• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.2
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• pp.99-105
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• 2021

This study was conducted to identify the efficacy related to skin barrier functions such as anti-inflammatory, anti-allergic, cornified envelope formation and the alleviation effect of keratinocyte damage caused by S. aureus using the callus extract, which was induced and extracted from the leaves of Gynostemma pentaphyllum in Ulleungdo Island. In order to confirm the anti-inflammatory effect of the G. pentaphyllum callus extract on the skin, the expression of inflammatory cytokines was investigated in primary epidermal keratinocytes (HEKa) activated with PAR-2 agonist, and the G. pentaphyllum callus extract showed IL-8, IL-25, and TSLP production inhibitory effect. β-Hexosaminidase assay using RBL-2H3 cells was performed to confirm the anti-allergic efficacy, and G. pentaphyllum callus extract showed the effect of inhibiting the release of β-hexosaminidase. In addition, G. pentaphyllum callus extract showed the cornified envelope formation effect in HaCaT cells, and through the co-culture experiment with HaCaT cells and S. aureus, it showed alleviation effect of keratinocyte damage caused by S. aureus. Therefore, G. pentaphyllum callus extract is considered to be a useful cosmetic material for improving skin barrier with anti-inflammatory, anti-allergic and alleviation effect of keratinocyte damage caused by S. aureus.

• Research in Community and Public Health Nursing
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• v.8 no.2
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• pp.395-402
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• 1997

인지능력 손상으로 인해 치매환자의 정상 언어 사용은 점차 감소되고 좌절감과 스트레스는 상승된다. 신체접촉은 비언어적 의사소통의 한 형태로서 치매환자를 지지하고 스트레스 상황에서 겪는 불안을 완화한다. Hollinger와 Buschmann은 1993년 신체 접촉 모형을 개발하였으며, 그 모형을 적용하여 신체접촉 인지도와 우울과의 관계와 신체 접촉의 우울증감소 효과를 정상 노인과 우울증 노인을 대상으로 연구했다. 그러나, 모형을 치매환자 연구에 적용시켜 검토한 연구는 언다. 본 연구의 목적은 신체 접촉 모형을 비평 분석하는 것이다. 또한, 분석을 기초로 하여 모형을 치매 환자 연구에 적용하도록 변형시켰다. 치매 환자의 인지, 언어 능력은 손상되었지만, 환경에 반응하는 감정과 접촉 감각은 유지되고 있다는 것은 신체 접촉 모형을 치매환자에게 적용할 때 반드시 고려해야 할 점이다. 개인의 문화 차이는 신체 접촉에 대한 인지와 반응에 영향을 준다. 따라서, 연구대상자 선택시 대상자가 신체 접촉을 긍정적으로 받아들이고 있는지를 확인해야 할 것이다. 대상자는 인지 능력 손상으로 면담이나 질문지에 적당히 반응할 수 없으므로 연구시 관찰 방법의 이용을 제언한다.

• Proceedings of the Korean Nuclear Society Conference
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• 1998.05a
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• pp.795-800
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• 1998

월성 발전소에서의 중대사고 진행을 예측하고 분석하기 위하여 CANDU 발전소의 중대사고 해석코드인 ISAAC을 이용하여 능동 안전 장치들이 동작하지 않는 발전소 정전사고에 대한 분석을 수행하였다. ISAAC은 사고 관리용 전산코드로 개발된 MAAP4/PWR를 근간으로 월성 발전소의 고유 특성에 관한 모델들을 추가하여 개발되었다 월성 발전소의 경우 칼랜드리아 안의 감속재와 칼랜드리아 볼트 안의 냉각수는 피동 열침원으로, 능동 안전 장치들이 동작하지 않는 중대사고시 노심으로부터의 붕괴열을 제거하여 노심 손상을 지연시킬 수 있다. 발전소 정전사고에 대한 ISAAC 계산 결과 노심 손상후 칼랜드리아 파손까지 약 40 시간이 예상되며, 이 동안에 운전자는 사고를 완화시킬 수 있는 방안을 모색할 수 있다. 따라서, 월성발전소의 피동안전장치는 사고 관리 전략 수립에 중요한 기능을 담당한다.

• Journal of Life Science
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• v.20 no.6
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• pp.870-876
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• 2010

The purpose of this study was to examine the effect of kinesio taping on muscle strength and changes of muscle fatigue and damage. 10 male subjects participated in 1-RM and isometric cybex muscle strength tests with and without taping application. Muscle strength (bench press, leg press) and extension (knee, shoulder) strength were significantly increased after taping, but there was no significant difference in flexion (knee, shoulder) strength. The concentration of fatigue factors (ammonia, phosphorous), muscle damage index substances (CK, LDH), IGF-I and creatinine were reduced after taping, but there were no significant differences.

• Journal of Life Science
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• v.29 no.11
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• pp.1258-1266
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• 2019

Yangkyuksanhwa-Tang (YKSH), consisting of nine different herbs, is commonly used in Soyangin-type individuals with stroke, based on the Sasang Constitution Theory in Korea. However, no evidence has yet confirmed a beneficial effect of YKSH in ischemic stroke treatment. In this study, we investigated the effects of YKSH on ischemic brain injury in a mouse model of cerebral ischemia. Focal cerebral ischemia in mice was induced by photothrombosis, and behavioral recovery was evaluated. Infarct volume, inflammation, and newly generated cells were evaluated by histology and immunochemistry. YKSH treatment resulted in a significant recovery from the motor impairments induced by focal cerebral ischemia, as determined with wire grip and rotarod tests. YKSH treatment also decreased the infarct volume and the number of cells positive for tumor necrosis factor-${\alpha}$ and myeloperoxidase when compared with a vehicle-treated control group. By contrast, YKSH treatment considerably increased the number of cells positive for glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1, as well as the number of cells doubly positive for Ki67/doublecortin when compared with the vehicle-treated group. These results suggest that YKSH treatment attenuated the infarct size by anti-inflammatory action, astrocyte and microglia activation, and neuronal proliferation, thereby facilitating neurofunctional recovery from a cerebral ischemic assault. YKSH could therefore be a potential treatment for neurofunctional restoration of the injured brains of patients with stroke.

• Korean Journal of Materials Research
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• v.3 no.2
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• pp.197-204
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• 1993

Abstract The effects of the hole size and the specimen width on the fracture behavior of several fabric composite plates are experimentally investigated in tension. Tests are performed on plain woven glass/ epoxy, plain woven carbon/epoxy and satin woven glass/polyester specimens with a circular hole. It is shown in this paper that the characteristic length according to the point stress criterion depends on the hole size and the specimen width. An excellent agreement is found between the experimental results and the analytical predictions of the modified failure criterion. The notched strength increase with an increase in the damage ratio, which is explained by a stress relaxation due to the formation of damage zone. When the unstable fracture occurred, the critical crack length equivalent for the damage zone is about twice the characteristic length. The critical energy release rate $G_c$ is independent of hole size for the same specimen width. The variation of $G_c$ according to the material system, fiber volume fraction and specimen width relates to the notch sensitivity factor. $G_c$ increases with a decrease in the notch sensitivity factor, which can be explained by a stress relaxation due to the increase of damage zone.

• Composites Research
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• v.37 no.1
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• pp.21-31
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• 2024

This review paper investigates the use of shockwave attenuating materials within composite structures to enhance personnel protection against blast-induced traumatic brain injury (bTBI). This paper also introduces experimental methodologies exploited in the generation and measurement of shockwaves to evaluate the performance of the shock dissipating composites. The generation of shockwaves is elucidated through diverse approaches such as high-energy explosives, shock tubes, lasers, and laser-flyer techniques. Evaluation of shockwave propagation and attenuation involves the utilization of cutting-edge techniques, including piezoelectric, interferometer, electromagnetic induction, and streak camera methods. This paper investigates phase-separated materials, including polyurea and ionic liquids, and provides insight into composite structures in the quest for shockwave pressure attenuation. By synthesizing and analyzing the findings from these experimental approaches, this review aims to contribute valuable insights to the advancement of protective measures against blast-induced traumatic brain injuries.

• Journal of Life Science
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• v.27 no.11
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• pp.1349-1356
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• 2017

Potassium channel openers (KCOs) produce physiological and pharmacological defense mechanisms against cell injuries caused by oxidative stress of diverse origins. Openings of mitochondrial and plasmalemmal $K^+$ channels are involved in the defense mechanisms. This study tested whether NS 1619, an opener of large-conductance BK channels, has a similar beneficial influence on the pigment epithelial cells of retinas. The human retinal pigment epithelial cell line ARPE-19 was exposed to $H_2O_2$-induced oxidative stress in the absence and presence of NS 1619. The degrees of the cells' injuries were assessed by analyzing the cells' trypan-blue exclusion abilities and TUNEL staining. NS 1619 produced remarkable protections against cell injuries caused by $H_2O_2$. It prevented apoptotic and necrotic cell deaths. The protective effect of NS 1619 was significantly diminished when the cells were treated with NS 1619 in combination with the BK channel-blocker paxilline. NS 1619 significantly ameliorated cellular ATP deprivations in $H_2O_2$-treated cells. It helped mitochondria preserve their functional integrity, which was estimated by their MTT reduction abilities and mitochondrial membrane potential. In conclusion, it was suggested that NS 1619 had a beneficial effect on mitochondria in regards to preserving their functional integrity under oxidative stress, and it produces defense mechanisms against oxidant-induced cell injuries in ARPE-19 cells.

• Korean Journal of Plant Resources
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• v.37 no.2
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• pp.101-109
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• 2024

In this study, we investigated the antioxidant effects and active ingredients of Gynura Procumbens extracts obtained through various extraction methods for the development of natural-based cosmetics and pharmaceutical materials. The contents of compounds, total flavonoids, chlorogenic acid, and caffeic acid were compared at different concentrations, revealing the highest content of active ingredients in the 100% ethanol extract. Antioxidant activity assessed by DPPH and ABTS radical scavenging assays showed a concentration-dependent increase in antioxidant activity with the ethanol concentration. Additionally, we validated the DNA damage inhibition and anti-inflammatory effects of Gynura Procumbens extracts through UVB irradiation on Hs68 cell models. The 100% ethanol extract demonstrated significant inhibition of the expression of p-p53, γ-H2AX, iNOS, and COX-2 induced by UVB, indicating its potential in alleviating photodamage effects. Consequently, the efficient extraction of Gynura Procumbens for skin functional material development was confirmed, suggesting the suitability of ethanol or alcohol-based solvents.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.1
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• pp.81-88
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• 2020

Diesel particulate matter (DPM) induces inflammatory cytokines in HaCaT and stimulates XRE promoter activity through AhR binding. Thus, it increases CYP gene family expression. In this study, we have elucidated inhibitory effect of LG Herbal Medicine Complex (LG-HMC) on DPM-induced XRE promoter activity and inflammatory cytokine expression. First of all, the XRE promoter activity was overexpressed by DPM treatment and the LG-HMC abrogated the XRE promoter activity. Morus alba bark extract, Scutellaria baicalensis root extract and constituents of LG-HMC, were found to be main effecters against DPM induced XRE promoter activation. We also found that DPM treatment elevated inflammatory cytokines in HaCaT and the treatment of LG-HMC, Morus alba bark extract and Scutellaria baicalensis root extract down-regulated the DPM induced inflammatory cytokine expression. Additionally, Morus alba bark extract and Scutellaria baicalensis root extract were found to act as free radical scavengers. In conclusion, we confirmed skin protective effect of LG-HMC and uncovered two components, Morus alba bark extract and Scutellaria baicalensis root extract, that play major role in protecting epidermal kertinocytes from damage.