• YAKHAK HOEJI
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• v.49 no.4
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• pp.268-274
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• 2005

Paclitaxel is an effective antineoplastic agent against ovarian, colon and breast tumors. But there have been many difficulties to formulate this drug due to the extremely low aqueous solubility. Paclitaxel is currently formulated in a vehicle composed of Cremophor EL and absolute ethanol mixture which is $5\~20$ fold diluted in normal saline or $5\%$ dextrose solution before I.V. injection. However, this formulation has many problems such as allergic reactions and drug precipitation on aqueous dilution. To overcome these problems, we prepared the micelle and microemulsion systems for parenteral administration of paclitaxel by using glycofurol, $Soluto^{(R)}lHS$ 15 and oleic acid. Phase diagram, pH-rate stability, particle size distributions and pharmacokinetics of the systems were studied. Micelles and microemulsions formulated as nano-particle delivery system were physically and chemically stable. Therefore, these formulations might be the promising alternative candidate for the parenteral delivery of paclitaxel.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.2 no.3
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• pp.143-151
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• 1990

The sediment transport in shallow water regions has been studied in various ways and, accordingly, many formulas have been proposed. However, when these formulas are applied practically in the field, they are not sufficient to fully estimate the sediment transport rate yet. The primary reason is how to take into account the effect of irregularities of field waves : wave heights, periods and directions. Therefore, it is necessary to investigate stochastic and kinematic characteristics of waves in three dimensional random seas in order to more accurately estimate it. In particular, the asymmetrical properties of directional spectrum become significant and play an important role in various phenomena in a shallow water region. In this study, their effects of incident waves the joint distribution of wave heights, periods and directions are investigated through field measurements.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.13 no.1
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• pp.1-8
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• 2001

Wave-induced currents drive nearshore transport processes, and hence an accurate understanding of wave-current interaction is required for proper management of coastal zone. This paper presents details of an adaptive quadtree grid based numerical model of the coupled wave climate and depth-averaged current field. The model accounts for wave breaking, shoaling, refraction, diffraction, wave-current interaction, set-up and set-down, mixing processes, bottom friction effects, and movement of land-water interface at the shoreline. The wave period- and depth-averaged governing equations arc discrctized explicitly by means of an Adarns¬Bashforth second-order finite difference technique on adaptive hierarchical staggered quadtree grids. Results from the numerical model are in reasonable agreement with the laboratory data of longshore current generated by oblique waves on a plane beach (Visser 1980, 1991).

• Journal of the Korean Society for Railway
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• v.12 no.3
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• pp.329-334
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• 2009

Subway is used as a useful transportation method to solve the metropolitan traffic problem for its advantages of being not only accurate, safe and massive, but also of not producing any exhaustion gas in compare with the other ground transportation systems. However, noise inside the car due to concrete based rail track and tunnel structure has become a social problem. So, an analysis on the noise characteristics according to their routes and locations was made on the basis of the actually measured results from the trial run. To reduce the interior noise of subway train, the side part of rolling stock should have a noise blocking system fur low band frequency noise, the floor of it should have that for medium range frequency noise and the side part as well as lower part of it should have good noise reduction and absorption function.

• Journal of the Korean Society of Propulsion Engineers
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• v.24 no.6
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• pp.53-60
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• 2020

In liquid-fuel spray combustion, an experimental study was conducted to observe the effect of ultrasonic excitation on the ultrasonically-atomized liquid fuel flame by controlling pressure field through an ultrasonic standing wave. Flame of the ultrasonically-atomized kerosene aerosol was visualized by using a high speed camera, DSLR, and Schlieren photography. The amount of fuel consumed was obtained by a precise flow-rate measurement technique during combustion, through which the ratio of carrier gas (air) to fuel mass was able to be obtained, too. As a result, it could be found that the combustion reaction-rate of the liquid-fuel aerosol was increased by applying an ultrasonic standing wave to the secondary flame zone of the flame.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.4B
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• pp.243-251
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• 2012

To investigate the characteristics of rip current occurring at Haeundae beach, observations obtained from a buoy and a CCTV were analyzed and numerical experiments were conducted. During observed rip-current events, the CCTV images showed that a couple of wave-trains, which are close to regular waves with slightly different directions, propagated to the beach, and wavelet analyses of data from the buoy showed very narrow-banded spectra with a peak frequency. From the evidences, it was inferred that a known mechanism of generating rip current due to the nodal line area of honeycomb-patterned wave crest was one of the significant factors of rip current occurrences of Haeundae beach. The mechanism has been explained by the following: When two wave-trains with slightly different directions propagate to a beach, wave crests of the incident wave-trains form honeycomb pattern due to nonlinear interaction. The nodal lines of honeycomb pattern are developed in the cross-shore direction. And longshore currents flow toward the nodal line area which has very low wave energy. Consequently their mass flux is expelled through the area toward the sea direction. To confirm the generation, numerical experiments were performed using a nonlinear Boussinesq equation model. In the cases with two incident wave-trains with slightly different directions and with a monochromatic wave propagating over a submerged shoal, it was seen that the honeycomb pattern of wave crests was well developed, and thus rip currents were evolved along the nodal lines.

• International Union of Geodesy and Geophysics Korean Journal of Geophysical Research
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• v.23 no.1
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• pp.18-33
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• 1995

Under the synoptic scale strong westerly winds flowing over the large steep mountains in the eastern coastal region, the strong downslope wind storms such as internal gravity waves should be generated in the lee-side of mountain. Int he daytime as sea breeze circulation induced by meso-scale thermal forcing from sea toward inland confines to the offshore side of coastal sites due to the eastward internal gravity waves. Thus, surface winds near the coastal seas were relatively weaker than those in the open sea or the inland sites. Evidently, two different kinds of atmospheric circulations such as an internal gravity wave circulation with westerly wind and a sea breeze circulation with both easterly wind near the sea surface and westerly in the upper level were apparently produced. Under this situation the atmospheric pollutants at Kangnung city should be trapped by two different circulations in the opposite directions and resulted in the high concentrations of Total Suspended Particles (TSP) and ozone (O3). At night a meso-scale land breeze from land toward the more intensification of westerly winds in the coastal regions. The concentrations of TSP controled by the strong surface winds blowing from the mountain side toward the coastal sea were relatively higher at night than those in the daytime case and the concentrations of O3 due to the downward transport of ozone from the upper atmosphere toward the surface were also much higher at night than during the day. Consequently, the atmospheric pollutant concentrations in the mountainous coastal region under the downslope wind storms were higher than those after and before the occurrences of wind storms.

• Economic and Environmental Geology
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• v.37 no.2
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• pp.185-193
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• 2004

A physical model experiment was conducted using a sand and gravel-filled tank model, to investigate the influence on the GPR response of LNAPL vapor phase effects in the unsaturated zone and of residual phase of LNAPL trapped in the saturated zone. Background measurements of GPR were made with only water in the tank using a fluctuating water table model. Gasoline was, then, injected into the bottom of the model tank to simulate a subsurface discharge from a leaking pipe or tank at depth, obtaining GPR data with rising and lowering of water table. Results from the experiment show the GPR sensitivity to the changes in the moisture content in the vadose zone and its effectiveness for monitoring minor fluctuation of the water table. The results also demonstrate a potential of GPR for monitoring possible vapor phase effects of volatile hydrocarbons in the vadose zone as a function of time, and for detecting the effects of residual phase of hydrocarbons in the water saturated system. In addition, the results provide the basis for a strategy that has the potential to successfully detect and delineate residual LNAPL contamination in the water-saturated system at field sites where the conditions are similar to those simulated in the physcial models described herein.

• Economic and Environmental Geology
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• v.47 no.6
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• pp.625-633
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• 2014

The Aquistore project is the world's first commercial capture, transportation, utilization and storage project of post-combustion $CO_2$ from a coal-fired thermo electric power plant, and the proposed storage is a saline aquifer at a depth of about 3,500 m. Deep saline aquifer, compared to hydrocarbon reservoir, provides the great volumetric potential for storage of $CO_2$ anywhere in the world, therefore the research results from the project may be exported globally to other sites. Geological $CO_2$ storage characterization for saline aquifer instead of hydrocarbon reservoir needs to estimate the geophysical properties of subsurface geology. This study calculated the geophysical property of water-saturated formation by applying amplitude variation analysis developed from oil and gas exploration. We correlated horizon tops at the well logs to seismic traveltime of 1,815 and 1,857 ms as Winnipeg and Deadwood formations. Gradient analysis from seismic traces showed correlation coefficient of 45 - 81 % on amplitude variation with respect to incident angle. Crossplot of intercept and gradient shows the inverse proportional trend which represents typical water saturated sediments. Product attribute of intercept and gradient described the base of wet sediment. Poisson's ratio change attribute increased at the top of target area satisfying with wet sediment and decreased at the top of basement in a dry rock bed.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.29 no.6
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• pp.399-409
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• 2017

This study numerically investigates the characteristics of the velocity field including the average flow velocity, longshore current and turbulent kinetic energy acting as the main external forces of the salient formed behind the permeable submerged breakwaters. Shoreline response is also predicted by the longshore-induced flux. In this paper, a three-dimensional numerical wave tank based on the OLAFOAM, CFD open source code, is utilized to simulate the velocity field around permeable submerged breakwaters under the formation condition of salient. The characteristics of the velocity field around permeable submerged breakwaters with respect to the gap width between breakwaters and the installing position away from the shoreline under a range of regular waves for different wave height are evaluated. The numerical results revealed that as the gap width between breakwaters increases, the longshore currents become stronger. Furthermore, as the gap width becomes narrower, the point where flow converges moves from the center of the breakwater to the head part. As a result, it is possible to understand the formation of the salient formed behind the submerged breakwaters. In addition, it was found that the longshore currents caused by the gap width between breakwaters and the installation position away from the shoreline are closely related to the turbulent kinetic energy.