• Applied Chemistry for Engineering
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• v.34 no.2
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• pp.121-125
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• 2023

Casein is a milk protein and one of the most important nutrients in milk. The composition is over 80% in cow's milk and about 20~45% in human's milk. Casein is highly biocompatible and biodegradable, so it has been studied for various biomedical materials applications as well as drug delivery systems. It is widely known that casein can be prepared as nanoparticles in the presence of the Ca²⁺ metal ion. Because casein is amphiphilic, hydrophobic drugs could be loaded inside to form a protein-based drug delivery system. In this study, we studied the optimum conditions for casein nanoparticle formation using natural metal ions present in the body, such as calcium, magnesium, zinc, and iron. It was confirmed that nanoparticles have a uniform size of around 150 nm and negative zeta potential values. In addition, it was demonstrated that casein nanoparticles have a cell viability of more than 80% and efficient intracellular uptake properties using confocal microscopy. From the results, it was also shown that the casein nanoparticles prepared using various metal ions have the potential to be biocompatible drug delivery carriers.

• Journal of agriculture & life science
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• v.46 no.1
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• pp.91-103
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• 2012

The aim of this study was to develop a rapid and cheap bioassay of four lignans (schisandrin, schisandrin C, the gomisin A and gomisin N) isolated from Schizandra chinensis Baill on seed germination and seedling growth of the radish. Its structure was determined by analysis of MS and NMR spectroscopic data. Radish seeds immersed for 1 hr in the solutions of $10^{-5}M$, $10^{-6}M$ and $10^{-7}M$ of schisandrin, schisandrin C, gomisin A, and gomisin N, seed germination was observed with in 60 hr after all of the treatments. Also, the seeds were germinated faster compared to untreated controls. At early germination stage, 48 hr after the treatment of the lignans, the suppression of germination was observed from all treatments; the suppression due to schisandrin and gomisin A was the highest at the concentration of $10^{-6}M$. The level of suppression increased as the concentration increased in the treatment of schisandrin C and gomisin N. Percent germination of seed after 184 hr was increased 90% at all treatments. For the effects of lignan treatment on seedling growth in radish, the growth of hypocotyl was promoted by gomisin A and gomisin N at all concentrations. Root elongation was significantly promoted by schisandrin and gomisin N at $10^{-5}M$ and $10^{-6}M$, respectively. Fresh and dry weights of the seedlings were high at a low concentration of $10^{-7}M$, but significantly reduced by schisandrin C at a high concentration of $10^{-5}M$. The results of the germination activity and seedling growth of the lignans from S. chinensis suggest their potential use as natural growth regulators.

• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.7
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• pp.1073-1077
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• 2010

This study was aimed to evaluate the estimated availabilities and contents of major minerals (Ca, P, and Mg) in seven different seaweeds using the neutral detergent fiber (NDF) which could bind minerals. The estimated availability was calculated by subtracting the NDF-bound major mineral contents from the total major mineral contents of seaweeds. Average estimated availability of Ca, P, and Mg contents of seven seaweeds were 96.31, 73.24, and 96.79%, respectively. These results may suggest that seaweeds could be one of the good sources of major minerals for human nutrition because of their high average estimated availabilities of Ca, P, and Mg.

• Journal of Bio-Environment Control
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• v.18 no.4
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• pp.316-325
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• 2009

Adequate conditions of water content and aeration of container media are major environmental factors in the production of pot plant. This experiment was carried out to find optimum physical property of media for the production of small potted Ardisia in capillary mat irrigation system. The plant materials used in this experiment were Ardisia pusilla and Ardisia japonica. Seven substrates were formulated by blending perlite or fresh rice hulls at 20%, 40%, 60% (v/v) with sphagnum peat. Total pore space (TPS) increased by blending sphagnum peat with fresh rice hulls, but decreased by blending sphagnum peat with perlite. As fresh rice hull (FRH) and perlite content increased, air filled pore space (AFP) of substrate increased but container capacity (CC) decreased. Substrate blended with fresh rice hull was higher AFP than blended with perlite and the rate of increase was higher for FRH-containing substrate. As AFP increased, the $CO_2$ concentration in the pot decreased and the $CO_2$ concentration of substrate blended with FRH was higher than blended with perlite. The fresh and dry weight of Ardisia pusilla and A. japonica was the highest in the substrate contained 60% FRH, but the ratio of shoot dry weight to root dry weight was the lowest. The optimum total pore space, air-filled pore space, water holding capacity of substrate for the growth of Ardisia pusilla and A. japonica in the capillary mat irrigation system were 82.8%, 25.6%, and 57.2% respectively.

• Horticultural Science & Technology
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• v.16 no.1
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• pp.37-39
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• 1998

This study was carried out to investigate the effects of nutrient solution concentration, irrigation frequency on growth, flowering, and cut flower longevity of Dendranthema grandiflorum (Ramat.) Kitamura 'Shuhouno-chikara' hydroponically grown in perlite media. Not only stem length but also mineral contents of each plant organ in nutrient solution culture were much higher than those in soil culture. 1/2S of nutrient solution was good at early stage, but 1S of nutrient solution was better as chrysanthemum growth progressed. Among different concentrations of nutrient solution, mineral contents of each plant part showed no significant difference. 1S treatment of nutrient solution increased the vase life by 3 days than 2S treatment. The growth and mineral contents of each plant organ were great in plants irrigated 8 times a day, because of high moisture contents of medium and high water availability, followed by more frequent nutrient replenishment near roots. There was no correlation between nutrient solution concentration and vase life of cut flower grown in nutrient solution culture. Cut flowers irrigated twice per day had the longer vase life than other treatments (4, 8 times).

• Journal of Life Science
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• v.12 no.6
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• pp.731-739
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• 2002

The growth of V. parahaemolyticus was inhibited by the combination of natural products having antioxidative capacity. The growth of V. parahaemolyticus was controlled effectively by each or the combination of Paeonia japonica, Acanthodanacis cortex, Phellodendri cortex, Mori cortex radicis, Theae folium, Galla rhois, Coptidis rhizomn and Astragali radix. The growth inhibition ratio of the combination of Astragali radix, Phellodendri cortex, Coptidis rhizotna and Paeonia japonica was 95%, and its antioxidative capacity was also 5.4 times higher, and the elimination ratio of hydroxyl radical was more than 80% compared with control. As natural products might activate some parts of human body, they could be utilized as pharmaceuitcal applications, functional foods, antiaging tea, and multifunctional fermentative beverages.

• Journal of the Korean Society of Food Science and Nutrition
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• v.31 no.6
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• pp.1119-1125
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• 2002

The growth of C. pefringens was inhibited by the combination of natural products which have antioxidative capacity C. perfringens was controlled very effectively by each or the combination of Paeonia japonica, Atractylodis rhizome alba, Epimedii herba, Acori graminei rhizoma, Schizandraefructus, Lyciifructus, Cinnamomi cortex Sophorae flos Phellodendri cortex, Nelumbo nuclfera gaertner, Asparagi tuber, Mori cortex radicis, Astrafali radix and Coptidis rhizome The combination of Phellodendri cortex, Epimedii herba, Astragali radtx and Glycyrrhizae radix inhibited the growth of C. pefringen by 75% and increased the antioxidative activity by 4.4 times. This combination also eliminated more than 80% of hydroxyl radical. These natural products can be utilized as pharmaceuticals, functional foods, antiaging tea, and multifunctional fermentative beverages.

• Radiation Oncology Journal
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• v.20 no.2
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• pp.186-192
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• 2002

Purpose : Measurement of transmission dose is useful for in vivo dosimetry. In this study, previous algorithm for estimation of transmission dose was modified for use in cases with tissue deficit. Materials and Methods : The beam data was measured with flat solid phantom in various conditions of tissue deficit. New algorithm for correction of transmission dose for tissue deficit was developed by physical reasoning. The algorithm was tested in experimental settings with irregular contours mimicking breast cancer patients using multiple sheets of solid phantoms. Results : The correction algorithm for tissue deficit could accurately reflect the effect of tissue deficit with errors within ${\pm}1.0\%$ in most situations and within ${\pm}3.0\%$ in experimental settings with irregular contours mimicking breast cancer treatment set-up. Conclusion : Developed algorithm could accurately reflect the effect of tissue deficit and irregularly shaped body contour on transmission dosimetry.

• Journal of the Korea Organic Resources Recycling Association
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• v.5 no.2
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• pp.39-45
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• 1997

This study was performed to investigate the growth response of earthworm (Eisenia foetida) in cow manure added Cadmium (Cd) and therefore, to estimate the toxic threshold level of Cadmium and the levels of Cadmium in cow manure for obtain-ing the maximum Cadmium-concentration enable to accumulate in earthworm tis-sue. Seven different concentrations of Cadmium added in cow manure were 0 (control), 50, 100, 200, 400, 800, 1600 mg/kg, respectively. Survival rate (SR), mean fresh weight of adult worm at final time ($FW_2$), increasing rate (IR), number of cocoon (NC), number of young worm (NY) and residual matter (RW) were not significantly different among Cadmium concentrations in cow manure. Of the measured growth-characteristics, survival rate (SR) had a significantly positive correlation (p<0.001) with number of cocoon (NC). But mean fresh weight of adult worm at final time ($FW_2$) had a significantly negative correlation (p<0.05) with residual matter of cow manure. The maximum Cadmium concentration accumulated in tissue was ranged from 283.8 mg/kg to 396.2 mg/kg. It was obtained at the level of 956.5 mg/kg and 1116.6 mg/kg in cow manure added Cadmium, respectively.

• Journal of Biomedical Engineering Research
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• v.25 no.6
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• pp.489-496
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• 2004

Insertion of cannulae into vessels may disturb the blood flow doing non-physiological load and stress on blood cells such that ADP may increase and result in hemolysis. Authors used the computational method to simulate the 3-dimensional blood flow inside of the cannula using numerical method. We limited the research to within the drainage cannulae with side holes inserted through the human vein. In this paper, 9 different cannulae with side holes categorized by the number of side holes of 4, 12, and 20, and also categorized by the array type of side holes of staggered array, in-line array, and alternative in-line array were studied and compared to the cannula with no side holes by using CFD analysis. We evaluated the flow rate, the wall shear stress, and the shear rate and compared them with one another to estimate the effect of the side holes. The flow rate is not proportional to the number of the side holes. However, larger number of side holes can reduce the mean shear rate. Both the number and the array type of side holes play an important role on the fluid dynamics of the blood flow in cannulae.