• Analytical Science and Technology
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• v.22 no.1
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• pp.101-108
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• 2009

The bioequivalence of two pioglitazone tablets, Actos$^{(R)}$ tablet (Takeda Chemical Industries, reference drug) and Pioglitazone tablet (Boryung Company, test drug) was evaluated according to the guidelines of Korea Food and Drug Administration. Twenty-eight healthy male Korean volunteers received each medicine (pioglitazone dose of 30 mg) in a $2{\times}2$ crossover study with one week washout interval. After drug administration, blood samples were collected at specific time intervals from 0-36 hours. The plasma concentrations of pioglitazone were determined by high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). The total chromatographic run time was 5 min and calibration curves were linear over the concentration range of 5-2000 ng/mL for pioglitazone. The method was validated for selectivity, sensitivity, linearity, accuracy and precision. The pharmacokinetic parameters were determined from the plasma concentration-time profiles of both formulations. The primary calculated pharmacokinetic parameters were compared statistically to evaluate bioequivalence between the two preparations. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Pioglitazone tablet and Actos$^{(R)}$ tablet were log0.9422~log1.1040 and log0.9200~log1.1556, respectively. Based on the statistical considerations, we can conclude that the test drug, Pioglitazone tablet was bioequivalent to the reference drug, Actos$^{(R)}$ tablet.

• The Journal of the Convergence on Culture Technology
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• v.9 no.3
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• pp.415-423
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• 2023

The purpose of this study was to prepare basic data for improving school library information service by investigating the information usage behavior of specialized high school students. Preferred information sources for each situation requiring information and the level of solving information problems using information sources were investigated, and difference analysis was conducted by department and grade. As a result of the survey, the percentage of students who preferred Internet portal services, personal information sources (teachers, friends, parents), and social media was high, while the percentage of students who preferred traditional print information sources and mass media was very low. The average score of the information problem solving level was 3.55, and the problem solving level in the areas of employment and career/admission was relatively low. Preferred sources of information were similar regardless of grade and department, and the difference between departments in information problem solving level was not statistically significant, but the difference between grades was statistically significant. In addition, there is an academic contribution in this field that specific examples of youth information use behavior have been added. Based on the results of the study, librarians should make efforts to verify the reliability of Internet portal site information, improve and promote library information sources, and expand library use education. In future studies, it was suggested to develop customized information services.

• Journal of Korea Water Resources Association
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• v.55 no.4
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• pp.257-266
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• 2022

Inundation damage is increasing every year due to localized heavy rain and an increase of rainfall exceeding the design frequency. Accordingly, the importance of hydraulic structures for flood control and defense is also increasing. The hydraulic structures are designed according to its purpose and performance, and the amount of flood is an important calculation factor. However, in Korea, design rainfall is used as input data for hydrological analysis for the design of hydraulic structures due to the lack of sufficient data and the lack of reliability of observation data. Accurate probability rainfall and its temporal distribution are important factors to estimate the design rainfall. In practice, the regression equation of temporal distribution for the design rainfall is calculated using the cumulative rainfall percentage of Huff's quartile method. In addition, the 6^th order polynomial regression equation which shows high overall accuracy, is uniformly used. In this study, the optimized regression equation of temporal distribution is derived using the variable selection method according to the principle of parsimony in statistical modeling. The derived regression equation of temporal distribution is verified through the significance test. As a result of this study, it is most appropriate to derive the regression equation of temporal distribution using the stepwise selection method, which has the advantages of both forward selection and backward elimination.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.2C
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• pp.109-120
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• 2006

SPT-Uphole test is a seismic field test using receivers on ground surface and a SPT (Standard penetration test) source in depth. Even though this method is simple and economic, it makes hesitate to apply in real field that it is difficult to obtain reliable travel time information of shear wave because of the characteristics of SPT impact source. To overcome this shortcoming, in this paper, modified SPT-Uphole method using two component surface geophones was suggested. Numerical analysis was performed using finite element method for understanding the characteristics of surface motion induced by in-depth vertical source, and comparison study of the various methods which determine the travel time information in SPT-Uphole method was performed. In result, it is thought that the most reasonable method is using the first local maximum point of the root mean square value signals of vertical and horizontal component in time domain. Finally, modified SPT-Uphole method using two component surface geophones was performed at the site, and the applicability in field was verified by comparing wave velocity profiles determined by the SPT-Uphole method with the profiles determined by SASW method and SPT-N values.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.6A
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• pp.977-988
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• 2006

The goal of this study is to develop a realistic methodology for determination of the Life-Cycle Cost (LCC)-effective optimal seismic retrofit and maintenance strategy of deteriorating bridges. The proposed methodology is based on the concept of minimum LCC which is expressed as the sum of present value of seismic retrofit costs, expected maintenance costs, and expected economic losses with the constraints such as design requirements and acceptable risk of death. The proposed methodology is applied to the LCC-effective optimal seismic retrofit and maintenance strategy of a steel bridge considered as a example bridge in the accompanying study, and various conditions such as corrosion environments and Average Daily Traffic Volumes (ADTVs) are considered to investigate the effects on total expected LCC. In addition, to verify the validity of the developed methodology, the results are compared with the existing methodology. From the numerical investigation, it may be positively expected that the proposed methodology can be effectively utilized as a practical tool for the decision-making of LCC-effective optimal seismic retrofit and maintenance strategy of deteriorating bridges.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.6B
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• pp.579-587
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• 2010

The mid-range streamflow forecast was performed using NWP(Numerical Weather Prediction) provided by KMA. The NWP consists of RDAPS for 48-hour forecast and GDAPS for 240-hour forecast. To enhance the accuracy of the NWP, QPM to downscale the original NWP and Quantile Mapping to adjust the systematic biases were applied to the original NWP output. The applicability of the suggested streamflow prediction system which was verified in Geum River basin. In the system, the streamflow simulation was computed through the long-term continuous SSARR model with the rainfall prediction input transform to the format required by SSARR. The RQPM of the 2-day rainfall prediction results for the period of Jan. 1~Jun. 20, 2006, showed reasonable predictability that the total RQPM precipitation amounts to 89.7% of the observed precipitation. The streamflow forecast associated with 2-day RQPM followed the observed hydrograph pattern with high accuracy even though there occurred missing forecast and false alarm in some rainfall events. However, predictability decrease in downstream station, e.g. Gyuam was found because of the difficulties in parameter calibration of rainfall-runoff model for controlled streamflow and reliability deduction of rating curve at gauge station with large cross section area. The 10-day precipitation prediction using GQPM shows significantly underestimation for the peak and total amounts, which affects streamflow prediction clearly. The improvement of GDAPS forecast using post-processing seems to have limitation and there needs efforts of stabilization or reform for the original NWP.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.3D
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• pp.373-379
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• 2009

Cost estimation in the early phase enables government to plan public budgeting more efficiently by providing information about construction cost. However, cost estimation in the early phase is difficult to predict because only a little information can be utilized. The cost estimation method now being used by the government is calculated by length of the road multiplied by unit cost per length and shows high error rate because it cannot reflect the unique characteristics of each project. As the project is being proceeded, level of available information also changed. So, reflecting available information of a project is important. This paper divided early phase into two parts : planning phase and early design phase, and developed cost estimation model considering level of available information of each phase. Total 143 cases are utilized to find influencing variables and develop cost estimation model and model validation is done by adopting required accuracy level. This cost estimation model reflecting level of available information can be applied to public budgeting, feasibility test, and comparison between routes.

• 한국노년학
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• v.30 no.3
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• pp.815-830
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• 2010

This study is a nonequivalent control group pretest-posttest study to determine the effects of a make up program on the self-esteem and anxiety of the elderly female dementia patients. This research was done between April 13th and May 1st, 2009. The subjects were 41 dementia patients in an elderly hospital in Honam Area. Twenty dementia patients in the experimental group got the make up measures during the two week experimental period and twenty one dementia patients in the contrast group didn't get any measure during the two week period. Make up measures were given to the experimental group 10 times for the two week period. This study used the self-esteemscale which was developed by Rosenberg(1965) and was translated and modified by Jeon Pyung Je(1974) into Korean. The anxiety status scale which this study used was developed by Spielberger(1970) and was translated and modified by Kim Jeong Taek(1991) into Korean. Collected data were analyzed with SPSS Win 12.0. T-test and multivariate analysis were done to test the hypothesis. This study also used a method of observation. The results of this study are following. After the two week make up measures, the experimental group had more self esteem and less anxiety status than the contrast group. The differences were statistically significant. The result of the observation also supported the research hypothesis. Based on this result, we suggest the make up program as an appropriate and useful nursing care intervention program for female dementia patients.

• The Journal of the Korea Contents Association
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• v.22 no.8
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• pp.258-273
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• 2022

This study examines the effect of SNS tourism value (economic, social) and social capital (bonding, bridging) on SNS tourism satisfaction using SNS and the effect of SNS tourism satisfaction on reuse intention. In addition, in the relationship between SNS tourism satisfaction and reuse intention, a future-oriented time perspective variable was applied to investigate the moderating effect. We verified 326 people who had accommodation tourism experience using SNS. SPSS 25.0 and Smart PLS 3.0 were used to analyze reliability and validity. The study results are as follows. First, economic and social values had a positive effect on satisfaction. Second, it was found that bridging social capital had a positive effect on satisfaction, but bonding social capital had no effect. Third, satisfaction was confirmed to have a positive effect on reuse intention. Fourth, in the relationship between satisfaction and reuse intention, the future-oriented time perspective was found to have a significant moderating effect. The overall implications are presented through the research results, and it is expected that these will be used as basic data for the development plan of the tourism industry.

• 지역과문화
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• v.4 no.1
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• pp.1-26
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• 2017

The 21st century recognizes culture as a high value-added strategic industry as it is called the culture era, and the cultural industry plays a role in driving regional economic development by raising the value added of other industries due to various ripple effects. As the institutional apparatus for developing such cultural industry, the Culture Industry Promotion Basic Law was enacted. Based on this, the Central Government designated the Jung-gu Dong and Seo-gu Dong as the Cultural Industry Promotion District of Andong City in 2010 but it has not been activated until 2017. The purpose of this study is understanding the situation and problems of the Cultural Industry Promotion District of Andong city and to discuss the direction of development. The research methods were analyzed by using questionnaires using AHP analysis technique for experts and practitioners related to culture industry. SPSS 23 was used for the validity and reliability of the questionnaire, and VBA was used for weighting and consistency index calculation in AHP analysis. As a result in the upper layer, Economy efficiency was found to be the most important factor of the three upper layer factors (Economy, Publicity, and Sociality) in order to activate the Cultural Industry Promotion District of Andong city. In the case of the Lieutenant layer, it is analyzed that the Job Creation is an important factor in the Economy category, the Settlement and Environment for Cultural Industry in the Publicity category, and the Activation of Urban Culture Activity in the Sociality category. As a result of analyzing the direction of promotion of the Cultural Industry Promotion District of Andong City centered on these factors, it concluded that the industry related to performance should be focused.