• KSBB Journal
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• v.20 no.3
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• pp.220-227
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• 2005

Doxorubicin is an anthracycline-family polyketide compound with a very potent anti-cancer activity, typically produced by Streptomyces peucetius. To understand the potential target biosynthetic genes critical for the doxorubicin everproduction, a doxorubicin-specific DNA microarray chip was fabricated and applied to reveal the growth-phase-dependent expression profiles of biosynthetic genes from two doxorubicin-overproducing strains along with the wild-type strain. Two doxorubicin-overproducing 5. peucetius strains were generated via over-expression of a dnrl (a doxorubicin-specific positive regulatory gene) and a doxA (a gene involved in the conversion from daunorubicin to doxorubicin) using a streptomycetes high expression vector containing a strong ermE promoter. Each doxorubicin-overproducing strain was quantitatively compared with the wild-type doxorubicin producer based on the growth-phase-dependent doxorubicin productivity as well as doxorubicin biosynthetic gene expression profiles. The doxorubicin-specific DNA microarray chip data revealed the early-and-steady expressions of the doxorubicin-specific regulatory gene (dnrl), the doxorubicin resistance genes (drrA, drrB, drrC), and the doxorubicin deoxysugar biosynthetic gene (dnmL) are critical for the doxorubicin overproduction in S. peucetius. These results provide that the relationship between the growth-phase-dependent doxorubicin productivity and the doxorubicin biosynthetic gene expression profiles should lead us a rational design of molecular genetic strain improvement strategy.

• Journal of the Korean Association of Geographic Information Studies
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• v.25 no.2
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• pp.59-71
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• 2022

This study considered regional differences in the university-industry collaboration of Korean universities and performed cluster analysis to identify the spatial range with high university-industry collaboration connectivity. By university establishment type, it was found that the university-industry collaboration capacity of the major national university was superior overall, especially in the technology transfer & commercialization sector and the infrastructure sector, compared to private universities and general national universities. The spatial pattern of university-industry collaboration capacity showed relatively clear differences by city and province. In terms of university-industry collaboration capacity by sector, it was confirmed that the regional gap was not large in the talent training sector and the infrastructure sector, but the regional gap was relatively large in the technology transfer & commercialization sector and the start-up sector. As a result of the cluster analysis to identify a spatial range with high connectivity in terms of similarity and spatial proximity of university-industry collaboration patterns, it is divided into 15 clusters. It is found that most of major national universities are included in one of 15 clusters where all sectors of university-industry collaboration are strong. Therefore, as a policy measure to achieve regional innovative growth through enhancing the effectiveness of university-industry collaboration, we propose the establishment of a hub & spoke network-type collaboration system in which a major national university acts as a hub and nearby local universities play a spoke role.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.27 no.2
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• pp.75-79
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• 2017

Honeycomb-shaped Ag-grid transparent conductive electrodes (TCEs) were fabricated using two different processes, high density plasma etching and lift-off, and the optical and electrical properties were compared according to the fabrication method. For the fabrication of the Ag-grid TCEs by plasma etching, etch characteristics of the Ag thin film in $10CF_4/5Ar$ inductively coupled plasma (ICP) discharges were studied. The Ag etch rate increased as the power increased at relatively low ICP source power or rf chuck power conditions, and then decreased at higher powers due to either decrease in $Ar^+$ ion energy or $Ar^+$ ion-assisted removal of the reactive F radicals. The Ag-grid TCEs fabricated by the $10CF_4/5Ar$ ICP etching process showed better grid pattern transfer efficiency without any distortion or breakage in the grid pattern and higher optical transmittance values of average 83.3 % (pixel size $30{\mu}m/line$ width $5{\mu}m$) and 71 % (pixel size $26{\mu}m/line$ width $8{\mu}m$) in the visible range of spectrum, respectively. On the other hand, the Ag-grid TCEs fabricated by the lift-off process showed lower sheet resistance values of $2.163{\Omega}/{\square}$ (pixel size $26{\mu}m/line$ width $18{\mu}m$) and $4.932{\Omega}/{\square}$ (pixel size $30{\mu}m/line$ width $5{\mu}m$), respectively.

• The Korean Journal of Financial Management
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• v.14 no.3
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• pp.23-56
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• 1997

본 연구는 주식의 시장가치와 거래빈도, 기관지분비율, 거래량 등에 따라 주식수익률의 시계열상관이 일정한 패턴을 갖는 것으로 나타나고 있다는 사실을 실증적으로 확인하고, 주식수익률의 시계열상관에 주된 영향을 미치는 요인을 횡단면 분석방법을 이용하여 살펴보고 있다. 1985년부터 1995년까지의 기간에 걸친 일별수익률자료를 이용하여 분석한 결과를 요약하면, 1) 규모, 거래빈도, 기관지분비율, 거래량 등이 작은 주식들로 구성된 포트폴리오일수록 수익률이 강한 양의 자기상관을 갖게 되며, 또한 그러한 변수들의 크기가 큰 주식들로 구성된 포트폴리오의 수익률에 대하여 후행하는 관계에 있다는 보여주고 있다. 2) Lo and MacKinlay(1990a)의 비거래모형을 이용한 분석결과에서는 한국주식수익률의 시계 및 상관이 전적으로 비거래로 인하여 나타나는 현상이 아니라는 것을 보여주고 있다. 3) 시계열상관의 정도를 나타내는 후행척도를 상기한 변수들에 대하여 회귀분석한 결과는 모든 변수들이 주식수익률의 시계열상관에 동시적으로 영향을 주고 있다는 것을 보여준다. 특히 시계열상관을 야기하는 요인들 중에서 거래빈도는 분석기간에 관계없이 항상 시계열상관에 음의 영향을 미치는 것으로 나타나고 있다. 기관지분비율과 거래량은 분명히 시계열상관에 음의 영향을 미치지만, 분석기간에 따라 유의성에 다소 차이를 보여주고 있다. 수익률의 변동성은 전반기의 경우에 시계열상관과 음의 관계를, 후반기의 경우에는 양의 관계를 갖는 것으로 나타나고 있다. 이러한 검증결과들로 미루어, 한국주식수익률의 시계열상관은 주가의 반응에 영향을 주게되는 시장구조나 투자패턴 등이 전 후반기에 있어서 서로 다르기 때문에 나타나는 현상으로 보인다.력(事前賣却努力)이 협의발행하에서 더 높았으나 발행일 직후의 주가회복은 보이지 않아 인수방식에 따른 가격안정화(價格安定化) 노력의 차이는 없었다. 발행기업들간의 주가차별화의 정도를 분석한 결과 협의발행에서 인회활동(認淮活動) (certification effects)을 더 잘 할 수 있다는 사실을 지지하지 못했다.범위(範圍)에 벗어나 한국주식시장(韓國株式市場)에서 주식시장(株式市場)의 비효율성(非效率性)을 배제할 수 없는 것으로 나타났다. 뿐만 아니라 차기에도 이어지고 화폐량과 소득이 주가의 결정에 영향을 미치고 있으며 다른 금융변수(金融變數)들은 영향을 미치지 않고 있다. 그러나 실질화폐잔고와 실질주가 장단기수익비율 화폐차등수익률과 소득변화률과는 장기적(長期的) 정상적(定常的) 균형관계(均衡關係)를 형성하고 있다. 따라서 장기적 관점에서 증권시장은 경제성장을 위한 통화정책과 각 분야의 균형적 성장을 유발할 수 있는 재정정책(財政政策)이 요청되고 있다. 위의 논의에서 유추할 수 있는 것은 화폐의 영향을 완화시키기 위하여 option시장의 개발과 농산물, 광물, 기타 실물 및 금융에 대한 선물시장의 개설이 요청된다. 이와 같은 시장을 통하여 통화 정책이 증권시장에 미치는 과도한 효과를 축소시켜 합리적이고 건전한 증권시장(證券市場)의 발전(發展)과 금융시장(金融市場)의 원활한 발전이 이룩될 수 있을 것이다. 자본시장이론(資本市場理論)에서는 화폐는 무시하고 실물적인 관점에서 증권가격의 결정을 연구하거나 위험분석에 주안점이 주어져 왔었다. 본 연구를 통하여 통화정책의 결과가 자본시장에 직접적으로 영향을 미치고 있음을 확인하였다. 통화금융정책과 주가의 유기적 관계를 확인한 본 논문의 결과를 정책당국이 참고하여

• Journal of Animal Environmental Science
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• v.12 no.1
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• pp.13-20
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• 2006

This experiment was carried out to determine the effect of breed and sex on behavioral characteristics and economic traits of performance-tested pigs. Totally 32 tested pigs in 4 different breeds were assigned for behavioral observation. Behavior was recorded for 4 hours(each 2 hours, before and after none) of tested pigs in each tested pen. The average daily gain, age at 90 kg and feed efficiency on the basis of the performance data were collected from 8,477 performance-tested pigs in which pure breeds of Duroc, Yorkshire, Landrace and Berkshire at the Korea Swine Testing Station. The results obtained in this study are summarized as follows; The effect of breed was statistically significant for all traits studied. Average daily gain were the highest(P<0.05) in Duroc and ages at 90 kg were the highest(P<0.05) in Berkshire. In feed efficiency of male, Landrace and Yorkshire were the most efficient. The average daily gain and feed efficiency were superior to those of female, however, the age at 90 kg was not different. Overally, females were superior to males in various traits examined. Berkshire breed had more proportion of time spent in ventral tying and sitting whereas the proportion of time spent in walking, drinking and eating was less than that of other breeds. The male pigs showed more time spent in standing and social behavior.

• Culinary science and hospitality research
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• v.20 no.6
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• pp.200-210
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• 2014

The purpose of this study was to investigate the quality changes and contamination of microorganisms such as Escherichia coli, mold and yeast in cherry tomatoes during storage at different temperatures, gas composition and periods(7 and 14 days). This study determined pH, color change and the growth pattern of microorganisms in cherry tomato during storage at $5^{\circ}C$, $10^{\circ}C$ and $15^{\circ}C$. According to the results, pH level was a little raised with storage period. On average, $L^*$, $a^*$ and $b^*$ value of cherry tomato were irregular value of increase and decrease of all gas packaging with storage period. In regard of the types of microorganism, aerobic count plate, coliform count, mold and yeast were detected when cherry tomatoes were stored at $5^{\circ}C$, $10^{\circ}C$ and $15^{\circ}C$ during storage for 14 days. Equally, all microorganisms of cherry tomato were irregular with storage period and complex gas packaging. However, this study determined that packaging with a higher $CO_2$ concentration than $O_2$ concentration can reduce growth of microorganism. These studies can be used as primary data for determining the optimal complex gas to storage enlargement.

• Journal of the Economic Geographical Society of Korea
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• v.22 no.4
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• pp.488-512
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• 2019

This study examines the 'Asia Decoupling' hypothesis, focusing on changes in trade patterns between regions and countries, based on the latest value added trade statistics. As an analytical tool, indicators that can directly measure the degree of distribution of actual value added were used. Main findings are: Firstly, creating potential at regional level which used to be the growth engine of East Asia until the mid-2000s declined sharply after the global financial crisis. Secondly, in the development pattern of the value added distribution network, no positive change has been detected in the give-out or gain capacity of emerging countries that can generate future growth in East Asia through GVC development. Lastly, China's value added contributing capacity, as different from the hub countries in other regions such as US and Germany, has declined significantly since the mid 2000s, while its capability to benefit greatly increased, and the gain potential of advanced group countries in competition with China is decreasing. We suggest the establishment of intra-regional economic cooperation mechanism including all countries in East Asia for expanding the value creating capacity in the region.

• Journal of Korea Water Resources Association
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• v.46 no.11
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• pp.1115-1128
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• 2013

The purpose of this study is to evaluate the suspended solids and eutrophication processes relationships in Chungju lake using CE-QUAL-W2, two-dimensional (2D) longitudinal/vertical hydrodynamic and water quality model. For water quality modeling, the lake segmentation was configured as 7 branches system according to their shape and tributary distribution. The model was calibrated (2010) and validated (2008) using 2 years of field data of water temperature, suspended solids (SS), total nitrogen (TN), total phosphorus (TP) and algae (Chl-a). The water temperature began to increase in depth from April and the stratification occurred at about 10 m early July heavy rain. The high SS concentration of the interflow density currents entering from the watershed was well simulated especially for July 2008 heavy rainfall event. The simulated concentration range of TN and TP was acceptable, but the errors might occur form the poor reflection for sedimentation velocity of nitrogen component and adsorption-sediment of phosphorus in model. The concentration of Chl-a was simulated well with the algal growth patterns in summer of 2010 and 2008, but the error of under estimation may come from the use of width-averaged velocity and concentration, not considering the actual to one side inclination by wind effect.

• Proceedings of the Korea Multimedia Society Conference
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• 2002.05c
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• pp.501-506
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• 2002

사람은 누구나 잭이나 문서를 읽을 때 중요한 부분에 강조, 해설, 설명을 하기 위해서 표시를 하거나 글을 입력한다. 이와 같이 원본문서에 추가되는 부가 정보를 Annotation이라고 한다[6][7]. Annotation을 이용하면 차후에 원본문서를 재창조하거나 다른 사람이 원본문서를 참조할 경우 과중한 정보의 양을 극복할 수 있으므로[4], 원본문서의 이해도를 향상시킬 수 있다. 따라서, Annotation은 한번 사용하고 그치는 정보가 아닌 재사용할 수 있는 점보임을 의미한다[1,2,3]. 이러한 Annotation 기능을 웹 문서에 적용하게 되면 종이문서에서 얻을 수 있는 장점뿐만 아니라 웹 환경의 특징인 공유[5], 검색[4], 재편집 등의 기능이 가능하다. 이와 관련한 많은 연구가 진행중에 있다. 그러나, 기존의 Annotation 연구는 Anchor 입력된 다수의 Annotation이 무의미한 출력 순서로 제공되고 있으며, 또한 Anchor에 입력된 Annotation의 출력으로 인해 문서 구조가 변경되거나, 가려지는 등의 문제점으로 사용자들이 쉽게 사용 및 이해할 수 있는 Annotation 출력 인터페이스에 대한 연구가 부족한 실정이다. 따라서, 본 논문에서는 Anchor에 입력된 다수의 Annotation들 간의 의미적 순서를 부여하여 보다 적절한 Annotation에 대한 우선 접근이 가능하도록 계층적인 Annotation 우선처리 기법을 제안하고, Annotation 출력으로 인한 문서 변경 문제를 해결하기 위한 유동적인 Annotation 표현 기법을 제안한다. 또한 Annotation이 문서에 부가된 부가정보의 역할을 뿐만 아니라, 다양한 활용이 가능하도록 XML 표준에 기반한 저장 구조를 지원하며, 원본문서와 분리하여 저장한다.속도를 개선시켰고, 국소적인 변형이 있는 패턴과 특징의 수가 다른 패턴의 경우에도 좋은 인식률을 얻었다.r interferon alfa concentrated solution can be established according to the monograph of EP suggesting the revision of Minimum requirements for biological productss of e-procurement, e-placement, e-payment are also investigated.. monocytogenes, E. coli 및 S. enteritidis에 대한 키토산의 최소저해농도는 각각 0.1461 mg/mL, 0.2419 mg/mL, 0.0980 mg/mL 및 0.0490 mg/mL로 측정되었다. 또한 2%(v/v) 초산 자체의 최소저해농도를 측정한 결과, B. cereus, L. mosocytogenes, E. eoli에 대해서는 control과 비교시 유의적인 항균효과는 나타나지 않았다. 반면에 S. enteritidis의 경우는 배양시간 4시간까지는 항균활성을 나타내었지만, 8시간 이후부터는 S. enteritidis의 성장이 control 보다 높아져 배양시간 20시간에서는 control 보다 약 2배 이상 균주의 성장을 촉진시켰다.차에 따른 개별화 학습을 가능하게 할 뿐만 아니라 능동적인 참여를 유도하여 학습효율을 높일 수 있을 것으로 기대된다.향은 패션마케팅의 정의와 적용범위를 축소시킬 수 있는 위험을 내재한 것으로 보여진다. 그런가 하면, 많이 다루어진 주제라 할지라도 개념이나 용어가 통일되지 않고 사용되며 검증되어 통용되는 측정도구의 부재로 인하여 연구결과의 축적이 미비한 상태이다. 따라서, 이에 대한 재고와 새로운 방향

• Korean Journal of Food Science and Technology
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• v.53 no.5
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• pp.657-668
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• 2021

We prepared the growth and survival models of enterohemorrhagic Escherichia coli (EHEC) and Campylobacter jejuni in milk as a function of temperature and assessed the microbiological risks associated with the consumption of whole milk. EHEC and C. jejuni were not detected in whole milk (n=195) in the retail market. The minimum growth temperature of EHEC in milk was 7℃. The lag time of EHEC in whole milk was longer than that in skim milk. The survival ability of C. jejuni in milk was better at 4℃ than at 10℃. Lower delta values were observed in whole milk than in skim milk, indicating that C. jejuni survived better in skim milk. The probability of foodborne illness from whole milk consumption was 5.70×10^-5 for EHEC and 9.86×10^-9 for C. jejuni. Sensitivity analysis results show that the market temperature of EHEC and the dose-response model of C. jejuni are correlated with the probability of foodborne illness.