• Journal of Adhesion and Interface
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• v.2 no.2
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• pp.28-34
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• 2001

의료용 감압 접착제(PSAs)는 접착되어지는 피부가 매우 다양한 타입이 있고 그 응용범위가 다양하므로 요구되어지는 것들이 매우 까다롭다. 본 총설은 의료용 PSAs의 특이한 성질의 합성을 포함하여 1985년 이후의 주된 화학적 개발동향에 그 초점을 두고 있다. 응집력 향상으로 Hot melt형 접착제를 주로 검토할 것이다.

• The Journal of Korean Academy of Prosthodontics
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• v.48 no.2
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• pp.87-93
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• 2010

Purpose: The purpose of this study was to compare the retention of the two denture adhesives with a silicone edentulous model and a resin denture base in vitro study. Material and methods: The experimental groups were used two denture adhesives and classified into 5 subgroups each. Subgroups were divided by the number of times the saliva sprayed. The control group was used synthetic saliva only. Dislodging tensile strengths were applied to the resin denture base using Instron in 3 directions ; vertical, lateral, and anterior-posterior. Results: The retention of two denture adhesives was increased significantly than saliva alone (P <.05). In each denture adhesives, the retention of saliva sprayed first was decreased than denture adhesive alone, but it didn't have significant differences. Whenever saliva sprayed repeated, the retention was decreased significantly than saliva sprayed first (P <.05). In each denture adhesives, vertical retentive force was highest than lateral and anterior-posterior retentive forces, and anterior-posterior retentive force was higher than lateral retentive force. This results were significantly different (P < .05). Significant differences of the retentive ability among two denture adhesives were not observed. Conclusion: From the results, use of the denture adhesives resulted in improved retentive ability of denture. Especially retentive force was highest in vertical direction.

• Journal of Adhesion and Interface
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• v.20 no.2
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• pp.71-75
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• 2019

Tannic acid is one of the most commonly found polyphenols in the vegetable field. Initially, research on tannins concentrated on physiological functions such as antioxidants. Recently, however, tannic acid has attracted much interest as a molecular glue as it has been found to interact virtually all bio-macromolecules such as proteins and DNA. The various properties of tannic acid are expected to control the wettability of the surface, contribute to energy storage and generation, and show potential as a medical agent. Here, tannic acid will be discussed about the interaction of with bio-macromolecules as a molecular glue, surface modification, and utilization of itself as biomaterials.

• Polymer(Korea)
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• v.37 no.5
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• pp.625-631
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• 2013

Mucoadhesive property is the major function as an adhesive for medical devices, and therefore, these days many researches have conducted to develop polymers having this property. Recently, biomimetic technology has been used for developing mucoadhesive polymers. Among many technologies, mussel-inspired approaches have received noticeable attention because of its thread's strong adhesive characteristics. In this study, we synthesized mucoadhesive biomimetic polymers employing catechol structures which are abundant in mussel adhesive proteins, and their structures and molecular weights were characterized by using nuclear magnetic resonance spectroscopy and gel permeation chromatography. To evaluate in vitro mucoadhesive strength, the sheet type of the small intestinal porcine submucosa was prepared. Compared to commercial fibrin glue adhesives, catechol-containing mucoadhesive polymers showed enhanced adhesive strength. The study of adhesive strength with considering diverse factors, such as temperature, pressure, and oxidant amount indicated that mussel-inspired mucoadhesive polymer could be a promising candidate for an adhesive in various biomedical applications.

• Journal of Biosystems Engineering
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• v.29 no.4
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• pp.347-356
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• 2004

치아인회석, 키토산, 시아노아크릴레이트 등의 생분해성 생체재료를 이용해 새로운 생체흡수성 골시멘트를 개발하고자 하였다. 이들 골시멘트들에 대해서 중합온도, 응고시간 등의 조작특성과 압축강도, 전단강도 등의 물성을 분석하였다. 특히, 치아인회석과 키토산의 미립가루와 부틸 시아노아크릴레이트의 강력접착제를 이용한 시멘트(B)에 대해서는 직접 접촉방법과 XTT 방법을 통해 세포독성을 분석하였고, 또한 쥐를 이용한 동물실험에서 시멘트(B)의 처리그룹에 따라 생체적합성을 분석하였다. 시아노아크릴레이트를 이용한 골시멘트의 최대중합온도는 약 33$^{\circ}C$, 조작(응고)시간은 3-6분, 압축강도는 약 15-25㎫, 전단강도는 약 0.4-l.7 ㎫를 나타내었다. 첨가제로 사용된 Lipiodol은 골시멘트의 주사성과 강력접착제의 초기 중합지연도를 높였고, 특히 송진가루는 시아노아크릴레이트의 초기중합을 지연시켰다. 시아노아크릴레이트를 이용한 시멘트(B)의 세포독성을 분석한 결과, 대부분의 처리 그룹에서 낮게 나타났고, 특히 키토산과 치아인회석을 사용한 경우 각각 세포 독성이 더 낮게 나타났다. 그리고 골시멘트(B)의 동물 생체적합성 실험의 방사선상 및 조직학적 분석에서도 뼈 형성 및 결합이 우수하게 나타났다.

• Journal of Adhesion and Interface
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• v.2 no.1
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• pp.23-30
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• 2001

• Journal of Adhesion and Interface
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• v.9 no.4
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• pp.34-42
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• 2008

잠재적인 생체의료용 소재로서 홍합접착단백질은 그 동안 커다란 관심을 받아왔었다. 홍합접착단백질은 환경친화적인 수중접착제로써 강하면서도 유연하게 다양한 물질들의 표면에 접착하며 수분에 강하고 인체에 무해하며 생분해되는 특성을 가지고 있다. 여러 가지의 홍합접착단백질들이 홍합으로부터 발견되어 그 특성들이 연구되었으며 홍합의 접착기작에 대한 생화학적 지식들이 축적되어 왔다. 또한 이렇게 가능성이 높은 해양홍합유래의 바이오-접착소재를 현실화하려는 많은 노력들이 시도되어 왔다. 본 고에서는 홍합접착단백질의 기능적 생산에 초점을 맞추어 다양한 개발 접근방법들의 진행들의 추이를 정리하였다.

• Journal of Adhesion and Interface
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• v.1 no.1
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• pp.56-62
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• 2000

• Journal of Veterinary Clinics
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• v.29 no.4
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• pp.319-322
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• 2012

This case presents application of bioadhesive for inguinal hernia repair of Jeju native pigs. An inguinal hernia was diagnosed in Jeju native pigs, respectively, 3 days of age and 30 days of age, by physical and radiographic examination. Inguinal herniorrhaphy was performed under sedation with azaperone. After excision of scrotal sac, gently separated testis and intestinal loops. Herniated testis was isolated from scrotal sac and intestinal loops were replaced in the abdominal cavity. The external inguinal ring surface and skin closed using the technique of tissue adhesive. The patients were recovered without post-operative complications. This result considered that bioadhesive application could be a simple method to reduction of scrotal hernia without post-treatment like removal of sutures.

• Journal of Adhesion and Interface
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• v.23 no.3
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• pp.70-74
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• 2022

Tannic acid, one of plant-derived polyphenols, has been studied as a molecular adhesive, surface modification, energy storage and generating device, and biomedical application as it can interact with biopolymers. In this study, we synthesized porous silica nanoparticles that are widely used in biomedical engineering fields such as drug delivery and bioimaging, and then analyzed tannic acid mediated surface modification of mesoporous silica nanoparticles.