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Korean Medicine Treatment for a Patient with Post-COVID-19 Pulmonary Fibrosis: A Case Report (코로나 19 후 폐섬유화(Post COVID-19 pulmonary fibrosis)에 대한 복합 한의치험 1례)

  • Jeong-Won Shin;Jiwon Park;Su-Hyun Chin;Kwan-Il Kim;Hee-Jae Jung;Beom-Joon Lee
    • The Journal of Internal Korean Medicine
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    • v.44 no.6
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    • pp.1294-1317
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    • 2023
  • Background: Post-COVID-19 pulmonary fibrosis (PCPF) is a common complication in severe COVID-19 cases, often associated with acute respiratory distress syndrome or mechanical ventilation. Patients with PCPF frequently experience a decline in their quality of life due to persistent COVID-19 sequelae, including cough and chest pain. However, there is currently no established standard treatment, and the efficacy of existing medications remains uncertain. Case Report: A 65-year-old female patient presenting with cough, dyspnea, chest pain, and fatigue due to PCPF received Korean medicine treatment for 25 days. Symptom evaluation utilized the modified Medical Research Council scale, the Leicester Cough Questionnaire, and the Numeral Rating Scale. Quality of life and functional status were assessed using the Post-COVID-19 Functional Status and the EuroQol 5-Dimensional 5-Level. The extent of pulmonary fibrosis was assessed by comparing chest computed tomography (chest CT) scans before and after hospitalization. Following treatment, the patient demonstrated clinically meaningful improvement in clinical symptoms, enhanced quality of life, and decreased fibrotic lesions on CT scans. Conclusion: This case report suggests that Korean medicine treatment may be effective in improving clinical symptoms, such as cough and dyspnea caused by PCPF, while also enhancing post-COVID-19 quality of life and ameliorating pulmonary fibrotic lesions.

Research on APC Verification for Disaster Victims and Vulnerable Facilities (재난약자 및 취약시설에 대한 APC실증에 관한 연구)

  • Seungyong Kim;Incheol Hwang;Dongsik Kim;Jungjae Shin;Seunggap Yong
    • Journal of the Society of Disaster Information
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    • v.20 no.1
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    • pp.199-205
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    • 2024
  • Purpose: This study aims to improve the recognition rate of Auto People Counting (APC) in accurately identifying and providing information on remaining evacuees in disaster-vulnerable facilities such as nursing homes to firefighting and other response agencies in the event of a disaster. Methods: In this study, a baseline model was established using CNN (Convolutional Neural Network) models to improve the algorithm for recognizing images of incoming and outgoing individuals through cameras installed in actual disaster-vulnerable facilities operating APC systems. Various algorithms were analyzed, and the top seven candidates were selected. The research was conducted by utilizing transfer learning models to select the optimal algorithm with the best performance. Results: Experiment results confirmed the precision and recall of Densenet201 and Resnet152v2 models, which exhibited the best performance in terms of time and accuracy. It was observed that both models demonstrated 100% accuracy for all labels, with Densenet201 model showing superior performance. Conclusion: The optimal algorithm applicable to APC among various artificial intelligence algorithms was selected. Further research on algorithm analysis and learning is required to accurately identify the incoming and outgoing individuals in disaster-vulnerable facilities in various disaster situations such as emergencies in the future.

A Study on Information Sharing Methods for Casualties in Maritime Emergency Scenes (해양응급현장에서의 사상자 정보 공유 방안에 관한 연구)

  • Seungyong Kim;Incheol Hwang;Dongsik Kim;Jungjae Shin
    • Journal of the Society of Disaster Information
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    • v.20 no.1
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    • pp.206-212
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    • 2024
  • Purpose: This study conducted research on the sharing of information to enhance the survival rate of emergency patients by swiftly transferring them to appropriate hospitals through sharing the patients' conditions, treatment histories, and transportation information with the Maritime Police Agency and relevant agencies when emergencies occur in the marine environment. Methods: In this study, emergency patient information classified in a smartphone app was received, stored, and transmitted using the LoRa communication method by electronic triage tags, and the transmitted emergency patient information was implemented to be collected in real-time through a hybrid triage system along with LoRa receivers. Results: Through the hybrid triage system, it was possible to receive emergency patient information according to the distance or confirm delayed reception. It was observed that most data were received when the distance was short, while data reception was unsuccessful in relatively longer distances. Conclusion: It was confirmed that in mass disaster environments where internet communication is impossible, rapid and accurate understanding of casualty information at disaster sites and appropriate disaster responses can be achieved using self-networking methods such as LoRa communication. However, limitations inherent in communication methods were also recognized. Further research on various communication methods is required to collect emergency patient information and transfer them to appropriate hospitals in situations where internet communication is unavailable.

Inhibitory effect of ethanol extract of Gryllus bimaculatus on platelet aggregation and glycoprotein IIb/IIIa activation (쌍별귀뚜라미 에탄올 추출물의 혈소판응집반응과 당단백질 IIb/IIIa 활성화 억제 효과)

  • Hyuk-Woo Kwon;Man Hee Rhee;Jung-Hae Shin
    • Journal of Applied Biological Chemistry
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    • v.66
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    • pp.236-243
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    • 2023
  • Platelets act a fundamental role in primary- and secondary-hemostasis, however, platelet activation may cause thrombosis simultaneously. Therefore, control of platelet aggregation is crucial in preventing thrombosis-mediated diseases. Recently, the development of insect materials is attracting attention. Among the highly nutritious functional food sources, insects such as two-spotted cricket (Gryllus bimaculatus). Gryllus bimaculatus (G. bimaculatus) contains high protein and unsaturated fatty acids and has been registered as a food material September 2015 by the Ministry of Food and Drug Safety of Korea. In this study, we examined whether G. bimaculatus extract (GBE) inhibits platelet aggregation, intracellular calcium mobilization, thromboxane A2 production and glycoprotein IIb/IIIa (integrin αIIb/β3) activation. We investigated whether GBE can regulate signaling molecules, such as 1, 4, 5-triphosphate receptor type I, extracellular signal-regulated kinase, cytosolic phospholipase A2, mitogen-activated protein kinases p38, vasodilator-stimulated phosphoprotein, phosphatidylinositol-3 kinase, Akt, glycogen synthase kinase-3α/β, and SYK. Taken together, GBE is a potential therapeutic drug candidate to prevent platelet-related thrombosis and cardiovascular disease.

The Parathyroid Gland: An Overall Review of the Hidden Organ for Radiologists (부갑상선: 부갑상선 영상에 익숙하지 않은 영상의학과 의사들을 위한 전반적인 검토)

  • Suho Kim;Jung Hee Shin;Soo Yeon Hahn;Haejung Kim;Myoung Kyoung Kim
    • Journal of the Korean Society of Radiology
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    • v.85 no.2
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    • pp.327-344
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    • 2024
  • Parathyroid glands are small endocrine glands that regulate calcium metabolism by producing parathyroid hormone (PTH). These are located at the back of the thyroid gland. Typically, four glands comprise the parathyroid glands, although their numbers may vary among individuals. Parathyroid diseases are related to parathyroid gland dysfunction and can be caused by problems with the parathyroid gland itself or abnormal serum calcium levels arising from renal disease. In recent years, as comprehensive health checkups have become more common, abnormal serum calcium levels are often found incidentally in blood tests, after which several additional tests, including a PTH test, ultrasonography (US), technetium-99m sestamibi parathyroid scan, single-photon-emission CT (SPECT)/CT, four-dimensional CT (4D-CT), and PET/CT, are performed for further evaluation. However, the parathyroid gland remains an organ less familiar to radiologists. Therefore, the normal anatomy, pathophysiology, imaging, and clinical findings of the parathyroid gland and its associated diseases are discussed here.

Comparison of Soil Profile Development Index of the Residuum Soils Derived from Conglomerate (역암지대(礫岩地帶) 잔적토양(殘積土壤)의 토양단면발달지수(土壤斷面發達指數) 비교(比較))

  • Kim, Jung-Kon;Jung, Yeun-Tae;Son, Il-Soo;Yoon, El-Soo;Um, Ki-Tae
    • Korean Journal of Soil Science and Fertilizer
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    • v.19 no.2
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    • pp.99-105
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    • 1986
  • This study was carried out to compare the soil profile development indices of Sinjeong series according to the distribution areas in Yeongnam district. The results obtained were as follows; 1. The soils studied were belong to fine loamy family of hilly residual soils derived from conglomerate. These soils were well drained and dominantly had 30-60% slopes, and used for forest. 2. The surfaces were typified by brownish red (5YR) or brownish yellow (10YR) loam, subsoils were clay loam of reddish brown (5YR) or reddish yellow (7.5YR) and the substrata were in dark reddish brown (5YR) or pink (7.5YR) sandy loam. 3. The indices of horizon development of the soils studied were from 0.18 to 0.38 and the index in illuvial horizons with clay films were over 0.36, that were higher than the others. The profile development indices were similar to each other ranging from 30.18 to 35.93. 4. Positive correlations were observed among horizon development indices and normalized values of structure, texture and consistences, but the relationship between profile development indices and consistences were not the same. 5. The amount of clay minerals formed in the soil horizons per 100g of parent materials were 1.1-1.6g and the rates of the clay leached were around 4.4-5.9%. 6. The sphericity and roundness of the gravels contained in the soils studied were 0.741 and 0.715, respectively. These similarity of "well rounded" gravels certify that the parent rocks were formed under similar environments.

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Usefulness of tibia counter rotator (TCR) for treatment of tibial internal torsion in children (경골 내염전 환아에서 경비골 역회전 교정장치(TCR)의 치료 효과)

  • Song, Dong Ho;Lee, Yoon;Eun, Baik-Lin;Lee, Kwang Jae;Kang, Sang Kuk;Vaq, Sung Gin;You, Sung;Shin, Jung Bin;Kim, Bong Ok
    • Clinical and Experimental Pediatrics
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    • v.50 no.1
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    • pp.79-84
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    • 2007
  • Purpose : Tibial internal torsion is prevalent in East Asian countries such as Korea and Japan, where sitting on the floor is common behavior. Tibial internal torsion or excessive lateral tibial torsion may cause esthetical, functional, or psychological problems and also may induce degenerative arthritis in older age. The aim of this study is to evaluate the therapeutic effect of Tibial Counter Rotator (TCR) in patients with tibial internal torsion. Method : One hundred forty nine children (274 limbs) with tibial internal torsion participated in this study. Transmalleolar angle were measured with gravity goniometer. When tibial internal torsion was detected, TCR was applied at least for 3 hours a day during sleep. The patient's progress was followed monthly and transmalleolar angle was reevaluated by the same examiner. Results : Transmalleolar angle was significantly increased in patients with tibial internal torsion during TCR application (P<0.001). Conclusion : TCR can be one of the effective methods for correcting tibial internal torsion in children under 12 years old of age.

Suggestion for Establishment of Temporary MRLs and Safe use Guideline of the Organophosphorus Insecticides in Jinpi (한약재 진피에 대한 유기인계 살충제의 잠정 MRL 설정 및 안전사용기준 제안)

  • Lee, Ju-Hee;Shin, Kab-Sik;Jeon, Young-Hwan;Kim, Hyo-Young;Hwang, Jeong-In;Lee, Byung-Hee;Kang, In-Hoo;Kang, Shin-Jung;Kim, Tae-Hwa;Kim, Jang-Eok
    • Korean Journal of Environmental Agriculture
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    • v.29 no.1
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    • pp.66-71
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    • 2010
  • Jinpi(Aurantii nobilis Pericarpium) is one of the most important material of oriental herbal medicine which is made from the peel of mandarin by washing with hot water and drying. Pesticides have necessarily used for mandarin cultivation according to their preharvest intervals (PHIs) but their maximum residue limits (MRLs) and PHIs for Jinpi are not established yet. This study is to know residue amount of organophosphorus insecticides in Jinpi and to establish the MRLs and PHIs for fenitrothion and phenthoate in Jinpi. Fenitrothion was sprayed once, twice and three times with 7 days interval before harvest. Its residue amount ranged from 0.14 to 1.17 mg/kg in mandarin, 0.59 to 4.02 mg/kg in its peel and 1.66 to 22.38 mg/kg in Jinpi. In case of phenthoate, it was sprayed with 10 days interval for 10 days before harvest. Its residue amounts in mandarin, its peel, and Jinpi ranged from 0.16 to 0.65, 0.69 to 2.41 and 1.69 to 11.3 mg/kg, repectively. Proposed MRLs of fenitrothion and phenthoate for Jinpi are suggested to 22.39 and 11.30 mg/kg, respectively. So we recommend PHIs of the pesticides that fenitrothion can be sprayed 3 times 7 days before harvest and in case of phenthoate, sprayed 3 times 10 days before harvest.

Finite Element Method Modeling for Individual Malocclusions: Development and Application of the Basic Algorithm (유한요소법을 이용한 환자별 교정시스템 구축의 기초 알고리즘 개발과 적용)

  • Shin, Jung-Woog;Nahm, Dong-Seok;Kim, Tae-Woo;Lee, Sung Jae
    • The korean journal of orthodontics
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    • v.27 no.5 s.64
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    • pp.815-824
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    • 1997
  • The purpose of this study is to develop the basic algorithm for the finite element method modeling of individual malocclusions. Usually, a great deal of time is spent in preprocessing. To reduce the time required, we developed a standardized procedure for measuring the position of each tooth and a program to automatically preprocess. The following procedures were carried to complete this study. 1. Twenty-eight teeth morphologies were constructed three-dimensionally for the finite element analysis and saved as separate files. 2. Standard brackets were attached so that the FA points coincide with the center of the brackets. 3. The study model of a patient was made. 4. Using the study model, the crown inclination, angulation, and the vertical distance from the tip of a tooth was measured by using specially designed tools. 5. The arch form was determined from a picture of the model with an image processing technique. 6. The measured data were input as a rotational matrix. 7. The program provides an output file containing the necessary information about the three-dimensional position of teeth, which is applicable to several finite element programs commonly used. The program for a basic algorithm was made with Turbo-C and the subsequent outfile was applied to ANSYS. This standardized model measuring procedure and the program reduce the time required, especially for preprocessing and can be applied to other malocclusions easily.

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Enzymatic synthesis of structured lipids containing conjugated linolenic acids extracted from pomegranate seed oil and their physicochemical characteristics (석류 종자유로부터 얻어진 Conjugated Linolenic Acid를 함유한 기능성 고체지의 효소적 합성 및 이화학적 특성 연구)

  • Lee, Koo;Shin, Jung-Ah;Lee, Ki-Teak
    • Korean Journal of Agricultural Science
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    • v.39 no.3
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    • pp.395-405
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    • 2012
  • Lipozyme TL IM-catalyzed esterification was carried out to produce functional hard fat (structured lipid, SL) using palm stearin (PS) and hydrolysate of pomegranate seed oil (HPSO) of 1:6 molar ratio. HPSO contained conjugated linolenic acid (CLnA, about 80%). The reaction was performed at non-solvent system and solvent (n-hexane) system using Lipozyme TL IM (10% of total substrates, w/w) for 12, 24, and 72 hr in a shaking water bath ($55^{\circ}C$ and 185 rpm), respectively. SL synthesized in non-solvent system (NH-SL) and SL synthesized in n-hexane system (H-SL) were refined after deacidification, respectively. Their physicochemical properties were compared to obtain desirable functional hard fat. The content of CLnA in NH-SL increased from 34.38% to 40.63% with increasing reaction time. Similar results also observed in H-SL resulting in 36.81~45.83% of CLnA. In triacylglycerol (TAG) composition, the main molecules of LnLnLn (Ln=linolenic acid, PN=36) and the LnLnP (P=palmitic acid, PN=40) were newly synthesized in NH-SL and H-SL with increasing reaction time. After 72 hr reaction, iodine values of NH-SL (136.49) and H-SL (140.37) showed high values because of the high content of CLnA. Solid fat index (SFI) in NH-SL was higher than that in H-SL at each measured temperature. The predominant polymorphic forms of NH-SL and H-SL obtained after esterification for 72 hr were the desirable crystalline structure of the ${\beta}$' form.