• Journal of Life Science
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• v.33 no.12
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• pp.987-994
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• 2023

This study examined the associations between the genotypes of the galactose mutarotase (GALM) gene and carcass traits in the Hanwoo population of Jeju Island, South Korea. The GALM genotypes were determined by the 14-bp (5'-GGTCTAATGACCAG-3') insertion/deletion (InDel) polymorphisms of the 3'-untranslated region (UTR). All three genotypes (LL, LS, and SS) were found in the Hanwoo steer population. The association analysis showed significant associations between genotypes and several carcass traits, including traits related to intramuscular fat content, such as meat quality, marbling score, and backfat thickness (p<0.05). Animals harboring the SS genotype showed not only higher levels of intramuscular fat content but also lower levels of backfat thickness than animals harboring the LL and LS genotypes. On the other hand, no significant associations were found between the GALM genotypes and carcass weight, eye muscle area, meat color, or fat color (p>0.05). Deleting the 14-bp segment in the 3'-UTR resulted in the modification of the secondary structure of RNA and appeared to affect gene expression by interfering with the binding ability of GALM mRNA with RNA-binding proteins and microRNAs. These results suggest that the 14-bp InDel polymorphism in the 3'-UTR region of the GALM gene affects cattle growth traits and carcass quality through galactose metabolism-mediated fat accumulation in muscle and backfat tissues.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.1127-1134
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• 2023

This study is a qualitative study to uncover the meaning and structure of nursing students' online psychiatric nursing practice experience by applying Parse's research method. The subjects of the study were 9 fourth-year nursing students at K University who took psychiatric nursing practice online in the COVID-19 situation. Data collection was conducted from March 7, 2022 to May 27, 2022. As a result of the study, the core concepts of nursing students' online practice experience in psychiatric nursing in the COVID-19 situation were: 'Recognizing the importance of understanding oneself and others', 'Preparing for communication to build therapeutic relationships', and 'A perspective on the future through exploration of the meaning of nursing'. Structural transposition was presented as 'Empathy for self and others', 'Mindset for interpersonal human relationship', 'Exploring the essence of nursing and self-realization'. Conceptual integration appeared as 'Valuing', 'Revealing-Concealing', 'Revealing-Concealing'. In conclusion, nursing students' online practice experience in mental health nursing in the COVID-19 situation was an experience of growing and transcending as future nurses by recognizing the importance of human understanding and communication for the therapeutic relationship that is the purpose of mental nursing. This study will serve as basic data for efficient clinical practice operations in various unpredictable situations, such as future pandemics.

• Journal of Intelligence and Information Systems
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• v.29 no.4
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• pp.31-49
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• 2023

With the growth of the food-catering industry, consumer preferences and the number of dine-in restaurants are gradually increasing. Thus, personalized recommendation services are required to select a restaurant suitable for consumer preferences. Previous studies have used questionnaires and star-rating approaches, which do not effectively depict consumer preferences. Online reviews are the most essential sources of information in this regard. However, previous studies have aggregated online reviews into long documents, and traditional machine-learning methods have been applied to these to extract semantic representations; however, such approaches fail to consider the surrounding word or context. Therefore, this study proposes a novel review textual-based restaurant recommendation model (RT-RRM) that uses deep learning to effectively extract consumer preferences from online reviews. The proposed model concatenates consumer-restaurant interactions with the extracted high-level semantic representations and predicts consumer preferences accurately and effectively. Experiments on real-world datasets show that the proposed model exhibits excellent recommendation performance compared with several baseline models.

• Journal of Life Science
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• v.34 no.4
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• pp.227-235
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• 2024

Hepatocyte damage caused by medications or herbal products is one of the important problem when these compounds are chronically administrated. Thus, improving hepatocyte survival during treatment offers a wide range of opportunities. Valproic acid (VPA), a branched short-chain fatty acid derived from naturally occurring valeric acid, is commonly used to treat epilepsy and seizures. Although VPA exerts numerous effects in cancer, HIV therapy, and neurodegenerative disease, its effects on the liver and its mechanism of action have not been fully elucidated. Here, we demonstrated that VPA caused moderate liver cell toxicity and apoptosis. Interestingly, VPA treatment increased transcription levels of PPAR alpha (PPAR-α) and fibroblast growth factor 21 (FGF21) in murine (Hepa1c1c7) hepatoma cells in a time and concentration dependent manner. VPA-induced FGF21 expression was significantly weaker under PPAR-α silencing condition than in cells transfected with non-targeting control siRNA. Subsequent experiments showed that cell viability was significantly lowered when the FGF21 signaling pathway was blocked by FGF receptor antagonist. Finally, we further determined that AMPK phosphorylation was not responsible for VPA-induced FGF21 expression and PPAR-a increments. These results indicate that increases of FGF21 expression alleviate VPA-induced hepatic toxicity, thereby making FGF21 a potential biomarker for predicting liver damage during VPA treatments.

• The Journal of Bigdata
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• v.8 no.2
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• pp.149-163
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• 2023

Due to the continuous growth of the E-commerce market, the volume of orders that fulfillment centers have to process has increased, and various customer requirements have increased the complexity of order processing. Along with this trend, the operational efficiency of fulfillment centers due to increased labor costs is becoming more important from a corporate management perspective. Using historical performance data as training data, this study focused on real-time box recommendations applicable to packaging areas during fulfillment center shipping. Four types of data, such as product information, order information, packaging information, and delivery information, were applied to the machine learning model through pre-processing and feature-engineering processes. As an input vector, three characteristics were used as product specification information: width, length, and height, the characteristics of the input vector were extracted through a feature engineering process that converts product information from real numbers to an integer system for each section. As a result of comparing the performance of each model, it was confirmed that when the Gradient Boosting model was applied, the prediction was performed with the highest accuracy at 95.2% when the product specification information was converted into integers in 21 sections. This study proposes a machine learning model as a way to reduce the increase in costs and inefficiency of box packaging time caused by incorrect box selection in the fulfillment center, and also proposes a feature engineering method to effectively extract the characteristics of product specification information.

• Korean Journal of Poultry Science
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• v.8 no.1
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• pp.1-5
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• 1981

In trying to predict the effect of genetics on the broiler in the year 2000, this is a relatively short period of time as far as broiler genetics in concerned. Modern broiler genetics started around 1945 and tremendous gains when made in past 35 years. Futher improvements on broiler will depend on the evolution and revolution: 1. Evolution: (1) Growth rate has been made 4-5% per year. (2) Feed conversion has improved approximately 1% per year. (3) Abdominal fat is becoming a major complaint in broiler. (4) Because of the changing life-style, broiler meat sales in the future will be more and more in cut-up form. (5) Breeding for stress resistance and selection for docile temperament can be important in order to funker improve fled efficiency. (6) In female parent stock, reproduction characteristics are in many can negatively correlated with the desired broiler traits. (7) Egg production and hatchability in moot commercial parent nod m at a fairly high level. (8) In male parent stock, the heavier and mon super-meat-type male lines are desired to Product better broilers. 2. Revolution: Trying to forecast revolutionary change in broiler genetics is highly speculative, as sudden change are aften unpredictable. (1) Species hybridization, such as a turkey-chicken cross (2) Biochemical tools, such as blood typing. (3) Mutation breeding by radiation or chemical mutagentia. (4) Broiler breeding would be to change the phenotypic appearance by single gene, such as naked, wingless. (5) Changes in production techniques. such as growing in cage or growing in filtered air positive pressure houses.

• Archives of design research
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• v.19 no.5 s.67
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• pp.129-138
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• 2006

It is expected that the typical lifestyle of the future will be transformed into an opulent and comfortable existence as the quality of life improves due to the increase in household income and reduction in working hours. In the meantime, as the standard of living becomes increasingly more comfortable and plentiful, the toll on physical health becomes magnified as a result of obesity and insufficient exercise caused by super nutrition and change in labor conditions (from physical labor to mental labor). This has instigated a deep awareness in fitness on the part of many people, forcing them to recognize the significance of daily exercise and physical activity. The high annual growth rate in the fitness and athletic apparatus market, which is more than 20%, is attributed to this phenomenon. The Elliptical Cross Trainer(ECT), which has drawn wide attention recently, is a non-impact athletic apparatus that not only promotes exercise of the upper body parts in such sports as skiing but also the exercise of lower parts of the body on a treadmill. It is a type of cross training athletic gear that has been developed for aerobic exercise throughout the entire body. It has already formed a market as big as that of the treadmill in Europe, America, etc. Recently, its demand is growing sharply in the Korean markets as well as those in Northeast Asian countries, Despite such demand increase and expansion, since most of the expensive ECTs are exclusively supplied by suppliers in only a few advanced countries, localization of the ECT is urgently required in order to enhance competitiveness of Korean manufacturers and to expand the market. This paper introduces the process and results of a design-engineering cooperative study that was peformed for the development of the ECT.

• Journal of the Korean Association of Geographic Information Studies
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• v.23 no.2
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• pp.53-69
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• 2020

The increase of the impermeable area due to industrialization and urban development distorts the hydrological circulation system and cause serious stream drying phenomena. In order to manage this, it is necessary to develop a technology for impact assessment of stream drying phenomena, which enables quantitative evaluation and prediction. In this study, the cause of streamflow reduction was assessed for dam and weir watersheds in the five major river basins of South Korea by using distributed hydrological model DrySAT-WFT (Drying Stream Assessment Tool and Water Flow Tracking) and GIS time series data. For the modeling, the 5 influencing factors of stream drying phenomena (soil erosion, forest growth, road-river disconnection, groundwater use, urban development) were selected and prepared as GIS-based time series spatial data from 1976 to 2015. The DrySAT-WFT was calibrated and validated from 2005 to 2015 at 8 multipurpose dam watershed (Chungju, Soyang, Andong, Imha, Hapcheon, Seomjin river, Juam, and Yongdam) and 4 gauging stations (Osucheon, Mihocheon, Maruek, and Chogang) respectively. The calibration results showed that the coefficient of determination (R²) was 0.76 in average (0.66 to 0.84) and the Nash-Sutcliffe model efficiency was 0.62 in average (0.52 to 0.72). Based on the 2010s (2006~2015) weather condition for the whole period, the streamflow impact was estimated by applying GIS data for each decade (1980s: 1976~1985, 1990s: 1986~1995, 2000s: 1996~2005, 2010s: 2006~2015). The results showed that the 2010s averaged-wet streamflow (Q95) showed decrease of 4.1~6.3%, the 2010s averaged-normal streamflow (Q185) showed decreased of 6.7~9.1% and the 2010s averaged-drought streamflow (Q355) showed decrease of 8.4~10.4% compared to 1980s streamflows respectively on the whole. During 1975~2015, the increase of groundwater use covered 40.5% contribution and the next was forest growth with 29.0% contribution among the 5 influencing factors.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.7 no.2
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• pp.195-205
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• 2012

This study examines runaway youths at risk in a youths' shelter who are preparing for an independent life and both the facilitating and adverse factors to personal characteristics and independence of runaway youths at risk with the aim to grasp their recognition of independence and level of desire for it and find out necessary factors for a successful independence in multidimensional perspectives including the economic independence, educational independence, psychological independence, and social independence for their sound growth. This will provide the basis for desirable interventions for youths runaway youths at risk to prepare for an independent life. The findings of this study on the factors that affect the preparation for an independent life are as follows: First, as a result of analyzing the effect of micro-systematic factors on the preparation for an independent life, it turned out that problem-solving abilities and self-efficacy had influence on the preparation for a career Second, as a result of analyzing the effect of mesoscopic-systematic variables on the preparation for an independent life, it turned out that the preparation for a career were affected by whether to participate in independence preparation programs and institutional supports, and that career maturity of runaway youths at risk were affected only by the relationship with teachers and participation in independence preparation programs. Third, as a result of analyzing the effect of macro systematic variables on the preparation for an independent life, it turned out that the preparation for a career were affected by participation of the local community and service network, and that participation of the local community was an predictor variable that would affect a career maturity of runaway youths at risk. Fourth, as a result of analyzing ecological systematic variables that might affect the preparation for a career, it turned out that intervening variables and macro systematic variables had the most powerful influence on the preparation for a career among runaway youths at risk. It is necessary, therefore, to provide education programs organized by policies in order to develop problem-solving abilities and vocational capabilities so that runaway youths at risk, and to train and appoint more professional teachers at shelters. Programs for independence preparation need to be developed actively and practically in consideration of the characteristics of shelters, and the network with the local community for support also need to be established in utilization of the human resources and service programs of the community. With the understanding of leaving home of runaway youths at risk as the previous stage of an independence, there should be a housing support for their stable settlement in the perspective of housing welfare until become adults. In addition, there should be education specialized programs for occupation and careers to train runaway youths at risk as professionals including such areas as health, mentality, learning, and voluntary work for their sound growth.

• Korean Journal of Poultry Science
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• v.41 no.4
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• pp.287-296
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• 2014

Chicken eggs undergo various physiological changes during egg maturation. To study genes associated with the egg maturation in pre-ovulation (immature) and post-ovulation (mature), we compared gene expression patterns between in the immature egg and mature egg using RNA sequencing data. Mature and immature eggs were obtained from a Heuksaek Jaerae-jong of Korean native chicken. Total RNAs obtained from the eggs were sequenced by Illumina HiSeq 2000 platform, and the generated sequence reads were mapped to Galgal4 reference sequence assembly using Tuxedo Protocol. From the comparison of the RNA sequencing data, 315 genes were differentially expressed between mature and immature eggs, and 46 genes were only detected in immature egg. Further gene ontology (GO) analysis was performed for the differentially expressed genes using DAVID, showing that 29 and 28 GO terms were independently clustered from mature and immature, respectively. From those clustered GO terms, genes related to germ cell development, sex differentiation and defense response to bacterium were mainly expressed in the immature egg, while genes related to regulation of apoptosis, steroid metabolic process and lipid homeostasis were mainly detected in the mature egg. Our results could contribute to understand egg maturation before and after ovulation, and develop genetic markers for improving egg quality and productivity.