• Childhood Kidney Diseases
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• v.5 no.2
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• pp.87-99
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• 2001

Purpose: We studied to find out apo-E genotype polymorphism in minimal change nephrotic syndrome(MCNS) and IgA nephropathy(IgAN) and to determine the relationship between apo-E genotype and clinical course of MCNS. Materials and Method: 43 MCNS patients and 15 IgAN patients were examined for apo-E polymorphism. 50 healthy blood donors were examined for apo-E genotype as control. Genomic DNA was prepared front peripheral blood leukocytes according to standard procedures. Results: As compared with control group, e4 allele frequency was significantly increased in MCNS (p<0.01). However, in IgAN e2 allele frequency, however, was 2.6 times higher than normal control (P<0.01). The frequency of e4 allele of frequent relapser group was 4.6 times higher than normal control and was 2 times higher than infrequent relapser group. Conclusion: We think that apo-E typing might be one of the parameters, which should be considered to predict the course of MCNS in children. MCNS with risky HLA profile and E4/4 genotype could indicate the need for a longer steroid administration. And apo-E genotype needs to be considered for the evaluation of therapeutic responses to other drugs. (J, Korean Soc Pediatr Nephrol 2001 ; 5 : 87-99)

• Journal of Veterinary Clinics
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• v.29 no.5
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• pp.372-376
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• 2012

Acute kidney injury (AKI) is a serious problem associated with high morbidity and mortality. Ischemia-reperfusion is an important cause of acute kidney injury. This study was performed to ascertain clinically useful biomarkers for the diagnosis of AKI. In three miniature pigs, AKI were induced by 60 minutes of bilateral renal ischemia by the clamping renal artery. Blood and urine samples were collected from the pigs prior to clamping (baseline) and 0, 1, 3 and 5 days post-clamping. Serum blood urea nitrogen (BUN), creatinine, sodium and uric acid were measured in serum and urine samples. Fractional excretion of sodium ($FE_{Na}$) and fractional excretion of uric acid ($FE_{UA}$) were calculated. Also, interleukin (IL)-6, IL-18, liver type fatty acid binding protein (L-FABP) and glutathione-S-transferase (GST) were detected by Western immunoblotting. Serum BUN and creatinine levels were increased significantly at day 1 post-clamping in all three miniature pigs. However, $FE_{Na}$ and $FE_{UA}$ showed marked individual differences. Western immunoblotting revealed significantly increased levels of IL-6, IL-18, L-FABP and GST in post-ischemic urine, compared to pre-clamping. While more research concerning the variance of $FE_{Na}$ and $FE_{UA}$ is needed, serum BUN, creatinine, IL-6, IL-18, L-FABP and GST may be sensitive urine biomarkers for diagnosis of AKI together with other biomarkers in the porcine ischemia-reperfusion model.

• Journal of Applied Biological Chemistry
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• v.65 no.1
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• pp.43-48
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• 2022

Medicinal herb demonstrated in many pharmacological effects and recognized to be safe has been used for a long time. However, side effects including safety of medicinal herb have not been identified yet. The aim of the study was to estimate safety evaluation of Magnoliae Flos used for the treatment of pain, rhinitis, and pneumonia in Korea, China and Japan through four-week dose range finding toxicity test in male and female Sprague-Dawley rats. Magnoliae Flos was orally administered to male and female SD rats once a day for 28 days at 1,500 and 3,000 mg/kg. The safety evaluation was determined to examine clinical signs, mortality, body weight, food intake, hematology, serum biochemistry and relative organ weights and there were no significant changes related toxicity. Consequently, these findings indicates that Magnoliae Flos did not show any side effects including toxicity in dose range finding toxicity test and the no observed adverse effect level for Magnoliae Flos was estimated as more than 3,000 mg/kg.

• Environmental and Resource Economics Review
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• v.32 no.2
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• pp.127-147
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• 2023

This study is trying to analyze the economic effect of replacing thermal power generation, one of the government's carbon-neutral policies, with new and renewable energy. For this analysis, scenario A is set to replace 100% of thermal power generation with new and renewable energy, and scenario B is set to replace 60% of thermal power generation with new and renewable energy. In addition, costs are incurred when replacing thermal power generation with new and renewable energy, and scenario 1 is the same cost as the current cost, and scenario 2 is120% higher than the current cost. Therefore, when converting thermal power generation to new and renewable energy, the scenarios are largely organized into four cases. In the case of replacing thermal power generation with new and renewable energy, the production inducement coefficient of thermal power generation decreased from the current level regardless of the scenario. However, the value-added inducement coefficient and the greenhouse gas emission inducement coefficient are lower than the current level when thermal power is converted to renewable energy by 100%, while the value-added inducement coefficient and greenhouse gas emission inducement coefficient are higher than the current level. In addition, the greenhouse gas emission induction coefficient of most industries was found to decrease, while the production induction coefficient and the value-added induction coefficient increased. Scenario A seems appropriate because the purpose of the government's policy is to reduce greenhouse gas emissions by converting thermal power into new and renewable energy. However, as a result of this, the production inducement coefficient and value-added inducement coefficient of some industries decrease, so the government's support policy is needed to solve this problem

• Analyses & Alternatives
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• v.7 no.3
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• pp.27-59
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• 2023

This study aims to serve as a critical comparison of the currently controversial 'new cold war' discourse. It took three triggers for the 'new cold war' discourse to emerge as a major issue in the media and academia and to have real political impact. With the launch of China's 'Belt and Road' project and Russia's annexation of Crimea leading to the 'Ukraine crisis,' the 'new cold war' discourse has begun to take shape. Trump's U.S.-China trade spat has brought the 'new cold war' debate to the forefront. The 'new cold war' debate is currently being intensified by the Biden administration's framing of "democracy versus authoritarianism" and Putin's invasion of Ukraine. Currently, there is no consensus among scholars on whether the controversial 'new cold war' is a new version, or a continuation of the historically defined concept of the Cold War. The term 'New Cold War' is less of an analytical concept and more of a topical term that has yet to achieve analytical status, let alone a theoretical validation and systematization, and the related debate remains at the level of assertion or discourse. Through this comparative analysis, I will argue that the ongoing discourse of the 'New Cold War' does not have the instrumental explanatory power to analyze the transitional phenomena of the world order today.

• Korea Petroleum Association Journal
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• s.299
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• pp.4-9
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• 2016

• Disaster Prevention Review
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• v.14 no.4
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• pp.254-257
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• 2012

• The monthly packaging world
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• s.18
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• pp.155-161
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• 1994

• New & Renewable Energy
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• v.1 no.1 s.1
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• pp.15-23
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• 2005

• Landscaping Tree
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• s.123
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• pp.56-58
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• 2011