• Progress in Medical Physics
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• v.25 no.3
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• pp.167-175
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• 2014

The purpose of this study is to evaluate the variation of the dose which is delivered to the patients with glottis cancer under IMRT (intensity modulated radiation therapy) by using the 3D registration with CBCT (cone beam CT) images and the DIR (deformable image registration) techniques. The CBCT images which were obtained at a one-week interval were reconstructed by using B-spline algorithm in DIR system, and doses were recalculated based on the newly obtained CBCT images. The dose distributions to the tumor and the critical organs were compared with reference. For the change of volume depending on weight at 3 to 5 weeks, there was increased of 1.38~2.04 kg on average. For the body surface depending on weight, there was decreased of 2.1 mm. The dose with transmitted to the carotid since three weeks was increased compared be more than 8.76% planned, and the thyroid gland was decreased to 26.4%. For the physical evaluation factors of the tumor, PITV, TCI, rDHI, mDHI, and CN were decreased to 4.32%, 5.78%, 44.54%, 12.32%, and 7.11%, respectively. Moreover, $D_{max}$, $D_{mean}$, $V_{67.50}$, and $D_{95}$ for PTV were increased or decreased to 2.99%, 1.52%, 5.78%, and 11.94%, respectively. Although there was no change of volume depending on weight, the change of body types occurred, and IMRT with the narrow composure margin sensitively responded to such a changing. For the glottis IMRT, the patient's weight changes should be observed and recorded to evaluate the actual dose distribution by using the DIR techniques, and more the adaptive treatment planning during the treatment course is needed to deliver the accurate dose to the patients.

• Radiation Oncology Journal
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• v.13 no.4
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• pp.331-338
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• 1995

Purpose : To evaluate our clinical experience with the combination of teletherapy and intraluminal brachytherapy in patients with unresectable or inoperable esophageal cancers. Materials and Methods : From Nov 1989 to Mar 1993, twenty patients with esophageal cancer were treated with radical radiotherapy and intraluminal brachytherapy at Yonsei Cancer Center. All patients had squamous histolgy and stage distribution was as follows: stage II, 4($20{\%}$)patients; III, 15 ($75{\%}$)patients; IV, 1($5{\%}$)patients. A dose of S-12Gy/1-3weeks with intraluminal brachytherapy (3-5Gy/fraction) to 5mm from the outside of the esophageal tube using high dose rate Iridium-192 remotely afterloading brachytherapy machine was given 2 weeks after a total dose of 59-64Gy with external radiotherapy. Induction chemotherapy using cisplatin and 5-FU was performed in 13 patients with median 3 cycles(1-6 cycles), Response rate, local control rate, survival and complications were analysed retrospectively. Results : Two-year overall survival rate and median survival were $15.8{\%}$ and 13.5 months. Response rates were as follows complete remission(CR) 5($25{\%}$): partial remission a(PRa) 7($35{\%}$): partial remission b(PRb) 7($35{\%}$), no response(NR) 1($5{\%}$). Patterns of failure were as follows; local failure 13($65{\%}$), local and distant failure 3($15{\%}$), distant failure 0($0{\%}$). Ultimate local control rate was $20{\%}$. Treatment related complications included esophageal ulcer in two patients and esophageal stricture in one. Conclusion : Though poor local conrol rate, median survival was improved as compared with previous results of radiation therapy alone(8months) and chemoradiation combined treatment(11 months) in Yonsei Cancer Center High-dose-rate intraluminal brachytherapy following external irradiation is an effective treatment modality with acceptable toxicity in esophageal cancer.

• Proceedings of the Korean Society of Postharvest Science and Technology of Agricultural Products Conference
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• 1994.07a
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• pp.15-16
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• 1994

옥수수 전분의 추출공정 개선 연구의 일환으로 메 밀 찰옥수수에 0-10 kGy범위의 감마선을 조사한 후 전분 추출시험과 추출전분의 이화학적 특성을 펴가하였다. 적정선량 범위의 감마선조사는 전분추출을 위한 침지시간을 기존 50시간에서 40시간으로 단축 시킬 수 있었으며, 환경기준 물질인 옥수수침지액(아황산용액)의 농도를 기존 0.8-1.2% 에서 0.2%로 크게 감소시킬 수 있었다. 또한 옥수수전분 추출액에 있어서 감마선 조사된 메옥수수와 찰옥수수는 비조사군에 비해 10-30% 이상의 추출율 증대효과를 나타내었다. 추 전분의 이화학적 특성시험에있어서는 두 시료 모두 감마선조사에 의해 alkaili number와 광투과도가 크게 증가 하였으며, 물 결합능력 및 swelling power는 다소 감소하는 경향이었다.전분의 색도는 조사군과 비조사군 사이에 유의적인 차이가 없었다. 효소반응 시험에서는 감마선 조사량이 증가함에 따라 효소반응 생성물인 포도당과 환원당 함량이 크게 증가하였다. Amylograph에 의한 물성시험에서는 감마선조사에 의해 전분호화액의 점도는 감소되었고, 그 경향은 메옥수수보다 찰옥수수에서 더욱 현저하였다. 또한 감마선의 이용은 옥수수 전분의 breakdown ratio 및 setback ratio를 향상시킬 수 있어 식품가공에서 전분의 고존도 사입 가능성을 시사하였다. 시사하였다.

• Radiation Oncology Journal
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• v.27 no.3
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• pp.120-125
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• 2009

Purpose: We wanted to present the preliminary results of intensity-modulated radiotherapy (IMRT) for the treatment of tonsillar cancer. Materials and Methods: We retrospectively analyzed 12 patients who underwent IMRT for tonsillar cancer at Asan Medical Center between November 2002 and February 2007. Seven patients (58%) received definitive treatment, and five (42%) were treated in the postoperative setting. Among the definitively treated patients, 6 patients received cisplatin-based chemotherapy regimens. Simultaneous modulated accelerated radiation therapy (SMART) was used in nine patients. The prescribed dose was 72 Gy at 2.4 Gy/fraction for the definitively treated cases and 61.6 Gy at 2.2 Gy/fraction for the postoperative cases. The median follow-up period was 34 months. Results: All twelve patients completed treatment without interruption, and eleven showed a complete response. One patient had persistent loco-regional disease after treatment. The three-year estimates of loco-regional control, disease-free survival and overall survival were 91.7%, 91.7%, and 100%. The worst acute mucositis was Grade 1 in four patients, Grade 2 in five patients, Grade 3 in two patients and Grade 4 in one patient. Grade 3 xerostomia was observed in six patients. Conclusion: Intensity-modulated radiotherapy was shown to be a safe and effective treatment modality for tonsillar cancer. Further studies with a larger number of patients and a longer follow-up period are needed to evaluate the ultimate tumor control and late toxicity of IMRT for treating tonsillar cancer.

• Radiation Oncology Journal
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• v.12 no.3
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• pp.393-399
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• 1994

Spinal cord compression, an oncologic emergency, is a rare complication of hematologic malignancy Our experience was obtained with a series 32 Patients following retrospective analysis for assessing the role of radiation therapy and identifying the prognostic factors affecting on treatment outcome. Diagnosis was usually made by means of radiologic study such as myelography or computerized tomography (CT) or magnetic resonance imaging (MRI) and neurologic examination. Five cases were diagnosed by subjective symptom only with high index of suspicion. In 31 cases, the treatment consisted in radiation therapy alone and the remained one patient had laminectomy before radiation therapy because of diagnostic doubts. Total treatment doses ranged from 800 cGy to 4000 cGy with median of 2000 cGy. Initially large fraction size more than 250 cGy were used in 13 patients with rapidly progressed neurologic deficit. The clinical parameters considered in evaluating the response to treatment were backache, motor-sensory performance and sphincter function. Half of all patients showed good response. Partial response and no response were noted in $37.5\%$ and $12.5\%$, respectively. Our results showed higher response rate than those of other solid tumor series. The degree of neurologic deficit at that time of diagnosis was the most important predictor of treatment outcome. The elapsed time from development of symptoms to start of treatment was significantly affected on the outcome. But histology of primary tumor total dose and use of initial large fraction size were not significantly affect on the outcome. These results confirmed the value of early diagnosis and treatment especially in radiosensitive hematologic malignancy.

• Radiation Oncology Journal
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• v.16 no.1
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• pp.51-61
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• 1998

Purpose : Treatment of choice for uterine cervix cancer stage IIB is radiotherapy. We analyzed survivals, Prognostic factors, patterns of failure and complications. Materials and Methods : This is a retrospective analysis of 167 patients with stage IIB carcinoma of uterine cervix treated with curative external pelvic and high dose rate intracavitary radiotherapy at the Department of Therapeutic Radiology, Soonchunhyang University Hospital from August 1985 to August 1994. All the patients followed up from 3 to 141 months(mean 60 months) and age of patients ranged from 31 to 78 years at presentation(mean : 55 years). Results : Overall complete response rate was $84\%$. The response rate for squamous cell carcimoma and adenocarcinoma were $86\%$ and $60\%$, respectively. Overall 5-years survival rate and disease free survival rate was 62 and $59\%$, respectively Mass size and treatment response were significant Prognostic factors for survival Pathologic type and parametrial involvement were marginally significants Prognostic factors. Local failure was 43 cases, distant metastasis was 14 cases and local failure plus distant metastasis was 3 cases, and most of local failures occurred within 24 months, distant metastasis within 12 months after treatment Twenty eight($16.8\%$) patients developed late rectal and urinary complications There were tendency to increasing severity and frequency according to increased fractional dose and total(rectal and bladder) dose. Conclusions : Survival rate was significantly related to tumor size and radiotherapy response. Tumor size should be considered in the clinical s1aging. To increased survival and local control, clinical trials such as decreasing duration of radiotherapy or addition of chemotherapy is needed. To detect early recurrence, regular follow up after RT is important. Because total rectal and bladder dose affected late complications. meticulous vaginal packing is needed to optimize dose of normal tissues and to decrease late complications.

• Proceedings of the Korean Institute of Industrial Safety Conference
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• 2003.05a
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• pp.434-439
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• 2003

원전 계통에서는 gas circulator, fuel handling system 등에 수 천여 개의 봉합(seal) 부위가 존재하며, 그 형상 또한 5 mm 에서부터 600 mm로 다양하다. 이러한 sealing 재료는 사용온도가 유리전이온도 이상인 열가소성 수지이며, 유연성 있는 segment의 조합으로 자유운동을 가지게 되는데 이러한 구조는 비교적 낮은 방사선 선량에 대해 취약하며, 원전계통에서는 NBR 및 ethylene-propylene 계열의 높은 내방사선 특성을 가지는 O-ring이 주로 사용되어지며, 10년을 교체시기로 주기적으로 교체하는 실정이다[2]. 이러한 seal 부위는 공정 전체에 걸쳐 다양한 열화요인에 노출되며, 최대 20$0^{\circ}C$의 온도, 압력 40 bar, 연간 1Gy~1MGy의 방사선에 노출된다.(중략)

• Proceedings of the KIEE Conference
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• 2005.10b
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• pp.442-444
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• 2005

방사선을 센싱하는 센서들에는 어려 종류가 있으며, 그 센서에 따라서 감도나 센싱방식이 다양하다. 본 연구에서는 해상도가 높은 범용 CCD 센서를 이용하여 방사선을 검출하는데, 감도를 높이기 위해서 신실레이터라는 물질을 CCD CHIP 앞에 부착하였고, 들어오는 영상에서 방사선에 반응하여 생기는 백색량을 처리하여 방사선량을 측정할 수 있다는 것을 보여주고 있다. 또한 Panning을 하며 공간상에서 방사선이 가장 많이 나오는 포인터를 제시할 수 있다. 추후 스테레오 카메라 방식을 구현하여 방사선원까지의 거리 산출과 영상을 합성하여 입체화 시키는 연구도 진행할 예정이다. 논 연구의 결과물로 예기치 않은 방사선 사고의 경우 효과적인 사고처리에 활용될 수 있을 것이다.

• Proceedings of the KIEE Conference
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• 2002.07c
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• pp.1562-1565
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• 2002

속중성자 피폭 시 실리콘 다이오드 내부에서 발생되는 변위 손상을 이용한 속중성자 탐지용 PIN 다이오드를 개발하고 중성자장에서 특성변화 및 감도 실험을 통하여 성능을 검증하였다. 시뮬레이션과 다양한 구조로 제작된 소자에 대한 방사선 실험을 거쳐 집합체 형태와 개별 PIN 다이오드를 제작한 다음 중성자 반응 특성과 감도 분석을 위한 중성자 방사선 실험을 수행하였다. 여러 개의 PIN 다이오드 샘플에 대한 중성자 특성변화를 실시간으로 측정하기 위해 디지털 정전류 구동 방식의 온라인 전자적 선량계 모듈을 제작하여 사용한 실험의 결과. 본 연구에서 개발한 PIN 다이오드 소자는 중성자 방사선에 대하여 우수한 감도 특성을 갖는다는 것과 입사 중성자에 대한 방향 의존성이 거의 없다는 사실을 알 수 있었다. 그리고 이어 수행된 300여 시간의 열화실험을 통하여 본 연구에서 제작된 PIN 다이오드 소자는 중성자 탐지소자로서의 사용 가능성이 충분함을 확인할 수 있었다.

• Journal of radiological science and technology
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• v.32 no.2
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• pp.205-212
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• 2009

The response correction factor ( h) is a factor to convert the response of the chamber in solid phantom to the response in water. In RW3 solid phantom, the dependency of beam quality and depth for high energy X-rays are known characteristics, however the dependency of field size, SSD, and chamber type are unknown. In this work we have studied the unknown characteristics on the dependency of response correction factor. The farmer type chamber (FC65G) and small chamber (CC13) were used and two beam qualities of 6 and 15 MV were evaluated. The measured response correction factors at the depth of 5 cm and 10 cm were h = 1.015 and 1.021 for 6 MV X-rays, and h = 1.024 and 1.029 for 15 MV X-rays. In conclusion the response correction factor did not depend on the field size and SSD while depending on the beam quality and depth. In the chambers, there are small differences between the two chambers used in this study but we think additional study for more chambers should be required. The results in this study can be used for analyzing the measured values from ionization chamber dosimetry in RW3.