• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.7
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• pp.565-568
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• 2017

Sjogren's syndrome is an autoimmune disease characterized by dry mouth and neutropenia. Although it does not commonly involve the central nervous system, Sjogren's syndrome sometimes affects small vessels through microangiopathic alterations. A 34-year-old woman was hospitalized for left upper quadrantanopia and a tingling sensation in the left hemibody. Brain magnetic resonance imaging revealed acute infarction in the right posterior cerebral artery territory. In laboratory tests, antinuclear (FANA2+) and anti-DNA antibodies (anti-SS-A (Ro)) were detected. Salivary gland scintigraphy revealed moderately decreasedexcretion of saliva. Based on these findings, we concluded she had Sjogren's syndrome. As in this patient, large vessel involvement in Sjogren's syndrome is far less common. Furthermore, it is difficult to administer antiplatelet drugsto patients with thrombocytopenia in Sjogren's syndrome. This is a case of the patient with Sjogren's syndrome that involved thrombocytopenia and large vessel invasion who was treated with antiplatelet drugs and hydroxychloroquine.

• Tuberculosis and Respiratory Diseases
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• v.64 no.3
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• pp.230-235
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• 2008

We described herein the first case of primary $Sj{\ddot{o}}gren^{\prime}s$ syndrome in Korea which presented with multiple cysts caused by only peribronchiolar lymphocytic infiltration, a rare pulmonary manifestation in $Sj{\ddot{o}}gren^{\prime}s$ syndrome, and was confirmed by surgical lung biopsy. A brief review of the literature has been included.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.6
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• pp.341-348
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• 2021

Serum amylase is a representative enzyme secreted by the salivary gland and pancreas. This study investigates the clinical significance of serum amylase levels in Sjögren's syndrome (SS). Totally, 70 female subjects were enrolled, who were diagnosed as SS and had no accompanying afflictions that affected the serum amylase levels. Unstimulated salivary flow rate (U-SFR) and stimulated SFR (S-SFR), salivary gland scan, and disease activity markers (ESSDAI and ESSPRI), as well as blood tests including ESR, CRP, and amylase, were evaluated. Serum amylase showed significant positive correlation with the U-SFR and S-SFR, and was increased with higher ejection fraction (EF) of the parotid gland. However, there was no significant correlation with disease activity and inflammatory markers. Based on their average amylase levels, subjects were divided into two groups. The group with higher serum amylase levels showed a statistically significant increase in the S-SFR and EF of the parotid gland. Considering the results of the salivary gland scan, we conclude that serum amylase is significantly correlated with SFR and the EF of the parotid gland, thereby indicating that the salivary gland function remains intact in SS.

• The Journal of Internal Korean Medicine
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• v.37 no.2
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• pp.251-256
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• 2016

Objective: This case report examines the effects of Jaeumganghwa-tang as a treatment option for Sjögren’s syndrome.Methods: We provided the patient with Jaeumganghwa-tang twice a day, as well as acupuncture and bee venom therapy (both twice a week), for 30 days. Symptoms were charted and evaluated using the European League Against Rheumatism (EULAR) Sjögren’s Syndrome Patient Reported Index (ESSPRI).Results: The patient’s ESSPRI score decreased from 8 to 6 after the 30-day treatment.Conclusions: Jaeumganghwa-tang may be helpful in alleviating Sjögren’s syndrome.

• Tuberculosis and Respiratory Diseases
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• v.52 no.2
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• pp.179-185
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• 2002

A bronchus-associated lymphoid tissue(BALT) lymphoma of the lung is a rare disorder of patients with Sj$\ddot{o}$gren's syndrome. A 49-year-old woman was admitted for an evaluation of exertional dyspnea and general weakness which had persisted for two years. The patient had suffered from dry mouth and dry eyes for five years. The physical examinations showed a coarse breath sound with inspiratory crackles on the whole lung field, particularly on the both basal lungs. The laboratory data disclosed high titers of anti-nuclear antibodies, and anti-SSA (Ro), and anti-SSB (La) antibodies. Chest radiographs demonstrated the presence of bilateral, diffuse, reticulonodular densities in both lungs. Thin-section CT scans showed diffusely distributed mosaic pattern of an inhomogeneous attenuation extending over the entire lung zone. The histological findings from an open-lung biopsy specimen revealed an accumulation of lymphoid cells around the bronchioles and an extension of malignant lymphoma cells from the bronchiolar epithelium toward the alveolar space. Immunohistochemically, the neoplastic cells reacted positively to the CD 20 antigen and were focally positive for the UCHL 1 antigen. The histological diagnosis was consistent with a low grade marginal zone B-cell lymphoma originating in the BALT. Here, we present a case of a histologically proven BALT lymphoma of the lung in a patient with primary Sj$\ddot{o}$gren's Syndrome.

• Annals of Clinical Neurophysiology
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• v.10 no.1
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• pp.58-61
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• 2008

Sj$\ddot{o}$gren's syndrome (SS) is an autoimmune disease characterized by keratoconjunctivitis sicca and xerostomia. About thirty percent of patients with Sj$\ddot{o}$gren's syndrome experience nervous system involvement such as myelopaty, optic neuropathy, and peripheral neuropathy. The most common pattern of peripheral nerve involvement is axonal polyneuropathy. We present a case of demyelinating polyneuropathy in a patient with Sj$\ddot{o}$gren's syndrome, which had been proven by electrophysiology and pathology.

• The Journal of Internal Korean Medicine
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• v.38 no.5
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• pp.763-768
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• 2017

Objectives: The purpose of this study is to report the clinical effectiveness of Korean medicine, especially Gami-onchung-eum, for treatment of a patient with Sjogren's syndrome. Methods: The patient, diagnosed with Sjogren's syndrome, was suffering from systemic symptoms accompanied by dry mouth, dry eye, and fatigue. We treated her with Korean medicine involving a herbal decoction, acupuncture, moxibustion, and cupping. We used the European League Against Rheumatism $Sj{\ddot{o}}gren^{\prime}s$ Syndrome Patient Reported Index for assessment. Results: Based on the European League Against Rheumatism $Sj{\ddot{o}}gren^{\prime}s$ Syndrome Patient Reported Index, after 28 days of treatment, dry mouth decreased to a score of 5, dry eye decreased to 2, and fatigue decreased to 3. Conclusions: Korean medicine, including Gami-onchung-eum, may be an effective treatment for Sjogren's syndrome.

• Journal of Pharmacopuncture
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• v.11 no.4
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• pp.95-99
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• 2008

Objective Sjogren's Syndrome is a chronic inflamatory disorder characterized by lymphocytic infiltration of lacrimal and salivary gland. It may be associated with renal disease such as tubulonephritis or glomerulonephritis. Proteinuria is a kidney disorder resulting in an abnormally high amount of protein in the urine. When the glomeruli are damaged, proteins of various sizes pass through them and are excreted in the urine. This report is a case of proteinuria with Sjogren's Syndrome. Methods The patient was diagnosed as kidney yang deficiency syndrome and treated with Woogyu-eum, Sa-am acupuncture therapy and bee venom acupuncture therapy. Visual Analog Scale was used to estimate the clinical symptoms. Results Clinical symptoms and proteinuria were improved without steroid therapy. Conclusion Therefore, we concluded that oriental medical therapy may be useful to treat proteinuria with Sjogren's Syndrome.

• The Journal of Internal Korean Medicine
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• v.40 no.5
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• pp.1007-1013
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• 2019

Objectives: The purpose of this study was to report the treatment of a patient suffering from $Sj{\ddot{o}}gren^{\prime}s$ Syndrome with influenza A virus infection with Korean medicine. Methods: We used herbal medicine, acupuncture, and moxibustion to treat a patient during hospitalization. We observed the changes in symptoms using the European League against Rheumatism $Sj{\ddot{o}}gren^{\prime}s$ Syndrome Patient Reports Index (ESSPRI) and a visual analogue scale (VAS). Results: After treatment for 17 days, the patient's symptoms showed improvement in joint pain, dry eye, and dry mouth. The ESSPRI score was decreased from 10 to 5.3. The VAS for dry mouth and dry eye were decreased from 10 to 6 and from 10 to 5, respectively. Conclusion: This clinical case study suggests that Korean medicine treatment that includes Insamyangyoung-tang-gami could be effective in the treatment of $Sj{\ddot{o}}gren^{\prime}s$ Syndrome.

• Journal of Sasang Constitutional Medicine
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• v.25 no.3
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• pp.264-275
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• 2013

Objectives This study was designed to evaluate the effects of Korean medicine therapy(Cheongsimyeonja-tang) on Taeeumin patients diagnosed with Sj$\ddot{o}$gren's syndrome with arthritis. Methods The Sj$\ddot{o}$gren's syndrome with arthritis patient was treated with Cheongsimyeonja-tang. The progress was evaluated with the visual analogue scale and erythrocyte sedimentation rate on hematologic examination. Results There was improvement in the patient's Sj$\ddot{o}$gren's syndrome symptoms. The patient's symptoms of the alimentary system, dried fever and arthralgia evaluated with the visual analogue scale improved. Erythrocyte sedimentation rate was decreased on hematologic examination. Conclusions This study suggests that Korean medicine(Cheongsimyeonja-tang) is effective in the treatment of Sj$\ddot{o}$gren's syndrome on Taeumin patients.