• Journal of Oral Medicine and Pain
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• v.36 no.3
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• pp.199-205
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• 2011

During root canal treatment, overinstrumentation with hand or mechanically driven files can perforate the mandibular canal, allowing the extrusion of endodontic sealers, dressing agents, and irrigant solutions out of the tooth and into the canal. The patient may report symptoms such as pain, hyperesthesia, hypoesthesia, anesthesia, dysesthesia and paresthesia. Such problems must be resolved as quickly as possible to avoid irreversible sequelae caused by certain neurotoxic materials that form part of endodontic sealants. Although there have been no controlled trials of treatment protocols involving endodontically related injuries to the inferior alveolar nerve, the normal therapeutic sequence for this complication is the control of pain and inflammation and, whenever possible, the surgical elimination of the cause. However, total resolution of pain and reduction in or disappearance of paraesthesia after a non-surgical management have been reported. Antiepileptic drugs such as gabapentin or pregabalin have been used for the treatment of neuropathic pain. This article describes a case of inferior alveolar nerve(IAN) damage after endodontic treatment of a mandibular right second molar and the treatment with non-surgical approach using prednisone and gabapentin medication, monitoring the patient's condition with clinical neurosensory examination and current perception threshold test(Neurometer).

• Korea and Global Affairs
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• v.3 no.2
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• pp.59-86
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• 2019

This study explores "4.27 Panmunjom Declaration" and "9.19 Pyongyang Declaration" for the peace and prosperity of the Korean Peninsula in terms of inter-Korean exchanges and scrutinizes the Declarations in conjunction with the New Economic Initiative of the Korean Peninsula. The leadership of President Moon Jae-in pursues the value of the "peaceful and prosperous Korean Peninsula" of which pre-requisite and requirement are exchanges and cooperation between South and North Koreas. The New Economic Initiative of the Korea Peninsula for economic prosperity proposed in the inter-Korean summit premises complete denuclearization in the Peninsula. It is accentuated that the Initiative provides a new tonic impetus to the Korean economy in recession, and simultaneously, shapes a necessary foundation for the economic development of North Korea. The Initiative with connotation of the two Korea's mutual opulence aims at proceeding to a new Korean Peninsular system. The new system implies the new peace-cooperative community where confrontation and discord are ceased, and the new economic-cooperative one where the age of ideological rivalry comes to an end. The two Koreas have to lead the new age of peaceful and prosperous Northeast Asia as a buffer zone of peace.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.239-239
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• 1994

신경쇠약의 치료로 상용하며, 빈혈의 치료와 예방의 효과가 있으며, 노화방지에 도움이 되어 민간약으로는 장수(長壽)약으로 꼽히고 있는 구기자가 글루타메이트에 의한 신경독성을 차단하며, 이러한 효과는 구기자의 성분 중 betaine에 의하여 나타난다. Betaine이 어떠한 작용 기전에 의하여 글루타메이트에 의한 신경독성을 차단하는 지를 밝히기 위하여 글루타메이트가 작용하는 각기 다른 수용체인 NHDA 및 non-NMDA 수용체에 어떻게 작용하는 지를 알아보았다. 각 수용체의 선택적인 효능제인 NMDA, kainate 및 quisqualate 각각을 사용하여 인위적으로 독성을 유도시킨 후 이에 대한 betaine의 작용을 알아 본 결과 betaine은 quisqualate에 의하여 유도된 신경독성에서 모두 유사한 정도의 효과를 나타내었다. 이러한 효과는 betaine과 구조가 유사한 glycine의 다른 구조 유사체인 dimethylglycine이나 sarcosine과는 다른 작용양상을 나타내는 것이다. Dimethylglycine과 sarcosine은 kainate에 의한 독성에 대하여 미약한 효과를 나타냈으나, NMDA에 의한 독성에는 정상대조군의 LDH 값의 50% 이상에까지 이르게하는 효과를 나타내는 것으로 보아 이들이 NMDA에 의한 신경독성을 효과적으로 차단한다는 것을 암시해 준다고 할 수 있다. 그러나 betaine의 글루타메이트에 의한 신경독성을 차단하는 효과는 다른 glycine 구조 유사체처럼 glycine과 경쟁적으로 작용하여 나타나는 결과는 아니라고 여겨진다. 또한 글루타메이트에 의한 신경독성이 일어나는 기전 중의 하나가 calcium 이온의 세포내의 과도한 유입으로 인한 것으로 알려져 있으나 세포내의 calcium 이온의 양을 측정하여 본 결과 betaine은 글루타메이트로 인한 세포내 calcium 이온의 증가에 대하여 별다른 효과를 나타내지 않았다. 따라서 betaine의 글루타메이트에 의한 신경독성 차단 효과는 이미 미생물에서 보고된 바 있는 betaine의 세포내 삼투압에 대한 보호작용이나 항산화작용과 관련된 기전에 의하여 나타나는 것일 가능성이 높은 것으로 추측되어진다.

• The Journal of Korean Orthopaedic Ultrasound Society
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• v.1 no.2
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• pp.128-133
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• 2008

Nerve compression is caused by external force or internal pathology, which symptom develops along nerve distribution. There are median, ulnar and radial nerve compression neuropathies below elbow. Carpal tunnel syndrome at the flexor retinaculum is most common among all the entrapment neuropathies. Other causes of median nerve neuropathy include Struther's ligament, biceps aponeurosis, pronator teres, FDS aponeurosis and aberrant muscles, which induce pronator syndrome or anterior interosseous nerve syndrome. Ulnar nerve can be compressed at the elbow by arcade of Struther, medial epicondylar groove, FCU two heads, which develops cubital tunnel syndrome, at the wrist by ganglion, fracture of hamate hook and vascular problem, which develops Guyon's canal syndrome. Radial tunnel syndrome is caused by supinator muscle, which compresses its deep branch. Treatment is conservative at initial stage like NSAID, night splint or steroid injection. If symptom persists, operative treatment should be considered after electrodiagnostic or imaging studies.

• The Journal of Korean Orthopaedic Ultrasound Society
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• v.5 no.2
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• pp.61-65
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• 2012

Purpose: The aim of this study was to evaluate the effectiveness of ultrasound-guide steroid injection according to Morton's neuroma size. Materials and Methods: From October 2008 to September 2011, 17 patients (23 cases) diagnosed with Morton's neuroma were investigated. All cases were female and mean age was 52.6 years old. Neuroma were measured by the horizontal and longitudinal length of the mass and underwent ultrasound-guided steroid (5 mg dexamethasone) injection. The efficacy of the injection was determined by Visual Analogue Scale pain score and patient satisfaction(subdivided 4 group-much improved, improved, not improved, aggrevation) Results: 7 of 23(30.4%) cases showed much improved and improved satisfaction and mean longitudinal and horizontal length were $0.71{\pm}0.39cm$ and $0.47{\pm}0.24cm$, respectively. 16 of 23(69.6%) cases showed not improved and aggrevation satisfaction and mean longitudinal and horizontal length were $0.83{\pm}0.42cm$ and $0.54{\pm}0.14cm$, repectively. There was a significant difference in VAS and patient satisfaction in case longitudinal and horizontal length were smaller than 0.5 cm and 0.4 cm. (p<0.05) Conclusion: The ultrasonography is a important modality in diagnosis and treatment of morton's neuroma. Ultrasound-guide steroid injection is effective in case longitudinal and horizontal length were smaller than 0.5 cm and 0.4 cm, respectively.

• Journal of Veterinary Clinics
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• v.25 no.4
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• pp.245-248
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• 2008

Herbal medicines are widely used to treat a variety of human diseases. However, therapeutic effect of herbal medicine on the canine facial nerve paralysis (FNP) has not been investigated. This study examined therapeutic effects of Oyaksungisan on the canine FNP. Ten dogs with the induced canine FNP were equally divided into the control and an herbal medicine-treated groups (5 dogs, Oyaksungisan-treated group), respectively. No treatment was given to the control group. In the Oyaksungisan-treated group, Oyaksungisan was administered orally, twice per day for 2 weeks (50 mg/kg) after inducing FNP. Significant differences in the clinical scores were detected between the Oyaksungisan-treated and control groups on day 14 (p < 0.05). The serum creatine kinase (CK) activities in the Oyaksungisan-treated group showed a tendency to decrease but there was no significant difference compared with those of the control group. In conclusion, Oyaksungisan was effective for the induced canine FNP.

• Clinical and Experimental Pediatrics
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• v.50 no.11
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• pp.1067-1071
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• 2007

Purpose : The aim of this study was to determine whether improved survival of extremely low birth weight infants (ELBWI) was associated with decreased neurodevelopmental disability later in life, and also to identify the factors influencing this disability. Methods : ELBWI admitted to the neonatal intensive care unit of Samsung Medical Center, survived, and followed up until the corrected age of 18 months were enrolled. They were divided into two groups according to admission time: period I (1994-1999, n=36) and period II (2000-2004, n=98). Clinical data were collected retrospectively from the medical records. Results : Survival rates increased from 60.0% to 74.7%, cerebral palsy rates decreased from 22.2% to 8.2% and catch-up growth rate increased from 25.0% to 51.0% during period I and II. Despite less gestational age and birth weight, ELBWI during period II had less periventricular leukomalacia (PVL), sepsis and bronchopulmonary dysplasia compared to period I. The highest risk factors for cerebral palsy were intraventricular hemorrhage (IVH) (${\geq}$Grade III), failure of catch-up growth and PVL. Conclusion : In summary, improved viability was associated with decreased neurodevelopmental disability in ELBWI. Improved neonatal care with resultant decrease in PVL and IVH, and better nutritional support seem to be primarily responsible for this improved outcome.

• Journal of the Korean Institute of Intelligent Systems
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• v.11 no.2
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• pp.109-114
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• 2001

본 논문에서는 비선형 제어시스템의 성능 개선을 위한 새로운 신경망 직접 적응제어 알고리즘을 제시하였다. 제어칙은 Gaussian RBF 신경망을 이용한 제어입력과 근사화 오차 및 외란의 영향을 제거하기 위한 보조제어 입력으로 구성하였다. 또한 신경망에 사용된 가중치와 보조입력의 파라미터를 조정하기 위한 적응칙은 Lyapunov 안정도 이론에 의하여 구하였다. 이렇게 함으로써 외란이나 근사화 오차에 관계없이 플랜트와 기준모델 사이의 오차가 0이 되도록 하는 알고리즘을 구할 수 있었다. 또한 제시된 알고리즘의 효용성을 알아보기 위하여 Duffing forced oscillation 시스템에 대하여 시뮬레이션 하여본 결과 만족할만한 성능을 얻을 수 있었다.

• The Transactions of the Korea Information Processing Society
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• v.5 no.12
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• pp.3265-3274
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• 1998

본 논문에서는 인간의 칼랄 인식 특성인 명도, 채도 및 색조의 관계를 학습시킨 신경회로망을 이용하여 열화된 영상의 채도 부분을 향상하는 칼라영상향상법으 제안하였다. 제안한 방법은 우선 표준영상으로부터 여러 단계 열화된 영상들로부터 얻은 다양한 명도, 채도 및 색조의 관계를 신경회로망의 입력으로 하고 표준영상의 채도를 목표차로 해서 신경회로망을 학습시킨다. 그리고 이렇게 학습된 신경회로망에 열화된 영상의 명도, 채도, 색조 그리고 향상시킨 명도를 입력하면 향상된 채도를 얻을 수 있는 칼라영상향상방법이다. 본 논문에서는 제안한 방법이 기존의 칼라영상향상법에서 가장 문제가 되었던 영상 향상 시 칼라범위를 초과하는 문제와 채도 향상비의 인위적 선택문제를 해결하고 채도의 대비를 향상시켜 선명한 영상을 얻을 수 있는 방법임을 밝혔다.

• Proceedings of the Korea Information Processing Society Conference
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• 2003.05a
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• pp.671-674
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• 2003

본 논문에서는 고차 신경망 (High-order Neural Network) 을 이용한 LCD 모니터의 색 보정 방법에 관해 제안하였다. 스캐너를 통해 입력받는 영상과 LCD 모니터상에 보여지는 영상의 색을 고차 신경회로망을 통해 보정하였다. 측색기를 이용하여 색표의 값을 측정하고 이를 신경회로망의 출력으로, LCD 모니터에 나타나는 값을 입력으로 하여 학습하였다 입력은 측정값들의 상관항으로 구성되는 집합을 구성하여 고차 신경회로망의 입력으로 사용하였다. 최적의 실험결과를 얻기 위해 은닉층의 수와 노드 수를 변경하며 실험하였다. 실험을 통해 고차 선경회로망을 이용한 방법으로 원색에 가깝게 보정 됨을 확인하였다.