• Journal of the Korean Society of Food Science and Nutrition
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• v.34 no.10
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• pp.1545-1552
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• 2005

Sanguisorba officinalis L. has been used as a traditional remedy for arthritis, neuralgia, diarrhea, vomiting, gastric ulcer and gastro-intestinal disorders. This study was performed to investigate the protective effects of ethylacetate fraction of Sanguisorba officinalis L. ethanol extract (SOE) on the gastric mucosal damage and gastric ulcer induced by HCI-ethanol, indomethacin, Shay-ligation method, restraint and water-immersion stress, and cysteamine in rats. The experiment animals were divided into four groups: a negative control group (CON), positive control group (cimetidine 100 mg/kg-CMT or omeprazol 100 mg/kg administrated group-OMT), SOE 200 mg/kg administrated group (SOL) and SOE 400 mg/kg administrated group (SOH), respectively. Rats were given an oral or intraduodenal administration of SOE, and all SOE treatment groups compared with the CON significantly inhibited HCI-ethanol-induced acute gastritis and indomethacin-induced gastric ulcers in dose-dependent manner, of which effects were lower in a positive control drug (CMT). The inhibition rates ($\%$) on the acute gastritis induced by HCI-ethanol and the gastric ulcers induced by indomethacin in rats, 17.66$\%$ and 48.28$\%$ in SOL, 21.71$\%$, and 51.08$\%$ in SOH, and 47.26$\%$ and 58.26$\%$ in CMT compared with CON, respectively, In pylorus ligated rats, the groups of SOE showed decreases in the volume of gastric secretion and acid output. However, no significant differences were observed in the pepsin activity between treated groups . In addition, SOH also depressed gastric ulcers induced by restraint and water-immersion stress and duodenal ulcers induced by cysteamine. These results suggest that Sanguisorba officinalis L. has remarkable antigastric ulcer effects and could be developed as a new antigastric ulcer agents.

• Journal of Korean Academy of Nursing
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• v.27 no.2
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• pp.289-302
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• 1997

The main purpose of this study was to identify the effects of integrated stress management program on the stress symptoms of psychophysiological patients. especially patients with peptic ulcer. The study employed a quasi-experimental design using two different experimental groups. The samples in the integrated stress management program participated in autogenic training with biofeedback. discussions on effective coping method. cognitive. behavioral, and emotional management. They were also provided with an educational booklet on stress management and an tape on progressive muscie relaxation. Each session lasted one hour and the program consisted of seven sessions over four weeks. The other group was only given an tape on progressive muscle relaxation. The data were collected from May 20 to september 25, 1996. A total 47 patients from one university hospital located in Seoul participated, experiment group 1(integrated stress management training) had 23 subjects and experiment group 2(progressive muscle relaxation training) had 24 subjects. The effects of these programs were measured by the stress symptom scale developed by Kogan(1991) which was translated by Lee(1992) and the healing status of the ulcer evaluated by a physician. The data were analyzed using Chi-square test, t- test, ANOVA, repeated measure ANOVA. The result are as follows : 1. The integrated stress management group reported a significantly lower stress symptom score than the group given the progressive muscle relaxation only. 2. The integrated stress management group showed a significantly improved ulcer status as compared to the group given a progressive muscle relaxation only. In conclusion, it was found that the integrated stress management program was more effective in decreasing self-reported stress and physiological symptoms among patients with peptic ulcer as compared to the progressive muscle relaxation group. Based on this finding, the following suggestions can be made. 1. It is necessary to broaden the scope of nursing practice for psychophysiological patients so nurses can include stress management as part of patient care. 2. It is necessary to develop stress management program for other patients whose symptoms are known to be related to stress. 3. It is necessary to replicated this study with a larger sample in different settings.

• 대한임상약리학회:학술대회논문집
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• 1997.12a
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• pp.32-33
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• 1997

• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.115-115
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• 1995

저자 등은 일련의 식물엑스에 대하여 항위염 및 항궤양효능에 관한 검색을 실시하여 오리나무수피의 MeOH엑스가 현저한 효과가 있음을 예지 하였으므로 그에 대하여 보다 구체적인 실험을 실시하였다. 즉 MeOH엑스를 Hexane, CMCl$_3$, BuOH로 계통적으로 추출하여 상기의 분획 및 잔사인 물분획을 제조하여 이에 대한 실험을 실시하였다. 소화성궤양이 공격인자와 방어인자의 불균형에 의해 형성됨을 Shay가 주장함으로써 공격인자의 억제를 알아보기 위한 Mizui 등의 방법인 HClㆍEtOH 유발 위손상 실험과 Guth 등의 Aspirin 위손상 실험 방법에 따라서 위 손상정표를 관찰하였다. Shay의 방법에 따라서 위궤양 모텔은 유문을 결찰하고 검체를 십이지장내에 투여하고 처치를 완료하고 12시간 후에 궤양정도와 또한 4시간의 유문결찰에 의한 위액분 비량, pH 및 산분비량에 미치는 영향을 관찰하였다. 또 염산과 pepsin 등에 의한 점막 손상에 대한 방어인자의 증강요인인 위 mucous membrane의 mucus분비를 알아보기 위한 absoluteㆍ에탄올 위손상에 대한 예방효과 시험을 시행하였다. 이 실험의 결과, 오리나무 MeOH엑스의 항위염 및 항위궤양효과는 BuOH 분획에서 강력한 작용이 있었으며 이 분획은 aspirin 유발 위손상 및 shay 궤양에 효과를 나타내었고 또한 mucin량의 증가를 보여주었다. 그러나 이 분획은 위액, pH 및 산분비량에 영향을 나타내지 아니하였다.

• Korea Journal of Hospital Management
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• v.5 no.1
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• pp.24-39
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• 2000

This paper aims to analyze the effects that marketing mix variables have on the marketing performance of pharmaceutical manufacturers. It examines how product characteristics, price, marketing channel and promotion effort influence the sales and market share of anti-ulcer drugs in the markets for clinics and hospitals separately. Empirical results from 29 products of anti-ulcer drugs show that sales in hospitals are affected by the profit per prescription to the physician, brand name drugs relative to generics, and the age of ingredients since its introduction to the markets. Profit per prescription to the hospital, relative price, age of ingredients and promotion effort have positive effects on the market share.

• Herbal Formula Science
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• v.19 no.1
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• pp.253-261
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• 2011

Objectives : The prevalence of peptic ulcer disease is estimated about 10% in Korea, and has declined due to Helicobacter pylori eradication therapy. Symptoms of peptic ulcer are postprandial epigastric pain, hunger pain, anorexia, nauea, vomiting, soreness, postprandial fullness, postparandial discomfort. The purpose of the study was to evaluate the effectiveness of the Anjungsan in the improvement of the symptoms in patients with peptic ulcer. Methods : After taking Anjungsan to patient with peptic ulcer, Examined to assess the improvemnet by Ordinal Scale VI grade and VAS. Results : Patients with symptoms of the appeal was taking Anjungsan gets better after 3 dyas appeared to be more than half. And 11 days after treatment all symptoms were improved under the VAS 1-2 except for epigastric lump sensation. Conclusions : After treatment with Anjungsan, patient showed improvement in all symptoms associated with peptic ulcer.

• Korean Journal of Microbiology
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• v.31 no.2
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• pp.113-122
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• 1993

Aeromonas veronii was isolated from the haemorrhagic ulcer of the snakehead that had been infected in natural condition, This bacterium was injected hypodermically into the healthy snakeheads and the effect was compared to the naturally infected fish. Both groups showed severe necrosis, falling off of epidermal tissue and hypodermal muscle. In both groups, severe histophathological changes were observed in gill, digestive tract and kidney just before death. Artificially injected fish showed necrosis of tissue in skin, gill and digestive tract from 2 days after injection. Then it showed necrosis or cell atrophy of tissue in kidney from 5 days after injection, and in liver and spleen just before death. Snakehead infected with haemorrhagic ulcer died within 9 days after infection, showing the symptom of skin damage and metabolic inhibition in respiration" digestion, excretion, etc. It was concluded that Aeromonas veronii (CA26) that was isolated from the naturally infected fish is the main bacterium causing haemorragic ulcer in the snakehead.

• Journal of Pharmaceutical Investigation
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• v.14 no.3
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• pp.131-135
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• 1984

The effect of pH and magnesium ion on the hydrolysis of dicyclomine HCl was investigated by comparing the rate constant and activation energy. The hydrolysis of dicyclomine HCl was acid-base catalytic reaction and the most stable range of pH was $3{\sim}5$. The magnesium ion accelerated the hydrolysis of dicyclomine HCl in aqueous solution.

• Journal of the korean academy of Pediatric Dentistry
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• v.36 no.4
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• pp.575-579
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• 2009

Behcet's disease(BD) is a multisystem vasculitis that almost any organ in the body may be involved. Its diagnosis bases on clinical criteria in the absence of any specific laboratory test to confirm it. The clinical criteria proposed for the diagnosis for BD include recurrent oral and genital ulceration, skin lesion, ocular changes, and positive response to pathergy test. Besides these essential features, BD may manifest itself on the gastrointestinal tract, central nervous system, and other systemic involvements. Among these clinical features, recurrent oral ulcers are present in most BD patients, often as the initial symptom, preceding other manifestations by many years. Therefore, dentists are in the important position for the early detection and diagnosis of BD. In this case report, we are presenting a case of 6 year-old girl, who came to the pediatric dentistry department for evaluation and treatment of pain and dysphagia caused by severe recurrent oral ulcers. Through taking detailed dental and medical history and clinical examination, we reported the possibility of BD to the medical team and prescribed topical lidocaine to relief pain during swallowing. The medical team, which involved pediatrics, ophthalmology, dermatology, and gastroenterology, finally confirmed BD through various examinations. Detection of the possibility of BD in the dental field helped early diagnosis and proper management by the medical team.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.37-37
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• 1993

1) 급성독성시험: 랫드와 마우스 공히 투여후 5~6일에 농도의존적의 강한 독성이 발현 되었으며 표적장기로는 소화기계, 임파계, 조혈기계 등으로 나타났다. 랫드에서의 반수 치사량은 암수 각각 771.9(505.6~1178.4)mg/kg과 479.8(302.7~760.4)mg/kg이었으며 마우스에서는 암수 각각 527.4(393.7~701.1)mg/kg과 463.0(308.8~694.2)mg/kg 이었다. 2) 유전독성: S. typhimurium을 이용한 복귀돌연변이시험, CHL세포를 이용한 염색체이상 시험, 마우스에서의 소핵시험결과 DA-125는 돌연변이 유발능을 갖는 것으로 나타났다. 3) 국소자극성: 혈관주위주사에 의한 피부자극성 시험결과 DA-125는 adriamycin의 3배 용량에서 궤양, 괴사등 유사한 병변이 유발되었으나, 병변회복은 adriamycin에 비해 빠른 것으로 나타났다. 또한 토끼에서의 안점막자극시험 결과에서 DA-125는 실제적으로 자극이 없는 것으로 나타났다.