• Clinical and Experimental Pediatrics
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• v.48 no.11
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• pp.1232-1238
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• 2005

Purpose : Though more than 15 years have passed after introduction of Lorenzo's oil therapy in X-linked adrenoleukodystrophy(ALD), its efficacy is still fully not known. In patients who already have neurologic symptoms, most reports indicate that the neurologic disability continues to increase. We evaluated its efficacy in X-linked ALD patients. Methods : Four patients who were treated with Lorenzo's oil for at least 12 months were enrolled from 1996 to 2003. During treatment, changes of neurologic symptoms, brain magnetic resonance imaging(MRI) findings, and serum saturated very long-chain fatty acid(C26:0) were assessed. Results : Two patients with childhood cerebral ALD had progression of neurologic symptoms and MRI lesions during treatment. One asymptomatic patient developed childhood cerebral ALD after six year treatment of Lorenzo's oil. One "Addison only" patient remained neurologically intact after three years. During Lorenzo's oil therapy, serum C26:0 levels which had increased at diagnosis decreased in all four patients. Conclusion : Treatment with Lorenzo's oil did not prevent disease progression in childhood cerebral ALD patients who were already symptomatic. Long term follow up will be needed in asymptomatic ALD including "Addison only" to reveal the efficacy of Lorenzo's oil.

• Proceedings of the Korean Information Science Society Conference
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• 1999.10b
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• pp.467-469
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• 1999

Independent component analysis (ICA)는 주어진 데이터를 통계적으로 독립인 요소들의 선형 결합으로 표시하는 통계학적 방법이다. ICA의 주요한 적용분야중의 하나는 source들의 선형 mixture로부터 어떠한 서전 정보도 없는 상태에서 원래의 통계학적 독립변수인 source를 복원하는 blind separation이다. ICA와 source separation을 위한 다양한 신경 학습 알고리듬이 제시되어왔다. ICA의 학습 알고리듬에서는 비선형 함수가 중요한 역할을 한다. 이 논문에서는 generalized 가우시안 prior를 도입하여 다양한 확률분포를 갖는 source들의 mixture를 분리하는 효율적인 source separation 알고리즘을 제시한다. 모의실험을 통하여 제안된 방법의 우수성을 살펴본다.

• Journal of Veterinary Clinics
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• v.27 no.4
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• pp.450-452
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• 2010

A 4-year-old male Yorkshire terrier was referred to us with signs of vomiting and unconsciousness due to a blunt head trauma. Gross examinations detected facial edema, subcutaneous hemorrhage and hypersalivation. A survey radiograph located an occipital fragment which was displaced caudally. A three-dimensional computed tomographic reconstruction demonstrated that the ventral portion of the fragment was attached incompletely. Because of the instability of the fragment, it was decided to perform an esquillectomy. After removing the fragment, the defect was reinforced with a muscular flap originating from the splenius muscle. The patient's condition gradually improved except for a slightly ataxic gait. At 20 months follow-up, there was no evidence of ataxia. The neurological status did not deteriorate before starting surgical intervention, although the patient sustained a skull fracture with severe intracranial hemorrhage. It is likely that the fragment being displaced outwardly played an important role in preventing an increase in intracranial pressure which could have led to neurological deterioration.

• Clinical and Experimental Pediatrics
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• v.50 no.9
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• pp.901-904
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• 2007

Purpose : Reversible posterior leukoencephalopathy syndrome is a complex disorder with characteristic clinical and radiologic findings that mainly involve the white/gray matter of the parieto-occipital lobes. The purpose of this study was to determine its clinical and radiological characteristics. Methods : A total of 15 pateints were involved in the study. Their medical records and radiological features of brain MRI were retrospectively reviewed and analyzed. Results : Fifteen pateints were involved. (9 males and 5 females). The patients' ages ranged from 2-20 years (mean age : 10 years). The brain MRI revealed fairly symmetric areas of increased T2 signal involving both white and gray matter of parieto-occipital regions. The condition seemed to be associated with cyclosporin A and steroid therapy or a variety of other conditions in which blood pressure rises acutely. Conclusion : Reversible posterior leukoencephalopathy syndrome is a complicated neurological condition, but a better understanding of this complex syndrome may obviate unnecessary investigations and lead to prompt and appropriate management of the associated problems.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.15 no.2
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• pp.115-122
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• 2004

It is difficult to think of any behavioral process that is more intrinsically important to human beings than social attachment. Feeding, sleeping and locomotion are all necessary for survival, but humans are 'a social animal' and it is our social attachment that we live for. One of the early pioneers in this area, Harry Harlow, described the different behavioral processes that are involved in the formation of parent-infant, filial and pair(male-female) bonds. Each of these involves multi-sensory processing and complex motor responses. Over the past decades, studies in a range of vertebrates, including humans, have begun to address the neural basis of attachment at a molecular, cellular and systemic level. This review describes some of important insights from these works, involving three different areas：1) Neurobiological research of infant-parent, parent-infant attachment, 2) Animal studies regarding attachment, 3) Neurobehavioral studies of maltreatment/deprivation causing serious breakdown of attachment relationship in humans.

• Applied Microscopy
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• v.42 no.1
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• pp.17-26
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• 2012

Histologic and microstructural changes during the postembryonic development of the wolf spider Arctosa kwangreungensis were studied using light and scanning electron microscopy to examine the relationship between a morphological differentiation and behavioral properties. The postembryo with abdominal yolk sac was stayed inactive in the egg case because its muscular and visual systems were not fully developed to a functional level. The first instar spiderlings, developed from the postembryo by a first molting process, started to exhibit its pigmentation on their body cuticles. In particular, undifferentiated cell clusters of central nervous system (CNS) were densely distributed within the cephalothorax, and highly differentiated abdominal ganglion was observed. They had a characteristic visual system looks more like its adult counterpart, and had segmented appendages looks more like the tiny spiders containing well oriented muscular system. After 3rd instar, spiderlings grew more rapidly with accordance to their consistent growth and periodical molting processes. Thus, the relative area of CNS with respect to cephalothorax was gradually decreased, instead a pair of venom glands, musculature, and connectives occupied the residual area. It has been revealed that the early development of spider can be controled by the feeding condition of larval period, since histologic and microstructural differentiations in both appendages and optic system were completed at the second instar. In particular, behavioral properties of the wandering spiders that depend on vision and their running ability were deeply related to physiological differentiation of the microstructural development.

• Applied Microscopy
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• v.35 no.3
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• pp.165-176
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• 2005

Studies on molecular plasticity of Bermann glia (BG) after harmaline-induced Purkinje cell (PC) degeneration in the rat cerebellum. The intimate structural relationship between BG and PC, evidenced by the sheathing of the PC dendrites by veil-like process from the BG has been suggestive of the close functional relationship between these two cell types. However, little is known about metabolic couplings between these cells. This study designed to investigate molecular plasticity of BG in the rat cerebellum in which PCs were chemically ablated by harmaline treatment. Immunohistochemical examination reveals that harmaline induced PC degeneration causes a marked glial reaction in the cerebellum with activated BG and microglia aligned in parasagittal stripes within the vermis. In these strips, activated BG were associated with upregulaion of metallotheionein, while GLAST and was down regulated, as compared with nearby intact area where both BG are in contact with PCs. The data from this study demonstrate that BG can change their phenotypic expression when BG loose their contact with PCs. It is conceivable that activated BG may upregulate structural proteins, metallothionein expression to use for their proliferation and hypertrophy; metallothionein expression to cope with oxidative stress induced by PC degeneration and microglial activation. On the contrary, BG may down regulated expression of GLAST because sustained loss of contact with PCs would eliminate the necessity for the cellular machinery involved glutamate metabolism. In conclusion, BG might respond man to death of PCs by undergoing a change in metabolic state. It seems possible that signaling molecules released from PCs regulates the phenotype expression of BG. Also ultrastructures in the organelles of normal PC and BG are distinguished by mitochondrial appearance, and distributed vesicles at the synaptic area in the cytoplasm.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1991.06a
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• pp.11-12
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• 1991

편측 성대마비의 음성개선을 위하여 현재까지 알려진 치료방법은 teflon 또는 silicone 주입술, 외과적 성대 내전술, 갑상연골 성형술, 신경재식술, 등이 있으며, 근래까지는 Teflon 또는 Gelform 주입술이 제일 효과적인 방법이라 알려져 있으나, 이는 음의 높낮이 조절능력의 한계가 있고, 신경재식술의 결과 역시 만족스럽지 못한 경우가 많다. 따라서 저자는 발성기능의 생리학적인 측면에서, 보다 효과적인 음성개선의 방법을 찾기 위하여, 사람의 후두와 비교적 유사한 특성을 가진 개를 사용하여 실험을 하였다. 반회신경을 절단하여 편측 성대 마비를 유발한 뒤, 동측의 유일한 외전근인 후윤상피열근을 절제후 절단된 신경을 문합하여, 성대의 외전근 작용의 소실과, 발성시에 주로 작용하는 내전근만의 작용을 유도하여, 공동운동의 차단과, 내전운동의 향상을 기대하였다. 본 실험에 앞서, 임의적으로 신경을 자극시킬 수 있는 신경자극기와, 주위조직으로부터 신경만을 분리하여 자극할 수 있는 전극을 개발하여 사용하였으며, 또한 성대의 발성음을 임의대로 유발시킬 수 있는 생체 내 후두발성 모형(in vivo laryngeal phonation model)을 Moore(1987, 1988)등이 발표한 모형을 토대로 자체 개발하여 사용하였다. 실험은 13마리의 개를, 반회신경 절단군(3 마리), 반회신경 절단 및 후윤상피 열근 절제군(3 마리), 후윤상피열근 절제군(3 마리), 반회신경 문합 및 후윤상피 열근 절제군(4 마리)등으로 나누어 실험하였으며, 3 개월 후, 현수후두경, 후두 내시경, videolaryngoscopy, 신경자극 검사 등으로 성대의 내전운동 및 위치 변화의 관찰, 발성음의 음향분석 및 갑상피열근의 형태학적 변화를 관찰하여 다음과 같은 결과를 얻었다. 1. 반회신경 절단군과 반회 신경 절단 및 후윤상피열근 절제군은, 수술후 3 개월에 성대의 움직임이나 각도의 변화가 없었으며, 음향분석 결과 발성음이 아닌 잡음만이 포착되었다. 즉, 절단된 신경의 문합 없이 후윤상피열근 절제 만으로는 음성개선은 기대할 수 없었다. 2. 후윤상피열근 절제군에서는 수술 후 3 개월에 정상적인 성대의 내전운동이 관찰되었으며, 음향분석상 기본주파수 동요율 및 발성음의 강도는 약간의 증가를 보였다. 즉, 반회신경이 절단되지 않은 상태에서 후윤상피 열근 만을 절제하면, 발성음의 변화는 거의 없었다. 3. 반회신경을 절단후 문합하고 후윤상피열근을 절제한군 에서는 수술후 3 개월에, 성대의 정상적인 내전운동을 보였고, 음향분석상 수술직후에는 잡음만이 포착되었으나, 3 개월 후에는 잡음이 아닌 발성음을 들을 수 있었으며, 이 발성음의 기본주파수 및 강도는 수술전보다 감소되어 있었으나, 기본주파수 동요율은 증가되어 있었다. 즉 이 술식으로 인한 뚜렷한 발성음의 향상이 있었다. 이상의 결과로 미루어, 편측 신경 절단으로 인한 성대마비시, 절단된 신경을 봉합하고 성대의 유일한 외전근인 후윤상피열근을 절제하면, 공동운동의 차단과, 내향운동의 향상으로, 음성개선에 효과적이라고 사료되었으며, 이 방법이 편측 성대마비 환자의 효과적인 음성개선의 치료방법의 하나로 응용될 수 있으리라 생각된다.

• Journal of the Korean Data and Information Science Society
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• v.24 no.1
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• pp.13-22
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• 2013

Smartphone addiction has become more serious than internet addiction since people can download and run numerous applications with smartphones even without internet connection. However, smartphone addiction is not sufficiently dealt with in current studies. The S-scale method developed by Korea National Information Society Agency involves so many questions that respondents are likely to avoid the diagnosis itself. Moreover, since S-scale is determined by the total score of responded items without taking into account of demographic variables, it is difficult to get an accurate result. Therefore, in this paper, we have extracted important factors from all data, which affect smartphone addiction, including demographic variables. Then we classified the selected items with a neural network. The result of a comparative analysis with backpropagation learning algorithm and multiclass support vector machine shows that learning rate is slightly higher in multiclass SVM. Since multiclass SVM suggested in this paper is highly adaptable to rapid changes of data, we expect that it will lead to a more accurate self-diagnosis of smartphone addiction.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.05a
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• pp.205-208
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• 2008

In numerical analysis numerical values of thermodynamic properties such as temperature, pressure, specific volume, enthalpy and entropy are required. But most of the thermodynamic properties of the steam table are determined by experiment. Therefore they are supposed to have measurement errors. In order to make noised thermodynamic properties corresponding to errors, random numbers are generated, adjusted to appropriate magnitudes and added to original thermodynamic properties. the neural networks and quadratic spline interpolation method are introduced for function approximation of these modified thermodynamic properties in the saturated water based on pressure. It was proved that the neural networks give smaller percentage error compared with quadratic spline interpolation. From this fact it was confirmed that the neural networks trace the original values of thermodynamic properties better than the quadratic interpolation method.