• 대한임상전기생리학회지
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• 제1권1호
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• pp.1-15
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• 2003

The purpose of this study was to determine the effect of neuromuscular electrical stimulation(NMES) on the alteration of spinal motor neuron excitability. In this article, I would like to experiment on a standard capacity of clinical electrophysiology, a difference in applying methods and a clinical efficiency of NMES by Nerve conduction velocity. We used normal eight subjects without neuromuscular disease and all subjects participated 3 session, which at least 1 week between session. Participants classified according to each group in Antagonist, Agonist, Antagonist-Agonist by the NMES. The test was measured continuously pre test, post-test, post 20 minute test by EMG including H reflex, F wave, motor nerve conduction velocity(MNCV). The following results were obtained; 1. H-reflex latencies and H/M intervals were significantly increased in agonist and antagonist-agonist group(p<.01). 2. H-reflex amplitudes and H/M ratios were significantly decreased in agonist and antagonist-agonist group(p<.01). In agonist group, H-reflex amplitudes and H/M ratios were more significantly decreased than antagonist group. 3. F-wave latencies were significantly increased in agonist and antagonist-agonist group(p<.01). F/M intervals were significantly increased in antagonist-agonist group(p<.01). F wave conduction velocities were significantly increased in agonist and antagonist-agonist group(p<.01) but F/M ratios were not significant. 4. MNCV were significantly decreased in agonist(p<.01). These results lead us to the conclusion that agonist and Antagonist-agonist was significantly decreased excitability of spinal motor neuron. Conversely, Antagonist does not decreased. Therefore, A further direction of this study will be to provide more evidence that NMES have an effect on excitability of spinal motor neurons in UMN syndrome.

• 대한임상전기생리학회지
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• 제5권1호
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• pp.59-71
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• 2007

The purpose of this study was to study for the change of neural adaptation by muscle contraction force when neuromuscular electrical stimulation(NMES) was applied. Sixteen subjects(8 male, 8 female) without neuromuscular disease volunteered to participate in the study. All subjects were divided into two subgroups: control(no electrical stimulation) group, NMES(50% maximal voluntary isometric contraction) group. NMES training program was performed in the calf muscle over three times a week for 12 weeks. Before and after experiment MVIC of ankle plantar flexor was measured by use of dynamometer. H-reflex and V-wave in tibial nerve were measured. The following results were obtained; MVIC and V/Mmax ratio were significantly increased in the electrical stimulation groups. However, H/Mmax ratio was not changed. It was closely relationship between MVIC and V/Mmax ratio. In this study, the effect of neural adaptation of central neural adaptation was found in this study. Accordingly, NMES means not only a change of muscle fiber and skeletal muscle volume but also a effect of neural adaptation of central neural drive. Also, it was found that there was closely relationship between MVIC and neural adaptation of central neural drive by NMES.

• 대한물리치료과학회지
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• 제9권1호
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• pp.89-94
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• 2002

Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, constitutively expressed cyclooxygenase(COX)-1 and COX-2, which is induced at sites of inflammation. Inhibition of COX-2 is desirable as this may avoid side effects seen with NSAIDs. We examined the effects of transcutaneous electrical nerve stimulation and cold therapy on the levels of muscle cycloooxygenase-2 mRNA in rats of carrageenan-induced inflammatory. The method of behavioral assessment were paw withdrawal latency(PWL) and tail flick test(TFT). The COX-2 mRNA levels were quantified by reverse transcription-polymerase chain reaction (RT-PCR). Following the transcutaneous electrical nerve stimulation and cold therapy, PWL and TFT were increased and COX-2 mRNA expression in gastrocnemius muscles were decreased. These results suggest that a transcutaneous electrical nerve stimulation and cold therapy were good therapy for a muscle pain.

• Journal of Yeungnam Medical Science
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• 제9권2호
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• pp.382-395
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• 1992

GABA는 중추신경계의 대표적인 신경전달 물질로서 $GABA_A$수용체 또는 $GABA_B$수용체에 작용하여 진정 작용, 항 불안 작용, 및 근이완 작용을 하는 것으로 알려져 있다. 근래에는 말초조직에도 GABA가 존재하며 신경조정인자 혹은 신경전달인자로서 작용한다는 보고가 있다. 정관에 대한 자율신경 지배는 아드레날린성, 콜린성과 비콜린성 비아드레날린성 신경섬유들이 분포하고 있으나, 종 혹은 부위에 따라 이들 구성요소들의 수축성에 대한기여도가 다른 것으로 알려져 있다. 본 실험에서는 흰쥐의 전립선 부위 정관의 기본장력 및 전기장 유발 수축에 대한 교감 신경성, 부교감 신경성 및 퓨린성 효현제의 영향을 관찰하였으며, 정관의 흥분성 약물 및 전기장 유발 수축에 미치는 GABA 및 GABA 관련 약물의 영향을 관찰함으로서 정관의 수축운동에 대한 GABA의 작용기전을 규명해 보고자 흰쥐(Sprague-Dawley)의 전립선 부위 정관 절편을 적출 근편 실조에 현수하고, 등척성 장력을 측정하여 다음과 같은 결과를 얻었다. 1. GABA, muscimol 및 baclofen은 전기장자극(0.2 Hz, 1 msec, 80 V) 유발 수축을 농도 의존적으로 억제하였으며 그 효력은 GABA, baclofen 그리고 muscimol 순이었다. 2. GABA의 억제작용은 $GABA_B$ 수용체 길항제인 DAVA에 의하여 길항되었으나, $GABA_A$ 수용체 길항제인 bicuculline에 의해서는 길항되지 않았다. 3. Baclofen의 억제작용은 DAVA에 의하여 길항되었으나 muscimol의 억제작용은 bicuculline에 의해서는 길항되지 않았다. 4. Norepinephrine과 ATP는 농도 의존적으로 정관의 수축력을 증가 시켰으나 acetylcholine은 영향을 미치지 못하였다. 5. GABA, baclofen 및 muscimol은 정관의 기본 장력에는 영향을 미치지 않았으며, GABA는 norepinephrine과 ATP 유발 수축에는 영향을 주지 못하였다. 6. 적출 정관을 20초간 전기장 자극을 가하였을 때 ATP 수용체 탈감작제인 mATP를 전처치한 경우에는 FPC가 감소되었고, 신경원에서 catecholamine을 고갈시키는 reserpine을 전처치한 경우에는 STC가 감소되었다. 7. GABA는 mATP를 전처치한 군에서는 정관의 전기장 유발 수축에 영향을 주지 못하였으나, reserpine을 전처치한 군에서는 전기장 유발 수축을 억제하였다. 이상의 결과로 보아 흰쥐정관의 전립선 부위에는 아드레날린성 신경전달기전과 퓨린성 신경전달기전이 동시에 작용하고 있으며, GABA는 주로 신경원의 $GABA_B$ 수용체를 통하여 ATP의 유리를 억제하는 것으로 사료된다.

• The Journal of Korean Physical Therapy
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• 제11권3호
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• pp.89-96
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• 1999

The purpose of this study was to examine the effects of neuromuscular electrical stimulation(NMES) on the spasticity of elbow flexor. Ten spastic hemiplegia who have been at EUL-JI medical college hospital in Taejon with age range of 35 to 70 years$(56.8\pm9.5)$, were participated in this study. The subjects (5male, 5female) took neuromuscular electrical stimulation therapy on the triceps of the affected elbow. To compare the effect of the treatment, the grade of spasticity of affected elbow flexor was measured at pre-treatment and the end of each weeks using modified Ashworth scale. Then, the range of extension of the affected elbow was measured at pre-treatmen and the end of each weeks using full circle goniometer. The data were analyzed with ANOVA to determine significant differences with the passage of time. The results were as follows: 1. ANOVA test showed significant differences in reducing spasticity of NMES group with the passage of time (p<.01). 2. ANOVA test showed significant differences in increasing range of motion with the passage of time of NMES group(p<.01). The neuromuscular electrical stimulation is a effective method to reduce the spasticity of elbow flexor.

• 전기학회논문지P
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• 제64권3호
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• pp.175-181
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• 2015

In this paper, the neuromuscular electrical stimulation medical devices for non-implantable incontinence treatment other than vaginal insertion type was developed and commercialized. The structure of medical devices for electrical stimulation based on the anatomy of the pelvic floor muscle designed. Then, the optimum parameters that may be effective in pelvic floor muscle electrical stimulation was set. The circuit system based on the optimum parameters were designed and manufactured. The frequency of the pulse voltage for electrical stimulation is 75[Hz], the pulse width is 300[${\mu}s$], the development of medical devices was to have seven program functions to the various treatments. The circuit system of medical devices was composed of microcontroller, comparator and converter. The performance of the developed circuit system in KTC(Korea Testing Certification) were carried out medical equipment inspection test. Test results, test specifications were satisfied with the medical device, the performance was verified to be commercialized as a medical device. The development of medical devices were validated risk assessment and product performance through a software validation. Commercialization of medical equipment was acquired to enable the certification standards of the international standard IEC 60601-1.

• 대한물리치료과학회지
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• 제10권1호
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• pp.65-73
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• 2003

The purpose of this study was to determine whether neuromuscular electrical stimulation(NMES), applied over the antagonist or the agonist, would alter the H reflex. Attention was focused on the roles of stimulus location. We used normal eight subjects without neuromuscular disease which were divided into 3 groups; the subjects were diveded into group of antagonist, agonist, antagonist-agonist. All groups were meted of eight subjects. Neuromuscular electrical stimulation was administered for 15 minutes. All subjects were subjected to three tests, including a pre-test, post-test and post-20 minute test. The data were analyzed by repeated measures ANOVA and paired t-test. The results were as follows; 1. H latencies were significantly increased in agonist and antagonist-agonist group (p<.01). 2. H/M intervals were significantly increased in agonist and antagonist-agonist group (p<.01). 3. H amplitudes were significantly increased in agonist (p<.001) and antagonist-agonist group (p<.01). 4. H/M ratios were significantly decreased in agonist and antagonist-agonist group (p<.01). In agonist group. H-reflex amplitudes and H/M ratios were more significantly decreased than antagonist group. Future studies will need to determine what influence NMES may have on the excitability of spinal motor neurons in people having UMN syndrome.

• 대한통합의학회지
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• 제7권2호
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• pp.181-187
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• 2019

Purpose: The purpose of this study was to investigate the activity of respiratory muscle and lung capacity during deep breathing with electrical stimulation of the vagus nerve. Methods: This study was conducted on 30 healthy adults in their 20s. Subjects were randomly performed to deep breathing or deep breathing with vagus nerve electrical stimulation. All subjects' diaphragm and internal oblique muscle activity were measured during deep breathing by electromyography, and lung capacity was measured by spirometry immediately after beep breathing. In the vagus nerve stimulation method, the surface electrode was cut into the left ear and then electrically stimulated using a needle electric stimulator. Results: The activity of diaphragm was significantly increased in deep breathing with vagus nerve electrical stimulation than in deep breathing. However, lung capacity did not show any significant difference according to the condition. Conclusion: Vagus nerve electrical stimulation could induce diaphragm activity more than deep breathing alone. Deep breathing with vagus nerve electrical stimulation may enhance the activity of the respiratory muscles and is expected to be an effective treatment for the elderly or COPD patients with poor breathing ability.

• 한국전문물리치료학회지
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• 제7권2호
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• pp.76-87
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• 2000

Delayed onset muscle soreness (DOMS) is a common problem that can interfere with rehabilitation as well as activities of daily living. The purpose of this study was to determine the effects of both transcutaneous electrical nerve stimulation (TENS) and microcurrent electrical neuromuscular stimulation (MENS) on DOMS, Twenty-seven untrained and male volunteer subjects were randomly assigned to one of three treatment groups: 1) a group that received TENS (7 Hz), 2) MENS (60 ${\mu}A$, .3 pps) or 3) a control group that received no treatment. Subjects performed repeated eccentric exercise of the non-dominant forearm flexor muscle with submaximal intensity by the simply designed eccentric exercise devices. Treatments were applied after 24 hours and 48 hours. Subjects attended on two consecutive days for treatment and measurement of elbow flexion, extension, resting angle (universal goniometer), and pain (visual analogue scale: VAS) on a daily basis. Measurements were taken after treatment. Analysis of results were as follows; 1) There were no significant differences between TENS and MENS by one-way repeated ANOVA, 2) The t-test for pain, resting, flexion and extension angle revealed significant differences within TENS group, 3) The t-test for resting angle revealed significant differences within MENS group.

• 대한임상전기생리학회지
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• 제3권1호
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• pp.49-59
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• 2005

This study assigns each 8 of 24 normal persons to control group(Group I), strength increase group(Group II) and endurance increase group(Group III) to analyze differences in changes of strength and endurance with surface electromyography and kinetics according to application modes of neuromuscular electrical stimulation(NMES). Group I had not any treatment, group II performed 15 repeated contraction with 60% intensity of maximal voluntary isometric contraction(MVIC) by setting 10-sec on time and 50-sec off time and group III conducted 30 repeated contraction with 30% intensity of MVIC by setting 10-sec on time and 20-sec off time. For neuromuscular electrical stimulation, 2,500 Hz of Russian current, 35 pps of pulse rate and 200 of pulse width. Neuromuscular electrical stimulation was conducted by five times for total 4 weeks. Before and after experimentmotor unit action potential of vastus medialis, rectus femoris and vastus lateralis were measured with sEMG, median frequency(MDF) was analyzed, and thus the following results were obtained. There was significant difference in the period of measuring vastus medialis and rectus femoris in change of MDF and interaction among groups with analysis of surface electromyography before and after neuromuscular electrical stimulation(p<.001) and in particular, there was a remarkable change among groups according to the period of measurement. In conclusion, NMES influenced changes of strength and endurance according to its application modes and in particular, it was found that strength increment application had a significant influence on strength increment in applying short-time NMES.