• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
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• pp.75-75
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• 1993

The general pharmacological profiles of SKI 2053R were investigeted on the central nervous system, autonomic nervous system, respiratory-cardiovascular system, digestive system and other systems. SKI 2053R had no significant pharmacological effects. Pharmacokinetic studies on time-course of blood levels, tissue distribution and excretion of SKI 20S3R were performed in rats and beagle dogs after intravenous administration of $^{14}$ C-labeled SKI 2053R. The blood level of radioactivity decreased in bi-or tri-exponential manners: rapidly decreased at $\alpha$-phase but slowly decreased at $\beta$-or ${\gamma}$-phase. $^{14}$ C SKI 2053R was well distributed to all tissues except central nervous system. Tissue concentration profiles of radioactivity were almost consistent wi th those of blood, but higher than those of plasma from 1 to 168 hrs after administration. Also, these results were consistent wi th those of whole body ARG study. The urinary and fecal excretions of radioactivity within 168 hr after administration were 84-87 and 9-11 ％ of total radioactivity of $^{14}$ C-SKI 2053R administered. In lactating rats, the levels of radioactivity in the milk were significantly lower than that in the blood, but slightly higher than that in the plasma. The disapperance of the radioactivity from the milk was similar as that in the plasma.

• 디지털융복합연구
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• 제11권1호
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• pp.237-242
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• 2013

최근 페이스북(Facebook)과 트위터(Twitter) 등의 폭발적인 성장에 따라 SNS는 사회적 학문적인 관심의 대상으로 부상하고 있다. 그러나, SNS는 이용자의 신상 정보와 사적인 의견 교환을 근간으로 사용자의 프라이버시가 노출될 수 있는 문제가 존재한다. 본 논문에서는 현재 SNS에서 이용자의 개인 프라이버시를 보호하기 위해 사용되고 있는 블록킹 대신 데이터 분리와 데이터 허위 정보를 이용한 SNS 사용자 프라이버시 보호 모델을 제안한다. 제안 모델은 사용자의 내용 정보를 분리하여 분리된 내용 정보에 허위 정보를 추가함으로써 제3자가 사용자의 내용 정보를 수집하여도 정확한 정보를 추출하지 못하도록 하고 있다. 또한, 제3자가 이용자의 정보를 불법적으로 악용하지 않도록 SNS 서비스 제공자가 이용자의 정보를 활용할 경우 이용자에게 사전에 동의를 구한다.

• 한국콘텐츠학회논문지
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• 제11권12호
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• pp.273-283
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• 2011

최근 몇 년간 성폭력범죄는 우리의 머릿속에서 크게 인식되어 일반시민의 범죄 두려움은 크게 증가하였다. 이러한 성폭력범죄의 경우 다른 폭력범죄와 달리 암수성이 강하며, 이와 동시에 범죄자의 재범률이 매우 높은 특징을 가지고 있다. 우리나라의 성폭력범죄자 실태를 살펴보면, 성폭력범죄에서 가장 많은 비중을 차지하고 있는 강간의 경우 2009년도에 발생한 강간범죄 중 약 62%가 범죄경력이 있는 자들로서, 범죄경력자 들에 의한 범죄가 많이 발생하였으며 범죄경력자에 의한 피해가 심각한 사회문제로 대두되고 있다. 따라서 본 연구에서는 이렇게 심각한 사회문제를 발생시키는 성폭력범죄에 대한 대책방안으로 법무부, 여성가족부에서 실시하는 사전예방적 성범죄자 예방을 위한 활동과 재범방지를 위한 활동에 대해서 살펴보고 경찰의 우범자관리 및 성범죄 전력자 신상정보 등록대상자 1:1 담당 경찰관 운영 제도, 그리고 외국의 성범죄 전력자에 대한 관리제도를 살펴보았다. 이를 바탕으로 우리 경찰의 법적, 제도적, 실무상의 어려움을 제시하였으며 해결방안으로서 매뉴얼 제작, 관련법 개정, 전문 경찰관교육 등과 같은 해결방안을 제시하였다.

• Journal of Pharmaceutical Investigation
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• 제18권2호
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• pp.55-59
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• 1988

The size of furosemide was reduced by the recrystallization method in order to increase the dissolution rate of the drug. Surfactants or hydrophilic polymers were used to suppress the aggregation in the crystal formation-growth process of microparticles by dispersing action. Dissolution rate of microparticles increased remarkably due to the size reduction of microparticle. The particle size decreased with increasing the concentration of the drug and the dispersing agents, i.e., surfactants or hydrophilic polymers. No polymorphic transition occurred during the microcrystallization process, but the habit of crystal formation was altered in the case of anionic surfactant.

• 생약학회지
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• 제15권3호
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• pp.147-149
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• 1984

To examine pollen preparations which are being sold as a health food, one of these pollen tablets and one of the capsules were selected and investigated by microscopy. It was shown that the pollen coat which can act as a potent allergen was not removed and that the tablets contained other impurities. The results suggest that they are not safe as a food and that they may cause systemic allergy to certain persons. On the contrary, the pollens of the capsule preparation did not have the pollen coat and, therefore, have a less risk of causing allergy.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 추계학술대회 논문집 학회본부 C
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• pp.1164-1166
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• 1999

본 연구에서는 3차원 회전체 구조물을 제조하기 위해 회전노광장치를 설계하여 제작하고 마이크로렌즈 제작용 X-선 마스크와 PMMA 기판을 정밀하게 회전시켜 노광함으로써 3차원의 마이크로렌즈를 제작하였다. 제작된 마이크로렌즈의 크기는 직경이 $50{\sim}700{\mu}m$이었고, 또한 이러한 방법으로 원통형 렌즈, 계란형 렌즈 등을 제작함으로써 X-선 사진식각공정으로 정밀도가 높은 다양한 3차원의 회전체 구조물을 제조하는 방법을 제시하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 추계학술대회 논문집 학회본부 C
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• pp.1157-1159
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• 1999

A new method was developed to fabricate 1-3 piezo composite, a part of ultrasonic transducer. PZT rod arrays were made by pressing PZT green sheet with LIGA mold, and were sintered. Its dielectric constant and electro-mechanical coupling coefficient showed 4000 and 55% at 1kHz, respectively. So, PZT rod arrays made by means of this process can be applied to ultrasonic transducer.

• Journal of Pharmaceutical Investigation
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• 제19권1호
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• pp.29-37
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• 1989

For the prevention of the aggregation during microencapsulation, the effects and role of polyisobutylene(PIB), as a protective colloid, were studied. The effects of sealant treatment on the microencapsulation were studied. Methyldopa was microencapsulated with ethylcellulose (EC) by polymer deposition from cyclohexane by temperature change using PIB. The EC-microencapsulated methyldopa was sealed with spermaceti. The dissolution of methyldopa was influenced by the drug to wall ratio. When PIB was used, low aggregation of microcapsules occurred and the surface was smooth with a few pores. Treatment of microcapsules with spermaceti retarded the release of methyldopa, the release being affected by the percentage of sealant used and the particle size of the product.

• 약학회지
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• 제28권3호
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• pp.169-177
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• 1984

Release characteristics of salicylic acid from ethylcellulose(EC) films containing varying ratio of dieththylphthalate (DEP) were studied. Mathematical analysis of the release data showed that the release behavior actually conforms with the Higuchi's diffusion-controlled model. The release rate constants(k) were independent from the film thickness and the pH of release medium, but were proportional to the concentration of salicylic acid itself. The logarithm of the release rate constant (log k) increased as the concentration of DEP was increased. In conclusion, hydrophobic plastisizer DEP seemed to be very useful in controlling release rate constant of slightly soluble drugs as like salicylic acid without changing it's release characteristics.

• 약학회지
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• 제51권3호
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• pp.186-193
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• 2007

This study was performed to analyse the economic value of abciximab which is used in PCI to prevent high-risk patients with ischemic complications. The effectiveness of abciximab was extracted from published clinical trials by search-ing CCIS, and the direct medical costs relevant to using abciximab were estimated from the NHI claims database. The results in terms of cost per life-year gained (LYG) and cost per QALY gained showed that abciximab was cost-effective enough to deserve its cost. Social net benefit resulting from abciximab in PCI was estimated to be 60-70 billion Won per year.