• Journal of the Korean Society of Radiology
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• v.84 no.2
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• pp.427-440
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• 2023

Purpose This study aimed to investigate the correlation between the fat signal fraction (FF) of the fat-dominant bone tissue of the knee joint, measured using the MRI Dixon method (DIXON) technique, and bone mineral density (BMD). Materials and Methods Among the patients who underwent knee DIXON imaging at our institute, we retrospectively analyzed 93 patients who also underwent dual energy X-ray absorptiometry within 1 year. The FFs of the distal femur metaphyseal (Fm) and proximal tibia metaphyseal (Tm) were calculated from the DIXON images, and the correlation between FF and BMD was analyzed. Patients were grouped based on BMD of lumbar spine (L), femoral neck (FN), and common femur (FT) respectively, and the Kruskal-Wallis H test was performed for FF. Results We identified a significant negative correlation between TmFF and FN-BMD in the entire patient group (r = -0.26, p < 0.05). In female patients, TmFF showed a negative correlation with FN-BMD, FT-BMD, and L-BMD (r = -0.38, 0.28 and -0.27, p < 0.05). In male patients, FmFF was negatively correlated with only FN-BMD and FT-BMD (r = -0.58 and -0.42, p < 0.05). There was a significant difference in the TmFF between female patients grouped by BMD (p < 0.05). In male patients, there was a significant difference in FmFF (p < 0.05). Conclusion Overall, we found that FF and BMD around the knee joints showed a negative correlation. This suggests the potential of FF measurement using DIXON for BMD screening.

• Journal of the Korean Society of Radiology
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• v.7 no.1
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• pp.81-84
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• 2013

The use of the dosimetry have been increasingly recognized as high radiation energy and radiation treatment planning(RTP) have rapidly developed in radiotherapy. There are many types of detectors for the dosimetry such as ionization chamber, film, TLD, diode, and etc. Among such detectors, the diode detector uses a photoconductor materials that generate electrical signals by the incident radiation energy. Though many research groups are recently interested in such materials, there is few experimental results except for silicon in the radiation therapy field. In this study, the feasibility of photoconductor materials was verified as a dosimeter through the evaluation of response properties at a high radiation energy. For the fabricated detectors based on $HgI_2$ and $PbI_2$, reproducibility, linearity, and pulse-rate response were analyzed. Such evaluations are essential factors for the use of dosimeter. From results, linearity and reproducibility of the fabricated $HgI_2$ detector indicated about 7% error. The fabricated $PbI_2$ detector showed 1.7% error in linearity, and 12.2% error in reproducibility.

• The Journal of the Acoustical Society of Korea
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• v.35 no.3
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• pp.202-207
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• 2016

Most of noises from cars or home appliances accompany successive impulsive noise due to repeated operation. A human auditory system is able to perceive the successive impulsive noise as either a set of independent noise or amplitude modulated noise according to its occurrence period. This study is to identify main influence factors on understanding of impulsive characteristics and find most appropriate sound quality metrics to express the successive impulsive noise. To do this, the successive impulsive noises were designed and utilized to perform a listening test for identifying conditions where successive impulsive noise can be recognized to have impulsive characteristics. These results were analyzed with sound quality metrics such as loudness, fluctuation strength, and roughness in order to compare the subjective results with the objective results. Consequently, the results revealed that the successive impulsive noise exhibits impulsive characteristics when its occurrence frequency is less than 50 Hz. It was also observed that roughness and fluctuation strength results are not applicable to express the successive impulsive noise because they heavily depend on the amplitude modulation characteristics. On the other hand, loudness results are considered to be useful as an evaluation factor of the successive impulsive noise through the use of loudness limen because it does not depend on the amplitude modulation characteristics.

• Korean Journal of Optics and Photonics
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• v.26 no.3
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• pp.155-161
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• 2015

We report the design and performance analysis of an off-axis three-mirror telescope as the fore optics for a new hyperspectral sensor aboard a small unmanned aerial vehicle (UAV), for low-altitude coastal remote sensing. The sensor needs to have at least 4 cm of spatial resolution at an operating altitude of 500 m, $4^{\circ}$ field of view (FOV), and a signal to noise ratio (SNR) of 100 at 660 nm. For these performance requirements, the sensor's optical design has an entrance pupil diameter of 70 mm and an F-ratio of 5.0. The fore optics is a three-mirror system, including aspheric primary and secondary mirrors. The optical performance is expected to reach $1/15{\lambda}$ in RMS wavefront error and 0.75 in MTF value at 660 nm. Considering the manufacturing and assembling phase, we determined the alignment compensation due to the tertiary mirror from the sensitivity, and derived the tilt-tolerance range to be 0.17 mrad. The off-axis three-mirror telescope, which has better performance than the fore optics of other hyperspectral sensors and is fitted for a small UAV, will contribute to ocean remote-sensing research.

• Korean Journal of Microbiology
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• v.49 no.4
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• pp.301-308
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• 2013

Programmed Death-1 (PD-1) is one of the important immune-inhibitory molecules which was expressed in T cells, B cells, NKT cells, and macrophages activated by various immune activating factors. Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is one of the crucial immunogens for PD-1 expression. However, there are only a few reports on the expression mechanisms of PD-1 in innate immune cells. In this study, we investigate the expression mechanisms of PD-1 in LPS-stimulated Raw264.7 cell lines by RT-PCR, Western Blot, flow cytometry as well as ChIP assay and co-immunoprecipitation. When Raw264.7 cells were stimulated with LPS, PD-1 expression was greatly up-regulated via PI3K and p38 signaling. Primary macrophages isolated from LPS-injected mice were also shown the increased expression of PD-1. In promoter assay, NF-${\kappa}B$ and IRF-1 binding regions in mouse PD-1 promoter are important for PD-1 expression. We also found that the co-activation of NF-${\kappa}B$ and IRF-1 is indispensable for the maximum PD-1 expression. These results indicate that the modulation of PD-1 expressed in innate immune cells could be a crucial for the disease therapy such as LPS-induced mouse sepsis model.

• Journal of the Institute of Electronics and Information Engineers
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• v.49 no.9
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• pp.251-258
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• 2012

Recently, NAND Flash memory structure is evolving from SDR (Single Data Rate) to high speed DDR(Double Data Rate) to fulfill the high performance requirement of SSD and SSS. Accordingly, the proper ways of transferring data that latches valid data stably and minimizing data skew between pins by using PHY(Physical layer) circuit techniques have became new issues. Also, rapid growth of speed in NAND flash increases the operating frequency and power consumption of NAND flash controller. Internal voltage variation margin of NAND flash controller will be narrowed through the smaller geometry and lower internal operating voltage below 1.5V. Therefore, the increase of power budge deviation limits the normal operation range of internal circuit. Affection of OCV(On Chip Variation) deteriorates the voltage variation problem and thus causes internal logic errors. In this case, it is too hard to debug, because it is not functional faults. In this paper, we propose new architecture that maintains the valid timing window in cost effective way under sudden power fluctuation cases. Simulation results show that the proposed technique minimizes the data skew by 379% with reduced area by 20% compared to using PHY circuits.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.11
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• pp.89-94
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• 2008

In this paper, a cascade of a wideband amplifier and a high-Q bandpass filter (BPF) has been realized in a 0.18mm CMOS technology for the applications of subsampling direct-conversion receivers. The wideband amplifier is designed to obtain the -3dB bandwidth of 5.4GHz, and the high-Q BPF is designed to select a 2.4GHz RF signal for the Bluetooth specifications. The measured results demonstrate 18.8dB power gain at 2.34GHz with 31MHz bandwidth, corresponding to the quality factor of 75. Also, it shows the noise figure (NF) of 8.6dB, and the broadband input matching (S11) of less than -12dB within the bandwidth. The whole chip dissipates 64.8mW from a single 1.8V supply and occupies the area of $1.0{\times}1.0mm2$.

• Journal of the Microelectronics and Packaging Society
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• v.22 no.3
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• pp.31-38
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• 2015

In order to achieve a high speed and high quality silicon wafer bonding, the room-temperature direct bonding using atmospheric pressure plasma and sprayed water vapor was developed. Effects of different plasma fabrication parameters, such as flow rate of $N_2$ gas, flow rate of CDA (clear dry air), gap between the plasma head and wafer surface, and plasma applied voltage, on plasma activation were investigated using the measurements of the contact angle. Influences of the annealing temperature and the annealing time on bonding strength were also investigated. The bonding strength of the bonded wafers was measured using a crack opening method. The optimized condition for the highest bonding strength was an annealing temperature of $400^{\circ}C$ and an annealing time of 2 hours. For the plasma activation conditions, the highest bonding strength was achieved at the plasma scan speed of 30 mm/sec and the number of plasma treatment of 4 times. After optimization of the plasma activation conditions and annealing conditions, the direct bonding of the silicon wafers was performed. The infrared transmission image and the cross sectional image of bonded interface indicated that there is no void and defects on the bonded wafers. The bonded wafer exhibited a bonding strength of average $2.3J/m^2$.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.11 no.5
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• pp.15-26
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• 2012

Government agencies including the national police agency have executed diverse efforts including continuous improvements of traffic facilities and operation methods, education, enforcements in order to improve traffic operation systems; nevertheless there have been continuous criticisms on irrationality in traffic signal and road facility operation. One of the reasons may be the lack of systematic preliminary evaluations on various alternatives. However, there was no appropriate tool to evaluate the mobility and safety of thus alternatives in a systematic way. Therefore, this study proposes the systematic use of microscopic traffic simulation models as a comprehensive evaluation tool. In addition, this study verified the potential of using a microscopic traffic simulation model using the case of operating an overlap phase on a shared-left-turn lane through a systematic way where the evaluation was conducted through data collection, building networks, calibrating microscopic simulation models, producing performance measures, evaluating mobility and safety, and so on. As a result, the operation of overlap phase on a shared-left-turn lane showed no big difference from other operation scenarios such as leading left-turn on exclusive left turn lane in terms of mobility. However the operation of overlap phase on a shared-left-turn lane decreased safety by increasing potential conflicts.

• Journal of the Korean Society of Food Science and Nutrition
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• v.46 no.3
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• pp.289-297
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• 2017

The objective of this study was to identify and compare the anti-diabetic effects of mulberry leave (ML), silkworm (SK), mulberry fruit (MF), and Cudrania tricuspidata BUREAU (CT) extracts in high fat diet (HFD)-induced obese and diabetic mice. C57BL/6N mice were assigned to six groups: normal diet (ND, n=7), HFD (n=10), HFD with 5% ML powder (ML, n=10), HFD with 2% SK powder (SK, n=10), HFD with 5% MF powder (MF, n=10), and HFD with 5% CT powder (CT, n=10). Mice were fed their assigned diet for 14 weeks. ML group showed significant reduction in levels of plasma glucose and insulin compared with the HFD group. Plasma total cholesterol (T-C) was significantly reduced by ML and SK compared with the HFD group. Plasma high-density lipoprotein cholesterol (HDL-C) and HTR (HDL-C to T-C ratio) levels of the ML, SK, MF, and CT groups were significantly elevated compared to the HFD group. Moreover, concentrations of hepatic T-C and triglycerides in the ML, SK, MF, and CT groups were significantly reduced in comparison to the HFD group. Levels of pAKT, pS6K, and pAMPK significantly increased in the ML group compared with the HFD group. Taken together, ML appears to be the most potent anti-diabetic and anti-dyslipidemic substance among sericultural products. ML could be developed as a potential agent for diabetes and its complication management.