• Journal of Biomedical Engineering Research
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• v.20 no.6
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• pp.561-571
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• 1999

심실세동은 환자의 생명을 위협하는 가장 치명적인 부정맥으로서, 심실세동의 발견즉시 특별한 조치를 취하지 못할 경우 환자는 급사한다. 심실세동을 정지시키는 유일한 방법은 전기적 제세동이며 이는 환자의 심장 부위에 전기적 에너지를 가해 정상 심장 리듬을 되찾도록 하는 방법이다. 심실세동의 발생은 예측할 수 없고, 이를 진단하기 위한 심전도 교육을 모든 의료인에게 할 수 없으므로 심전도를 자동 분석하여 심실세동을 조기에 검출하는 자동 분석장치의 개발은 심실세동에 의한 급사를 줄이는데 매우 중요하다. 본 연구에서는 교차간섭성분의 제거 능력이 뛰어나며 쉽게 구사할 수 있는 Choi-Williams distriguteion (CWD) 방법을 이용하여 급사를 초래할 수 있는 심실세동을 자동 검출하는 알고리즘을 개발하였다. 그리고 개발된 알고리즘의 성능을 검증하기 위하여 본 논문에서는 두 그룹의 심실세동 데이터를 사용하였다. 검출 알고리즘은 심실세동의 시간 및 주파수 특성을 일곱가지 조건들에 대한 만족 여부를 이용하여 심실세동을 판정하였고, 실험의 민감도와 선택도는 각각 92.1%, 97 .2% 이다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.20 no.4
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• pp.320-328
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• 1991

The present study was designed to evaluate the effects of dietary vitamin E and coenzyme $Q_{10}$ supplementation on adriamycin (ADR) -induced lipid petoxidation in rats. After feeding the experimental diets for e weeks. Ann treatment significantly decreased growth performance of rats. But this decrement was not modified by supplementation of vitamin E or coenzyme $Q_{10}$ . Lipid peroxide values of plasma and heart mitochondria were elevated by Ann treatment. But these values were significantly decreased according to vitamin E or coenzyme $Q_{10}$ supplementation. Adriamycin treatment elevated glutathione peroxidase (GSH-Px) activity of rats, but this increment was modified by vitamin E supplementation. There was a tendency of higher superoxide dismutase (SOD) activity in ADR-treated rats. However, vitamin E or coenzyme $Q_{10}$ administration reduced this enzyme activity. With ADR treatment, arachidonic acid (20 : 4) was greatly increased, but docosahexaenoic acid (22 : 6) was not detected. Arachidonic acid was decreased and docosahexaenoic acid increased by supplementation of higher level of vitamin E or coenzyme $Q_{10}$ . Present data showed that dietary vitamin E and coenzyme $Q_{10}$ influenced on ADR-induced lipid peroxidation in rats, and also the degree of antioxidative effect was greater in vitamin E-supplemented rats.

• Proceedings of the KSCN Conference
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• 2003.05a
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• pp.138-138
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• 2003

흡연은 각종 암의 발병율을 높이고 동맥경화증, 혈전증과 같은 관상심장질환의 주요 발병요인이 되는 것으로 알려져 있다. 흡연자에게 보여지는 지질과산화작용에 의한 LDL의 산화는 구리나 철과 같은 항산과 관련 무기질에 의해 촉진되며, 특히 구리는 매우 연관성이 높은 물질로 보고되었다. 따라서 흡연자의 혈중 무기질 함량의 측정은 항산화 능력과 심혈관계 질병의 진단 및 예후 판정에 민감한 지표로 사용할 수 있을 것으로 사료된다. (중략)

• The Monthly Diabetes
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• s.210
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• pp.32-33
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• 2007

사단법인 한국당뇨협회 산하 <한마음 산악회>에서는 걷기로 4월 산행을 대신했다. '걷기'는 대표적인 유산소운동으로 등산과 더불어 당뇨인에게 권장되는 운동 중의 하나. 유산소운동은 근육에 산소를 전달해 주어 심장, 혈관, 혈액 등의 순환기능과 폐, 기관지 등의 호흡기능을 향상시켜 산소 섭취 능력을 높여 줄 뿐만 아니라 당뇨인들에게는 인슐린의 작용을 높여 혈당 관리에 도움이 된다. <한마음 산악회> 회원들은 지난 4월 11일(수) 독립역에서 모여 독립문-안산-무악재에 이르는 7km를 3시간에 걸쳐 함께 걸었다.

• The Zoological Society Korea : Newsletter
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• v.18 no.1
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• pp.49-54
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• 2001

재생에 관한 연구는 정상적인 발생 및 분화의 기작을 이해하는데 있어서 유용한 연구모델이며 재생의 기작을 규명함으로써 재생의 능력이 없는 동물에 이를 적용하고 응용할 수 있을 것으로 생각된다. 지렁이는 재생연구의 대상동물로 여러 가지 장점을 갖고 있는데 특히 뇌, 심장 등과 같은 중추기관의 재생을 연구할 수 있는 유일한 동물이라고 사료된다. 현재 지렁이에 관한 연구는 여러 방향으로 진행되고 있는데 재생아세포의 기원, 재생시 발현이 촉진되는 단백질분해효소의 특성, Hox 유전자의 발현양상 등에 관한 연구가 진행되고 있다.

• Journal of Chest Surgery
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• v.37 no.12
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• pp.1022-1024
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• 2004

Pulmonary aspergillosis is the most common disease of fungal infection and has lower infectivity. Pulmonary asergillosis is classified by aspergilloma, bronchopulmonary aspergillosis, necrotic and invasive aspergillosis. Invasive aspergillosis is found in immune compromised host, immunosuppressive treatment after organ transplantation, anticancerous chemotherapy, blood abnormality, AIDS patients etc. We reported a case of invasive aspergillosis in an immunocompetent host, with review of literatures.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.119-119
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• 1993

안트라싸이클린계 항암항생제의 부작용 발생기전으로는 C-고리의 퀴논 부위에 전자가 전달되어 퀴논 고리가 환원되는 과정이 제시되고 있으며 그 중 하나의 전자가 전달되어 생성되는 활성산소(activated oxygen)가 심장독성과 관련이 있는 것으로 알려져 있다. 이 때 퀴논 고리의 환원력(전자흡수능력)이 C-고리자체의 변환, 또는 인접 B-고리에 도입된 치환체의 영향으로 억제될 수 있다는 보고를 이론적 근거로 하여 안트라싸이클리논 골격을 전자흡수 능력을 가진 acridone 골격으로 치환한 화합물(1)과 안트라싸이클리논 골격을 유지하면서 aminosugar 부위를 pentopyranose계열을 도입 한 2 합성하였다. 화합물 1은 1,3-butadiene 과 1,4-benzoquinone 의 Diels-Alder adduct 3을 출발물질로 하여 7 단계의 반응과정으로 합성하였다.

• Journal of the korean academy of Pediatric Dentistry
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• v.42 no.1
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• pp.80-86
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• 2015

Dentists who want to perform sedation must have abilities to control any emergent situation that may occur during treatment procedures. In the 2010 guideline for the use of sedation by dentists, he/she must has valid certifications for basic life support (BLS) and for advanced cardiovascular life support (ACLS). The Korean Association of Cardiopulmonary Resuscitation (KACPR) has made a contract with the American Heart Association for education and certification. From 2004, they have held many courses for BLS and ACLS providers and instructors. The author of this research participated in the above mentioned courses and qualified as a BLS provider, BLS instructor and ACLS provider. The present paper was intended as an introduction to and arrangement of BLS and ACLS courses for health care providers through a year of experience. However, the previous course of the ACLS provider was focused more toward medical doctors. It is necessary to develop a new advanced course for dentists who employ sedation in their medical practices.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.2
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• pp.267-274
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• 2019

To investigate the effect of high-intensity interval training (HIIT) on the outcomes of cardiac rehabilitation(CR) in elderly and younger patients with myocardial infarction(MI). Of the MI patients who received hospital-based CR from 2015 to 2017, we retrospectively reviewed the medical records of the patients who continued follow-up through the outpatient clinic. A total of 39 patients (20 elderly patients (${\geq}60year$($64.1{\pm}3.6$)) and 19 younger patients (< 60 year($55.6{\pm}2.3$)) was included in this study. The HIIT program was composed of 10 minutes of warm-up, 30 minutes of interval aerobic exercise, and 10 minutes of cool down. The aerobic exercise based on their initial exercise tolerance test outcome consisted of 3-minute usual intensity phase (60-70% of heart rate/VO2 reserve) and 4-minute of high-intensity phase (70-90% of heart rate/VO2 reserve). Exercise capacity was measured by exercise tests before and after hospital- based CR. Before CR, elderly group had a significantly lower exercise capacity in Exercise time, peak VO2, METs, Anaerobic threshold, VEmax, 02pulse than younger group. Both group showed similar improvement of cardiopulmonary exercise capacity after CR. And HIIT is safe and effective in elderly patients. It is considered necessary to further expansion for the participation of high intensity interval training in elderly patients.

• Journal of the Korean Society of Radiology
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• v.84 no.6
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• pp.1324-1336
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• 2023

Purpose This study aimed to compare the diagnostic performance of cardiac CT and transthoracic echocardiogram (TTE) depending on the degree of valvular calcification and bicuspid aortic valve (BAV) subtype. Materials and Methods This retrospective study included 266 consecutive patients (106 with BAV and 160 with tricuspid aortic valve) who underwent cardiac CT and TTE before aortic valve replacement. Cardiac CT was used to evaluate the morphology of the aortic valve, and a calcium scoring scan was used to quantify valve calcium. The aortic valves were classified into fused and two-sinus types. The diagnostic accuracy of cardiac CT and TTE was calculated using a reference standard for intraoperative inspection. Results CT demonstrated significantly higher sensitivity, negative predictive value, and accuracy than TTE in detecting BAV (p < 0.001, p < 0.001, and p = 0.003, respectively). The TTE sensitivity tended to decrease as valvular calcification increased. The error rate of TTE for CT was 10.9% for the twosinus type of BAV and 28.3% for the fused type (p = 0.044). Conclusion Cardiac CT had a higher diagnostic performance in detecting BAV than TTE and may help diagnose BAV, particularly in patients with severe valvular calcification.