• Journal of Yeungnam Medical Science
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• v.6 no.2
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• pp.241-245
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• 1989

Induction of A-V block by tachycardia is a well-known phenomenon. But there are few case reports of bradycardia-dependent A-V block. We report a case of bradycardia-dependent A-V block with review of literatures. This patient was a 52-year-old fe male who complained of dizziness and anterior chest discomfort. Electrocardiographic recording demonstrated complete A-V block. Monitor electrocardiographic recordings during sitting position and after atropine administration demonstrated decrease of degree of block from complete A-V block to first degree A-V block. The occurrence of complete A-V block for bradycardia during supine position suggests a phase 4-dependent block. After a permanent ventricular pacemaker was implanted, the patient recovered and was with out symptoms during 12 months follow up.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2009.05a
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• pp.173-176
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• 2009

심박동 변동에 반영되는 자율신경계 활동으로부터 정신적 부하 즉 스트레스 상태를 평가할 수 있다. 또한 일상생활 중에서 지속적인 심전도 모니터링인 가능하다면 심장에 부하를 줄 수 있는 운동 중에도 사전에 급작스러운 심장 이상 증세를 예상할 수 있다. 본 연구에서는 일상생활 속에서도 생체신호 측정이 가능한 무구속, 무자각, 무침습적인 심전도 측정 시스템을 개발하였다. 무선 통신을 사용하여 실시간으로 심장 활동 상태를 모니터링 할 수 있으며, 가슴에 부착이 가능한 패치 타입의 소형 전극 형태이다. 신뢰도 평가를 위하여 임상 심전도 신호와 본 전극으로 측정한 심전도 신호의 유사도를 평가하였으며 동잡음의 영향을 평가한 결과 $0{\sim}6m/h$로 걷는 경우, 심전도 파형이 안정적으로 나타나 일상생환에서의 활용가능성을 보여주었다. 동일한 피험자를 대상으로 HRV에 반영되는 스트레스의 영향을 평가하기 위하여 패치형 전극으로 심전도를 측정하여 불안, 스트레스 항목에 대한 설문지 평가, 스트레스 호르몬양을 측정하였다. 일상 상태와 스트레스 상태를 비교한 결과, 많은 파라미터에서 유의한 차이가 나타났다. 이러한 결과로부터 패치형 전극은 일상생활에서 건강 모니터링 시스템으로 활용도가 높을 것으로 기대된다.

• The Korean Journal of Nuclear Medicine Technology
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• v.16 no.1
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• pp.91-95
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• 2012

Purpose: In this study, we evaluated the ejection fraction (EF) according to the difference of patient position in Gated Blood Pool (GBP) scan. Material and Methods: The analysis was performed to 80 patients ($51.2{\pm}17.4$ years old) who examined GBP scan in Department of nuclear medicine, National Cancer Center from March 2011 to August 2011. We divided the patients into two groups; one group received conventional position (raise left arm up supine) and supine position (group 1) and the other group received conventional position and left arm back down supine position (group 2). To observe the change EF according to patient position difference, the image was reconstructed and analyzed by Xeleris (GE, USA). We measured body mass index (BMI) of patients. Result: In group 1, EF error less than 3% occurred at a rate of 72.5% (29 of the 40 patients). In group 2, EF error less than 3% occurred at a rate of 79% (32 of the 40 patients). The patient's BMI did not affect ejection fraction. Conclusion: The EF error of left arm back down supine position closer to conventional position than in supine position shows the results.

• The Korean Journal of Pharmacology
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• v.23 no.2
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• pp.123-131
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• 1987

The possible inolvement of central opiate system in the control of cardiovascular function and in the antihypertensive action of clonidine has been examined in unanesthetized rats with shamoperated or 2-kidney, 1-clip (2K1C) renal hypertension. In both groups of rats, intraventricular clonidine $(3-30\;{\mu}g/kg)$ produced hypotension and bradycardia. Hypotensive action of clonidine was more potent in the hypertensive rats than in the normotensive sham-operated rats. Yohimbine $(30\;{\mu}g/kg,\;i.v.t.)$ inhibited the hypotension and bradycardia produced by clonidine. Naloxone ($50\;{\mu}g/kg$, i.v.t.) inhibited the action of clonidine in 2K1C hypertensive rats but not influenced in the sham-operated rats. Intraventricular morphine $(10-100\;{\mu}g/kg)$ also reduced rats. Intraventricular morphine $(10-100\;{\mu}g/kg)$ also reduced blood pressure and heart rate in both groups of rats. But these effects were not affected by yohimbine, but antagonized by naloxone ($50\;{\mu}g/kg$, i.v.t.). Chronic treatment of 2K1C rats with clonidine ($3{\times}20\;{\mu}g/kg$, p.o.,) for 14 days from 1 day after 2K1C operation) suppressed the development of hypertension and maintained the blood pressure in normal level and this errect of clonidine was abolished by naloxone (2 mg/kg, i. p.). In the 2K1C hypertensive rats, immunoreactive ${\beta}-endorphin$ content was significantly decreased, but maximum binding (Bmax) of $(^3H)-naloxone$ was significantly increased in brain of 2K1C hypertensive rats. However, Kd value was not changed. These results suggest that the opioidergic component might be involved in the antihypertensive action of clonidine only in hypertensive and that central opiate system might play important roles in pathophysiology of development and maintenance of hypertension.

• Exercise Science
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• v.21 no.2
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• pp.231-242
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• 2012

The purpose of this study was to develop the prediction model of VO₂max using submaximal metabolic responses from the Bruce protocol, HR responses at several stages and 1,200 m running record, and to compare and analyse the validity of these prediction models. The subjects were consisted of 255 male(133 male for 1,200 m running). They were participated maximal exercise testing with Bruce protocol, and the metabolic responses were measured in the end of the first(3 minute), second stage(6 minute), and 1,200 m running record. Measurement items were VO₂(㎖/kg/min), VCO₂(㎖/kg/min), VE(L/min), HR(bpm) of 3 and 6 minute, time to HR 150 bpm and 170 bpm, HR difference between Bruce protocol 6 and 3 minute, 1,200 m running record. Analyzing with all variables using enter method, the multiple R of total variable model was 0.642(p<.01), SEE was 4.38 ㎖/kg/min, CV was 10.8 %, but multicolinearity was appeared. The multiple R of 3 minutes model 1 and model 2 were 0.341 and 0.461, SEE was 6.05 and 5.72 ㎖/kg/min, CV was 14.9 and 14.1%, and multicolinearity did not appeared. The multiple R of 6 minutes model 1 and model 2 were 0.350 and 0.456, SEE was 6.03 and 5.74 ㎖/kg/min, CV was 14.9 and 14.2%, and multicolinearity did not appeared. The R of HR 170 and HR 170 model were 0.151 and 0.154, SEE were 6.36~6.37 ㎖/kg/min, CV were 15.7%. The R of 1,200 m running model was 0.444, SEE was 4.82 ㎖/kg/min, CV were 11.9%. In conclusion, with considering usefulness and convenience through the validity of these prediction models, the prediction model of VO₂max recommended 6 and 3 minute model, and the validity of HR model and 1,200 m running model were moderately low.

• The Korean Journal of Pharmacology
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• v.23 no.1
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• pp.15-23
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• 1987

To elucidate the mechanism of splanchnic hyperemia associated with chronic portal hypertension, we have investigated the alteration in visceral reflexes in conjuction with circulatory hemodynamics in portal ligated portal hypertension in cats. When capsaicin, bradykinin and vasopressin were injected via splenic artery of sham cat, respectively, they caused not only reflex excitation of systemic arterial pressure, but also elevation of splenic venous pressure with unchanged heart rates. Simultaneously, they evoked the sympathetic efferent excitation of liver (spleno-hepatic reflex) as well as of spleen (spleno-splenic reflex). Similarly, capsaicin upon pledging on the liver surface evoked a significant increase in the pressor reflex with hepatic nerve excitation (hepato-hepatic reflex). After portal ligation, the splenic venous pressure was gradually elevated in association with decrease in systemic arterial pressure. However, the excitation of pressor reflex was enhanced on the and day, thereafter, being returned to the control, and the reflexly induced spleno-splenic, spleno-hepatic and hepato-hepatic sympathetic excitations were significantly diminished on the 8th day following portal vein ligation. In conclusion, it is suggested that sympathetic reflexes to spleen and liver are specifically intervened by the same central pathways and furthermore, the diminution of these viscero-visceral reflex excitations after portal ligation may be related to the intestinal hyperemia.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.1
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• pp.547-554
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• 2014

In this study, have researched 'a' index from three sound sources, effects on subject and finding optimal 'a' index, which can improve subject's stability, concentration and productivity. Check the health status of subjects who were selected 5 male and 5 female university students, and the period of this experiment was about two months. It were measured each subject's EEG, HRV and vibra image to analyze transition of stability, concentration, stress and heart beat. The results was measured in an environmental test room of temperature $25[^{\circ}C]$, the relative humidity 50 [%], illuminance 1,000 [lux] and air current speed 0.02[m/sec] with 'a' index of three sound sources which are a=1.106, a=1.749 and a=2.227. Results in a=1.106 compared to before exposure, relative $S{\alpha}$ wave, relative $L{\beta}$ wave and relative $M{\beta}$ wave have been revitalized, asymmetry index, stress and HRV have been decreased. Thus, to increase stability, concentration and productivity, also to decrease stress, changes in sound source of a=1.106 was found to be the most effective.

• Journal of Chest Surgery
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• v.29 no.7
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• pp.723-727
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• 1996

An adequate exposure is important in thoracoscopic procedures. The insufflation of $CO_2$has been demonstrated to aid in compressing lung parenchyma, and act as a retractor when combined with changes in patient's position. However, a recent study demonstrated that $CO_2$insufflation during thoracoscopy in the pig has adverse hemodynamic consequences. We prospectively studied 12 patients undergoing thoracoscopy to evaluate the effect of $CO_2$insufflation in the clinical setting. The mean arterial pressure, heart rate, central venous pressure, arterial oxygen saturation, and end-tidal $CO_2$pressure were monitored. Measurements were determined at baseline, at the initiation of one-lung ventilation, and at intrapleural pressure of 5, 10, 15 mmHg and following results were obtained. 1) The insufflation of 5 to 15 mmHg of $CO_2$had no significant effect on the mean arterial pressure, heart rate, arterial oxygen saturation. 2) The end-tidal $CO_2$pressure rose from 31.00$\pm$1.67 mmHg to 38.49$\pm$1.82 mmHg at an intrapleural pressure of 15 mmHg(p<0.05). 3) The central venous pressure rose from 7.75$\pm$0.76 mmHg to 12.83$\pm$1.64 mmHg and 16.16$\pm$l.97mmHg at an intrapleural pressure of 10 and 15 mmHg(p<0.05). 4) The low pressure (<10 mmHg) insufflation is a safe adjunct to the conduct of thoracoscopic surgical procedures.

• Journal of Acupuncture Research
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• v.20 no.4
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• pp.157-169
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• 2003

Objective : The effects of electroacupuncture(EA) stimulation on heart rate variability(HRV) for healthy adults are investigated with power spectrum analysis(PSA) of HRV. Methods : The HRVs of every 10 minute for 22 healthy volunteers(13 men and 9 women) were measured for an hour with SA-3000P(Medicore Co., Ltd., Korea). The median age with arithmetic range of 13 men and 9 women was 26.00 years with 22.75~27.00 years. The initial 20 minutes were defined as baseline period(pre-EA period), the following 20 minutes as the EA period and the last 20 minutes as the post-EA period. In each EA periods, volunteers received EA(2Hz, 0.6~0.8ms duration, maximal tolerated stimulation without discomfort) on the right Zusanli(ST36), Shangjuxu(ST37) acupoints while supine, resting. Results : Heart rate of volunteers at post-EA period was significantly decreased compare to that of pre-EA period, while SDNN at post-EA period was significantly increased. Heart rate at EA period was significantly decreased compare to that of pre-EA period, but Ln(LF) and LF/HF at EA period were significantly increased. Ln(HF) at post-EA period was significantly decreased compare to that of EA period, while the other variables were not significantly changed. Conclusions : The results suggest that EA in healthy adults is associated with changed activity in the sympathetic and parasympathetic nervous system. Further study is needed for investigating the effects of EA on HRV and autonomic nervous system.

• Science of Emotion and Sensibility
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• v.12 no.2
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• pp.161-168
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• 2009

In this study, we have developed the patch type HAMS (Heart Activity Monitoring System) which is non-restricted, non-awarable and non-invasive. The module using wireless telecommunication to receive the ECG (electrocardiogram) signal at the computer has mobility which it easily monitors the heart activity of subjects in no time for long term at any time and places. We developed the small patch type electrode which can be attached on the chest. Also the reliability and moving artifact of ECG signal measured by this electrode have been verified. Using HAMS, we measured the HRV (Heart Rate Variability) parameters, the questionnaire evaluation for anxiety and stress and the amount of stress hormone (cotisol) to evaluate the stress effect in HRV on the same subject. As a result of comparing the values under non stressed and stressed condition, there was significant difference on many parameters. And the parameter highly related with stress on Pearson's Correlation Coefficient has been examined. These show that using HAMS is able to evaluate the function of autonomic nervous system. Therefore, we can predict heart problem in daily life by using HAMS. Also we expect that this module can be applied for more application as health monitoring system.