listening to music on the cardiovascular reactivity to sympathoexcitation. In this crossover design study, 15 healthy adults(23.1±1.94(yrs) were randomized to either (1)acute listen to the subject's preferred music for 30 minutes and (2)sat as a time control by an experiment coordinator. After completing each trial, the cold pressor test(CPT) was conducted. Heart rate(HR) and blood pressure(BP) were measured for 4 times at baseline, during and after the CPT. Heart rate variability(HRV) were measured for 3 times at baseline, prior and after the CPT. HR and BP increased during the CPT in both trial and returned to baseline after CPT(time effect, p < .001). After CPT, brachial systolic BP reactivity to the CPT was attenuated in listening to music trial compared to control trial(p = . 008). As a result of heart rate variability(HRV), the difference values between the baseline and prior to the CPT showed a significant increase in standard deviation of the NN intervals(SDNN), total power(TP) and high frequency(HF) only in the music trial (p = .001, p = .002, p = .011). The difference value between prior to and after the CPT did not show significance. But compared with the control trial, the music trial was confirmed that SDNN, TP and HF were more activated. Therefore, listening to music alleviated anxiety and tension before the CPT, and it is estimated that it had a favorable effect on stability after the CPT. This findings showed that listening to music may have a positive effect on brachial systolic BP and HRV to sympathoexcitation.

• 한국체육학회지인문사회과학편
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• v.51 no.4
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• pp.407-417
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• 2012

The purpose of the study was to determine the effects of pilates mat exercise on cardiovascular disease risk factors and inflammation markers in sarcopenic obesity elderly. All subjects were sarcopenic obesity(height for each of the arms, legs, appendicular muscle mass ratio of 1.16kg/m², 4.31kg/m², 5.21kg/m² under and % body fat is more than 30%) elderly performed the pilates mat exercise during 12-week for 60 minutes 3 times a weeks. All subjects of this study were examined the changes in cardiovascular disease risk factors(TC, TG, HDL-C, LDL-C, Glucose, Insulin) and inflammation markers(fibrinogen, adiponectin, leptin, CRP). The results of the study in the exercise group were as follows; The weight, % body fat, TC, TG, LDL-C, fibrinogen, CRP had significantly decreased and muscle mass, HDL-C, adiponectin had significantly increased. And also, pilates mat exercise can effective to improve sarcopenic obesity, and pilates mat exercises performed coy shrink obesity to cardiovascular disease and inflammatory response indicators of older women as old man's physical features of the deterioration of the prevention of obesity and muscle strength loss, causing the effective exercise method is meant to be.