• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.22 no.6
• /
• pp.314-320
• /
• 2021

With the increasing age of motherhood in recent years, attributed to late marriages due to social or environmental factors, the Down's syndrome screening test using biochemical markers has become essential for pregnant women. The process of diagnosing Down's syndrome pregnancy in the high-risk group subjects involves chromosomal analysis, which is performed on samples obtained through invasive procedures such as chorionic biopsy or amniotic fluid. Thus, to reduce unnecessary invasive tests and lower the risk to mother and fetus, it is important to identify a screening test with low risk and high Down's syndrome detection rate. Recently, as the average age of mothers has increased, numerous inspection agencies have classified high-risk mothers as women over the age of 35 years. This study evaluated a total of 36,436 pregnant women aged between 17 to 46 years, and who requested prenatal screening at an inspection agency in Yongin in 2018. Test (13,690 people) Four tests were conducted by applying the time-resolved fluoroimmunoassay method using the direct sandwich and indirect sandwich technology, and the immunoassay method using the sandwich method. We aimed to confirm the difference in positivity rate with increasing age of the subjects. We believe that in future, data obtained from this study will be very useful for the prevention and treatment of Down's syndrome risk at varied inspection institutions, and for prospective mothers.

• Journal of the Korean Society of Radiology
• /
• v.12 no.1
• /
• pp.53-64
• /
• 2018

Using the AUDIT-K (Korean versions of alcohol use disorders identification test), it was able to select a large number of potential danger drinkers who routinely live. There were no statistically significant differences in age, religion, marital status, occupation, family history of alcohol drinking, age at onset of alcohol use, smoking, and BMI (body mass index). However, only education and drinking periods were statistically significant. These results are consistent with the previous study, which suggests that alcohol consumption is higher among men who are educated. The level of education also suggests that there is a need to look at the differences depending on what you learned and how. Alcohol consumption by education also shows different results. Also, drinking at a young age will lead to a longer drinking period, which is consistent with previous studies on the age at onset of drinking. In this study, drinking period was the most important factor of alcohol use disorder and it is considered that measures and education of national government system which can delay drinking age as much as possible is needed as a method to shorten drinking period.

• Nuclear Medicine and Molecular Imaging
• /
• v.42 no.6
• /
• pp.444-450
• /
• 2008

Purpose: The aim of this study was to evaluate the usefulness of whole body positron emission tomography (PET) using $^{18}F-fluorodeoxyglucose$ ($^{18}F-FDG$) for cancer screening in asymptomatic subjects. Materials and Methods: The subjects were 1,762 men and 259 women who voluntarily underwent $^{18}F-FDG$ PET for cancer screening as a part of a routine health examination. Final diagnosis was decided by other diagnostic studies, pathological results or clinical follow-up for 1 year. Results: Of 2,021 subjects, 40 (2.0%) were finally proved to have cancer. Abnormal focal $^{18}F-FDG$ uptake suggesting malignancy was found in 102 subjects (5.0%). Among them, 21 subjects (1.0%) were proved to have cancer. Other tests in the routine health examination could not find 9 of 21 cancers (42.9%) detected by PET. The sensitivity, specificity, positive predictive value, and negative predictive value of PET for cancer screening were 52.5%, 95.9%, 20.6%, and 99.0%, respectively. Pathologies of cancers missed on PET were adenocarcinoma (n = 9; 3 colon cancers, 3 prostate cancers, 2 stomach cancers, and 1 rectal cancer), differentiated thyroid carcinoma (n = 6), bronchioalveolar cell carcinoma (n = 2), urinary bladder cancer (n = 1), and melanoma (n = 1). More than half of cancers which were not detected by PET were smaller than 1 cm in diameter. Conclusion: $^{18}F-FDG$ PET might be useful for cancer screening in asymptomatic subjects due to its high specificity and negative predictive value and playa supplementary role to the conventional health check-up, but it could not replace due to limited sensitivity for urological cancers, small-sized tumors and some hypometaboic cancers.

• Journal of The Korean Society of Inherited Metabolic disease
• /
• v.18 no.2
• /
• pp.35-42
• /
• 2018

Purpose: To follow up Korean patients with metabolic and endocrine disorders ascertained by Korea Genetics Research Center, and assess the long-term effectiveness of extended newborn screening program in Korea. Methods: From January 2000 to December 2017, tandem mass spectrometry and fluoroimmunoassay were employed in extended newborn screening (NBS). The NBS program obtained dried blood spots from 283,626 babies, 48 hours after birth, and screened for galactosemia, congenital hypothyroidism (CH), congenital adrenal hyperplasia (CAH), and 50 preventable inborn errors of amino acid, fatty acid, and organic acid metabolism. Results: 28 cases of amino acid disorders, 75 cases of organic acid disorders, 27 cases of fatty acid disorders, 51 cases of urea cycle disorders, 127 cases of CH, 14 cases of CAH, and 15 cases of galactosemia were ascertained through NBS and subsequent confirmatory laboratory tests. Patients with amino acid metabolic disorders, galactosemia, CH, or CAH were more likely to have a better long-term outcome if detected early. Early management of MSUD led to much better outcome in over 90%. Despite early intervention, 32% of other organic acidemia cases still resulted in developmental delay and neurological problems. Fatty acid disorders showed varied results; those with EMA and MCAD had a good outcome, but those with VLCAD had serious neurological problems and considerably higher mortality. 75% with UCD experienced serious neurological complications and higher mortality. Conclusion: The nation-wide NBS program must be accompanied by comprehensive long-term management and physician and family education of inborn errors of metabolism for a better outcome.

• Korean Journal of Poultry Science
• /
• v.45 no.4
• /
• pp.285-290
• /
• 2018

This study was aimed to evaluate the possibility of application to the KS A ISO 2859-1 Easy test, an international standards sampling inspection, to replace a sampling method of the current grading standard of chicken meats for the first time. As a result of screening capability to check for defective products, the current sampling was 0.61 and the KS A ISO 2859-1 Normal test was 0.70, suggesting that the latter inspection method was more accurate. If the KS A ISO 2859-1 conversion principle is applied, 40,530 won per day is saved for a 50-lot inspection. The current sampling and the KS A ISO 2859-1 Easy test did not exceed the reject limit for the number of defective products to satisfy the grade $1^+$ on chicken carcass size numbers 12, 9 and 8. Freshness was not significantly different between the current sampling and the KS A ISO 2859-1 Easy test. It is expected that using the KS A ISO 2859-1 Easy test with a smaller sample volume will have the same level of quality evaluation as the current sampling method while reducing costs.

• The Journal of the Korea Contents Association
• /
• v.13 no.8
• /
• pp.308-313
• /
• 2013

Among 179 specimen diagnosed with ASCUS but did not go through biopsy or other tests, 26 cases (14.52%) showed positivity in HPV Hybrid Capture II Test. There were 25 cases of HPV high risk factor(+), marking 13.96%, and 3 cases of low risk factor(+) at 1.67%. According to cytology manifestation, patients with over LSIL can increase their complete recovery rate with continuous tests, but most patients diagnosed ASCUS do not go through any tests at all. It is considered that in order to prevent and start early treatment on cervical cancer, the HPV Hybrid Capture II Test must be enforced to patients diagnosed with ASCUS. Negative patients should go through routine screening, and positive patients should receive treatment after colposcopy.

• Journal of Korean Public Health Nursing
• /
• v.31 no.3
• /
• pp.464-477
• /
• 2017

Purpose: This study was conducted to investigate factors affecting the dementia screening test based on the health belief model. Methods: The survey was conducted with structured questionnaires assessing the knowledge of dementia, health beliefs, self-efficacy and cue to action for dementia screening. Study participants were 156 older adults and data from 121 respondents were analyzed. Descriptive statistics, frequency percentage, chi-squared (${\chi}^2$) test, t-test and logistic regression analysis were conducted using SPSS version 23.0. Results: Factors influencing the dementia screening test were found to be gender, self-efficacy on dementia screening, and the presence of family or friends who underwent dementia screening. Older adults who were female (OR=4.92, p=.003), showed an increasing average score of self-efficacy for dementia screening (OR=2.85, p=.002), and had family members or friends who underwent dementia screening (OR=4.60, p=.003) were more likely to receive dementia screening. Conclusion: This study showed that education and programs enhancing self-efficacy associated with the dementia screening test, as well as utilizing the network of family or friends are necessary to increase the rate of dementia screening.

• Child Health Nursing Research
• /
• v.12 no.3
• /
• pp.333-340
• /
• 2006

Purpose: This study was to restandardize the Child Development Review (CDR) which was developed by Dr. Ireton and based on Child Development Inventory (CDI). Method: The participants were 1143 children who were aged 12months to 6.3years old and parents. They were the sample for standardization study of CDI. The age level assigned to each item of Korean version of CDI were assessed. The reliability and validity was analyzed by reliability coefficient and concurrent validity analysis. Result: The item set was revised by the age level of each item at which at least 75 percent of parents answered YES to the statement. The child development chart was composed of 100 item which include social, self-help, gross motor, fine motor, and language sector. The internal consistency coefficient of the instrument was .93. The concurrent validity with Korean Denver II was good. Conclusions: The Korean version of CDR showed good reliability and validity. It could be utilized for developmental screening at pediatric clinic and child care center.

• Childhood Kidney Diseases
• /
• v.7 no.2
• /
• pp.223-228
• /
• 2003

Oligmeganephronia is congenital hypoplasia of kidney with renal pathology showing very small number of nephrons with compensatory hypertrophy of the remaining glomeruli. A 7-year-old girl was referred to our nephrology clinic due to hematuria detected on school screening urinalysis and diagnosed as chronic renal failure and oligomeganephronia on renal biopsy. We are reporting the clinical and histomorphometric changes for the four years follow-up with review of literatures.

• Childhood Kidney Diseases
• /
• v.18 no.2
• /
• pp.57-63
• /
• 2014

A number of kidney diseases of childhood may present as isolated proteinuria or/and hematuria, without any overt signs or symptoms. Urinalysis is a simple and inexpensive test used to evaluate various renal disorders. A school urine screening (SUS) program for kidney disease was conducted in Korea in 1998. Several research reports, including case reports and systemic reviews of SUS data, claimed that early detection and confirmatory diagnosis by renal biopsy seems to be helpful for determining the prognosis and intervention of progressive chronic renal disease. However, there is no global consensus as to whether screening for chronic kidney disease (CKD) should be undertaken in children and adolescents. This paper reviews the SUS for CKD in Korea, including the history and structure of the program, its assessment, related research, and associated problems.