• Journal of Chest Surgery
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• v.41 no.3
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• pp.369-372
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• 2008

A primary malignant lymphoma that originates in the heart is extremely rare. A 68-year-old male patient was admitted due to aggravated dyspnea. After echocardiography and chest computed tomography evaluation, a huge mass in the right atrium and the right ventricle was detected. We decided to perform emergency surgery due to a high risk of infarction and hemodynamic disturbance. After the near total removal of the huge mass in the right cardiac chamber, the interatrial septum and antero-lateral part of the right atrium were reconstructed by the use of a bovine pericardial patch. The final pathological diagnosis was a primary malignant lymphoma. The patient and his guardians refused chemotherapy (including radiotherapy), and the patient was discharged to his home, where the prognosis was hopeless.

• Journal of Chest Surgery
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• v.36 no.12
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• pp.943-951
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• 2003

We are now detecting an increasing number of solitary pulmonary nodules (SPNs) that are difficult to diagnosis. The purpose of this study was to evaluate the useful radiologic findings for differentiating benign from malignant pulmonary nodules. Material and Method: The high-resolution CT (HRCT) findings of SPNs smaller than 3 cm in largest diameter were evaluated in 134 patients with malignant and benign nodules in regard to internal structures, margin characteristics, and surrounding parenchymal responses. Result: The nodules with the area of ground-glass attenuation (GGA) greater then 50% were noted in adenocarcinoma, inflammatory lesions and some of metastatic tumors, and the lesions greater than 90% were noted only in adenocarcinoma. The area of GGA in non-adenocarcinoma, benign tumors and tuberculomas were less than 50%, and mainly less than 10%. The findings of air bronchogram, spiculation, lobulation, vascular involvement, and pleural indentation were some noted at every types of malignant tumors, but especially high over than 30% in adenocarcinomas. Conclusion: Most peripheral lung adenocarcinomas form a characteristic radiologic findings especially in HRCT. Evaluation of these findings would be helpful in differentiating between lung cancer, especially adenocarcinoma, and other lesions.

• Journal of Chest Surgery
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• v.42 no.1
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• pp.127-130
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• 2009

Primary leiomyosarcoma of the mediastinum is an extremely rare tumor that develops either in the mesenchymal cells of the visceral mediastinum or in the smooth muscle of the great vessels. In the literature, the most significant factor for determining survival is the ability to completely resect the tumor. But there is 30~64% recurrence rate and there is also a lack of data for the role of adjuvant therapy after complete resection. We report here on a case of recurred leiomyosarcoma of the mediastinum that was surgically removed via left thoracotomy 2 years previously and this was misdiagmosed as benign disease.

• Journal of the Korean Society of Marine Environment & Safety
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• v.22 no.5
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• pp.490-499
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• 2016

In this study, the marine ecological impacts of dephosphorized slag and steel slag on the initial life cycle of the rotifer Brachionus plicatilis and benthic copepod Tigriopus japonicus (in marine trophic structure as a first consumer) exposure to slag extracts have been considered using a marine ecotoxicological assessment. In the results of a screen test on slag extracts, the pH of an undiluted solution was measured to have high alkalinity (pH 8.89-12.16), but a toxic reaction to this undiluted solution before and after aging was divided according to test species. For non-aged slag, the toxic effect ($LC_{50}$) of neonate on B. plicatilis was seen to be severe with dephosphorized slag (20.8 %) than steel slag (63.8 %) with under pH-uncontrolled conditions. The toxic values of dephosphorized and steel slag were estimated to be 35.3 % and 36.0%, respectively, for nauplius with T. japonicus. However, the toxicity of slag extracts before and after aging were different for T. japonicus than for B. plicatilis based on the characteristics of the test materials, with pH-controlled conditions. In conclusion, the results of this study suggest that slag can be relatively stable after aging and may not be likely to influence marine environments, even given repetitive extracting under pH-uncontrolled conditions. This study confirms that a marine ecotoxicological assessment method applied to mechanically activated samples can give an idea of the resistance a marine environment has against the introduction of hazardous materials due to precipitation and weathering.

• Journal of Gastric Cancer
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• v.7 no.2
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• pp.102-106
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• 2007

Gastric carcinoid tumor is a neoplasm that arises from enterochromaffine-like (ECL) cells in the gastric fundus. It is a rare disease that comprises less than 2% of all gastric neoplasms; however its incidence has been recently increasing. We experienced one case of gastric carcinoid tumor that was revealed to be multiple polypoid lesions. A 29-year-old female patient visited a hospital three years ago due to syncope. The blood hemoglobin was measured as 6.0 g/dl. Gastroscopy revealed multiple polypoid lesions with bleeding; therefore endoscopic clipping was performed. The polyps were diagnosed as carcinoid tumor via endoscopic biopsy. She was transferred to our hospital because of persistent iron deficiency anemia that was caused by bleeding at the gastric polyps. Gastroscopy revealed more than twenty various-sized polypoid lesions from the mid-body to the antrum. The blood hemoglobin level was 9.0g/dl. Total gastrectomy was performed under the diagnosis of gastric carcinoid tumor with bleeding. All of the gastric polyps were diagnosed as carcinoid tumors, and any metastasis to the regional lymph nodes was not found. Eighteen months after operation, the blood hemoglobin was increased to 12.8g/dl with no evidence of recurrence. Surgical resection should be considered for treating gastric carcinoid tumor with continuous bleeding.

• Journal of Chest Surgery
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• v.34 no.5
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• pp.386-392
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• 2001

배경: 기관지에 광범위한 협착을 가지고 있는 환자들에게서 협착된 기관지 이하 부위에 있는 폐를 절제하지 않고 기관지 협착 부위를 교정하여 폐환기를 원할하게 하고자 하는 다양한 술식의 기관지 성형술이 고안시도되어 왔지만 만족할만한 술기는 아직 정립되어 있지 않다. 저자들은 이러한 기관지 협착을 교정하기 위한 술식의 하나로서 기관지 대치물을 이용한 기관 성형술의 효과를 조사하기 위하여 본 실험을 시행하였다. 대상 및 방법: 기관지 대치물로 사용한 두 종류의 첨포에 따라 성숙견을 실험 동물로 하여 두 군으로 분류하였으며 A군(5예)에서는 좌측 주기관지 전측방 부위를 0.5$\times$0.5cm 크기의 직사각형으로 절제한 후 늑연골에 자가 심낭편을 댄 동일한 크기의 첨포를 절제 부위에 부착하였고 B군(5예)에서는 동일한 크기의 기관지 절제 부위에 glutaraldehyde로 처리된 우심낭편을 부착하였다. 첨포를 이용한 기관지 성형술 12주후에 실험견을 도살하고 육안적 및 현미경적으로 관찰하였다. 결과: A군이 기관지 성형술 부위에서는 첨포의 외면은 주위의 결합조직과 막상유착을 이루고 있었으며 첨포의 가장자리는 자가 기관지에 잘 부착되어 있었다. 기관지 내면은 내경의 협착이 없이 윤기 있는 점막으로 잘 유지되어 있었고 자가 기관지와 첨호와의 경계면은 신생육아조직이 일부 차지하고 있었으며 새로운 이행 상피가 가교를 이루고 있는 현미경적 소견을 보았다. B군의 기관지 성형술 부위에서는 첨포의 와부는 암갈색으로 변화된 부분적 괴사의 양상을 보였다. 기관지 내면은 첨포와 가자기관지 경계부위에서 염증성 육아조직과 부분적 출현 양상을 보고 기관지 내경의 일부가 수축되었으며 자가 기관지로부터 첨포내로의 새로운 상피 형성은 되어 있지 않았다. 결론: 늑연골에 자가 심낭편을 댄 첨포는는 자가 기관지와 상피 가교를 형성하고 기관지 내강의 협착이 없이 구조를 유지하므로 기관지 협착 및 결손의 치료를 위한 기관지 성형술시에 기관지 대치물로 사용될수 있는 것으로 사료된다.

• Clinical and Experimental Pediatrics
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• v.52 no.5
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• pp.594-602
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• 2009

Purpose : Transforming growth factor (TGF)-${\beta}1$ reportedly increases neuronal survival by inhibiting the induction of inducible nitric oxide synthase (NOS) in astrocytes and protecting neurons after excitotoxic injury. However, the neuroprotective mechanism of $TGF-{\beta}1$ on hypoxic-ischemic (HI) brain injury in neonatal rats is not clear. The aim of this study was to determine whether $TGF-{\beta}1$ has neuroprotective effects via a NO-mediated mechanism and N-methyl-D-aspartate (NMDA) receptor modulation on perinatal HI brain injury. Methods : Cortical cells were cultured using 19-day-pregnant Sprague-Dawley (SD) rats treated with $TGF-{\beta}1$ (1, 5, or 10 ng/mL) and incubated in a 1% O2 incubator for hypoxia. Seven-day-old SD rat pups were subjected to left carotid occlusion followed by 2 h of hypoxic exposure (7.5% $O_2$). $TGF-{\beta}1$ (0.5 ng/kg) was administered intracerebrally to the rats 30 min before HI brain injury. The expressions of NOS and NMDA receptors were measured. Results : In the in vitro model, the expressions of endothelial NOS (eNOS) and neuronal NOS (nNOS) increased in the hypoxic group and decreased in the 1 ng/mL $TGF-{\beta}1-treated$ group. In the in vivo model, the expression of inducible NOS (iNOS) decreased in the hypoxia group and increased in the $TGF-{\beta}1$-treated group. The expressions of eNOS and nNOS were reversed compared with the expression of iNOS. The expressions of all NMDA receptor subunits decreased in hypoxia group and increased in the $TGF-{\beta}1$-treated group except NR2C. Conclusion : The administration of $TGF-{\beta}1$ could significantly protect against perinatal HI brain injury via some parts of the NO-mediated or excitotoxic mechanism.

• The Journal of the Korean bone and joint tumor society
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• v.9 no.2
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• pp.139-147
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• 2003

Purpose: The purpose of this study was to determine if bony union can be obtained when a bone graft substitute is transplanted in order to treat a benign bone tumor and if there is a difference between calcium sulfate and hydroxyapatite in the healing procedure when the degree of the bony union after the bone graft are compared. Materials and Methods: This study selected 20 cases, in which a curettage on the benign bone tumors was conducted and a bone graft substitute was transplanted. The area of the focus, the new bone formation, the recurrence of the focus in the plain radiographs and histological findings were observed. Results: Twenty cases (13 males, 7 females) were evaluated. Their mean age at surgery was 15.8 years (2~45), and the mean follow-up period was 3 years. The mean area of focus was 30.7 $cm^3$ in the radiographs, and 19 cases showed successful results in the ultimate visit, while 1 case has a recurrence of the focus. Conclusion: Calcium sulfate has osteoconduction and superior bioavailability, and is absorbed in vivo in proportion to the new bone formation. On the other hand, hydroxyapatite has good osteoconduction. It can result in better bone formation when it is combined with an autologous bone graft, autologous bone marrow, and an allogenic bone graft, but is absorbed in vivo more slowly than the former.

• Journal of Chest Surgery
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• v.37 no.3
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• pp.286-291
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• 2004

Mediastinum is a very rare primary site of liposarcoma. In general, wide surgical excision with adequate resection margin is the treatment of choice for lipesarcoma. We experienced a case of liposarcoma in a 24 year-old male who complained of dyspnea and chest discomfort. Symptoms had been developed a month before admission, and the intensity had been gradually increased. He visited another general hospital, and there he received left closed thoracostomy because hemothorax was suspected. Afterwards, he was transferred to our hospital without a specific diagnosis, on review of outside chest computed tomography film, mass shadow was detected in the mediastinum. For the further evaluation, we checked the chest sonography and chest magnetic resonance imaging. MRI showed 10 cm sized mass contacted with pulmonary artery trunk and left main pulmonary artery. The radiologist strongly suggested sarcoma. On the 4th day after admission, we performed emergent exploratory left thoracotomy for hematoma evacuation because mediastinal shifting progressed and heart rate was increased. Biopsy confirmed that the evacuated materials were extraskeletal myxoid chondresarcoma, so we performed extrapleural left pneumonectomy including diaphragm and a part of the pericardium. The final pathologic diagnosis was myxoid/round cell liposarcoma. He was discharged without complication and systemic chemotherapy was scheduled to begin 2 month later. During chemotherapy, local recurrence and peritoneal metastasis developed, and he died 10 month after the surgical excision. We report this case with reviewal of literature.

• Journal of Chest Surgery
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• v.31 no.2
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• pp.212-215
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• 1998

Pulmonary mucinous cystic tumor of borderline malignancy is very rare and distinguished from bronchogenic cyst or adenocarcinoma of bronchoalveolar type. We present the case of a 63-year-old woman with a right lower lobe mass, found by chest radiographs. The preoperative diagnosis was made as bronchoalveolar cancer by percutaneous needle aspiration of mass. Right lower lobectomy and lymph node dissections were performed. The lobectomy specimen contained variable sized multilocular cystic mucous masses, filled with mucus. Microscopically, the cystic masses are lined with tall columnar mucinous epithelium but some area contains focal cellular atypism and bronchoalveolar cancer like foci. This foci are lack of cellular atypism consistent with bronchoalveolar cancer cell. After lobectomy the patient has remained free from recurrence and distant metastasis for following 12 months period. Pulmonary mucinous cystic tumor of borderline malignancy appears to have a favorable prognosis and should be distinguished from other lung neoplasms.