• Journal of Life Science
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• v.13 no.2
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• pp.236-240
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• 2003

Human immune system acts to protect the host from infectious agents (bacteria, viruses, fungi, parasites) and from other noxious insults. However, immune diseases are sometimes caused by the impairment of immune system leading to abnormal immune response. Especially, autoimmune diseases are very diverse and often bring serious damage Although many active investigations to reveal the etiological mechanisms concerning the autoimmune diseases, it still remains unclear. After proposing a HERV (human endogenous retrovirus) as a candidate autoimmune gene in type I diabetes, it is newly attracting our attention for demonstrating that an endogenous human retroviral superantigen can be transactivated by interferon-$\alpha$ (IFN- $\alpha$) or Epstein-Barr virus (EBV) infection. These might provide us with powerful clues to carry out further studies to overcome autoimmune diseases as the presentation of a relatively clear connection between endogenous superantigens and human diseases.

• Journal of the Korean Society of Safety
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• v.16 no.2
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• pp.57-62
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• 2001

In order to analyze the mechanism of semiconductor device damages by ESD, this paper adopts a new charged-device model(CDM), field-induced charged nudel(FCDM), simulator that is suitable for rapid routine testing of semiconductor devices and provides a fast and inexpensive test that faithfully represents ESD hazards in plants. The high voltage applied to the device under test is raised by the fie]d of non-contacting electrodes in the FCDM simulator. which avoids premature device stressing and permits a faster test cycle. Discharge current md time are measured and calculated The FCDM simulator places the device at a huh voltage without transferring charge to it, by using a non-contacting electrode. The only charge transfer in the FCMD simulator happens during the discharge. This paper examine the field charging mechanism, measure device thresholds, and analyze failure modes. The FCDM simulator provides a Int and inexpensive test that faithfully represents factory ESD hazards. The damaged devices obtained in the simulator are analyzed and evaluated by SEM Also the results in this paper can be used for to prevent semiconductor devices from ESD hazards.

• Proceedings of the KIEE Conference
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• 2007.07a
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• pp.1321-1322
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• 2007

$Ar/Cl_2$, $Ar/CH_4$ 및 $Ar/Cl_{2}/CH_{4}$ 유도결합 플라즈마의 가스 혼합비에 따른 BLT 박막의 식각 메커니즘과 선택비, 식각 후 박막 표면의 조성변화를 조사하였다. BLT 박막의 최대식각률은 $Ar/Cl_2$ 플라즈마에서의 Ar 가스 혼합비가 80%일 때 50.8 nm의 값을 보였다. 이 때, 1sccm의 $CH_4$ 첨가를 통하여 선택비와 식각률을 개선할 수 있었다. 박막 표면의 xPS 분석을 통해 BLT 박막 표면의 조성변화는 Cl 원자와의 반응에 의한 화학적 식각 손상이 H 원자와의 반응에 의한 그것보다 크다는 것을 알 수 있었다.

• Journal of Power System Engineering
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• v.15 no.5
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• pp.22-29
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• 2011

In this study, the damage mechanism of large scale steam turbine due to water induction was analyzed and recovery characteristics were reviewed. A turbine consists of the rotating rotor and the stationary casing, and the clearance between them is very small for the efficiency enhancement. If water induction, while relatively cold steam or water is introduced into turbine, occurs, the considerable humping is caused at the casing near the initial water induction point and that induces the rubbing between rotor and casing. Finally, it leads to the catastrophic failure. Bowed rotor has the different characteristics in the recovery depending on damage degree. The elastic deformation due to light rubbing is recovered by turning the rotor with 3 rpm under normal operation condition, but most plastic deformation due to rubbing deforms the local microstructure and that results in permanent deformation which could not be recovered under normal operation condition. Bowed rotor has diverse characteristics depending on the recovery method, and the method is empirical and needs the cutting edge technology. Careful recovery treatment of the rotor will eliminate the risks and secure the high quality rotor similar to new rotor. If any critical error is made during the recovery, the rotor would not be recovered permanently and it should be scrapped.

• KEPCO Journal on Electric Power and Energy
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• v.5 no.1
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• pp.11-15
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• 2019

Recently, the circuit-breaker rated voltage is getting higher as the transmission voltage increases. To increase the circuit-breaker rated voltage, a multi-break circuit-breaker which has two or more breakers in series is adopted. For multi-break circuit-breaker, a grading capacitor is used to mitigate the Transient Recovery Voltage(TRV) and control the voltage distribution across the individual interrupter units. However, all over the world, there are many failures such as mechanical damage, explosion due to insulation breakdown. Therefore, it is necessary to study the causes of failure and the new performance verification method. In this paper, we investigate the causes of dielectric breakdown of the grading capacitors in the KEPCO power system and propose the performance verification method.

• Annual Conference of KIPS
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• 2023.05a
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• pp.206-208
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• 2023

비대면 활동 및 원격 작업 증가에 따라 문서 파일을 이용한 사이버 공격 빈도가 증가하고 있으며, 별도의 실행 파일 대신 문서 내의 기본적인 기능을 악용하는 문서 공격은 기존의 악성코드 탐지 메커니즘을 우회할 수 있기 때문에 큰 문제가 되고 있다. 이러한 문제에 대응하기 위한 여러 기술 중 CDR 기술은 악성 행위에 이용될 가능성이 있는 액티브 콘텐츠를 제거하거나 비활성화하여 사전에 악성코드로 탐지되지 않았던 파일에 대한 보안성을 제공하지만, 문서의 내용을 분석하고 안전하게 재조합하는 과정에서 오류가 발생하여 전달하고자 했던 내용을 제대로 표현할 수 없게 되거나, 파일을 사용할 수 없게 되는 문제가 발생할 수 있다. 본 논문에서는 파일을 후처리하는 방식으로만 CDR을 적용하는 것이 아니라, 확장 프로그램이나 가상 환경 등을 이용해 문서의 작성 단계에서부터 CDR 처리과정을 거치게 하는 방법을 제안하여 파일 손상이나 내용 누락 문제를 완화하고 사용자의 업무 효율을 높이는 동시에 강화된 보안성을 제공한다.

• Journal of the Korean Applied Science and Technology
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• v.40 no.5
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• pp.1010-1021
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• 2023

In this study, we would like to confirm the collagen recovery effect through cell experiments of the flavonoid apigenin and baicalein and propose results that can support the collagen recovery effect through comparative transcriptome analysis. As a result of the study, it was confirmed that apigenin and baicalein were effective in recovering type I collagen damaged by UV in the HS68 cell line, and that both substances resulted in changes in the expression of ECM-related genes. Not only did it show a common mechanism for regulating the ECM, but it also showed the results of changing different categories of genes, making it possible to predict that it would have various effects on cells.

• Journal of the Korea institute for structural maintenance and inspection
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• v.10 no.5
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• pp.121-129
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• 2006

This study look into the mechanisms of growth and magnification of the cracks and delamination in the pre-cracked RC beams repaired with carbon fiber sheets. The experimental parameters were loading type, loading speed and crack. In the experiments, it was confirmed that a failure of beams began with development and propagation of the stepped delamination in the below the loading point due to the rapid change of shear force, but mechanisms of the failure were not influenced with loading type, loading speed and pre-cracks. Particularly, in the case of beams having the pre-cracks, growth of crack concentrated at the special crack below the loading point and led to failure of the beam by delamination due to magnification of crack.

• Korean Journal of Clinical Laboratory Science
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• v.52 no.2
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• pp.112-118
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• 2020

This study was undertaken to examine the effects and to investigate the relevant mechanisms of overexpressing stromal cell-derived factor-1 (SDF-1) produced by engineered mesenchymal stem cells, in a neurogenic bladder (NB) rat model. Sprague-Dawley (SD) rats (N=48) were randomly divided into 4 groups comprising 12 rats each: control group, Injury group, Injury+imMSC group, and Injury+SDF-1 eMSC group. Rats in the Injury+imMSC group were treated with imMSCs, whereas the Injury+SDF-1 eMSC group were administered SDF-1 eMSCs. After 4-weeks therapy, the bladder and pelvic nerve (PN) tissues were examined by subjecting to Masson's trichrome staining and immunofluorescence. Administration of SDF-1 eMSC resulted in improved smooth muscle content in the bladder tissue, significantly increased β-III tubulin expression of the PN, and enhanced SDF-1 expression (P<0.05). The bladder wall repair can be attributed to the overexpression of SDF-1 by SDF-1 eMSCs. Significantly increased SDF-1 expression was obtained in the Injury+SDF-1 eMSC group (P<0.05). The crushed PN also showed significant recovery in the Injury+SDF-1 eMSC group (P<0.05). In conclusion, our results indicate that SDF-1 eMSCs express more SDF-1 in vivo, thereby facilitating the repair of injured nerve and recovery of NB in rats.

• Journal of Life Science
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• v.18 no.11
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• pp.1513-1520
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• 2008

The 4-Hydroxynonenal (HNE) affects vascular dysfunctions probably through the interruption of the cellular redox balance. To better understand vascular abnormalities resulting from the accumulation of HNE, we delineated mechanism by which mitochondrial apoptosis occurs in the YPEN-1 endothelial cells. HNE treatment led to the loss of mitochondrial membrane potential (${\delta}{\Psi}_m$), resulting in the release of cytochrome c. Data showed decreased Bcl-2 and increased Bax protein levels in HNE-treated cells. NAC, a reactive oxygen species (ROS) scavenger, and penicillamine, the peroxynitrite scavenger, blocked HNE-mediated ROS generation, thereby thwarting the cytochrome c release and apoptosis. The treatment of the cells with zVAD-fmk, a broad range caspase inhibitor did not suppress HNE-induced apoptosis, suggesting that the apoptosis might be the possibility of caspase-independent process. Our findings delineate the underlying mechanism of the HNE induced endothelial apoptosis by triggering depolarization of mitochondria membrane potential that can lead to the deterioration of vasculature homeostasis and subsequent vascular dysfunction with aging.