• The Journal of the Korean life insurance medical association
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• v.25
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• pp.63-77
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• 2006

The definition of 'critical cancer' in critical insurance(CI) is more insurance meanings than medical meanings. The difference between critical cancer of insurance and critical cancer of medical cancer is made difficult problem to the underwriting of insurer, contractor and medical doctor. The limited factors of underwriting in critical cancer of critical insurance as follows: (1) the limitation factors in the definition of 1st item critical cancer in CI 1) the definition differences of meanings in insurer, contractor, and medical doctor 2) the meanings of "the table of malignance" 3) the definition difference between 'critical cancer' and 'a large of medical expense cancer' (2) the limitation factors in the definition of second item critical cancer in CI 1) The limitation in the change of cancer character 2) The missing malignancy in pathological result due to localized cancer 3) The differences in the test result of hospital (3) the limitation factors in the definition of third item critical cancer in CI. 1) the lower items disobey the higher items 2) clinical malignancy of benign cancer pathologically 3) others: (1) low grade of malignant melanoma (2) early prostate cancer. (3) malignancy related HIV (4) all skin cancer excepted malignant melanoma (5) accepted clinically and a medical certificate by medical doctor as critical cancer of premalignant lesion, carcinoma-in-situ, and borderline cancer.

• Ocean and Polar Research
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• v.26 no.2
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• pp.245-253
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• 2004

The Intertropical Convergence Zone (ITCZ), where the southeast and northeast trade winds converge, is the effective climatological barrier that separates the southern and northern hemispheres in dust budget. Asian and N. American dusts dominate in fhe Pacific north of the ITCZ, while Central and S. American dust prevails south of the ITCZ. In order to understand the nature of latitudinal and depth-related variations of mineral composition in terms of relative position to the ITCZ, deep-sea core sediments were collected from $9^{\circ}N$ to $17^{\circ}N$ at a $2^{\circ}N$ interval along the $131.5^{\circ}W$ meridian and analyzed for mineral composition. The amount of illite in surface sediments decreases gradually from 65% at $17^{\circ}N\;to\;31^{\circ}N$ to 31% at 9f. In contrast, smectite increases from 11% to 56% southward. The observed mineralogical variation toward the ITCZ is attributed to the increased supply of volcaniclastic material transported via the southeast trade winds from the Central and South America source regions. Smectite-illite transition, a phenomenon that the amount of smectite increases over illite, occurs at around $10^{\circ}N$, the northern margin of the ITCZ. This result indicates that the change in latitudinal position of the ITCZ in geologic past could be recorded as a form of smectite-illite transition in deep-sea cores. The studied cores show down-core variation of mineral composition from illite-rich at the surface to smectite-rich clay suit at depths, similar to the latitudinal variation. The smectite-illite transitions observed in these cores are likely the records of changes in latitudinal position of the ITCZ. The depth and age of smectite-illite transition is getting shallower and younger toward equator, implying that the ITCZ was located farther north during late Tertiary and has shifted southward to the present position of $5^{\circ}N-10^{\circ}N$.

• Journal of the Korean Geographical Society
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• v.47 no.2
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• pp.159-178
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• 2012

Since the suggestions on the paleo-glacial landforms in and around the northern high mountains of Korean Peninsula by some western and Japanese scientists in the early 1900s, the likelihood of the glacier existence in the Baekdusan over the Quaternary glacial period has been had in common among most of the Korean geomorphologists. In the other meaning, some have cast doubt on the likelihood the paleo-glacier in the Baekdusan because there has been no unequivocal evidences for the glacier such as striation, moraines, except morphologic characteristic landforms possibly related to glacier. Here we show some evidences for the existence of the glacier in the Baekdusan and their cosmogenic $^{36}Cl$ exposure ages over the late Quaternary and would put forward a model on the Quaternary landscape evolution of the Baekdusan, with a focus on the relationship of 1000 AD explosive eruption and the glacial landforms. The exposure ages constrained by cosmogenic $^{36}Cl$ abundances of the col surface of the western slope located below the glacier yield 46~26 ka, which is inphase with the last glacial period. Given all the evidences above, we can draw a conclusion that the glacier existed on the Baekdusan over the late Quaternary and the style of glaciation changed from extensive ice cap through valley glacier to restricted cirque.

• Journal of Life Science
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• v.27 no.3
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• pp.325-333
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• 2017

High level of plasma cholesterol is strongly associated with the development of atherosclerosis and coronary heart disease. Clinical trials designed to reduce plasma cholesterol level by diet or pharmacological intervention have resulted in marked reduction of disease incidence. The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase which reduces cholesterol biosynthesis in the liver is the key enzyme of the mevalonate pathway that produces cholesterol. In this study, 71 naturally occurring phenolic compounds were tested for inhibitory activities against HMG-CoA reductase. Eleven compounds out of 71 showed inhibitory activities: three hydrolyzable tannin (geraniin, acetonyl geraniin and pentagalloyl ${\beta}-D-glucose$), four benzoic acid derivatives (benzoic acid, trans-cinnamic acid, 2,4-dihydroxybenzoic acid and 2,5-dihydroxybenzoic acid), and four naphthoquinone derivatives (1,2-naphthoquinone, 1,4-naphthoquinone, plumbagin and shikonin). At the concentration of $10{\mu}g/ml$, 1,4-naphthoquinone inhibited HMG-CoA reductase by 99.4%, and then plumbagin 91.4%, pentagalloyl ${\beta}-D-glucose$ 46.6%, 2,4-dihydroxybenzoic acid 40.9%, shikonin 37.7%, 1,2-naphthoquinone 36.6%, trans-cinnamic acid 32.0%, acetonyl geraniin 30.2%, benzoic acid 28.5%, geraniin 28.3% and 2,5-dihydroxybenzoic acid 22.3%, respectively. $IC_{50}$ values of 1,4-naphthoquinone and plumbagin was $2.1{\mu}g/ml$ and $5.8{\mu}g/ml$, respectively.

• Journal of Life Science
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• v.30 no.4
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• pp.379-385
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• 2020

Phlojodicarpus sibiricus and Artemisia kruhsiana Besser are medicinal plants traditionally used in Russia. Phlojodicarpus sibiricus extracts (PSE) have been shown to have anti-obesity properties, and Artemisia kruhsiana Besser extracts (AKBE) contain terpenoid compounds that exert various medicinal effects. Here, we investigated the potential pro-apoptotic effects of PSE and AKBE in diffuse large B-cell lymphoma (DLBCL) and elucidated the underlying mechanism. PSE and AKBE treatment of six DLBCL cell lines with various genetic abnormalities effectively reduced cell viability in a dose-dependent manner, while having a minimal impact on the survival of normal murine bone marrow cells and splenocytes. This suggests that the cytotoxic effects of PSE and AKBE are specific to DLBCL cells. Therefore, we expect limited side effects when these plant extracts are administered to DLBCL patients. Our JC-1 assays demonstrate that the pro-apoptotic effects of these plant extracts are produced by a reduction of anti-apoptotic Bcl-2 family members and, thereby, disruption of the mitochondrial membrane potential. Moreover, PSE and AKBE induce cell death independently of Myc, whose abnormalities are frequently observed in patients with DLBCL and are associated with poor prognosis. Our findings reveal hitherto uncharacterized pro-apoptotic effects of PSE and AKBE in DLBCL. Isolation of single compounds with anti-lymphoma activities should be pursued further.

• Journal of Chest Surgery
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• v.41 no.2
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• pp.253-259
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• 2008

Background: The incidence of cervical esophageal cancer is low compared with that of thoracic esophageal cancer, and the role of surgery for cervical esophageal cancer is limited compared with that of radiotherapy or chemotherapy. This study was carried out to determine the outcome of surgery for cervical esophageal cancer. Material and Method: We analyzed retrospectively medical records of 43 patients who had undergone curative surgical resection for cervical esophageal cancer from January 1989 to December 2002. Follow-up loss was absent and the last follow-up was carried out in February 28, 2004. Result: The mean age was 60 years old and the male to female ratio was 40:3. Histologic types were squamous cell carcinoma 42 patients and malignant melanoma 1 patient. The methods used for esophageal reconstruction were gastric pull-up 32 patients, free jejunal graft 7 patients and colon interposition 4 patients. Postoperative complications occurred in 31 patients (72%), and operative mortality occurred in 7 patients (16%). Pathologic stages were I 3, IIa 14, IIb 1, III 19, and IVa 6 patients. Tumor recurrence occurred in 16 patients (44%), and the 3 and 5-year survival rates were 29.3% and 20.9%. Conclusion: The reported surgical results for cervical esophageal cancer showed somewhat high operative mortality, postoperative complication rates and recurrence rates and a low long-term survival rate. It is suggested that multimodality treatment including surgery is needed for the treatment of cervical esophageal cancer because radiotherapy or chemotherapy without surgery could not relieve dysphagia or resolve the tumor completely.

• Journal of the Korean Society for Marine Environment & Energy
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• v.10 no.1
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• pp.13-20
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• 2007

This study was performed to provide fundamental data for long-term geomorphic predictions of estuarine sandbars in the Nakdong River. We monitored the geomorphic changes of Jinudo (Jinu Island), which is located on the far-southern side of the first western sandbar. We evaluated the temporal and spatial dynamics of the sandbar and the relationship between erosion and deposit speed with environmental factors. We found that: 1) The south side of Jinudo showed very rapid water channel closing and shoal generation. This phenomenon was more obvious during autumn (September and October) than during spring, with greater water depth reduction and variation between sides. 2) The mean deposit speed for Jinudo was approximately 0.85 mm/day. The deposit speed was 1.32 and 1.26 mm/day for the east and south sides of Jinudo, respectively. The maximum deposit and erosion speeds were 27 mm/day and 26 mm/day in July and December, respectively, on the east side of the island. 3) Mean surface deposit size was 0.18-0.26 mm. The newly deposited sandbar had a rotatively larger deposit size than the original land. 4) Correlation analysis showed that, on the southern side of the island, deposit activity prevailed in the winter due to low precipitation and a northerly wind, while erosion was dominant in the summer due to high water flow and a southerly wind. In contrast, the correlation analysis for the eastern side of the island showed that deposition is dominant when water flow is high. These results indicate that geomorphic dynamics vary among island sides.

• Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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• 2004.03a
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• pp.599-605
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• 2004

기존의 구축된 GIS 컴포넌트 혹은 개발 중이거나 향후개발을 목표로 설계단계에 있는 컴포넌트들의 최종 목표는 재사용성과 상호운용성의 가능성 여부이다. 하지만 컴포넌트 개발에 있어 시스템 개발환경의 다양성으로 인하여 그 재활용성은 생각만큼 쉬운 작업이 아니며, 특히 공간정보를 다루고 있는 GIS(Geographic Information System)분야에서의 GIS 컴포넌트 재활용은 전 세계의 산재한 각 데이터형의 포맷, 개발 환경, 운영환경을 고려하여 볼 때 시급한 일임에도 불구하고 그에 대한 노력이 상당히 미진한 실 정 이 다. 본 논문에서는 GIS 애플리케이션을 보다 효율적이고 유용하게 개발하기 위하여 GIS 컴포넌트의 개발과 관리에 이르는 전 과정을 관리 감독할 수 있는 COGIS(Component Oriented Geographic Information System)을 제안하고, COGIS 프로세스의 가이드라인이며 GIS 컴포넌트의 기능적인 면을 정의하기 위한 GCA(GIS based Component Architecture) 아키텍처를 제안하였다. 아울러 GIS 컴포넌트의 메타데이터를 분류 및 정의하여 GIS 컴포넌트의 비 기능적면을 제시하고 이를 이용하여 웹 기반 GIS 컴포넌트 등록/검색 에이전트 시스템을 개발하였으며 기존 GIS 컴포넌트 재사용 및 확장, 신규 컴포넌트의 등록, 검색이 가능하도록 한다. 사례연구로 웹 상에서 산불 발생 위험지수 표출을 위한 GIS 공간 분포도 작성이 쉽게 이루어지도록 2FDRV.avx와 2FDRC.exe 컴포넌트를 개발하였으며, COGIS 프로세스의 컴포넌트 관리방법을 통하여 여러 관련 컴포넌트를 조합함으로써 웹 기반 산불위험지수예보시스템을 구축하였다.입력 근거의 확보’, ‘갱신주체별 역할의 정의 및 유지관리 기준의 설정’, ‘분야별업무 특성을 고려한 관련 기준의 마련 및 타 시스템과 연계되는 항목을 고려한 절차 정의’ 등에 대한 다양한 접근을 시도하였다. 본 연구에서 제시하는 유지관리 모델을 기반으로 각 지자체별로 적절한 컨설팅이 진행되고 이에 따라 담당자의 실천이 이루어진다면 지자체 GIS의 투자대비 효과에 대한 기대는 이상이 아닌 현실로 다가오게 될 것이다.가오게 될 것이다. 동일하게 25%의 소유권을 가지고 있다. ？스굴 시추사업은 2008년까지 수행될 계획이며, 시추작업은 2005년까지 완료될 계획이다. 연구 진행과 관련하여, 공동연구의 명분을 높이고 분석의 효율성을 높이기 위해서 시료채취 및 기초자료 획득은 4개국의 연구원이 모여 공동으로 수행한 후의 결과물을 서로 공유하고, 자세한 전문분야 연구는 각 국의 대표기관이 독립적으로 수행하는 방식을 택하였다 ？스굴에 대한 제1차 시추작업은 2004년 3월 말에 실시하였다. 시추작업 결과, 약 80m의 시추 코아가 성공적으로 회수되어 현재 러시아 이르쿠츠크 지구화학연구소에 보관중이다. 이 시추코아는 2004년 8월 중순경에 4개국 연구팀원들에 의해 공동으로 기재된 후에 분할될 계획이다. 분할된 시료는 국내로 운반되어 다양한 전문분야별 연구에 이용될 것이다. 한편, 제2차 시추작업은 2004년 12월에서 2005년 2월 사이에 실시될 계획이다. 수백만년에 이르는 장기간에 걸쳐 지구환경변화 기록이 보존되어 있는 ？스굴호에 대한 시추사업은 후기 신생대 동안 유라시아 대륙 중부에서 일어난 지구환경 및 기후변화를 이해함과 동시에 이러한 변화가 육상생태계 및 지표지질환경에 미친 영향을 이해하는데 크게 기여할 것이다.

• Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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• 2004.03a
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• pp.389-397
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• 2004

본 연구는 GIS를 이용하여 아파트 단지의 UHF대역의 전파장애에 대한 예측모델을 제시한다. 전파예측모델은 기지국 및 중계기 위치설계와 전파음영지역 결정 등 무선네트워크 서비스에 결정적으로 활용된다 기존의 전파예측모델은 한국지형요소나 3차원 공간기술이 반영되지 않고 외국지형기반의 2차원적인 접근으로 개발되어 있다. 특히 많은 사람이 거주하는 아파트단지에 대해서는 고려가 되어 있지 않은 실정이며, 마치 아파트 단지가 일반 건물로 취급되어 전파환경 요소로 분류되지 않은 상태이다. 그리고 전파관리자가 기존 전파 예측모델을 이용한 무선네트워크 설계 및 운용등에 있어 정확한 의사결정지원에 어려움이 많다. 본 연구는 이러한 한계와 문제점을 해결하기 위해서 아파트 단지의 전파에 대한 영향을 3차원 공간밀집, 건물높이, 전파의 전송방향에 대한 건물배치등 3가지 요소로 분류하고 GIS 도구로 그 요소들을 분석하였다. 그 결과로 상관과 회귀분석등 정량적인 방법으로 평가하여 아파트 전파예측모델(GARP)을 개발하여 다음의 결과를 얻었다. 첫째, 아파트 단지가 UHF 대역의 전파에 대한 영향은 전파진행방향성이 57%, 공간밀집이 30%, 건물높이가 13%의 순으로 나타났다. 둘째, 본 연구에서 개발된 아파트 모델은 기존 모델에 비해 평균 6.3dBm, 최소 2.15 ～ 최대 12.48dBm의 개선 효과가 있다. 셋째, 급속히 확산되는 도시 개발에 3차원 공간상에서 전파예측모델을 시뮬레이션하여 전파의 영향을 예측할 수 있으며, 대단지 아파트 건설과 전파환경영향평가의 기초정보 수집에 활용될 수 있다. 본 연구는 GARP모델과 GIS 가시권 분석기능을 이용하여 실제 지형공간상에서 전파경로 손실치를 도시화함으로써 전파관리자가 무선서비스지역 설계, 전파음영지역 판단, 최적 중계기와 기지국 위치 선정에 기여할 것으로 판단된다.하지 않은 지역과 서로 다른 분광특성을 나타내므로 별도의 Segment를 형성하게 된다. 따라서 임상도의 경계선으로부터 획득된 Super-Object의 분광반사 값과 그 안에서 형성된 Sub-Object의 분광반사값의 차이를 이용하여 임상도의 갱신을 위한 변화지역을 탐지하였다.라서 획득한 시추코아에 대해서도 각 연구기관이 전 구간에 대해 동일하게 25%의 소유권을 가지고 있다. ？스굴 시추사업은 2008년까지 수행될 계획이며, 시추작업은 2005년까지 완료될 계획이다. 연구 진행과 관련하여, 공동연구의 명분을 높이고 분석의 효율성을 높이기 위해서 시료채취 및 기초자료 획득은 4개국의 연구원이 모여 공동으로 수행한 후의 결과물을 서로 공유하고, 자세한 전문분야 연구는 각 국의 대표기관이 독립적으로 수행하는 방식을 택하였다 ？스굴에 대한 제1차 시추작업은 2004년 3월 말에 실시하였다. 시추작업 결과, 약 80m의 시추 코아가 성공적으로 회수되어 현재 러시아 이르쿠츠크 지구화학연구소에 보관중이다. 이 시추코아는 2004년 8월 중순경에 4개국 연구팀원들에 의해 공동으로 기재된 후에 분할될 계획이다. 분할된 시료는 국내로 운반되어 다양한 전문분야별 연구에 이용될 것이다. 한편, 제2차 시추작업은 2004년 12월에서 2005년 2월 사이에 실시될 계획이다. 수백만년에 이르는 장기간에 걸쳐 지구환경변화 기록이 보존되어 있는 ？스굴호에 대한 시추사업은 후기 신생대 동안 유라시아 대륙 중부에서 일어난 지구환경 및 기후변화를 이해함과 동시에 이러한 변화가 육상생태계 및 지표지질환경에 미친 영향을 이해하는데 크게 기여할 것이다.lieve in safety with Radioactivity wastes control for harmony with Environment.d by the experiments under vari

• Journal of Yeungnam Medical Science
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• v.2 no.1
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• pp.191-202
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• 1985

As the result of a significant improvement in the economic situation and development of scientific techniques in Korea during the last 20 years, the life expectancy of the Korean people has lengthened considerably and as a result the number of old aged people has markedly increased. Such an increase of the number of aged people brought about many problems. Authors would like to take a medical look at the "Problem of old aged people" presently facing us in Korea. Currently the number of people over 65 has increased rapidly and is 1,620,000, 4% of total population. But it is still much lower than 8.9% in Japan, 10.7% in U.S.A., and 14.9% in the United Kingdom. Over 25% of these aged people were found to have at least more than one disease which requires medical care. Diseases occur in the circulatory system, 30.9%, respiratory system, 17.1%, digestive system 8.6%, mental disorders, 8.4%, malignant neoplasms, 7.0%. About 51% of the aged over 65 are under medical security benefit, mostly with partial coverage plan. Their clinic visit rate was very low (2.0% in 1981), which might be due to financial reasons. Since diseases affecting the aged progress chronically, early detection and long term care are utter most important. However there is almost no special facility, long term care center or geriatric specialist. For proper management of medical problems in the growing population of the Korean eldery expansion of medical security coverage, greater number of specialized facilities, education of geriatric special manpower and efficient operating system should be established.