• Applied Microscopy
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• v.29 no.1
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• pp.105-124
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• 1999

Histological and ultrastructural differentiations of the neuroepithelial cells in the mouse embryo during neurulation were observed. The neural plates and grooves consisted of pseudostratified columnar epithelium in the embryonic day (ED) 8 embryo were developed. In the ED 9 embryo, the neural tube was developed in all body length of embryo except both the cephalic and caudal ends. Secondary neurulation was shown at the tail bud of the ED 10 embryo. In the ED 8 embryo, the primitive streak was shown in the posterior end of the embryonic disc. The neuroepithelium, notochord and mesenchyme were well differentiated in the cephalic and cervical portions. In the ED 9 and 10 embryos, the roof plates of neural tubes were constituted of the closing of the surface ectodermal cells in the hindbrain and the neuroepithelial cells in the spinal cord. The floor plate of neural tube were consisted of the low pseudostratified columnar epithelium. The spinal motor nerve fibers were initially differentiated in the ED 10 embryo. According to the electron density of the cell and the differentiation of tell organelles, the neuroepithelial cells in the ED 9 and 10 embryos were classified into three types: dark, intermediate and light types. All types in the ED 9 embryo were observed but the dark cell in the ED 10 embryo was not done. The free ribosomes and polysomes in all neuroepithelial cells were developed. The RER and lipid droplets in the dark cell and the Golgi complex in the intermediate and light cells were observed. Many microfilaments in the cytoplasmic processes of intermediate cell and the microfilaments and microtubules in the light cell processes were observed to be well differentiated.

• Applied Microscopy
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• v.29 no.1
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• pp.57-66
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• 1999

The nervous tissue in the cerebral ganglion of Korean planaria was observed using electron microscope. The obtained results are as follows: A cerebral ganglion is composed of the nerve cells, neurosecretory cells, neuroglial cells and neuropils. The nerve cells are round or ovoidal-shaped cells (diameter, $5{\mu}m$), which has a large ellipsoidal nucleus containing the evenly developed heterochromatin. Their cytoplasms were found to be relatively simple, because of their undeveloped cell organelles. The neurosecretory cells are long and ellipsoid or spindle-shaped cells, where there were found a large ellipsoidal nucleus and cytoplasm filled with secretory granules (diameter, 60 nm). The neuroglial cells were seldom observed. They are spindle-shaped cells (size, $6\times0.8{\mu}m$), which were observed mainly among the nerve fibers. The neuropils are formed by the nerve fibers and nerve endings which are filled with mitochondria, neurotubules and secretory granules of four kinds (high electron dense granules of sizes 75 nm, 50 nm and 37 nm, and electron lucent granule of size 30 nm etc.). These granular vesicles are divided into single vesicle type and compound vesicle type in the nerve terminals, and neuronal synapses were observed to be the axo-dendritic and dendro-dendritic synapse type.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2003.05a
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• pp.264-273
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• 2003

인터넷의 발달로 전자 상거래는 오늘날 일상생활의 한 부분이 되었다. 그러나, 수많은 쇼핑몰들과 그 쇼핑몰들이 제공하는 다양한 제품들 속에서 소비자가 원하는 물건을 찾아내는 것은 점점 많은 시간과 노력이 필요하게 되었다. 본 논문에서는 멀티에이전트 시스템을 이용해 공급망(Supply Chain)에서 구매자의 요구에 부합하는 제품을 제공할 수 있는 생산자를 보다 쉽게 연결시켜주는 방법을 제안한다. 기존의 멀티 에이전트 기반 공급망에서 주로 사용되는 협동 전략인 Joint Intention Theory와 SharedPlan Theory, 이 논문에서 제안하는 신경망을 이용한 방법을 비교해, 신경망을 이용한 방법이 갖는 효율성을 알아보고, 신경망을 이용한 멀티에이전트 기반의 협등 모델을 제시하였다. 이 모델은 구매자가 제품을 선택할 때 사용하는 소비평가 기준의 가중치를 소비자로부터 받아들여 그 기준에 가장 부합하는 판매자를 신경망을 이용한 분류(classification)방법을 통해 찾아내고, 이렇게 선택된 생산자를 소비자에게 연결시켜준다.

• Journal of the korean academy of Pediatric Dentistry
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• v.21 no.2
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• pp.439-455
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• 1994

The purpose of this study was to investigate the distribution of nerves in the periodontal ligament of a dog's primary teeth by each developing stage. The distribution of nerves in the periodontal ligament were investigated by means of immunohistochemistry for detection of neurofilament protein (NFP). The results were as follows: The NFP-immunoreactive nerve fibers were found to be densely distributed in the apical third of the periodontal ligament, while they were sparse in the coronal two third, in both primary and permanent teeth. In generally the density of distribution and degree of arborization of nerve fibers in periodontal ligament of primary teeth revealed a poor appearance compared with that of permanent teeth. Periodontal ligament in anterior teeth showed more abundant nerve innervation than posterior teeth, and the periodontal ligament of the bifurcation area in posterior teeth roots were not observed to have nerve fiber. The density of nerve distribution in the periodontal ligament of primary teeth was reduced according to the physiological root resorption and nerve fibers were not observed in the surrounding area on the root of the exfoliation stage in primary teeth. The distribution of nerve fibers in mucogingival tissue, was poor innervated according to the aging of the dogs. A more abundant distribution of nerve fiber was represented in the lingual mucogingival tissue than in the labial side. Most of the nerve endings in the periodontal ligament of primary teeth showed a tree-like appearance. However, the typical Ruffini-like nerve endings were not observed.

• Journal of Educational Research in Mathematics
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• v.10 no.1
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• pp.11-34
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• 2000

수학학습장애는 독해장애와 더불어 학습장애의 주요영역으로 인식되고 있다. 그러나 독해 장애에 대한 연구와 비교하였을 때 상대적으로 주목받지 못한 분야로, 과연 수학학습장애는 무엇이며, 수학학습장애 아를 판별하는 기준을 어떻게 설정할 것인가의 문제가 여전히 논란이 되고 있다. 본고에서는 수학학습장애에 대한 최근의 세 가지 관점-신경학적 관점, 발달심리적 관점, 교육적 관점-의 고찰을 통해, 수학학습장애를 진단하기 위한 하나의 통합적 관점이 필요함을 제안하고 있다. 이것은 수학학습장애를 신경적 결함으로만 해석하려는 전통적 관점에 대한 발달심리학자들의 비판을 수용한 것이며, 오늘날 파행적인 교육체계에서 희생되고 소외되어온 학생계층을 포용하기 위한 한 가지 제안이 될 것이다.

• Journal of the Korean Child Neurology Society
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• v.26 no.4
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• pp.272-275
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• 2018

KBG syndrome is a rare neurodevelopmental disorder characterized by intellectual disability, skeletal anomalies, short stature, craniofacial dysmorphism, and macrodontia. ANKRD11 gene mutation and 16q24.3 microdeletion have been reported to cause KBG syndrome. Here, we report two patients with ANKRD11 mutations who initially presented with neurologic symptoms such as developmental delay and seizures. Patient 1 was a 23-month-old boy who presented with a global developmental delay. Language delay was the most dominant feature. He had hypertelorism, hearing impairment, and behavior problems characterized as hyperactivity. A c.1903_1907delAAACA (p.Lys635GInfsTer26) mutation in ANKRD11 was identified with diagnostic exome sequencing. Patient 2 was a 14-month-old boy with developmental delay and seizure. He also had atrial septum defect, and ventricular septal defect. Generalized tonic seizures began at the age of 8 months. Electroencephalography showed generalized sharp and slow wave pattern. Seizures did not respond to antiepileptic drugs. A loss of function mutation c.5350_5351delTC (p.ser1784HisfsTer12) in ANKRD11 was identified with diagnostic exome sequencing. In both cases, characteristic features of KBG syndrome such as short stature or macrodontia, were absent, and they visited the hospital due to neurological symptoms. These findings suggest that more patients with mild phenotypes of KBG syndrome are being recognized with advances in diagnostic exome sequencing genetic technologies.

• KOREAN POULTRY JOURNAL
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• v.33 no.11 s.385
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• pp.128-129
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• 2001

우리가 흔히 사용하고 있는 NRC는 가장 이상적인 관리상태에서 건강한 닭들을 기준으로 정해졌기 때문에 실제 상황에서는 조정적용이 필요하다. 면역계의 발달과 관련된 영양소들은 특히 신경을 써야 하는데, 탄수화물, 지방, 단백질과 같은 macro nutrient 나 비타민, 광물질, 필수아미노산과 같은 micro nutrient대부분의 영양소들은 면역 반응에 밀접한 영향을 주게된다.

• Clinical and Experimental Pediatrics
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• v.50 no.11
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• pp.1067-1071
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• 2007

Purpose : The aim of this study was to determine whether improved survival of extremely low birth weight infants (ELBWI) was associated with decreased neurodevelopmental disability later in life, and also to identify the factors influencing this disability. Methods : ELBWI admitted to the neonatal intensive care unit of Samsung Medical Center, survived, and followed up until the corrected age of 18 months were enrolled. They were divided into two groups according to admission time: period I (1994-1999, n=36) and period II (2000-2004, n=98). Clinical data were collected retrospectively from the medical records. Results : Survival rates increased from 60.0% to 74.7%, cerebral palsy rates decreased from 22.2% to 8.2% and catch-up growth rate increased from 25.0% to 51.0% during period I and II. Despite less gestational age and birth weight, ELBWI during period II had less periventricular leukomalacia (PVL), sepsis and bronchopulmonary dysplasia compared to period I. The highest risk factors for cerebral palsy were intraventricular hemorrhage (IVH) (${\geq}$Grade III), failure of catch-up growth and PVL. Conclusion : In summary, improved viability was associated with decreased neurodevelopmental disability in ELBWI. Improved neonatal care with resultant decrease in PVL and IVH, and better nutritional support seem to be primarily responsible for this improved outcome.

• The Journal of Korean Physical Therapy
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• v.11 no.2
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• pp.51-59
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• 1999

Standing up from a supine and prone position is very important for physical independence. All kinds of patients have a bed rest or lying on floor without special care. Even though the patient had complete from illness. He must train the functional activities before discharge. There are many method for the functional activity training. Likewise, sing of reflex, voluntary movement for muscle strength increasing, but clinically ideal method is approaching with motor developmental stage. Supine and prone progression of proprioceptive neuromuscular facilitation have a ideal reason. That is reflex integratation, development of muscle tone, develop of motor control, dynamic and static, motor behavior and cognition.

• Korean Journal of Biological Psychiatry
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• v.2 no.2
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• pp.169-176
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• 1995

두부 외상은 많은 발생율과 사망율을 차지하고 있으며, 건강한 생활을 위해 큰 관심을 갖게 되었다. 신경방사선영상은 외상성 뇌손상 환자들의 진단과 치료에 필수적인 방법이다. 뇌손상의 기본 기전, 병리, 그리고 영상 소견을 이해 하는 것은 매우 중요하다. 1970년대에 Glasgow coma scale의 형상과 전산화단층촬영(CT)의 발달은 임상의사들이 두부외상에 대한 평가와 환자들의 경과를 예상하는데 극적인 변화를 주었다. 최근 자기공명영상(MRI)의 발달로 외상성 뇌손상의 형태를 더욱 이해 하게 되었고, 두부 외상의 발견율이 높아지게 되었다.