• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.85-85
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• 1993

뇌동맥계는 일과성 저혈압에 반응하여 혈관확장이 야기되고, 혈압 상승시에는 혈관수축이 일어남으로서 뇌혈류가 일정하게 조절된다. 이러한 자가조절은 뇌손상 등의 병적 상태에서 야기된다. 연구의 목적은 \circled1 Cromakalim, CGRP(calcitonin-gene related peptide), 및 substance P에 의하여 뇌연막동맥의 직경이 어떻게 변동하는가를 관찰하고 \circled2 이들 신경성 peptide의 작용에 대하여 $K^{＋}$ 통로 개방 봉쇄제인 glibenclamide의 전처치 효과를 검색하고 \circled3 Capsaicin 전처치가 뇌혈류 자가조절에 어떻게 영향을 미치는가를 검색하였다. 그 결과는 다음과 같다. 1. 뇌혈류 자가조절은 대퇴동맥을 통한 사혈에 의하여 혈압하강을 일으킬 때 뇌연막 동맥은 이완하였고, reservoir내의 혈액을 체내로 주입함로서 혈압반전을 일으켰을 때는 혈관 수축이 일어났다. 2. 연막동맥은 glibenclamide (1~3$\mu$M)의 관류에 의하여는 영향을 받아니하였다. 3. 혈압변동에 따른 혈관직경의 변화를 회기직선으로 분석하였다. Glibenclamide 1과 3$\mu$M의 전처치 관류에 의하여 혈압하강에 따른 혈관 이완경사도와 혈압반전에 따른 혈관수축 경사도가 대조군에 비하여 현저히 약화되었다. 4. Cromakalim (0.1-30$\mu$M)의 각 농도를 대뇌표면에 관류시 연막동맥의 기초직경은 약물농도에 의존하여 증가되었고, 이는 glibenclamide (1$\mu$M) 전처치 관류에 의하여 억제되었다. 5. CGRP (0.1~100 nM)와 substance P (0.1~10nM)도 용량에 의존하여 혈관이완을 일으켰다. 전자는 glibenclamide (1$\mu$M) 전처치 관류에 의하여 억제되었으나 후자는 영향을 받지 아니하였다. 6. Capsaicin(50 nmol: intracisternally) 주사에 의하여 뇌혈류자가조절의 변동이 초래되었다. 이상의 결과들을 종합하면 CGRP가 혈압변동에 의하여 반사적으로 유리되고, 이는 glibenclamide-sensitive $K^{＋}$ 통로에 작용하는 것으로 시사된다.

• Journal of Food Hygiene and Safety
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• v.15 no.3
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• pp.226-234
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• 2000

Protective effect of Corydalis ternata against the carbon tetrachloride-induced toxicity was investigated. Carbon tetrachloride($CCl_4$) induces hepatotoxicity due to the reactive free radical(CCl$_3$ . ) generated by cytochrome P-450 enzyme. We examined effects of hexane, chloroform, butanol and water fractions prepared from the Corydalis ternata methanol extract. Rats were treated with those for 3 days, and liver microsomes and cytosols were prepared at 24 hour after last treatment. Hepatoprotective activity of the water fraction was higher than that of other fractions. To examine mechanism of the hepatoprotective effect of Corydalis ternuta, we measured contents of malondialdehyde(MDA), cytochrome P46O(CYP), glutathione, calcium as well as the activities of NADPH-CYP reductase, glutathione S-transferase(GST), superoxide dismutase(SOD), glutathione peroxidase(GPX) and catalase. The fraction inhibited production of MDA, content of CYP and calcium in liver of water fractions - treated rats as compared with those of CCl4-treated rats. The GST activity was increased. We speculate that the O2 radical scavenging activities of the water fraction might play a key role in the mechanism opposing the progression of $CCl_4$-induced hepatotoxicity, but the activities of SOD, GPX, CAT were decreased. These results suggest that the mechanism might be mainly due to the decrease of CYP contents, act as calcium channel blocker and increase of GST activity rather than $O_2$ radical scavenging activities.

• Journal of the Korean Society for Nondestructive Testing
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• v.31 no.4
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• pp.360-366
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• 2011

The Elasto-magnetic sensor is applied to detect the local cross-sectional loss of steel cables in this study while it was originally developed for measuring the tensile force in the previous works. To verify the feasibility of the proposed damage detection technique, steel bars which have 4-different diameters were fabricated and the output voltage value was measured at each diameter by the E/M sensor. Optimal input voltage and working point are chosen so that the linearity and resolution of results can ensure through repeated experiments, and then the E/M sensor was measured the output voltage values at the damage points of steel bar specimen that was applied the 4 types of damage condition based on the selected optimal experimental condition. This proposed approach can be an effective tool for steel cable health monitoring.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.10
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• pp.2819-2830
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• 2009

Load bearing structural members in a wide variety of applications accumulate damage over their service life. During experiment much effort and cost is needed for measuring structural safety assessment. The sparseness and errors of measured data have to be considered during the safety estimation of structures. This paper introduces parameter estimation and damage identification algorithm by a system identification using static and dynamic response. The equation error estimator and response error widely used in system identification are based on the minimization of least squared error between measured and calculated responses by a mathematical model of a structure. Since each estimator has a specific form of application in noisy environment and proposes different definitions for these forms. To study the behaviour of the estimators in noisy environment Using Monte Carlo simulation, and a data measured pertubation scheme is adopted to investigate the influence of measurement errors on identification results. The assessment result by static and dynamic response were compared, and the efficiency and applicabilities of the proposed algorithm are demonstrated through simulated static and dynamic responses of a dimensional truss type structures.

• Journal of Korean Society of Disaster and Security
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• v.11 no.2
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• pp.53-60
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• 2018

To diagnosis the local damages of the steel plates, magnetic flux leakage (MFL) method that is known as a adaptable non-destructive evaluation (NDE) method for continuum ferromagnetic members was applied in this study. To analysis the sensitivity according to thickness of steel plate in MFL method based damage diagnosis, several steel plate specimens that have different thickness were prepared and three depths of artificial damage were formed to the each specimens. To measured the MFL signals, a MFL sensor head that have a constant magnetization intensity were fabricated using a hall sensor and a magnetization yoke using permanent magnets. The magnetic flux signals obtained by using MFL sensor head were improved through a series of signal processing methods. The capability of local damage detection was verified from the measured MFL signals from each damage points. And, the peak to peak values (P-P value) extracted from the detected MFL signals from each thickness specimen were compared each other to analysis the MFL based local damage detection sensitivity according to the thickness of steel plate.

• Journal of Radiation Protection and Research
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• v.27 no.3
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• pp.181-188
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• 2002

We investigated the effect of Paeonia japonica (PJ) on radiation-induced oxidative damage to macromolecules in vitro and in vivo. The PJ reduced the tail moment (TM) which was a marker of DNA strand break in single-cell gel electrophoresis (SCGE; comet assay) in the human peripheral blood lymphocytes. Lipid peroxidation in the liver of the ICR mouse, measured as malondialdehyde (MDA), was also reduced by PJ administration. Ethanol fraction of PJ was more effective than polysaccharide fraction of that on reduction of TM in SCGE and lipid peroxidation. Also, Their activities to scavenge DPPH radicals and hydroxyl radicals were observed in vitro, and the activities were due to its ethanol fraction. It is plausible that scavenging of flee radicals by PJ extract may have played an important role in providing the protection against the radiation-induced damage. These results indicated that Paeonia japonica might be a useful radioprotector, especially since it is a relatively nontoxic natural product.

• Tuberculosis and Respiratory Diseases
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• v.46 no.4
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• pp.512-522
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• 1999

Background: Due to the paucity of suitable donor organs for lung allotransplantation, a number of techniques have been developed to improve the lung preservation. Ultrastructural studies of the morphologic changes of the flushing, preservation and reperfusion injury in donor lungs have rarely been reported. Methods: Adult dogs (n=46) were matched as donors and recipients for the single lung transplantation. The donor lungs were preserved after flushing with preservation solution and transplanted after 20-hours of preservation at $10^{\circ}C$. Ultrastructural features of the lung were examined after flushing, preservation and 2 hours after lung transplantation (reperfusion) respectively. Results: Electron microscopy after flushing showed focal alveolar collapse and mild swelling of type I epithelial cells. After preservation both type I epithelial cells and endothelial cells were swollen and destroyed focally. The endothelial cells showed protrusion of tactile-like structures into the lumina, blebs or vacuoles of the cytoplasm After reperfusion the lung tissue showed fibrin material in the alveoli, prominent type I epithelial cell swelling with fragmented cytoplasmic debris and marked endothelial cell swelling with vacuoles or tactile-like projections. The alveolar macrophages showed active phagocytosis. Scanning electron microscopic examination of the pulmonary parenchyma showed focally alveolar collapse and focal consolidation after the preservation and more prominent changes after the reperfusion procedure. The lungs preserved with low potassium dextran glucose solution, with additional prostaglandin $E_1(PGE_1)$ and verapamil(VP) showed relatively well preserved ultrastructures compared with those which were preserved with modified Euro-Collins or University of Wisconsin, and with additional $PGE_1$ and/or VP. Conclusion: The ultrastructural changes associated with flushing were mild in severity, the donor lungs were injured during the preservation, and further damage was occurred during the reperfusion. The reperfusion injury resulted in prominent pulmonary parenchymal alterations with a pattern of acute lung injury.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2008.04a
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• pp.139-144
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• 2008

In this study, damage detection method using harmony search method and frequency response is proposed. In order to verify this method, the following approaches are implemented. Firstly, damage detection method using harmony search is developed. To detect damage, objective function that minimize difference with natural frequency and modal strain energy from undamaged and damaged model is used. Secondly, finite element model for beam structure is created. And damage scenario is determined. Lastly, damage detection is performed by proposed method and utility of proposed method is verified.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.05a
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• pp.184-187
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• 2005

Physical changes in a structural system may cause changes in mechanical impedance of the system. Due to the electro-mechanical coupling effect in piezoelectric materials, this change can be monitoring by the electrical impedance of the piezoelectric sensor. In this paper, the variability of electro-mechanical impedance caused by temperature effect is assessed to adjust impedance data used for EMI based damage detection in beams. First experiments on beams are described. Next, experiments were performed under the temperature varying condition, in the range of $3^{\circ}C\;to\;23^{\circ}C$. Finally, the relationship between temperatures and impedance signatures is analyzed empirically temperature-frequency patten for the test structure.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2004.10a
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• pp.550-557
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• 2004

In this paper, structural damage in PSC bridges is monitored by using model-based damage detection methods. First numerical experiments on the test structure are described. Dynamic responses of the test structures are obtained fur several damage scenarios. The change in natural frequency and the change in nude shape curvature are selected as features to represent the states of the structure. Next a damage localization algorithm from monitoring the changes in natural frequency is outlined. Also, the damage localization algorithm from monitoring the changes in nude shapes is outlined. Finally, the damage localization algorithms are used to predict damage in the test structure. The results of the analysis indicate that the model-based damage detection methods correctly predicted damage in the test structure.