Enhancement of Dissolution Properties of Poorly Soluble Drugs(IV) -Micronization of Furosemide by Recrystallization Method-

난용성 약물의 용출 증가(제4보) -재결정법에 의한 푸로세미드의 미세화-

The size of furosemide was reduced by the recrystallization method in order to increase the dissolution rate of the drug. Surfactants or hydrophilic polymers were used to suppress the aggregation in the crystal formation-growth process of microparticles by dispersing action. Dissolution rate of microparticles increased remarkably due to the size reduction of microparticle. The particle size decreased with increasing the concentration of the drug and the dispersing agents, i.e., surfactants or hydrophilic polymers. No polymorphic transition occurred during the microcrystallization process, but the habit of crystal formation was altered in the case of anionic surfactant.