• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.4D
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• pp.451-457
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• 2008

Establishing realistic bus service coverage is needed to build optimum city bus line networks and reasonable bus service coverage areas. The purposes of this study are understanding the characteristics of the present walking time and marginal walking time of small-medium cities and constructing an ANFIS (Adaptive Neuro-Fuzzy Inference System) model to estimate the marginal walking time for certain age and income. The cities of Masan, Chongwon and Jinju are selected for study cities. The 80 percentile of present walking time of bus users of these cities are 10.2-11.1 minutes, thus the values are greater than the 5 minutes of the maximum walking time in USA and the marginal walking times of 21.1-21.8 minutes are much greater. An ANFIS model based on pulled data of the cities are constructed to estimate the marginal walking time of small-medium cities. Analyzing the relationship between marginal walking time and age/income by using the model, the marginal walking time decreases as the age increases, but is near constant from the age of 25 to 35. And the marginal walking time is inversely proportional to the income. In comparing the surveyed and the estimated values, as the statistics of coefficient of determination, MSE and MAE are 0.996, 0.163, 0.333 respectively, it may be judged that the explainability of the model is very high. The technique developed in this study can be applied to other cities.

• 한국노년학
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• v.31 no.2
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• pp.243-258
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• 2011

The purpose of this study is to achieve an understanding of psychosocial needs of elderly female residents living in the nursing home and their evaluation about psychosocial services from their perspectives. In-depth interview by constructivist inquiry was conducted to explore residents' needs. Purposive sampling was used to ensure that participants could communicate verbally and share their experience of living in the nursing home. 8 female residents who cognitively intact and aged 65 or over were invited to participate in this study. Data collection was conducted from January 1 to 5 in 2008. The interviews were recorded and transcribed. Constant comparison method was used for data analysis. Levels of psychological needs were identified as four categories-satisfied needs; unmet needs; hidden needs; lack of expression of needs. While nursing home generally focuses on medical care provision, residents' psychosocial needs tend to be relatively overlooked. The satisfaction of psychosocial needs is significant in guaranteeing well-being in later life.

• Asia Marketing Journal
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• v.13 no.1
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• pp.1-26
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• 2011

Measuring the quality of city life (QCL) is important for city marketing given that QCL influences the city brand image and resident city relationship. Despite its importance, most previous measures of community well being were developed in the context of small towns, and limited attention has been given to a subjective measure of QCL in the context of a large city. This study develops and tests a subjective measure of quality of city life (QCL) in the context of a large metropolitan city. Quality of city life (QCL) refers to the degree of need satisfaction and feelings of happiness one experiences during the course of city life. The results from a survey of 507 residents from 25 major districts in Seoul indicate that the QCL measure has convergent and discriminate validity. The results also indicate that QCL has predictive validity in relation to satisfaction with city services, trust in the city government, word of mouth communication, and a sense of citizen pride. The managerial and policy implications of this study are discussed.

• Korean Journal of Culture and Social Issue
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• v.11 no.1
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• pp.25-42
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• 2005

The present research examined the proposition that once people violate traffic regulations, they would experience cognitive dissonance and subsequently engage in changing their attitudes toward the law negatively in order to reduce the dissonance. In an experiment, participants were presented with three scenarios in which a person violated traffic laws, and they were asked to imagine themselves as the person of the scenarios and write statements supporting the unlawful behaviors. Participants' attitudes toward the general traffic law and the regulations related to the violations were measured 8 weeks before and right after the experimental treatment. The results, as expected, showed that their attitudes toward the general traffic law and the specific regulations in the scenarios changed negatively after writing the statements. In each secnarios, the participants who chose to wrote statements supporting the unlawful behaviors showed great attitude changes that those who did not write the statements. Furthermore, attitudes toward the regulations that were not directly related to the scenarios did not change significantly, and participants who were expected to experience stronger dissonance arousal (e.g.., supported more unlawful behaviors or had have more positive attitudes toward the law before the experiment) showed greater attitude changes. These results support the effects of trivial unlawful behaviors on attitudes toward the law and strongly suggest the role of cognitive dissonance underlying the effects.

• Geophysics and Geophysical Exploration
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• v.9 no.1
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• pp.30-36
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• 2006

Japan's first pilot-scale $CO_2$ sequestration experiment has been conducted in Nagaoka, where 10400 t of $CO_2$ have been injected in an onshore aquifer at a depth of about 1100 m. Among various measurements conducted at the site for monitoring the injected $CO_2$, we conducted time-lapse crosswell seismic tomography between two observation wells to determine the distribution of $CO_2$ in the aquifer by the change of P-wave velocities. This paper reports the results of the crosswell seismic tomography conducted at the site. The crosswell seismic tomography measurements were carried out three times; once before the injection as a baseline survey, and twice during the injection as monitoring surveys. The velocity tomograms resulting from the monitoring surveys were compared to the baseline survey tomogram, and velocity difference tomograms were generated. The velocity difference tomograms showed that velocity had decreased in a part of the aquifer around the injection well, where the injected $CO_2$ was supposed to be distributed. We also found that the area in which velocity had decreased was expanding in the formation up-dip direction, as increasing amounts of $CO_2$ were injected. The maximum velocity reductions observed were 3.0% after 3200 t of $CO_2$ had been injected, and 3.5% after injection of 6200 t of $CO_2$. Although seismic tomography could map the area of velocity decrease due to $CO_2$ injection, we observed some contradictions with the results of time-lapse sonic logging, and with the geological condition of the cap rock. To investigate these contradictions, we conducted numerical experiments simulating the test site. As a result, we found that part of the velocity distribution displayed in the tomograms was affected by artefacts or ghosts caused by the source-receiver geometry for the crosswell tomography in this particular site. The maximum velocity decrease obtained by tomography (3.5%) was much smaller than that observed by sonic logging (more than 20%). The numerical experiment results showed that only 5.5% velocity reduction might be observed, although the model was given a 20% velocity reduction zone. Judging from this result, the actual velocity reduction can be more than 3.5%, the value we obtained from the field data reconstruction. Further studies are needed to obtain more accurate velocity values that are comparable to those obtained by sonic logging.

• Journal of Life Science
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• v.27 no.5
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• pp.509-516
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• 2017

Perilla frutescens (L.) Britton var. sprouts (PFS) is a plant of the labiatae family. The purpose of this work was to assess the preventive effects of PFS ethanolic extracts (PFSEs) on cytokine-induced ${\beta}$-cell damage. Cytokines, which are released by the infiltration of inflammatory cells around the pancreatic islets, are involved in the pathogenesis of type 1 diabetes mellitus. The combination of interleukin-$1{\beta}$ (IL-1), interferon-${\gamma}$ (IFN-${\gamma}$), and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) induced formation of reactive oxygen species (ROS). Accumulation of intracellular ROS led to ${\beta}$-cell dysfunction and apoptosis. PFSEs possess antioxidant activity and thus lead to downregulation of ROS generation. Cytokines decrease cell viability, stimulate the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and induce the production of nitric oxide (NO). PFSEs prevented cytokine-induced cell viability in a dose-dependent manner. Incubation with PFSE resulted in significant reduction in cytokine-induced NO production that correlated with reduced levels of the iNOS and COX-2 protein expression. Furthermore, PFSE significantly decreased the activation of nuclear factor ${\kappa}B$ (NF-${\kappa}B$) by inhibition of $I{\kappa}B{\alpha}$ phosphorylation in RINm5F cells. In summary, our results suggest that the protective effects of PFSE might serve to counteract cytokine-induced ${\beta}$-cell destruction. Findings indicate that consumption of Perilla frutescens (L.) Britton var. sprouts alleviates hyperglycemia-mediated oxidative stress and pro-inflammatory cytokine-induced ${\beta}$-cell damage and thus has beneficial anti-diabetic effects.

• (The)Study of the Eastern Classic
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• no.68
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• pp.379-408
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• 2017

What I wish to show in this paper is the moral educational implication on "The Minor Annotations of Elementary Learning(小學枝言)" in a position to consider the alternatives about personality education problems by searching viewpoints on moral training theory on the book. "The Minor Annotations of Elementary Learning(小學枝言)" was written by Dasan Jeong-yakyong(茶山 丁若鏞, 1762-1836). In the oriental philosophy, a moral training theory is built on the base of human nature theory. Dasan's moral training theory was also built on his human nature theory. Undoubtedly we could consider that his difference from the moral training theory of Confucianism is reflected in his moral training theory putting stress on practice. Dasan criticized the moral training theory of Confucianism because of its static aspect contemplating mind internally. He stands on the position that the virtue can be come true by the concrete practice. The establishment ground of Dasan's moral training theory is on his theory of human nature's preference(性嗜好說). Dasan didn't consider benevolence, righteousness, propriety, and wisdom(仁義禮智) as human nature. He considered that the human nature prefers goodness. So there is no perfect human nature or principle originally to human beings but also directionality to be displayed. We can say that the virtue building by cultivation of directionality get connected to moral training theory. Dasan considered ?The Minor Annotations of Elementary Learning(小學枝言)? as a practice book for moral training which develops individuals' personality through practice in the reality. He thought that the book cause individuals to follow 'the elementary way(小道)' and to learn 'the elementary art(小藝)' more than academic pursuit. From this viewpoint he showed the practice(行事) of judgment(權衡) by keeping the attitude for the scripture interpretation to pursue the right principles(義理) based on Chinese exegetics(訓?) and the historical evidences(考證) through the whole book. And in the book he suggested the standard of the whole-person education to develop the human nature based on his theory of human nature's preference(性嗜好說), to cognize relationship as an ethical existence, and to pursue the harmony with graphonomy(字學) and Ethics(道學). So we can regard that he realized his practice centered moral education philosophy in the book.

• Korean Journal of Environment and Ecology
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• v.21 no.6
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• pp.565-575
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• 2007

The purpose of this study is to derive political implications and to look into the establishment of new directions for the biotope mapping across the Korean territory so that such biotope mapping process could be used as a means of actual plan for natural environment preservation through the comparative study of biotope mapping methodology with that of the biotope mapping pioneer-Germany. As for research methodology, this study collected literature and data related to the biotope mapping of Korea and Germany and examined the general characteristics and inclinations about biotope mapping of both country, at a level of the national territory, federal government, provincial government, city and settlement areas. As a result of the examination, first, it was found that Germany drew up a landscape eco-type map and ecological landscape grade map throughout the nation in order to preserve and manage effectively by differential landscape eco-type unit. In contrast, Korea drew up a map on which Degree of Green Naturality and Ecological Nature Status are reflected for natural environment preservation at a nationwide unit. Secondly, the biotope mapping of German was worked centering on natural areas and their corresponding areas at German provincial government level and it drew up a Red-list by each province, while Korea has yet to carry out biotope mapping at a provincial level corresponding to Germany's. Thirdly, the biotope mapping on German cities and settlement areas includes not only big city areas but also medium & small cities and rural areas whereas Korean biotope mapping is conducted mainly centering on urban areas. In conclusion, this study suggests that the biotope mapping including natural areas and anti-natural area, not limited to city areas should be revitalized in order to be a real means of the all territory's balanced natural environment and biotope preservation & management. In addition, for this purpose, this study suggests that research on biotope pattern catalog and biotope red-list applicable to all territory should be preceded.

• Journal of dental hygiene science
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• v.11 no.2
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• pp.69-76
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• 2011

The aim of this study was to compare the effects on the resistance to demineralization by the frequency and method of fluoride application in vitro. ninety-one human enamel specimens were embedded in acrylic resin with the labial surfaces exposes. The specimens were divided into 7 groups; (1) non-treated; (2) 1.23% APF gel 1 time; (3) 2% NaF sol 1 time; (4) 2% NaF sol iontophoresis 1 time; (5) 1.23% APF gel 4 time; (6) 2% NaF sol 4 time; (7) 2% NaF sol iontophoresis 4 time. All the groups were immersed in the remineralizing solution (RS) before baseline and divided into 7 test groups of 13 specimens each. All the specimens were exposed to a pH-cycling model which consisted of demineralization (6 hours) and remineralization (18 hours) for 5 days. The Vickers surface micro-hardness number of all the specimens was measured using microhardness tester and the specimen surfaces were observed by scanning electron microscope (SEM). The results were analyzed using one-way ANOVA followed a Tukey's multiple comparison at a significance level of 0.05. The group 7 showed higher level of microhardness after Fluoride application. The group 1 showed lowest level of microhardness but group 7 showed higher level of microhardness after pH-cycling model, there were significant differences between groups. After the modified pH-cycling, the 2% NaF solution with the iontophoresis group showed the best resistance to demineralization(p<0.05). These results were also confirmed by SEM. The fluoride iontophoresis method was the most effective of the regimens in increasing the acid resistance of the enamel.

• KSBB Journal
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• v.21 no.6 s.101
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• pp.466-473
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• 2006

Impaired insulin secretion from pancreatic beta-cells in response to glucose is an important feature in the pathology of non-insulin-dependent diabetes mellitus (NIDDM). In the course of screening for useful insulin secretagogues, we have isolated and identified YHB-2017 (Genistein) as a insulin secretion potentiator from fermentation broths of our in-house microbial library. The insulinotropic activity of YHB-2017 in isolated rat pancreatic islets was exerted only at high concentration of glucose (8.3-16 mM) but not at low concentration of glucose (3.3-5.5 mM). Also, in perifusion study with isolated rat pancreatic islets, YHB-2017 stimulated insulin secretion in a time-dependent manner when YHB-2017 was added to KRB buffer containing 16 mM glucose. In the presence of $200\;{\mu}M$ diazoxide and 35 mM KCI, which stimulates maximum $Ca^{2+}$ influx independently of KATP channel, YHB-2017 enhanced KATP channel-independent insulin secretion at high concentration glucose (16 mM). To elucidate the mechanisms of the glucose-dependent potentiation effect of YHB-2017, pharmacologic inhibitors for protein kinase A, protein kinase C and calcium/calmodulin kinase II were pre-treated and then the potentiation effect of YHB-2017 on insulin secretion was investigated. Pre-treatment of H89 as a PKA inhibitor had a significant inhibitory effect on YHB-2017-induced potentiation effect. Furthermore, western immunoblotting analyses revealed that YHB-2017 increased phosphorylation of PKA substrates and cAMP response element-binding protein (CREB) under high concentration of glucose. These results demonstrated that the insulinotropic effect of YHB-2017 is mediated through PKA signal pathway and activated amplifying $K_{ATP}$ channel-independent insulin secretion pathway.