• Journal of Life Science
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• v.12 no.3
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• pp.349-356
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• 2002

In order to observe the bioactivity of ovariectomized rats, nonovariertoized (sham) group, ovariectomized (Ovx) group, ovariectomized ginseng total saponin (GTS)-treated (Ovx+ GTS) group and ovariectomized ginseng water extract (GW)-treated (Ovx+CW) group were made. We measured AST (L-aspartate aminotransferase) and ALT (L-alanin aminotransferase) in sera, and MDA (malondialdehyde:lipid peroxidation), SOD (superoxide dismutase), catalase, total-glutathione (GSH + GSSG) and GPx (glutathione peroxidase) in liver tissue total homogenates of rat. AST activity of serum in Ovx group was 2.11 times increased, but ALT activity was not changed compared to Sham group. In AST activity, they tend to decrease significantly in each substance such as GTS and GW administered group. Lipidperoxides of each fraction in Ovx group were highly increased compared to Sham group. Extracts of ginseng-treated group markedly inhibited lipid peroxidation by 62% ∼72%. And as the result of the measurements of SOD, catalase, total-glutathione and GPx which are antioxidant enzyme, antioxidant enzymes in Ovx group much lower than in Sham group. But they were significantly increased in each substance such as GTS and GW, administered group. Based on the results, it is supposed that more produced free radicals decreased antioxidant enzyme. And it is also thought that extracts of ginseng can inhibit aging by reducing antioxidant enzyme.

• Journal of Life Science
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• v.33 no.9
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• pp.730-735
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• 2023

In the past decade, numerous studies have been carried out to quantify aging with the help of artificial intelligence. Using DNA methylation data, various models have been developed; these are commonly called epigenetic clocks. Epigenetic age acceleration is usually associated with disease conditions. Schizophrenia is a mental illness associated with severe mental and physical stress. This disease leads to high mortality and morbidity rates in young people compared with other psychological disorders. In the past, the research community considered this disease to be related to the accelerated aging hypothesis. In the current study, we wanted to investigate the epigenetic age acceleration changes in schizophrenia patients to obtain epigenetic insights into the disease. To measure the epigenetic age acceleration, we used two different DNA methylation clock models, namely, Horvath clock and Epi clock, as these are pan-tissue models. We utilized 450k array data compatible with both clocks. We found a slower epigenetic acceleration in the patients' samples when we used the Epi clock. We further analyzed the differentially methylated CpG sites between the control and cases and performed pathway enrichment analysis. We found that most of the CpGs are involved in neuronal processes.

• The Journal of the Korea Contents Association
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• v.9 no.9
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• pp.151-162
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• 2009

As the aging population has increased, the silver generation is getting to account for the considerable percent of economic activities and becomes the main body of production and consumption. Although the economic activity of silver generation is increased, the development of silver contents for the leisure activities is still not revitalized. The serious silver contents and the easy-to-use interface are very important because the silver generation is relatively weaker than young people in perception, studying, and exercise, and is fragile in mobility and vitality. This paper suggests methods to develop sensory bicycle, gate ball, and mole game contents haying lower body exercise effects for the silver generation to utilize leisure and maintain health. Along with fun as games, functional design factors suitable to the cognitive ability and bodily activity ability of the silver generation were considered and through sensory intefaces that are easy for the silver generation to use and customized progressing methods complying with individual characteristics, it was attempted to induce continued interests and lower body exercise effects.

• Therapeutic Science for Rehabilitation
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• v.12 no.1
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• pp.65-78
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• 2023

Objective : The typical decline in function due to aging includes limitations in vision, hearing, cognitive function, and activities of daily living. Therefore, this study evaluated the mediating effect of cognitive function on the relationship between vision and hearing and activities of daily living. Methods : The participants in this study were 36,767 persons from the long-term care database on older adults provided by the National Health Insurance Sharing Service. The extracted variables were: (i) independent variables: visual and hearing; (ii) dependent variables: basic and instrumental daily living activities; and (iii) mediator variables: cognitive function. Regression analysis was performed evaluate the mediating effects of the extracted variables. Results : Cognitive function showed a mediating effect of 30% on the relationship between vision and basic daily life activities and 42% in the relationship with instrumental daily life activities. The mediating effect was 50% in the relationship between hearing and basic activities of daily living, and 53% in the relationship with instrumental activities of daily living. Conclusion : Prevention programs for functional decline due to aging are in progress in Korea. Based on the results of this study, establishing a prevention program would help promote successful aging.

• Annual Conference of KIPS
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• 2015.10a
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• pp.1384-1387
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• 2015

고령화 사회로 진입하면서 노인들은 노화과정에 의한 보행능력의 감소 및 근력 약화와 같은 신체적 변화로 인해 잦은 낙상을 경험한다. 이에 따라 낙상 사고를 감지하는 연구가 활발히 진행되고 있다. 낙상은 사전 예방도 중요하지만 사고 발생 후의 신속한 대처도 중요하다. 낙상을 감지하고 의료진에게 즉시 낙상정보를 제공하여 후속적 조치를 취하는 것은 사고 후 대처의 핵심이다. 본 논문에서는 스마트폰 환경에서 사용자의 낙상 후 방향을 판별하기 위해 두 가지 센서 데이터의 특정 값들을 추출하였으며, 이에 5 가지 기계학습 알고리즘을 적용하였다. 사용자는 스마트폰을 착용한 상태로 전후좌우 4 방향 낙상 실험을 진행하며 스마트폰 내에 내장된 3 축 가속도 센서와 3 축 자이로 센서값을 측정한다. 피험자 11 명을 대상으로 낙상 실험 결과, 5 가지의 분류기 중 k-NN에서 98.6%의 인식률을 나타내었다. 뽑아낸 특징 값과 분류 알고리즘은 낙상의 방향 검출에 유용한 것으로 판단된다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.9
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• pp.1469-1475
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• 2004

Skin is the most frequently exposed tissues to oxidative stress from exogenous and endogenous sources. Dietary antioxidants, which suppress oxidative stress including reactive oxygen metabolites, play an important role in protecting skin from deleterious reactive oxygen species. Kimchi containing lots of antioxidative compounds shows anti-aging effect on skin. Therefore the morphologic changes on the skin of hairless mice fed diets containing Korean cabbage, mustard leaf, and buchu kimchi for 16 weeks were determined. Although epidermal thickness was decreased with age, kimchi prevented this thinning of epidermis compared to control group. In kimchi groups, the staining area of cytokeratin was smaller and stratum corneum was thinner than control group. It suggests that various kinds of kimchi diets prevent the increase of keratinization in epidermis with aging. Type Ⅳ collagen, a major structural protein of basement membrane supporting matrices, existed greater amount in kimchi groups than control group, especially in mustard leaf kimchi group. Rough endoplasmic reticulum (RER) of fibroblast was well developed in dermis of Korean cabbage and mustard leaf kimchi groups, which means collagen synthesis at dermis increased in those kimchi groups. This morphological changes of skin suggest that kimchi consumption can retard skin aging due to the presence of antioxidant and anti-aging compounds, especially some components of mustard leaf kimchi may largely affect on the skin rejuvenescence.

• Science of Emotion and Sensibility
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• v.20 no.4
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• pp.41-54
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• 2017

Physical activity has positive effects on cognitive functions by aging. However, it is rare to find research that have scientifically investigated the effects on the affective-cognitive function. Thus, this study aims to brain-scientifically research its effects of physical activity on the affective-cognitive function of adults in adolescence and senescence. As subjects of this study, a total of 60 males adults in D region were selected, and then equally divided into four groups of young exercise group(25~35y/o), young non-exercise group(26~35y/o), old exercise group(60~70y/o), and old non-exercise group(60~70y/o). As experiment tools, the EEG measuring equipment and International Affective Picture System(IAPS) were used. The experiment of this study used an affective-cognitive task where subjects pressed a button depending on emotional valence(positive, neutral, negative) shown in the pictures. During the task, EEG measured eight areas(Fp1, Fp2, Fz, C3, C4, Cz, T3, T4) out of brain areas in accordance with the international 10-20 electrode system, EEG was measured. For statistical analysis, a three-way ANOVA on $4(group){\times}3(stimulus){\times}8(area)$ was conducted. The results showed main effects of group in both reaction time and accuracy, and also in the latency of P3. And there was an interaction between group and stimulus the amplitude of P3. In conclusion, Physical activity has positive effects on the affective-cognitive function of people in adolescence and senescence.

• Proceedings of the Korean Society of Computer Information Conference
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• 2016.07a
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• pp.229-230
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• 2016

인체는 활동(운동)이 부족하면 체력이 떨어지고, 이로 인해 신체기관의 기능도 저하된다. 기능 저하는 노화의 진행을 당길 뿐 아니라 성인병 등 각종 질병의 원인이 되기도 한다. 성인병은 운동부족과 관련이 많기 때문에 이를 '운동부족병'이라고도 한다. 이 문제점을 해결하기 위한 건강 관리 앱을 이용해규칙적인 운동으로 인해 체력적, 심리적으로 긍정적인 결과를 기대할 수 있다.

• Korean Journal of Social Welfare Studies
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• v.44 no.3
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• pp.57-83
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• 2013

There has neither been enough research on how to approach the concept of active aging through an integrated view nor an examination to verify the relationship between preparation for old age and active aging in later life. Therefore, this research aims to verify that the elderly, who have prepared for their later life, affected their active aged life. In addition, by setting up self-efficacy and social support as mediator in the research model, this paper looks into the psycho-social resource mechanism of the relationship in depth. In order to verify the correlation of two variables, the Seoul welfare panel data, a mediating model structured by psycho-social resources created by Seoul welfare foundation in 2010, was used. The total sample size was a group of 1,492 elders aged over 65. When it came to our research methods, structured equation analysis was applied to verify the mediating effect and theoretical background. The results revealed that physical preparation, financial preparation, social preparation and leisure preparation directly affected their active aging level positively, thus, psycho-social resources showed a partial mediating effect between preparation for old age of the past and active aging level. The research implications are as follows. First, this research makes an effort to approach the concept of preparation for old age with an integrated perspective through making a construct by entire preparation types. Second, it will attempt to verify the relationship between preparation for old age in the past and active aging in terms of multi-dimension is meaningful. Third, this research reveals the function of psycho-social resource, self-efficacy and social support within the relationship. As far as the partial mediating effect is concerned, preparation for old age education for the middle-aged class should be modified as a decent field to enhance of the elderly.

• Journal of Korea Entertainment Industry Association
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• v.15 no.2
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• pp.149-157
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• 2021

One year has passed since the pandemic of COVID-19, which occurred in Wuhan, China, in November 2019 began. Worldwide, as of January 2021, more than 95 million people have been infected, and the death toll is higher than 2 million. In Korea, there are 74,262 infected and 1,328 dead, and government policies such as social distancing to prevent infection are being implemented. Accordingly, many inconveniences occurred in the physical activity environment, such as the closure of various sports facilities. It was necessary to consider physical activities to maintain healthy life while cooperating with the national policy while preventing infection. This study investigated the benefits of physical activity to reduce the risk of trichomoniasis and diabetes, improve bone mineral density, prolong healthy lifespan, maintain activity performance with aging, and improve psychological anxiety and depression. In addition, the physiological changes that may occur in the situation of stopping exercise due to social distancing to prevent COVID-19 infection were reviewed. In addition, moderate-intensity exercise that helps strengthen immune function by activating natural killer cells, neutrophils, and antibody responses was investigated. In addition, it reduces the level and function of blood B-cells, T-cells, and natural killer cells for several hours, decreases phagocytosis of neutrophils in the nasal cavity, increases inflammatory cytokines, decreases immune function, and increases infection. High-intensity exercise was considered. Therefore, in the age of COVID-19, long-term high-intensity exercise such as marathon, which causes impaired immune function, should be refrained from. And you should do moderate-intensity regular aerobic exercise such as fast walking to help prevent infection. It is also recommended to participate in resistance exercises to prevent loss of muscle mass.